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1. 1,1'-hbcb
2. Avagard
3. Chlorhexamed
4. Chlorhexidine Bigluconate
5. Chlorhexidine Digluconate
6. Corsodyl Ici
7. Curasept Ads 220
8. Dyna-hex
9. Eludril
10. Gibitan
11. Hexidine
12. Hibiclens
13. Hibident
14. Hibiscrub
15. Hibisol
16. Hibitane
17. Peridex
18. Perio Chip
1. Chlorhexidine Digluconate
2. Hibiclens
3. 18472-51-0
4. Peridex
5. Dyna-hex
6. Bioscrub
7. Chlorhexidine D-digluconate
8. Exidine
9. Microderm
10. Periochip
11. Periogard
12. Unisept
13. Brian Care
14. Steri-stat
15. Cida-stat
16. Hibistat
17. Pharmaseal Scrub Care
18. Chg Scrub
19. Prevacare
20. Chlorhexidine Digluconate Solution
21. Chlorhexidine Di-d-gluconate
22. Mor84mud8e
23. Nsc-753971
24. Hibiscrub
25. Hibitane
26. 1,1'-hexamethylene Bis(5-(p-chlorophenyl)biguanide), Digluconate
27. 1,1'-hexamethylenebis(5-(p-chlorophenyl)biguanide) Di-d-gluconate
28. Bacticlens
29. Chlorhexamed
30. Kleersight
31. Corsodyl
32. Disteryl
33. Hibident
34. Hibidil
35. Orahexal
36. Plurexid
37. Septeal
38. Abacil
39. Fight Bac
40. Plac Out
41. Prevacare R
42. Arlacide G
43. Hibitane 5
44. 2,4,11,13-tetraazatetradecanediimidamide, N,n''-bis(4-chlorophenyl)-3,12-diimino-, Di-d-gluconate
