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Pridinol

Suanfarma, at the Core of a Better Life.

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3 API Suppliers, 1 JDMF, 2 Listed Suppliers, $ API Reference Price

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1 JDMF
2 Listed Suppliers
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ANALYTICAL

2 BioAnalytical Methods

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2 BioAnalytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 511-45-5, 1,1-diphenyl-3-(piperidin-1-yl)propan-1-ol, Nonplesin, Lyseen, Parks, Parks 12

Molecular Formula

C₂₀H₂₅NO

Molecular Weight

295.4 g/mol

InChI Key

RQXCLMGKHJWMOA-UHFFFAOYSA-N

FDA UNII

9E75Q6SUUB

1 2D Structure

Pridinol

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1,1-diphenyl-3-piperidin-1-ylpropan-1-ol

2.1.2 InChI

InChI=1S/C20H25NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1-2,4-7,10-13,22H,3,8-9,14-17H2

2.1.3 InChI Key

RQXCLMGKHJWMOA-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CCN(CC1)CCC(C2=CC=CC=C2)(C3=CC=CC=C3)O

2.2 Other Identifiers

2.2.1 UNII

9E75Q6SUUB

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 3-(n-piperidinyl)-1,1-diphenyl-1-propanol Methanesulfonate

2. 3-piperidino-1,1-diphenylpropanol

3. 3-piperidinyl-1,1-diphenylpropan-1-ol

4. Myoson

5. Pridinol Mesylate

6. Pridinol Monohydrochloride

7. Pridinol Monomesylate

8. Ridinol

2.3.2 Depositor-Supplied Synonyms

1. 511-45-5

2. 1,1-diphenyl-3-(piperidin-1-yl)propan-1-ol

3. Nonplesin

4. Lyseen

5. Parks

6. Parks 12

7. Parks 12 Hommel

8. Pridinolum

9. Nonpressin (free Base)

10. C-238

11. Hh 212

12. 1,1-diphenyl-3-piperidino-1-propanol

13. Alpha,alpha-diphenyl-1-piperidinepropanol

14. 1,1-diphenyl-3-(1-piperidyl)-1-propanol

15. 1-piperidinepropanol, Alpha,alpha-diphenyl-

16. 3-(n-piperidyl)-1,1-diphenyl-1-propanol

17. 238 C

18. Nsc 23016

19. Nsc-23016

20. Nsc23016

21. 9e75q6suub

22. 1,1-diphenyl-3-piperidin-1-ylpropan-1-ol

23. 1,1-diphenyl-3-(1-piperidinyl)-1-propanol

24. Ridinol

25. Chebi:75247

26. Pridinol (inn)

27. Pridinol Mesilate

28. Benzhydrol, .alpha.-(2-piperidinoethyl)-

29. Pridinol [inn]

30. Nsc 23016; Nsc 403797; Nonplesin

31. .alpha.,.alpha.-diphenyl-1-piperidinepropanol

32. Dsstox_cid_25090

33. Dsstox_rid_80664

34. Dsstox_gsid_45090

35. Pridinol [inn:dcf]

36. Pridinolum [inn-latin]

37. 1-piperidinepropanol,.alpha.-diphenyl-

38. Cas-511-45-5

39. Hsdb 2684

40. Einecs 208-128-0

41. Unii-9e75q6suub

42. Benzhydrol, Alpha-(2-piperidinoethyl)-

43. Brn 0252983

44. A-carotene

45. Spectrum_001320

46. Pridinol [hsdb]

47. Pridinol [mi]

48. Prestwick0_000799

49. Prestwick1_000799

50. Prestwick2_000799

51. Prestwick3_000799

52. Spectrum2_001985

53. Spectrum3_001552

54. Spectrum4_000728

55. Spectrum5_001069

56. Pridinol [who-dd]

57. Ncistruc1_000328

58. Ncistruc2_000375

59. Bspbio_000938

60. Bspbio_003024

61. Kbiogr_000996

62. Kbioss_001800

63. 5-20-02-00247 (beilstein Handbook Reference)

