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Chemistry

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Also known as: 145-13-1, Arthenolone, 3beta-hydroxypregn-5-en-20-one, Pregnetan, Pregneton, Pregnolon
Molecular Formula
C21H32O2
Molecular Weight
316.5  g/mol
InChI Key
ORNBQBCIOKFOEO-QGVNFLHTSA-N
FDA UNII
73R90F7MQ8

Pregnenolone
A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.
1 2D Structure

Pregnenolone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
2.1.2 InChI
InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1
2.1.3 InChI Key
ORNBQBCIOKFOEO-QGVNFLHTSA-N
2.1.4 Canonical SMILES
CC(=O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
2.1.5 Isomeric SMILES
CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
2.2 Other Identifiers
2.2.1 UNII
73R90F7MQ8
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5 Pregnen 3 Beta Ol 20 One

2. 5-pregnen-3-beta-ol-20-one

2.3.2 Depositor-Supplied Synonyms

1. 145-13-1

2. Arthenolone

3. 3beta-hydroxypregn-5-en-20-one

4. Pregnetan

5. Pregneton

6. Pregnolon

7. Prenolon

8. Regnosone

9. Skinostelon

10. Enelone

11. 5-pregnen-3beta-ol-20-one

12. Natolone

13. Bina-skin

14. Delta5-pregnenolone

15. 5-pregnen-3-beta-ol-20-one

16. (3beta)-3-hydroxypregn-5-en-20-one

17. 5-pregnenolone

18. 3-beta-hydroxypregn-5-en-20-one

19. Nsc 1616

20. Prestwick_859

21. Pregn-5-en-20-one, 3-hydroxy-, (3beta)-

22. Prestwick3_000546

23. Pregnenolone (jan/inn)

24. Pregn-5-en-20-one, 3beta-hydroxy-

25. 3b-hydroxy-5-pregnen-20-one

26. 1-[(3s,8s,9s,10r,13s,14s,17s)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl]ethanone

27. Pregn-5-en-20-one, 3-hydroxy-, (3b)-

28. Pregn-5-ene-3beta-ol-20-one

29. Chebi:16581

30. 73r90f7mq8

31. 3.beta.-hydroxypregn-5-en-20-one

32. 3beta-hydroxy-5-pregnen-20-one

33. Dsstox_cid_16541

34. Dsstox_rid_79287

35. Dsstox_gsid_36541

36. 5-pregnen-3beta;-ol-20-one

37. Pregnenolona

38. Pregnenolonum

39. Pregnenolone [inn:ban]

40. Pregnenolonum [inn-latin]

41. Pregnenolona [inn-spanish]

42. Plo

43. Smr000112161

44. .delta.5-pregnenolone

45. Pregnenolone (3beta-hydroxypregn-5-en-20-one)

46. Sr-05000002128

47. Einecs 205-647-4

48. 3-hydroxypregn-5-en-20-one

49. 5-pregnen-3.beta.-ol-20-one

50. Pregnolone

51. Nsc-1616

52. Unii-73r90f7mq8

53. Nsc-18158

54. Pregn-5-en-20-one, 3-hydroxy-, (3-beta)-

55. Ncgc00163125-02

56. Pregn-5-en-20-one, 3.beta.-hydroxy-

57. Cas-145-13-1

58. Pregn-5-en-20-one, 3-beta-hydroxy-

59. Prestwick0_000546

60. Prestwick1_000546

61. Prestwick2_000546

62. Spectrum5_002057

63. Pregnenolone [mi]

64. Pregnenolone [inn]

65. Pregnenolone [jan]

66. Bmse000476

67. 5-pregnen-3b-ol-20-one

68. Pregnenolone [vandf]

69. Bidd:pxr0019

70. Bspbio_000591

71. Mls002153868

72. Mls002207138

73. Pregn-5-en-3b-ol-20-one

74. Pregnenolone [who-dd]

75. Schembl129572

76. Pregn-5-ene-3b-ol-20-one

77. Spbio_002512

78. 3b-hydroxypregn-5-en-20-one

79. Bpbio1_000651

80. Chembl253363

81. Gtpl2376

82. Pregn-5-en-3beta-ol-20-one

83. Dtxsid1036541

84. Delta5-pregnen-3beta-ol-20-one

85. 3beta-hydroxy-5-pregenen-20-one

86. 3beta-hydroxy-5-pregnene-20-one

87. 3beta-hydroxypregn-5-ene-20-one

88. Hms1569n13

89. Hms2090j15

90. Hms2096n13

91. Hms2268a04

92. Hms3713n13

93. Hms3884g16

94. Delta5-pregenen-3beta-ol-20-one

95. Delta5-pregnene-3beta-ol-20-one

96. 1-((3s,8s,9s,10r,13s,14s,17s)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl)ethanone

97. 1-[(3s,8s,9s,10r,13s,14s,17s)-10,13-dimethyl-3-hydroxy-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]ethanone

