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Prestwick3_000105

Renejix: CDMO with expertise in small molecule oral dosage, delivery tech, and multi-modality manufacturing.

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15 API Suppliers, 7 USDMF, 4 EU WC, 9 NDC API, 7 Listed Suppliers, $ API Reference Price

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9 NDC API
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12 FDA Orange Book
3 Europe
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4 South Africa
3 Listed Dossiers

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Chemistry

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Also known as: Danocrine, 17230-88-5, Chronogyn, Winobanin, Danol, Cyclomen

Molecular Formula

C₂₂H₂₇NO₂

Molecular Weight

337.5 g/mol

InChI Key

POZRVZJJTULAOH-LHZXLZLDSA-N

FDA UNII

N29QWW3BUO

A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.

Danazol is an Androgen. The mechanism of action of danazol is as an Androgen Receptor Agonist.

1 2D Structure

Danazol

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1S,2R,13R,14S,17R,18S)-17-ethynyl-2,18-dimethyl-7-oxa-6-azapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-ol

2.1.2 InChI

InChI=1S/C22H27NO2/c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3/t16-,17+,18+,20+,21+,22+/m1/s1

2.1.3 InChI Key

POZRVZJJTULAOH-LHZXLZLDSA-N

2.1.4 Canonical SMILES

CC12CCC3C(C1CCC2(C#C)O)CCC4=CC5=C(CC34C)C=NO5

2.1.5 Isomeric SMILES

C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC5=C(C[C@]34C)C=NO5

2.2 Other Identifiers

2.2.1 UNII

N29QWW3BUO

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Azol

2. Cyclomen

3. Danatrol

4. Danazant

5. Danazol Ratiopharm

6. Danazol-ratiopharm

7. Danocrine

8. Danol

9. Danoval

10. Ladogal

11. Norciden

12. Panacrine

2.3.2 Depositor-Supplied Synonyms

1. Danocrine

2. 17230-88-5

3. Chronogyn

4. Winobanin

5. Danol

6. Cyclomen

7. Danazolum

8. Ladogal

9. Danzol

10. Danatrol

11. Danazol, Usp

12. Win-17757

13. Win 17,757

14. Danazole

15. N29qww3buo

16. (1r,3as,3br,10ar,10bs,12as)-1-ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1h-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol

17. Win 17757

18. Danovaol

19. Chebi:4315

20. Danokrin

21. Nsc-270916

22. Ncgc00164400-01

23. Danogen

24. Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol, (17alpha)-

25. Dsstox_cid_2880

26. Danazolum [inn-latin]

27. Nsc 270916

28. Dsstox_rid_76772

29. Dsstox_gsid_22880

30. Bonzol

31. Danocrine (tn)

32. Smr000058321

33. Ccris 6747

34. Einecs 241-270-1

35. Unii-n29qww3buo

36. Vasaloc

37. 17-alpha-pregn-4-en-20-yno(2,3-d)isoxazol-17-ol

38. Optina

39. Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol, (17alpha)-

40. 17-alpha-2,4-pregnadien-20-yno(2,3-d)isoxazol-17-ol

41. 17alpha-pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol

42. Nsc270916

43. Win 17, 757

44. Prestwick_150

45. Cas-17230-88-5

46. Danazol [usan:usp:inn:ban:jan]

47. Danazol [vandf]

48. Ethynyl(dimethyl)[?]ol

49. 2,3-isoxazolethisterone

50. Danazol [usan]

51. Danazol [inn]

52. Danazol [jan]

53. Danazol [mi]

54. Danazol [mart.]

55. Prestwick0_000105

56. Prestwick1_000105

57. Prestwick2_000105

58. Prestwick3_000105

59. Danazol [usp-rs]

60. Danazol [who-dd]

61. Chembl1479

62. Schembl21107

63. Bspbio_000090

64. (1s,2r,13r,14s,17r,18s)-17-ethynyl-2,18-dimethyl-7-oxa-6-azapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4(8),5,9-trien-17-ol