64. Divk1c_000726

65. Schembl143298

66. Spbio_002169

67. Spbio_002877

68. Bpbio1_001032

69. Chembl404215

70. Dtxsid0045090

71. Kbio1_000726

72. Kbio2_001800

73. Kbio2_004368

74. Kbio2_006936

75. Kbio3_002524

76. Ninds_000726

77. Alpha-(2-piperidinoethyl)benzhydrol

78. Nci23016

79. Zinc1482149

80. Tox21_110022

81. Ccg-37974

82. Mfcd00242961

83. Ncgc00013289

84. Nsc403797

85. Akos016001547

86. Tox21_110022_1

87. Db13642

88. Nsc-403797

89. Idi1_000726

90. Ncgc00013289-01

91. Ncgc00013289-02

92. Ncgc00013289-03

93. Ncgc00013289-04

94. Ncgc00013289-05

95. Ncgc00013289-06

96. Ncgc00013289-07

97. Ncgc00013289-09

98. Ncgc00023906-03

99. Ncgc00023906-04

100. Ncgc00023906-05

101. Ac-24366

102. Nci60_001871

103. Sbi-0051765.p002

104. Ab00053638

105. 1,1-diphenyl-3-piperidin-1-yl-propan-1-ol

106. D08418

107. 1,1-diphenyl-3-(1-piperidinyl)-1-propanol #

108. 1-piperidinepropanol, .alpha.,.alpha.-diphenyl-

109. Ab00053638_16

110. Ab00053638_17

111. N-propanol, 1,1-diphenyl-3-(piperidin-1-yl)-

112. Ag-680/20240026

113. Q827515

114. Brd-k17565903-066-05-8

115. Brd-k17565903-066-15-7

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₅NO
Molecular Weight	295.4 g/mol
XLogP3	3.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	295.193614421 g/mol
Monoisotopic Mass	295.193614421 g/mol
Topological Polar Surface Area	23.5 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	294
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Therapeutic Uses

/EXPL THER/ A randomized, double-blind, placebo-controlled three-way cross-over study was performed to investigate the effect of two muscle relaxants (tolperisone hydrochloride and pridinol mesilate) on experimental jaw-muscle pain and jaw-stretch reflexes. Fifteen healthy men participated in three randomized sessions separated by at least 1 week. In each session 300 mg tolperisone, 8 mg pridinol mesilate or placebo was administered orally as a single dose. One hour after drug administration 0.3 mL hypertonic saline (5.8%) was injected into the right masseter to produce muscle pain. Subjects continuously rated their perceived pain intensity on an electronic 10-cm visual analogue scale (VAS). The pressure pain threshold (PPT) was measured and short-latency reflex responses were evoked in the pre-contracted (15% maximal voluntary contraction) masseter and temporalis muscles by a standardised stretch device (1 mm displacement, 10 ms ramp time) before (baseline), 1 hr after medication (post-drug), during ongoing experimental muscle pain (pain-post-drug), and 15 min after pain had vanished (post-pain). Analysis of variance demonstrated significantly lower VAS peak pain scores (5.9 +/- 0.4 cm) after administration of tolperisone hydrochloride compared with pridinol mesilate (6.8 +/- 0.4 cm) and placebo (6.6 +/- 0.4 cm) (P=0.020). Administration of pridinol mesilate was associated with a significant decrease in PPTs compared with tolperisone hydrochloride and placebo (P=0.002) after medication, but not after experimental jaw-muscle pain. The normalized peak-to-peak amplitude of the stretch reflexes were not significantly influenced by the test medication (P=0.762), but were in all sessions significantly facilitated during ongoing experimental jaw-muscle pain (P=0.034). In conclusion, tolperisone hydrochloride provides a small, albeit significant reduction in the perceived intensity of experimental jaw-muscle pain whereas the present dose had no effect on the short-latency jaw-stretch reflex. /Tolperisone hydrochloride and pridinol mesilate/

PMID:12935797 Svensson P et al; Eur J Pain 7 (5): 449-56 (2003)

5 Pharmacology and Biochemistry

5.1 ATC Code

M - Musculo-skeletal system

M03 - Muscle relaxants

M03B - Muscle relaxants, centrally acting agents

M03BX - Other centrally acting agents

M03BX03 - Pridinol

API SUPPLIERS

01

Jai Radhe Sales

India

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Katsura Chemical

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Olon S.p.A

Italy

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Katsura Chemical Co., Ltd.

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API Reference Price

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ROAD,","city":"MUMBAI,MAHARASHTRA","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"LUPIN LTD","customerCountry":"INDIA","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"7000","totalValueFC":"3856.4","currency":"EUR","unitRateINR":"642250","date":"30-Nov-2023","totalValueINR":"321125","totalValueInUsd":"3856.4","indian_port":"Bombay Air","hs_no":"29333990","bill_no":"8999625","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"DIREZIONE E UFFICI STRADA RIVOLTANAKM.6\/7 20053 RODANO (MI) Rodano, ,Italy Italy","customerAddress":"159, C.S.T. ROAD,"}]

Number of Transactions

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Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

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FDF Dossiers

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APIs

Pridinol Mesilate API needed in Bangladesh [ENA20542]

A company that focuses on research, development & manufacturing of OSDs, liquids, creams, ointments, suppositories, metered dose inhalers and injectables is looking for suppliers of Pridinol Mesilate API for Tablet formulation. The initial required quantity is 1 kg - 2 kg for development & later 10 kg - 15 kg for commercial purposes. The suppliers must support this enquiry with CoA.

14 Sep 2024

Pridinol Mesylate (3 kg) API needed in Germany [ENA17321]

A company that focuses on research, development and manufacturing of finished formulations in various therapeutic segments is looking for suppliers of Pridinol Mesylate (3 kg) API for development purposes. The suppliers must support this enquiry with USDMF & CoA.