45. Chlorhexidin Glukonatu
46. Peridex (antiseptic)
47. Bactoshield Chg 2%
48. Caswell No. 481g
49. Unii-mor84mud8e
50. Pwriochip
51. Chlorhexidin Glukonatu [czech]
52. 1,6-bis(n5-[p-chlorophenyl]-n1-biguanido)hexane
53. Phiso-med
54. Hibitane Gluconate
55. Hibiclens (tn)
56. Periogard (tn)
57. Drg-0091
58. Einecs 242-354-0
59. Peridex (tn)
60. Mfcd00083599
61. Chlohexidine Gluconate
62. Epa Pesticide Chemical Code 045504
63. Readyprep Chg
64. Chlorhexidine Gluconate [usan:usp:jan]
65. Ec 242-354-0
66. Schembl34468
67. 1,6-bis(5-(p-chlorophenyl)biguandino)hexane Digluconate
68. Chembl4297088
69. Dtxsid5034519
70. Chebi:28312
71. 1,1'-hexamethylenebis(5-(p-chlorophenyl)biguanide) Gluconate
72. 1,1'-hexamethylenebis(5-(p-chlorophenyl)biguanide)digluconate
73. Chx Plus Concentrate Premium Chlorhexidine Teat Dip Concentrate
74. Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-, Digluconate
75. Chlorhexidine Gluconate (jp17/usp)
76. Chlorhexidine Gluconate [jan]
77. Chlorhexidine Gluconate [usan]
78. Akos015896303
79. Akos025310696
80. Chlorhexidine Gluconate [mart.]
81. Chlorhexidine Gluconate [vandf]
82. Nsc 753971
83. Chlorhexidine D-digluconate [mi]
84. Chlorhexidine Digluconate [inci]
85. Chlorhexidine Gluconate [who-dd]
86. Gluconic Acid, Compd. With 1,1'-hexamethylene Bis(5-(p-chlorophenyl)biguanide) (2:1), D-
87. D-gluconic Acid, Compd. With N,n''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)
88. D-gluconic Acid, Compound With N,n''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)
89. Chlorhexidine Gluconate [orange Book]
90. Chlorhexidine Gluconate [usp Impurity]
91. Avagard Component Chlorhexidine Gluconate
92. C08038
93. D00858
94. Chlorhexidine Digluconate Solution, 20% In H2o
95. Soluprep Component Chlorhexidine Gluconate
96. Chloraprep Component Chlorhexidine Gluconate
97. Chlorhexidine Gluconate Component Of Avagard
98. Chlorhexidine Digluconate, 20% W/v Aqueous Solution
99. Chlorhexidine Gluconate Component Of Soluprep
100. J-011837
101. Chlorhexidine Gluconate Component Of Chloraprep
102. Chlorhexidine Digluconate Solution [ep Monograph]
103. 1,1'-hexamethylenebis[5-(4-chlorophenyl)biguanide] Digluconate
104. Chlorhexidine Digluconate, Pharmaceutical Secondary Standard; Certified Reference Material
105. 1,1'-hexamethylenebis[5-(p-chlorophenyl)biguanide] (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoic Acid(1:2)
106. 1-(4-chlorophenyl)-3-[n-[6-[[n-[n-(4-chlorophenyl)carbamimidoyl]carbamimidoyl]amino]hexyl]carbamimidoyl]guanidine; (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoic Acid
107. 2,4,11,13-tetraazatetradecanediimidamide, N,n''-bis(4-chlorophenyl)-3,12-diimino-, Digluconate
108. 2,4,11,13-tetraazatetradecanediimidamide, N,n'-bis(4-chlorophenyl)-3,12-diimino-, Di-d-gluconate
109. D-gluconic Acid, Compd With N,n''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)
110. D-gluconic Acid, Compd. With N,n''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecane Diimidamide (2:1)
111. D-gluconic Acid, Compd. With N1,n14-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)
112. N',n'''''-hexane-1,6-diylbis[n-(4-chlorophenyl)(imidodicarbonimidic Diamide)]--d-gluconic Acid (1/2)
| Molecular Weight | 897.8 g/mol |
|---|---|
| Molecular Formula | C34H54Cl2N10O14 |
| Hydrogen Bond Donor Count | 18 |
| Hydrogen Bond Acceptor Count | 16 |
| Rotatable Bond Count | 23 |
| Exact Mass | 896.3198018 g/mol |
| Monoisotopic Mass | 896.3198018 g/mol |
| Topological Polar Surface Area | 455 Ų |
| Heavy Atom Count | 60 |
| Formal Charge | 0 |
| Complexity | 819 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 8 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 2 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 3 |
| 1 of 2 | |
|---|---|
| Drug Name | Chlorhexidine gluconate |
| Drug Label | Chlorhexidine Gluconate is an oral rinse containing 0.12% chlorhexidine gluconate (1,11-hexamethylene bis[5-(p-chlorophenyl) biguanide] di-D-gluconate) in a base containing water, 11.6% alcohol, glycerin, PEG-40 sorbitan diisostearate, flavor, sodium... |
| Active Ingredient | Chlorhexidine gluconate |
| Dosage Form | Cloth; Solution; Sponge |
| Route | Dental; Topical |
| Strength | 0.12%; 2%; 4% |
| Market Status | Over the Counter; Prescription |
| Company | Lyne; Wockhardt; Sage Prods; Hi Tech Pharma; Teva; Xttrium; Becton Dickinson |
| 2 of 2 | |
|---|---|
| Drug Name | Chlorhexidine gluconate |
| Drug Label | Chlorhexidine Gluconate is an oral rinse containing 0.12% chlorhexidine gluconate (1,11-hexamethylene bis[5-(p-chlorophenyl) biguanide] di-D-gluconate) in a base containing water, 11.6% alcohol, glycerin, PEG-40 sorbitan diisostearate, flavor, sodium... |
| Active Ingredient | Chlorhexidine gluconate |
| Dosage Form | Cloth; Solution; Sponge |
| Route | Dental; Topical |
| Strength | 0.12%; 2%; 4% |
| Market Status | Over the Counter; Prescription |
| Company | Lyne; Wockhardt; Sage Prods; Hi Tech Pharma; Teva; Xttrium; Becton Dickinson |
Antiseptic; disinfectant. (Vet): antiseptic; disinfectant.