65. Mls001066617

66. Mls001306473

67. Danazol (jp17/usp/inn)

68. Danazol [orange Book]

69. Spbio_002029

70. Bpbio1_000100

71. Gtpl6942

72. Danazol [usp Monograph]

73. Dtxsid2022880

74. 2,4,17alpha-pregnadien-20-yno[2,3-d]-isoxa-zol-17-ol

75. Win-17,757

76. Hms1568e12

77. Hms2090a22

78. Hms2095e12

79. Hms2231m08

80. Hms3259m10

81. Hms3712e12

82. Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol,(17alpha)-

83. [1,2]oxazolo[4',5':2,3]-17alpha-pregn-4-en-20-yn-17-ol

84. 17.alpha.-pregna-2, {4-dien-20-yno[2,3-d]isoxazol-17-ol}

85. Bcp11914

86. Hy-b1029

87. Zinc3881958

88. Tox21_112114

89. Tox21_301940

90. Bdbm50423541

91. Mfcd00056838

92. S9506

93. Akos015961192

94. Tox21_112114_1

95. Ac-6836

96. Ccg-220105

97. Cs-4547

98. Danazol 100 Microg/ml In Acetonitrile

99. Db01406

100. Nc00557

101. Ncgc00179665-01

102. Ncgc00179665-02

103. Ncgc00179665-04

104. Ncgc00255335-01

105. (1r,3as,3br,10ar,10bs,12as)-1-ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1h-cyclopenta[7,8]phenanthro[3,2-d][1,2]oxazol-1-ol

106. 1-ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1h-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol

107. As-13035

108. C06938

109. D00289

110. 230d885

111. Q419652

112. Sr-01000760722

113. Sr-05000000445

114. Sr-01000760722-2

115. Sr-05000000445-2

116. W-107864

117. 17a-pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol

118. Brd-k48970916-001-03-0

119. (17a)-pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol

120. 17a-pregna-2,4-dien-20-yne-[2,3-d]isoxazole-17b-ol

121. 1-(p-tosyl)-3,4,4-trimethyl-2-imidazoliniumiodide

122. 17 Alpha-pregna-2,4-dien-20-yno[2,3-d] Isoxazol-17 Beta-ol

123. 17.alpha.-pregna-2,4-dien-20-yno(2,3)-disoxazol-17-ol

124. Pregna-2, {4-dien-20-yno[2,3-d]isoxazol-17-ol,} (17.alpha.)-

125. Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol,(17.alpha.)-

126. (1s,2r,13r,14s,17r,18s)-17-ethynyl-2,18-dimethyl-7-oxa-6-azapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-ol

127. 1-ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-1h-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol

128. 1h-cyclopenta[7,8]phenanthro[3,2-d]isoxazole- Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol Deriv.

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₂₇NO₂
Molecular Weight	337.5 g/mol
XLogP3	3.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	337.204179104 g/mol
Monoisotopic Mass	337.204179104 g/mol
Topological Polar Surface Area	46.3 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	677
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Danazol
PubMed Health	Danazol (By mouth)
Drug Classes	Endocrine-Metabolic Agent
Drug Label	Danazol is a synthetic steroid derived from ethisterone. It is a white to pale yellow crystalline powder, practically insoluble or insoluble in water, and sparingly soluble in alcohol. Chemically, danazol is 17-Pregna-2, 4-dien-20-yno [2, 3- ]-isox...
Active Ingredient	Danazol
Dosage Form	Capsule
Route	Oral
Strength	200mg; 100mg; 50mg
Market Status	Prescription
Company	Lannett; Barr

2 of 2
Drug Name	Danazol
PubMed Health	Danazol (By mouth)
Drug Classes	Endocrine-Metabolic Agent
Drug Label	Danazol is a synthetic steroid derived from ethisterone. It is a white to pale yellow crystalline powder, practically insoluble or insoluble in water, and sparingly soluble in alcohol. Chemically, danazol is 17-Pregna-2, 4-dien-20-yno [2, 3- ]-isox...
Active Ingredient	Danazol
Dosage Form	Capsule
Route	Oral
Strength	200mg; 100mg; 50mg
Market Status	Prescription
Company	Lannett; Barr