15 Jun 2023

Pridinol Mesilate (3 kg) API needed in Bangladesh [ENA16739]

A pharmaceutical company that manufactures more than 800 products in different dosage forms covering broader therapeutic categories which include anti-infective, cardiovascular, antidiabetics, gastrointestinal, CNS & respiratory disease is looking for suppliers of Pridinol Mesilate (3 kg) API for both development and commercial purposes. The suppliers must support this enquiry with DMF & CoA.

28 Mar 2023

Pridinol Mesylate & Daridorexant APIs needed in Bangladesh [ENA16142]

A company that focuses on research, development and manufacturing of tablets, capsules, parenterals, liquids, creams, ointments, suppositories, metered dose inhalers & ophthalmic drops is looking for suppliers of Pridinol Mesylate & Daridorexant APIs for development purposes. The required quantity is 250 g for each. The suppliers must support this enquiry with CoA.

19 Jan 2023

Various APIs needed in India [ENA15625]

A CRO that focuses on analytical and formulation development is looking for suppliers of Various APIs for development purposes. The suppliers must support this enquiry with CoA. 1. Pridinol API 2. Distigmine Bromide API 3. Dihydralazine API 4. Hydralazine HCl API

23 Nov 2022

Various EP/ BP Grade APIs needed in India [ENA15586]

A CRO that focuses on analytical and formulation development is looking for suppliers of Various BP/ EP Grade APIs for commercial purposes. The suppliers must support this enquiry with CEP. 1. EP/ BP Grade Pridinol API 2. EP/ BP Grade Distigmine API 3. EP/ BP Grade Dihydralazine API 4. EP/ BP Grade Hydralazine API

17 Nov 2022

Pridinol Mesylate API needed in Bangladesh [ENA14966]

A company that deals in various pharmaceutical products is looking for suppliers of Pridinol Mesylate API for commercial purpose. The suppliers must support this enquiry with GMP & CoA.

09 Sep 2022

Pridinol Mesylate (MOQ) API needed in India [ENA12929]

A company that deals in the manufacturing & packaging of a wide range of pharmaceutical and ayurvedic formulations is looking for suppliers of Pridinol Mesylate (MOQ) API for commercial purpose. The suppliers must support this enquiry with CoA.

08 Mar 2022

Pridinol Mesylate (5 kg) API needed in Egypt [ENA11164]

Praxo Pharm, a company that deals in the distribution of pharmaceuticals, cosmeceuticals & nutraceuticals is looking for suppliers of Pridinol Mesylate (5 kg) API for commercial purpose. Interested suppliers can contact them via their email: purchase@praxopharm.com.

20 Aug 2021

Various APIs needed in Bangladesh [ENA10527]

Pharmalink Trade Corporation, an indentor company based in Bangladesh is looking for suppliers of Various APIs. The suppliers must support this enquiry with CoA. Interested suppliers can contact them via their email: pharmalinktrade@hotmail.com. 1. Flibanserin API 2. Diflucortolone API 3. Vericiguat API 4. Voclosporin API 5. Pridinol API 6. Tiaprofenic Acid API 7. Felbinac API 8. Estetrol API 9. Magnesium Sulfate API

29 May 2021

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FDF DOSSIERS

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ANALYTICAL

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BioAnalytical Methods

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QUINTA-ANALYTICA s.r.o

Pridinol

Pharma, Lab & Chemical Expo

Not Confirmed

02

QUINTA-ANALYTICA s.r.o

Pridinol

Pharma, Lab & Chemical Expo

Not Confirmed

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ABOUT THIS PAGE

Pridinol Manufacturers

A Pridinol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pridinol, including repackagers and relabelers. The FDA regulates Pridinol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pridinol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Pridinol manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Pridinol Suppliers

A Pridinol supplier is an individual or a company that provides Pridinol active pharmaceutical ingredient (API) or Pridinol finished formulations upon request. The Pridinol suppliers may include Pridinol API manufacturers, exporters, distributors and traders.

click here to find a list of Pridinol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Pridinol JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Pridinol Drug Master File in Japan (Pridinol JDMF) empowers Pridinol API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Pridinol JDMF during the approval evaluation for pharmaceutical products. At the time of Pridinol JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Pridinol suppliers with JDMF on PharmaCompass.

Pridinol GMP

Pridinol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Pridinol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pridinol GMP manufacturer or Pridinol GMP API supplier for your needs.

Pridinol CoA

A Pridinol CoA (Certificate of Analysis) is a formal document that attests to Pridinol's compliance with Pridinol specifications and serves as a tool for batch-level quality control.

Pridinol CoA mostly includes findings from lab analyses of a specific batch. For each Pridinol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Pridinol may be tested according to a variety of international standards, such as European Pharmacopoeia (Pridinol EP), Pridinol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pridinol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.

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ACTIVE PHARMA INGREDIENTS

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$ API Reference Price

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ANALYTICAL

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ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 701

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