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PRILOCAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE

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ACTIVE PHARMA INGREDIENTS

17 API Suppliers, 4 USDMF, 6 CEP/COS, 1 JDMF, 3 EU WC, 2 KDMF, 12 NDC API, 13 Listed Suppliers, $ API Reference Price

17 API Suppliers
4 USDMF
6 CEP/COS
1 JDMF
3 EU WC
2 KDMF
12 NDC API
13 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

110 FDF Dossiers, 30 FDA Orange Book, 48 Europe, 31 Canada, 1 Listed Dossiers

110 FDF Dossiers
30 FDA Orange Book
48 Europe
31 Canada
1 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

INJECTABLE;INJECTION - 0.25%, INJECTABLE;INJECTION - 0.25%;0.0091MG/ML, INJECTABLE;INJECTION - 0.5%, INJECTABLE;INJECTION - 0.5%;0.0091MG/ML, INJECTABLE;INJECTION - 0.75%, INJECTABLE;INJECTION - 0.75%;0.0091MG/ML, INJECTABLE;INJECTION - 0.25%, INJECTABLE;INJECTION - 0.5%, INJECTABLE;INJECTION - 0.5%;0.0091MG/ML, INJECTABLE;INJECTION - 0.75%, INJECTABLE;INJECTION - 0.75%;0.0091MG/ML, INJECTABLE;INJECTION - 4%; EQ 0.0085MG BASE/1.7ML (4%; EQ 0.005MG BASE/ML), INJECTABLE;INJECTION - 4%;EQ 0.017MG BASE/1.7ML (4%;EQ 0.01MG BASE/ML), INJECTABLE;INJECTION - 0.5%;0.0091MG/ML, INJECTABLE;INJECTION - EQ 0.02MG BASE/ML;2%, INJECTABLE;INJECTION - EQ 0.01MG BASE/ML;2%

drugProductComposition
INJECTABLE;INJECTION - 0.25%
INJECTABLE;INJECTION - 0.25%;0.0091MG/ML
INJECTABLE;INJECTION - 0.5%
INJECTABLE;INJECTION - 0.5%;0.0091MG/ML
INJECTABLE;INJECTION - 0.75%
INJECTABLE;INJECTION - 0.75%;0.0091MG/ML
INJECTABLE;INJECTION - 0.25%
INJECTABLE;INJECTION - 0.5%
INJECTABLE;INJECTION - 0.5%;0.0091MG/ML
INJECTABLE;INJECTION - 0.75%
INJECTABLE;INJECTION - 0.75%;0.0091MG/ML
INJECTABLE;INJECTION - 4%; EQ 0.0085MG BASE/1.7ML (4%; EQ 0.005MG BASE/ML)
INJECTABLE;INJECTION - 4%;EQ 0.017MG BASE/1.7ML (4%;EQ 0.01MG BASE/ML)
INJECTABLE;INJECTION - 0.5%;0.0091MG/ML
INJECTABLE;INJECTION - EQ 0.02MG BASE/ML;2%
INJECTABLE;INJECTION - EQ 0.01MG BASE/ML;2%

RELATED EXCIPIENT COMPANIES

4 Actylis

relatedExcipients
4 Actylis

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 9 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
9 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

36 Finished Drug Prices

globalSalesInformation
36 Finished Drug Prices

MARKET PLACE

25 APIs, 3 FDF Dossiers

marketPlace
25 APIs
3 FDF Dossiers

REF. STANDARDS & IMPURITIES

6 EDQM , 1 USP , 2 JP , 1 Others

otherSolutions
6 EDQM
1 USP
2 JP
1 Others

Epinephrine Bitartrate

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 17,014

MARKET PLACE

API

FDF

1INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

110

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

4 RELATED EXCIPIENT COMPANIES

4EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: (-)-epinephrine bitartrate, Adrenaline bitartrate, Mls000028381, Epinephrine d-bitartrate, L-epinephrine bitartrate, Smr000058630

Molecular Formula

C₁₃H₁₉NO₉

Molecular Weight

333.29 g/mol

InChI Key

YLXIPWWIOISBDD-FVGYRXGTSA-N

The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.