O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 371
Cleanser: As a surgical hand scrub, skin wound and general skin cleanser, health care personnel hand wash, and for preoperative skin preparation. Chlorhedine gluconate significantly reduces the number of microorganisms on the hands and forearms prior to surgery or patient care. /Chlorhexidine gluconate-topical/
Drug Facts and Comparisons 2013. Wolters Kluwer Health St. Louis, MO 2013, p. 3180
EXPL THER To determine if chlorhexidine can be used as an intervention to prolong the time to relapse of oral candidiasis. SUBJECTS AND METHODS: A double-blinded randomized clinical trial was performed in 75 HIV/AIDS subjects with oral candidiasis. Clotrimazole troche was prescribed, and the subjects were re-examined every 2 weeks until the lesions were completely eradicated. The subjects were then randomly divided into two groups; 0.12% chlorhexidine (n = 37, aged 22-52 years, mean 34 years) and 0.9% normal saline (n = 38, aged 22-55 years, mean 38 years). They were re-examined every 2 weeks until the next episode was observed. RESULTS: The time to recurrence of oral candidiasis between the chlorhexidine and the saline group was not statistically significant (P > 0.05). The following variables were significantly associated with the time of recurrence; frequency of antifungal therapy (P = 0.011), total lymphocyte (P = 0.017), alcohol consumption (P = 0.043), and candidiasis on gingiva (P = 0.048). The subjects with lower lymphocyte showed shorter oral candidiasis-free periods (P = 0.034). CONCLUSIONS: Chlorhexidine showed a small but not statistically significant effect in maintenance of oral candidiasis-free period. This lack of significance may be due to the small sample size. Further study should be performed to better assess the size of the effect, or to confirm our findings.
PMID:18627504 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253386 Nittayananta W et al; Oral Dis. (7): 665-70 (2008)
/EXPTL Therapy:/ Rats were injected with 10 mg/kg azoxymethane sc weekly for 12 weeks to induce colorectal cancers. At 20 weeks, subtotal colectomies were performed on rats with colorectal tumors and without peritoneal implants or liver metastases. At the time of surgery, a cut portion of the tumor was placed in the abdomen for 30 minutes; the rats then randomly received peritoneal irrigation with chlorhexidine, or sterile water (control). Eight weeks postoperatively a necropsy was performed. At that time, obvious and suspected recurrences and the anastomotic area were sampled for histologic evaluation. Significant differences were seen with chlorhexidine vs. water for gross tumor (P=0.05) and microscopic tumor (P<0.05).
Stuntz M et al; Dis Colon Rectum 40 (9): 1058-8 (1997)
For external use only: For external use only. Keep out of eyes, ears, and mouth. Chlorhexidine gluconate should not be used as a preoperative skin preparation of the face or head. Misuse of products containing chlorhexidine gluconate has been reported to cause serious and permanent eye injury when it has been permitted to enter and remain in the eye during surgical procedures. If chlohexidine gluconate should contact these areas, rinse out promptly and thoroughly with cold water. Avoid contact with neninges. Do not use in genital area. /Chlorhexidine gluconate-topical/
Drug Facts and Comparisons 2013. Wolters Kluwer Health St. Louis, MO 2013, p. 3180
Sensitivity: Chlorhexidine gluconate should not be used by persons who have a sensitivity to it or its components.
Drug Facts and Comparisons 2013. Wolters Kluwer Health St. Louis, MO 2013, p. 3180
Hypersensitivity reactions: Irritation, sensitization, and generalized allergic reactions have been reported with chlorhexidine-containing products, especially in the genital areas. If adverse reactions occur and last more than 72 hr, discontinue use immediately and, if severe, contact a health care provider.
Drug Facts and Comparisons 2013. Wolters Kluwer Health St. Louis, MO 2013, p. 3180
Deafness: Chlorhexidine gluconate has been reported to cause deafness when instilled in the middle ear through perforate ear drums. /Chlorhexidine gluconate-topical/
Drug Facts and Comparisons 2013. Wolters Kluwer Health St. Louis, MO 2013, p. 3180
For more Drug Warnings (Complete) data for CHLORHEXIDINE (8 total), please visit the HSDB record page.
Anti-Infective Agents, Local
Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)
Dermatologic Agents
Drugs used to treat or prevent skin disorders or for the routine care of skin. (See all compounds classified as Dermatologic Agents.)
