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Chemistry

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Also known as: 19237-84-4, Prazosin hcl, Minipress, Vasoflex, Peripress, Furazosin hydrochloride
Molecular Formula
C19H22ClN5O4
Molecular Weight
419.9  g/mol
InChI Key
WFXFYZULCQKPIP-UHFFFAOYSA-N
FDA UNII
X0Z7454B90

Prazosin Hydrochloride
A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
1 2D Structure

Prazosin Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone;hydrochloride
2.1.2 InChI
InChI=1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
2.1.3 InChI Key
WFXFYZULCQKPIP-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC.Cl
2.2 Other Identifiers
2.2.1 UNII
X0Z7454B90
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Furazosin

2. Hcl, Prazosin

3. Hydrochloride, Prazosin

4. Minipress

5. Pratsiol

6. Prazosin

7. Prazosin Hcl

2.3.2 Depositor-Supplied Synonyms

1. 19237-84-4

2. Prazosin Hcl

3. Minipress

4. Vasoflex

5. Peripress

6. Furazosin Hydrochloride

7. Minipress Xl

8. Hypovase

9. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine Hydrochloride

10. Cp-12299-1

11. Prazosin (hydrochloride)

12. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine Monohydrochloride

13. Cp-12,299-1

14. Prazosinhydrochloride

15. (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)methanone Hydrochloride

16. [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone;hydrochloride

17. Mls000028454

18. Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-, Monohydrochloride

19. Nsc-292810

20. X0z7454b90

21. Deprazolin

22. Hypovasole

23. Pratsiol

24. Sinetens

25. Smr000058384

26. Minipress (tn)

27. 19237-84-4 (hcl)

28. 2-(4-(2-furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline Hydrochloride

29. 2-{4-[(furan-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine Hydrochloride

30. Chebi:8365

31. Hsdb 3298

32. Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanyl-, Hydrochloride (1:1)

33. C19h21n5o4.hcl

34. Nsc 292810

35. Prazosin Clorhidrato [spanish]

36. Prazosine Hydrochloride

37. Sr-01000003052

38. Einecs 242-903-4

39. Mfcd00058177

40. Unii-x0z7454b90

41. Pressin And Hypovase

42. Prazosin Hydrochloride [usan:usp:jan]

43. Prazosin Hydrochloride;

44. Opera_id_370

45. Chembl1558

46. Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-, Monohydrochloride

47. Schembl41257

48. Mls001148201

49. Mls001333696

50. Mls002153280

51. Mls002222304

52. Spectrum1500495

53. Prazosin Hcl (furazosin Hcl)

54. Piperazin-1-yl)(furan-2-yl)

55. Hy-b0193a

56. Dtxsid50172822

57. Hms1570n16

58. Hms1920j10

59. Pharmakon1600-01500495

60. Prazosin Hydrochloride [mi]

61. Bcp13643

62. Prazosin Hydrochloride (jp17/usp)

63. Prazosin Hydrochloride [jan]

64. Tox21_501002

65. Ac-699

66. Ccg-39227

67. Nsc292810

68. Nsc757286

69. Prazosin Hydrochloride [hsdb]

70. Prazosin Hydrochloride [usan]

71. S1424

72. Prazosin Hydrochloride [vandf]

73. Akos015895394

74. Prazosin Hydrochloride [mart.]

75. Af-0012

76. H37p844

77. Lp01002

78. Nsc-757286

79. Prazosin Hydrochloride [usp-rs]

80. Prazosin Hydrochloride [who-dd]

81. Sb17352

82. Prazosin Hydrochloride, >=99% (tlc)

83. Quinazoline, 4-amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)-, Hydrochloride

84. Ncgc00094296-01

85. Ncgc00094296-02

86. Ncgc00094296-03

87. Ncgc00094296-04

88. Ncgc00094296-05

89. Ncgc00261687-01

90. Ba164294

91. Db-044795

92. Prazosin Hydrochloride [ep Impurity]

93. Prazosin Hydrochloride [orange Book]

94. Eu-0101002

95. P0938

96. Prazosin Hydrochloride [ep Monograph]

97. Prazosin Hydrochloride [usp Monograph]

98. D00609

99. H11453

100. Minizide Component Prazosin Hydrochloride

101. Prazosin Hydrochloride 100 Microg/ml In Methanol

102. Prazosin Hydrochloride Component Of Minizide

103. Sr-01000003052-2

104. Sr-01000003052-8

105. W-107719

106. Q27108060

107. Piperazine,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-, Monohydrochloride

108. Prazosin Hydrochloride, European Pharmacopoeia (ep) Reference Standard

109. Prazosin Hydrochloride, United States Pharmacopeia (usp) Reference Standard

110. 1-(4-amino-6,7-dimethoxy-2-quinazol Inyl)-4-(2-furanylcarbonyl)piperazine Hydrochloride