98. Bcp23361

99. Hy-b0151

100. Zinc3861150

101. Tox21_112011

102. Tox21_302141

103. Bdbm50375319

104. Cmc_13393

105. Lmst02030088

106. Pregnenolone (progesterone Precursor)

107. S1914

108. 3beta-hydroxy-delta5-pregnen-20-one

109. Akos015841076

110. Akos015895418

111. Tox21_112011_1

112. (3b)-3-hydroxy-pregn-5-en-20-one

113. Ccg-220546

114. Cs-1970

115. Db02789

116. Ds-7794

117. Pregnenolone 0.1 Mg/ml In Acetonitrile

118. .delta.5-pregnen-3.beta.-ol-20-one

119. 5-pregnen-3beta-ol-20-one, >=98%

120. Ncgc00163125-03

121. Ncgc00163125-04

122. Ncgc00163125-06

123. Ncgc00255436-01

124. Ac-12806

125. Ac-32630

126. Bcp0726000217

127. Pregn-5-n-20-ne, 3-ydroxy-, (3)-

128. 3-hydroxypregn-5-en-20-one, (3.beta.)-

129. 3.beta.-hydroxy-.delta.5-pregnen-20-one

130. P0786

131. 3beta-3-hydroxy-pregn-5-en-20-one

132. (3alpha,8alpha)-3-hydroxypregn-5-en-20-one

133. C01953

134. D00143

135. 17beta-[1-ketoethyl]-delta5-androsten-3beta-ol

136. Pregn-5-en-20-one, 3-hydroxy-, (3.beta.)-

137. 145p131

138. Q412158

139. J-008059

140. Sr-05000002128-4

141. Sr-05000002128-5

142. .delta. Sup(5)-pregnen-3.beta.-ol-20-one

143. Brd-k43880410-001-14-4

144. 0f6367c4-e1fa-4aec-9846-7bcc5ada3417

145. Pregn-5-en-20-one, 3-(3-carboxy-, (3.beta.)-

146. 17.beta.-(1-ketoethyl)-.delta. Sup(5)-androsten-3.beta.-ol

147. 1-((3s,8s,10r,13s,17s)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl)-ethanone

148. 1-((3s,8s,9s,10r,13s,14s,17s)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl)ethan-1-one

149. 1-[(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16, 17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl)]ethanone

2.4 Create Date
2005-06-01
3 Chemical and Physical Properties
Molecular Weight 316.5 g/mol
Molecular Formula C21H32O2
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass316.240230259 g/mol
Monoisotopic Mass316.240230259 g/mol
Topological Polar Surface Area37.3 Ų
Heavy Atom Count23
Formal Charge0
Complexity550
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Metabolism/Metabolites

Pregnenolone has known human metabolites that include 1-(3,16-Dihydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone, 2-Hydroxy-1-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone, and Pregn-5-en-20-on-3b-yl sulfurate.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


API Reference Price

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","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"163","totalValueFC":"16455.4","currency":"USD","unitRateINR":"13789.8","date":"30-Sep-2024","totalValueINR":"1378980","totalValueInUsd":"16455.4","indian_port":"Ahmedabad Air","hs_no":"29420090","bill_no":"5875940","productDescription":"Intermediate","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NANJING","supplierAddress":"ADD:B1 BUILDING, CHINATOWN HONGKONG,ROAD,JIANGHAN DISTRICT WUHAN CHINA CN","customerAddress":"SUPER HOUSE, 79, TIRUPATI ESTATE,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728498600,"product":"16-DEHYDROPREGNENOLONE ACETATE (INTERMEDIATE)","address":"SUPER HOUSE, 79, TRUPATI ESTATE,","city":"AHMEDABD, GUJARAT, INDIA","supplier":"KHONSU INTERNATIONAL CO. 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05-Feb-2021
17-Oct-2024
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ABOUT THIS PAGE

Pregnenolone Manufacturers

A Pregnenolone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pregnenolone, including repackagers and relabelers. The FDA regulates Pregnenolone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pregnenolone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Pregnenolone manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Pregnenolone Suppliers

A Pregnenolone supplier is an individual or a company that provides Pregnenolone active pharmaceutical ingredient (API) or Pregnenolone finished formulations upon request. The Pregnenolone suppliers may include Pregnenolone API manufacturers, exporters, distributors and traders.

click here to find a list of Pregnenolone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Pregnenolone NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Pregnenolone as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Pregnenolone API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Pregnenolone as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Pregnenolone and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Pregnenolone NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Pregnenolone suppliers with NDC on PharmaCompass.

Pregnenolone GMP

Pregnenolone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Pregnenolone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pregnenolone GMP manufacturer or Pregnenolone GMP API supplier for your needs.

Pregnenolone CoA

A Pregnenolone CoA (Certificate of Analysis) is a formal document that attests to Pregnenolone's compliance with Pregnenolone specifications and serves as a tool for batch-level quality control.

Pregnenolone CoA mostly includes findings from lab analyses of a specific batch. For each Pregnenolone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Pregnenolone may be tested according to a variety of international standards, such as European Pharmacopoeia (Pregnenolone EP), Pregnenolone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pregnenolone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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