1 2D Structure

Epinephrine Bitartrate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2,3-dihydroxybutanedioic acid;4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol

2.1.2 InChI

InChI=1S/C9H13NO3.C4H6O6/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;5-1(3(7)8)2(6)4(9)10/h2-4,9-13H,5H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t9-;/m0./s1

2.1.3 InChI Key

YLXIPWWIOISBDD-FVGYRXGTSA-N

2.1.4 Canonical SMILES

CNCC(C1=CC(=C(C=C1)O)O)O.C(C(C(=O)O)O)(C(=O)O)O

2.1.5 Isomeric SMILES

CNC[C@@H](C1=CC(=C(C=C1)O)O)O.C(C(C(=O)O)O)(C(=O)O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

2. Acetate, Epinephrine

3. Adrenaline

4. Adrenaline Acid Tartrate

5. Adrenaline Bitartrate

6. Adrenaline Hydrochloride

7. Epifrin

8. Epinephrine

9. Epinephrine Acetate

10. Epinephrine Bitartrate

11. Epinephrine Hydrochloride

12. Epitrate

13. Lyophrin

14. Medihaler-epi

2.2.2 Depositor-Supplied Synonyms

1. (-)-epinephrine Bitartrate

2. Adrenaline Bitartrate

3. Mls000028381

4. Epinephrine D-bitartrate

5. L-epinephrine Bitartrate

6. Smr000058630

7. Adrenaline Bitartate

8. Adrenaline (as Tartrate)

9. Sr-01000075267

10. L-epinephrine Hydrogen Tartrate

11. Adrenalin Tartrate

12. Nsc-756755

13. Opera_id_1462

14. Epinephrini Hydrogenotartras

15. Lopac0_000502

16. Schembl597216

17. Chembl1256958

18. L-adrenaline Hydrogen Bitartrate

19. L-epinephrine Hydrogen Bitartrate

20. Hms2233k16

21. Hms3261f05

22. Tox21_500502

23. Akos030504417

24. Ccg-221806

25. Lp00502

26. Ncgc00093902-01

27. Ncgc00261187-01

28. A0175

29. Eu-0100502

30. E 4375

31. Sr-01000075267-1

32. Sr-01000075267-4

33. Sr-01000075267-6

2.3 Create Date

2006-06-15

3 Chemical and Physical Properties

Molecular Formula	C₁₃H₁₉NO₉
Molecular Weight	333.29 g/mol
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	6
Exact Mass	333.10598118 g/mol
Monoisotopic Mass	333.10598118 g/mol
Topological Polar Surface Area	188 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	288
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adrenergic alpha-Agonists

Drugs that selectively bind to and activate alpha adrenergic receptors. (See all compounds classified as Adrenergic alpha-Agonists.)

Adrenergic beta-Agonists

Drugs that selectively bind to and activate beta-adrenergic receptors. (See all compounds classified as Adrenergic beta-Agonists.)

Bronchodilator Agents

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)

Mydriatics

Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics. (See all compounds classified as Mydriatics.)

Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

Vasoconstrictor Agents

Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

API SUPPLIERS

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USDMF

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CEP/COS

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JDMF

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EU WC

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KDMF

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NDC API

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Listed Suppliers

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API Reference Price

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LTD.","customerCountry":"INDIA","quantity":"0.25","actualQuantity":"0.25","unit":"KGS","unitRateFc":"30000","totalValueFC":"7593.9","currency":"USD","unitRateINR":"2545500","date":"02-Sep-2024","totalValueINR":"636375","totalValueInUsd":"7593.9","indian_port":"Delhi Air","hs_no":"29379090","bill_no":"5370117","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"VIA E CURIEL 34-20067 PAULLO MI-ITA LY , , ITALY SDNF ITALY ITALY","customerAddress":"VILLAGE THANTHEWAL, ROPAR ROAD,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - INJECTABLE;INJECTION - 0.25%