111. Piperazine,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-, Monohydrochloride

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 419.9 g/mol
Molecular Formula C19H22ClN5O4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass419.1360319 g/mol
Monoisotopic Mass419.1360319 g/mol
Topological Polar Surface Area107 Ų
Heavy Atom Count29
Formal Charge0
Complexity544
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NamePrazosin hydrochloride
Drug LabelPrazosin hydrochloride, a quinazoline derivative, is the first of a new chemical class of antihypertensives. It is the hydrochloride salt of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl) piperazine and its structural formula is:Prazosin hydro...
Active IngredientPrazosin hydrochloride
Dosage FormCapsule
Routeoral; Oral
Strengtheq 5mg base; eq 2mg base; eq 1mg base
Market StatusPrescription
CompanyIvax Sub Teva Pharms; Teva Pharms; Mylan

2 of 2  
Drug NamePrazosin hydrochloride
Drug LabelPrazosin hydrochloride, a quinazoline derivative, is the first of a new chemical class of antihypertensives. It is the hydrochloride salt of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl) piperazine and its structural formula is:Prazosin hydro...
Active IngredientPrazosin hydrochloride
Dosage FormCapsule
Routeoral; Oral
Strengtheq 5mg base; eq 2mg base; eq 1mg base
Market StatusPrescription
CompanyIvax Sub Teva Pharms; Teva Pharms; Mylan

4.2 Therapeutic Uses

Adrenergic alpha-Antagonists; Antihypertensive Agents; Sympatholytics

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


Prazosin hydrochloride is used in the management of hypertension. Prazosin's efficacy in hypertensive patients is similar to that of thiazide diuretics, beta-adrenergic blocking agents, hydralazine, and centrally acting adrenergic inhibitors (eg, clonidine, methyldopa). ... Prazosin has been shown to be effective in the management of hypertension in patients undergoing chronic hemodialysis, and the drug may be particularly useful in the acute management of severe hypertension in patients with increased concentrations of circulating catecholamines.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1860


Prazosin has been used with good results alone or in combination with a beta-adrenergic blocking agent for the preoperative management of the signs and symptoms of pheochromocytoma in a limited number of patients; however, these patients may be particularly susceptible to a marked hypotensive response to the initial dose of prazosin. Limited data also suggest that prazosin may be useful for the treatment of Raynaud's disease or phenomenon and ergotamine induced peripheral ischemia.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1861


Prazosin may be used as an adjunct to digoxin and diuretics for the treatment of congestive heart failure. However, prazosin has not been shown to improve survival in these patients. /NOT included in US product labeling/

MICROMEDEX Thomson Health Care. USPDI - Drug Information for the Health Care Professional. 22nd ed. Volume 1. MICROMEDEX Thomson Health Care, Greenwood Village, CO. 2002. Content Reviewed and Approved by the U.S. Pharmacopeial Convention, Inc., p. 2430


For more Therapeutic Uses (Complete) data for PRAZOSIN HYDROCHLORIDE (11 total), please visit the HSDB record page.


4.3 Drug Warning

May cause syncope with sudden loss of consciousness, usually attributable to an excessive postural hypotensive effect; risk may be reduced by limiting the initial dose of the drug to 1 mg, and by subsequently increasing the dosage slowly. Adverse reactions include dizziness, drowsiness, and other CNS effects; patients should be cautioned regarding activities such as driving and operating machinery, as well as interactions with other CNS acting drugs including alcohol. Other adverse reactions include palpitations and nausea. The concurrent use of a beta-adrenergic blocking agent may increase the risk of hypotension. /Prazosin hydrochloride/

Hussar, D.A. (ed.). Modell's Drugs in Current Use and New Drugs. 38th ed. New York, NY: Springer Publishing Co., 1992., p. 135


When prazosin is used as a fixed-combination preparation that includes polythiazide, the cautions, precautions, and contraindications associated with thiazide diuretics must be considered in addition to those associated with prazosin.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1862


Caution should be used when adding prazosin to a preexisting antihypertensive regimen or when adding other hypotensive agents to a prazosin regimen in order to avoid a possible rapid fall in blood pressure. Caution should be used when administering prazosin to patients with chronic renal failure as they may require only small doses of the drug.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1862


Prazosin has been used alone or in combination with other hypotensive agents for the management of severe hypertension in a limited number of pregnant women without apparent adverse effect on the fetus. There are no adequate and well controlled studies to date using prazosin in pregnant women, however, and the drug should be used during pregnancy only when the potential benefits justify the possible risks to the fetus.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1862


For more Drug Warnings (Complete) data for PRAZOSIN HYDROCHLORIDE (18 total), please visit the HSDB record page.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Adrenergic alpha-1 Receptor Antagonists

Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Antagonists.)


Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
alpha-Adrenergic Blocker [EPC]; Adrenergic alpha-Antagonists [MoA]
5.3 Absorption, Distribution and Excretion

There is intraindividual and interindividual variation in the rate of absorption and plasma concentrations of prazosin. The absolute oral bioavailability of prazosin is also variable but is reported to average about 60% (range: 43-82%). Results of one study indicate that the presence of food may delay absorption of the drug in some patients, but does not affect the extent of absorption.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1863


Following oral administration of prazosin hydrochloride, plasma concentrations of the drug reach a peak in 2-3 hrs in most fasting patients. Plasma concentrations of prazosin generally do not correlate with therapeutic effect. One manufacturer reports that plasma concentrations of the drug after a single 5 mg dose range from 0.01-0.075 ug/ml. Blood pressure begins to decrease within 2 hr after an oral dose; the maximum decrease occurs in 2-4 hr. The hypotensive effect of prazosin lasts less than 24 hr.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1863


Animal studies indicate that prazosin is widely distributed in body tissues. After iv administration in dogs, highest concentrations of the drug are found in the lungs, coronary arteries, aorta, paw arteries and heart; the lowest concentrations are in the brain. During prazosin therapy, approximately 97% of the drug in plasma is bound to proteins. It is not known whether the drug crosses the placenta. Prazosin is distributed into milk in small amounts.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1863


Approximately 6-10% of a dose is excreted in urine and the remainder in feces via bile.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1863


The drug /prazosin hydrochloride/ is tightly bound to plasma proteins (primarily alpha1-acid glycoprotein), and only 5% of the drug is free in the circulation; diseases that modify the concentration of this protein (e.g., inflammatory processes) may change the free fraction. Prazosin is extensively metabolized in the liver, and little unchanged drug is excreted by the kidneys.

Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 246


5.4 Metabolism/Metabolites

Animal studies show that prazosin hydrochloride is metabolized extensively in the liver, principally by demethylation and conjugation, and excreted as unchanged drug (5-11%) and metabolites. Four of the metabolites have been shown to possess 10-25% of the hypotensive activity of prazosin and they may contribute to the antihypertensive effect of the drug.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1863


The 6-O-demethyl and 7-O-demethyl analogues of the new antihypertensive drug prazosin [2-[4-(2-furoyl)-piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline hydrochloride] have been unequivocally synthesized via separate 10-step reaction sequences starting from isovanillin and vanillin, respectively. The 6-O-demethyl derivative was found to be identical with the major prazosin metabolite formed in dog and rat, while the 7-O-demethyl derivative was identical with another, less prevalent but significant metabolite. Two minor metabolites of prazosin, 2-(1-piperazinyl)-4-amino-6,7-dimethoxyquinazoline and 2,4-diamino-6,7-dimethoxyquinazoline, are also described. All 4 metabolites are less potent blood pressure lowering agents in dogs than prazosin but may contribute to its antihypertensive effect, since they account for a major portion of the administered dose.

PMID:833813 Althius T, Hess H; J Med Chem 20 (1): 146-9 (1977)


5.5 Biological Half-Life

Elimination half-life approx 3 hr.

Haddad, L.M., Clinical Management of Poisoning and Drug Overdose. 2nd ed. Philadelphia, PA: W.B. Saunders Co., 1990., p. 1348


The plasma half-life of prazosin after oral administration has been reported to be 2-4 hr.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1863


5.6 Mechanism of Action

Animal studies indicate that prazosin does not have its antihypertensive effect in the CNS. Prazosin does not interfere with nerve impulse transmission across sympathetic ganglia nor does it cause adrenergic neuronal blockade.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 1862


The exact mechanism of the hypotensive action of prazosin is unknown. Prazosin causes a decrease in total peripheral resistance and was originally thought to have a direct relaxant action on vascular smooth muscle. Animal studies have suggested that the vasodilator effect of prazosin is also related to blockade of postsynaptic alpha-adrenoceptors. The results of dog forelimb experiments demonstrate that that the peripheral vasodilator effect of prazosin is confined mainly to the level of the resistance vessels (arterioles). Unlike conventional alpha- blockers, the antihypertensive action of prazosin is usually not accompanied by reflex tachycardia.

Medical Economics Co; Physicians Desk Reference 56th ed p. 2699 (2002)


Prazosin ... is a very potent and selective alpha 1-adrenergic antagonist. ... Interestingly, the drug also is a relatively potent inhibitor of cyclic nucleotide phosphodiesterases...

Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 246


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28-Jan-2025
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DOSAGE - CAPSULE;ORAL - EQ 1MG BASE

USFDA APPLICATION NUMBER - 17442

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DOSAGE - CAPSULE;ORAL - EQ 2MG BASE

USFDA APPLICATION NUMBER - 17442

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DOSAGE - CAPSULE;ORAL - EQ 5MG BASE

USFDA APPLICATION NUMBER - 17442

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ABOUT THIS PAGE

Looking for 19237-84-4 / Prazosin Hydrochloride API manufacturers, exporters & distributors?

Prazosin Hydrochloride manufacturers, exporters & distributors 1

13

PharmaCompass offers a list of Prazosin Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Prazosin Hydrochloride manufacturer or Prazosin Hydrochloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Prazosin Hydrochloride manufacturer or Prazosin Hydrochloride supplier.

PharmaCompass also assists you with knowing the Prazosin Hydrochloride API Price utilized in the formulation of products. Prazosin Hydrochloride API Price is not always fixed or binding as the Prazosin Hydrochloride Price is obtained through a variety of data sources. The Prazosin Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Prazosin Hydrochloride

Synonyms

19237-84-4, Prazosin hcl, Minipress, Vasoflex, Peripress, Furazosin hydrochloride

Cas Number

19237-84-4

Unique Ingredient Identifier (UNII)

X0Z7454B90

About Prazosin Hydrochloride

A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.

Prazosin HCL Manufacturers

A Prazosin HCL manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Prazosin HCL, including repackagers and relabelers. The FDA regulates Prazosin HCL manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Prazosin HCL API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Prazosin HCL manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Prazosin HCL Suppliers

A Prazosin HCL supplier is an individual or a company that provides Prazosin HCL active pharmaceutical ingredient (API) or Prazosin HCL finished formulations upon request. The Prazosin HCL suppliers may include Prazosin HCL API manufacturers, exporters, distributors and traders.

click here to find a list of Prazosin HCL suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Prazosin HCL USDMF

A Prazosin HCL DMF (Drug Master File) is a document detailing the whole manufacturing process of Prazosin HCL active pharmaceutical ingredient (API) in detail. Different forms of Prazosin HCL DMFs exist exist since differing nations have different regulations, such as Prazosin HCL USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Prazosin HCL DMF submitted to regulatory agencies in the US is known as a USDMF. Prazosin HCL USDMF includes data on Prazosin HCL's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Prazosin HCL USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Prazosin HCL suppliers with USDMF on PharmaCompass.

Prazosin HCL CEP

A Prazosin HCL CEP of the European Pharmacopoeia monograph is often referred to as a Prazosin HCL Certificate of Suitability (COS). The purpose of a Prazosin HCL CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Prazosin HCL EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Prazosin HCL to their clients by showing that a Prazosin HCL CEP has been issued for it. The manufacturer submits a Prazosin HCL CEP (COS) as part of the market authorization procedure, and it takes on the role of a Prazosin HCL CEP holder for the record. Additionally, the data presented in the Prazosin HCL CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Prazosin HCL DMF.

A Prazosin HCL CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Prazosin HCL CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Prazosin HCL suppliers with CEP (COS) on PharmaCompass.

Prazosin HCL WC

A Prazosin HCL written confirmation (Prazosin HCL WC) is an official document issued by a regulatory agency to a Prazosin HCL manufacturer, verifying that the manufacturing facility of a Prazosin HCL active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Prazosin HCL APIs or Prazosin HCL finished pharmaceutical products to another nation, regulatory agencies frequently require a Prazosin HCL WC (written confirmation) as part of the regulatory process.

click here to find a list of Prazosin HCL suppliers with Written Confirmation (WC) on PharmaCompass.

Prazosin HCL NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Prazosin HCL as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Prazosin HCL API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Prazosin HCL as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Prazosin HCL and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Prazosin HCL NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Prazosin HCL suppliers with NDC on PharmaCompass.

Prazosin HCL GMP

Prazosin HCL Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Prazosin HCL GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Prazosin HCL GMP manufacturer or Prazosin HCL GMP API supplier for your needs.

Prazosin HCL CoA

A Prazosin HCL CoA (Certificate of Analysis) is a formal document that attests to Prazosin HCL's compliance with Prazosin HCL specifications and serves as a tool for batch-level quality control.

Prazosin HCL CoA mostly includes findings from lab analyses of a specific batch. For each Prazosin HCL CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Prazosin HCL may be tested according to a variety of international standards, such as European Pharmacopoeia (Prazosin HCL EP), Prazosin HCL JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Prazosin HCL USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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