34 newborn infants who had been bathed in a standard manner with Hibiscrub were studied to find out whether it was absorbed percutaneously. Low levels of chlorhexidine were found in the blood of all 10 babies sampled by heel prick, and 5 of 24 from whom venous blood was taken. /Chlorhexidine gluconate/
PMID:475414 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1545570 Cowen J et al; Arch Dis Child 54 (5): 379-83 (1979)
Percutaneous absorption of the antimicrobial agent chlorhexidine (labelled with carbon-14) was studied in rats. Less than 5% of the topically applied chlorhexidine was absorbed during a 5-day period. Excretion of absorbed radioactivity occurred mainly in the feces.
Chow CP, et al; Toxicol Lett 1(4): 213-16 (1978)
The percutaneous absorption of chlorhexidine gluconate (chlorhexidine digluconate; Hibitane) through hairless rat skin with or without stratum corneum was studied. For tests carried out on whole skin, storage in cutaneous structures after 48 hr was more important than diffusion; the reverse was observed for stripped skin. When the skin was stripped, the amount absorbed was multiplied by approximately 100, and the amount stored in skin by approximately 10. The difference in chlorhexidine diffusion observed between whole and stripped skin was related to the physicochemical characteristics of chlorhexidine. /Chlorhexidine gluconate/
Lafforque C et al; Int J Pharm 147: 243-6 (1997)
To evaluate the elimination kinetics of chlorhexidine in milk when used as an intramammary infusion to stop lactation in cows. ... The study was performed in 2 phases. Three cows were studied in each phase. All cows were treated with chlorhexidine suspension by infusion into a mastitic mammary gland quarter after 2 milkings 24 hours apart. Foremilk samples (100 mL) were collected from treated and untreated (controls) mammary gland quarters of each cow. Chlorhexidine was extracted from raw milk, and residue concentrations were quantified by use of high-performance liquid chromatography. Foremilk samples from days 2, 5, and 8 were analyzed in phase I, and samples from time 0 and days 3, 7, 14, 21, 28, 35, and 42 were analyzed in phase II. In phases I and II, there was no quantifiable transference of chlorhexidine to milk in untreated mammary gland quarters. Measurable chlorhexidine residues were found in milk from treated mammary gland quarters of 2 cows throughout the 42-day sample period in phase II. Estimated mean elimination half-life for chlorhexidine in milk was 11.5 days.
PMID:12830870 Middleton JR et al; J Am Vet Med Assoc 222 (12): 1746-9 (2003)
To evaluate the elimination kinetics of chlorhexidine in milk when used as an intramammary infusion to stop lactation in cows. ... The study was performed in 2 phases. Three cows were studied in each phase. All cows were treated with chlorhexidine suspension by infusion into a mastitic mammary gland quarter after 2 milkings 24 hours apart. Foremilk samples (100 mL) were collected from treated and untreated (controls) mammary gland quarters of each cow. Chlorhexidine was extracted from raw milk, and residue concentrations were quantified by use of high-performance liquid chromatography. Foremilk samples from days 2, 5, and 8 were analyzed in phase I, and samples from time 0 and days 3, 7, 14, 21, 28, 35, and 42 were analyzed in phase II. In phases I and II, there was no quantifiable transference of chlorhexidine to milk in untreated mammary gland quarters. Measurable chlorhexidine residues were found in milk from treated mammary gland quarters of 2 cows throughout the 42-day sample period in phase II. Estimated mean elimination half-life for chlorhexidine in milk was 11.5 days.
PMID:12830870 Middleton JR et al; J Am Vet Med Assoc 222 (12): 1746-9 (2003)
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DOSAGE - AEROSOL, METERED;TOPICAL - 4%
USFDA APPLICATION NUMBER - 19127
DOSAGE - SOLUTION;TOPICAL - 2%
USFDA APPLICATION NUMBER - 19422
DOSAGE - TABLET;DENTAL - 2.5MG
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DOSAGE - SOLUTION;TOPICAL - 2%;70%
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DOSAGE - SPONGE;TOPICAL - 2%;70% (1.5ML)
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USFDA APPLICATION NUMBER - 21524
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