4.2 Drug Indication

For the treatment of endometriosis and fibrocystic breast disease (in patients unresponsive to simple measures). Also used for the prophylactic treatment of all types of hereditary angioedema in males and females.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Danazol is a derivative of the synthetic steroid ethisterone, a modified testosterone. It was approved by the U.S. Food and Drug Administration (FDA) as the first drug to specifically treat endometriosis, but its role as a treatment for endometriosis has been largely replaced by the gonadotropin-releasing hormone (GnRH) agonists. Danazol has antigonadotropic and anti-estrogenic activities. Danazol acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties.

5.2 MeSH Pharmacological Classification

Estrogen Antagonists

Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds. (See all compounds classified as Estrogen Antagonists.)

5.3 FDA Pharmacological Classification

5.3.1 Active Moiety

DANAZOL

5.3.2 FDA UNII

N29QWW3BUO

5.3.3 Pharmacological Classes

Androgen [EPC]; Androstanes [CS]; Androgen Receptor Agonists [MoA]

5.4 ATC Code

G - Genito urinary system and sex hormones

G03 - Sex hormones and modulators of the genital system

G03X - Other sex hormones and modulators of the genital system

G03XA - Antigonadotropins and similar agents

G03XA01 - Danazol

5.5 Metabolism/Metabolites

Hepatic, to principal metabolites, ethisterone and 17-hydroxymethylethisterone.

5.6 Biological Half-Life

Approximately 24 hours.

5.7 Mechanism of Action

As a gonadotropin inhibitor, danazol suppresses the pituitary-ovarian axis possibly by inhibiting the output of pituitary gonadotropins. Danazol also depresses the preovulatory surge in output of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), thereby reducing ovarian estrogen production. Danazol may also directly inhibits ovarian steroidogenesis; bind to androgen, progesterone, and glucocorticoid receptors; bind to sex-hormone-binding globulin and corticosteroid-binding globulin; and increases the metabolic clearance rate of progesterone. Another mechanism of action by which danazol may use to facilitate regression of endometriosis is by decreasing IgG, IgM, and IgA concentrations, as well as phospholipid and IgG isotope autoantibodies. In the treatment of endometriosis, as a consequence of suppression of ovarian function, danazol causes both normal and ectopic endometrial tissues to become inactive and atrophic. This leads to anovulation and associated amenorrhea. In fibrocystic breast disease, the exact mechanism of action of danazol is unknown, but may be related to suppressed estrogenic stimulation as a result of decreased ovarian production of estrogen. A direct effect on steroid receptor sites in breast tissue is also possible. This leads to a disappearance of nodularity, relief of pain and tenderness, and possibly changes in the menstrual pattern. In terms of hereditary angioedema, danazol corrects the underlying biochemical deficiency by increasing serum concentrations of the deficient C1 esterase inhibitor, resulting in increased serum concentrations of the C4 component of the complement system. (Source: PharmGKB)

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CHANDIGARH,? 160002"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727461800,"product":"2-((1S,2S)-1-ETHYL-2-BEZYLOXYPROPYL)-2,4-DIHYDRO-4-(4-(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL)-3H-1,2,4-TRIAZOL-3 ON","address":"FLAT NO.302, BHANU ENCLAVE","city":"HYDERABAD.AP","supplier":"HANGZHOU COPIORE CHEMICAL TECHNOLOGY CO,LTD","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"METROCHEM API PRIVATE LIMITED","customerCountry":"INDIA","quantity":"150.00","actualQuantity":"150","unit":"KGS","unitRateFc":"1040","totalValueFC":"157487","currency":"USD","unitRateINR":"87984","date":"28-Sep-2024","totalValueINR":"13197600","totalValueInUsd":"157487","indian_port":"Hyderabad Air","hs_no":"29349990","bill_no":"5849970","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"ROOM236,I-SHAPED NORTH BUILDING,NO 115 WENYI ROAD HANGZHOU ZHEJIANG PROVINCE CHINA CN","customerAddress":"FLAT NO.302, BHANU ENCLAVE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727634600,"product":"2-BROMO-5,6-DICHLORO-1H-BENZIMIDAZOLE","address":"ACME PLAZA, ANDHERI KURLA ROAD,","city":"MUMBAI, MAHARASHTRA.","supplier":"HANGZHOU PROSERRE CHEMICAL CO LTD","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"SUN PHARMACEUTICAL INDUSTRIES LIMITED","customerCountry":"INDIA","quantity":"110.00","actualQuantity":"110","unit":"KGS","unitRateFc":"600","totalValueFC":"66629.1","currency":"USD","unitRateINR":"50760","date":"30-Sep-2024","totalValueINR":"5583600","totalValueInUsd":"66629.1","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"5883698","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"ROOM NO 2002 , SUNON CENTRAL MANSIO N NO 200 SHIMIN ROAD , JIANGGAN DIS TRICT , HANGZHOU ZHEJIANG CHINA China","customerAddress":"ACME PLAZA, ANDHERI KURLA ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727634600,"product":"4-CHLORO-7-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1-(2,2,2-TRIFLUOROETHYL)-1H-INDAZOL-3-AMINE","address":"7-2-A2, HETERO CORPORATE,","city":"HYDERABAD-A.P.","supplier":"UNIBEST INDUSTRIAL CO ","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"HETERO DRUGS","customerCountry":"INDIA","quantity":"3.96","actualQuantity":"3.955","unit":"KGS","unitRateFc":"3700","totalValueFC":"14773","currency":"USD","unitRateINR":"313020","date":"30-Sep-2024","totalValueINR":"1237994.1","totalValueInUsd":"14773","indian_port":"Madras Air","hs_no":"29349990","bill_no":"5882229","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"11F BLDG1 YINCHEN INTERNATIONAL MANSION NINGBO SDNF CHINA","customerAddress":"7-2-A2, HETERO CORPORATE,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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List of Suppliers' Controlled Modified Release Excipients Application used in Prestwick3_000105 on PharmaCompass.com

Prestwick3_000105

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

15 API Suppliers

7 USDMF

4 EU WC

9 NDC API

7 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

25 FDF Dossiers

12 FDA Orange Book

3 Europe

3 Canada

4 South Africa

3 Listed Dossiers

RELATED EXCIPIENT COMPANIES

3 SPI Pharma

7 DKSH

9 Gangwal Healthcare

2 Nanjing Well Pharmaceutical

4 ACG Worldwide

1 Aeon Procare

3 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

8 BASF

4 DFE Pharma

1 Finar

3 Gangwal Chemicals

3 Ingredion Pharma Solutions

22 Kerry

3 Lonza Capsugel

10 Microlex e.U

1 Pharmatrans-Sanaq

4 Pluviaendo

2 Prachin Chemical

1 Qualicaps

12 Roquette

2 Seppic

2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

4 Sigachi Industries

1 Valens Pharmachem

2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

49 Fillers, Diluents & Binders

20 Direct Compression

16 Lubricants & Glidants

13 Coating Systems & Additives

13 Disintegrants & Superdisintegrants

11 Granulation

11 Co-Processed Excipients

10 Thickeners and Stabilizers

8 Film Formers & Plasticizers

8 Empty Capsules

6 Taste Masking

5 Topical

4 Controlled & Modified Release

3 Coloring Agents

3 Chewable & Orodispersible Aids

2 Emulsifying Agents

2 Parenteral

2 Solubilizers

1 Surfactant & Foaming Agents

DIGITAL CONTENT

1 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions

9 Finished Drug Prices

MARKET PLACE

7 APIs

REF. STANDARDS & IMPURITIES

1 USP

2 JP

1 Others

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 125