Corticosteroids diffuse across cell membranes and complex with specific cytoplasmic receptors. These complexes then enter the cell nucleus, bind to DNA (chromatin), and stimulate transcription of messenger RNA (mRNA) and subsequent protein synthesis of various inhibitory enzymes responsible for the anti-inflammatory effects of topical corticosteroids. These anti-inflammatory effects include inhibition of early processes such as edema, fibrin deposition, capillary dilatation, movement of phagocytes into the area, and phagocytic activities. Later processes, such as capillary production, collagen deposition, and keloid formation also are inhibited by corticosteroids.

Molecular Formula	C₂₇H₃₆O₈
Molecular Weight	488.6 g/mol
XLogP3	4.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	488.24101810 g/mol
Monoisotopic Mass	488.24101810 g/mol
Topological Polar Surface Area	116 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	982
Isotope Atom Count	0
Defined Atom Stereocenter Count	7
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

1 of 6
Drug Name	Dermatop
PubMed Health	Prednicarbate (Topical application route)
Drug Classes	Adrenal Glucocorticoid, Corticosteroid, Intermediate
Drug Label	DERMATOP Ointment (prednicarbate ointment) 0.1% contains the non-halogenated prednisolone derivative prednicarbate. The topical corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and anti-pruritic...
Active Ingredient	Prednicarbate
Dosage Form	Ointment
Route	Topical
Strength	0.1%
Market Status	Prescription
Company	Valeant Bermuda

2 of 6
Drug Name	Dermatop e emollient
PubMed Health	Prednicarbate (Topical application route)
Drug Classes	Adrenal Glucocorticoid, Corticosteroid, Intermediate
Drug Label	DERMATOP Ointment (prednicarbate ointment) 0.1% contains the non-halogenated prednisolone derivative prednicarbate. The topical corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and anti-pruritic...
Active Ingredient	Prednicarbate
Dosage Form	Cream
Route	Topical
Strength	0.1%
Market Status	Prescription
Company	Valeant Bermuda

3 of 6
Drug Name	Prednicarbate
Active Ingredient	Prednicarbate
Dosage Form	Ointment; Cream
Route	Topical
Strength	0.1%
Market Status	Prescription
Company	Fougera Pharms

4 of 6
Drug Name	Dermatop
PubMed Health	Prednicarbate (Topical application route)
Drug Classes	Adrenal Glucocorticoid, Corticosteroid, Intermediate
Drug Label	DERMATOP Ointment (prednicarbate ointment) 0.1% contains the non-halogenated prednisolone derivative prednicarbate. The topical corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and anti-pruritic...
Active Ingredient	Prednicarbate
Dosage Form	Ointment
Route	Topical
Strength	0.1%
Market Status	Prescription
Company	Valeant Bermuda

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

8 API Suppliers

2 USDMF

3 CEP/COS

1 KDMF

4 NDC API

6 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

29 FDF Dossiers

4 FDA Orange Book

21 Europe

1 Canada

3 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

OINTMENT;TOPICAL - 0.1% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

CREAM;TOPICAL - 0.1% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

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8 BASF

1 Finar

5 Microlex e.U

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1 Seppic

1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Valens Pharmachem

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EXCIPIENTS BY APPLICATIONS

14 Topical

8 Lubricants & Glidants

5 Fillers, Diluents & Binders

4 Emulsifying Agents

4 Thickeners and Stabilizers

3 Solubilizers

2 API Stability Enhancers

2 Film Formers & Plasticizers

1 Direct Compression

1 Surfactant & Foaming Agents

1 Controlled & Modified Release

1 Parenteral

1 Co-Processed Excipients

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions

21 Finished Drug Prices

MARKET PLACE

1 APIs

REF. STANDARDS & IMPURITIES

2 EDQM

4 USP

4 Others

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

47EXCIPIENTS BY APPLICATIONS

01

02

02

CEP 2011-144 - Rev 03

Valid

Chemical

OINTMENT;TOPICAL - 0.1% Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

CREAM;TOPICAL - 0.1% Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons