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    Chemistry

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    Also known as: Primaquine diphosphate, 63-45-6, Primaquine bisphosphate, Primaquine (diphosphate), Malquine, 1,4-pentanediamine, n4-(6-methoxy-8-quinolinyl)-, phosphate (1:2)
    Molecular Formula
    C15H27N3O9P2
    Molecular Weight
    455.34  g/mol
    InChI Key
    GJOHLWZHWQUKAU-UHFFFAOYSA-N
    FDA UNII
    H0982HF78B
    Primaquine Diphosphate
    An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
    1 2D Structure

    Primaquine Diphosphate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine;phosphoric acid
    2.1.2 InChI
    InChI=1S/C15H21N3O.2H3O4P/c1-11(5-3-7-16)18-14-10-13(19-2)9-12-6-4-8-17-15(12)14;2*1-5(2,3)4/h4,6,8-11,18H,3,5,7,16H2,1-2H3;2*(H3,1,2,3,4)
    2.1.3 InChI Key
    GJOHLWZHWQUKAU-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(CCCN)NC1=C2C(=CC(=C1)OC)C=CC=N2.OP(=O)(O)O.OP(=O)(O)O
    2.2 Other Identifiers
    2.2.1 UNII
    H0982HF78B
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Diphosphate, Primaquine

    2. Phosphate, Primaquine

    3. Primacin

    4. Primaquine

    5. Primaquine Diphosphate

    2.3.2 Depositor-Supplied Synonyms

    1. Primaquine Diphosphate

    2. 63-45-6

    3. Primaquine Bisphosphate

    4. Primaquine (diphosphate)

    5. Malquine

    6. 1,4-pentanediamine, N4-(6-methoxy-8-quinolinyl)-, Phosphate (1:2)

    7. Primaquine Phosphate;primaquine Bisphosphate

    8. N4-(6-methoxyquinolin-8-yl)pentane-1,4-diamine Bis(phosphate)

    9. H0982hf78b

    10. Nsc-149765

    11. N-(5-aminopentan-2-yl)-6-methoxyquinolin-8-amine; Bis(phosphoric Acid)

    12. Primaquine Bis(phosphate)

    13. Wr 2975

    14. Dsstox_cid_25248

    15. Dsstox_rid_80773

    16. Dsstox_gsid_45248

    17. Ccris 1946

    18. Sr-05000001864

    19. Ncgc00178754-06

    20. Einecs 200-560-8

    21. Nsc 149765

    22. Primaquine Phosphate [usp]

    23. Unii-h0982hf78b

    24. Primaquine (tn)

    25. Prestwick_406

    26. Primaquini Diphosphas

    27. Camden

    28. Sn13272 Diphosphate

    29. 8-((4-amino-1-methylbutyl)amino)-6-methoxyquinoline Diphosphate

    30. Cas-63-45-6

    31. Ncgc00016284-01

    32. 8-((4-amino-1-methylbutyl)amino)-6-methoxyquinoline Phosphate (1:2)

    33. Primachine Phosphate

    34. Schembl41096

    35. Chembl43128

    36. Primaquine Bisphosphate, 98%

    37. Spectrum1500500

    38. Dtxsid6045248

    39. Hms502i08

    40. Primaquine Phosphate (jan/usp)

    41. 8-(4-amino-1-methylbutylamino)-6-methoxyquinoline Diphosphate

    42. 8-(4-amino-1-methylbutylamino)-6-methoxyquinolinediphosphate

    43. Hms1569o14

    44. Hms1920j18

    45. Hms2092a19

    46. Hms2096o14

    47. Hms3652b19

    48. Hms3713o14

    49. Primaquine Phosphate [jan]

    50. Primaquine Diphosphate [mi]

    51. Ibscreen-bb Bb_sc-03079

    52. Primaquine Phosphate [vandf]

    53. Tox21_110350

    54. Ccg-40283

    55. Mfcd00013166

    56. Primaquine Phosphate [mart.]

    57. S4237

    58. Primaquine Phosphate [usp-rs]

    59. Primaquine Phosphate [who-dd]

    60. (+-)-8-((4-amino-1-methylbutyl)amino)-6-methoxyquinoline Phosphate (1:2)

    61. 1,4-pentanediamine, N(sup 4)-(6-methoxy-8-quinolinyl)-, Phosphate (1:2)

    62. Akos026749962

    63. Quinoline, 8-((4-amino-1-methylbutyl)amino)-6-methoxy-, Phosphate (1:2)

    64. Tox21_110350_1

    65. Cs-3875

    66. Primaquine Diphosphate [who-ip]

    67. 1,4-pentanediamine, N(sup 4)-(6-methoxy-8-quinolinyl)-, (+-)-, Phosphate (1:2)

    68. Ncgc00094767-01

    69. Ncgc00094767-02

    70. As-13148

    71. Hy-12651

    72. Primaquine Phosphate [orange Book]

    73. Db-054488

    74. Primaquine Phosphate [usp Monograph]

    75. Primaquine Diphosphate [ep Monograph]

    76. Primaquini Diphosphas [who-ip Latin]

    77. Sw196647-3

    78. D02126

    79. E75742

    80. 013p166

    81. Sr-05000001864-1

    82. Sr-05000001864-3

    83. Sr-05000001864-7

    84. Q27279400

    85. N4-(6-methoxyquinolin-8-yl)pentane-1,4-diaminebis(phosphate)

    86. 8-(4-amino-1-methylbutylamino)-6-methoxyquinoline Diphosphate Salt

    87. 1,4-pentanediamine, N^4-(6-methoxy-8-quinolinyl)-, Phosphate (1:2)

    88. 8-?(4-?amino-?1-?methylbutylamino)?-?6-?methoxyquinoline Diphosphate Salt

    89. Primaquine Diphosphate, European Pharmacopoeia (ep) Reference Standard

    90. Primaquine Phosphate, United States Pharmacopeia (usp) Reference Standard

    91. Quinoline, 8-((4-amino-1-methylbutyl)amino)-6-methoxy-, Diphosphate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 455.34 g/mol
    Molecular Formula C15H27N3O9P2
    Hydrogen Bond Donor Count8
    Hydrogen Bond Acceptor Count12
    Rotatable Bond Count6
    Exact Mass455.12225344 g/mol
    Monoisotopic Mass455.12225344 g/mol
    Topological Polar Surface Area216 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity312
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NamePrimaquine phosphate
    Drug LabelPrimaquine phosphate is 8-[(4-Amino-1-methylbutyl)amino]-6-methoxyquinoline phosphate, a synthetic compound with potent antimalarial activity. Each tablet contains 26.3 mg of Primaquine phosphate (equivalent to 15 mg of primaquine base). The dosage i...
    Active IngredientPrimaquine phosphate
    Dosage FormTablet
    RouteOral
    Strengtheq 15mg base
    Market StatusPrescription
    CompanyBayshore Pharms; Alvogen

    2 of 2  
    Drug NamePrimaquine phosphate
    Drug LabelPrimaquine phosphate is 8-[(4-Amino-1-methylbutyl)amino]-6-methoxyquinoline phosphate, a synthetic compound with potent antimalarial activity. Each tablet contains 26.3 mg of Primaquine phosphate (equivalent to 15 mg of primaquine base). The dosage i...
    Active IngredientPrimaquine phosphate
    Dosage FormTablet
    RouteOral
    Strengtheq 15mg base
    Market StatusPrescription
    CompanyBayshore Pharms; Alvogen

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antimalarials

    Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Antimalarial [EPC]

    API Reference Price

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D. MELLO ROAD, NEAR G.P.O.","city":"MUMBAI,MAHARASHTRA","supplier":"MANGALAM DRUGS & ORGANICS LTD","supplierCountry":"INDIA","foreign_port":"GUANGZHOU","customer":"TO THE ORDER","customerCountry":"CHINA","quantity":"9.00","actualQuantity":"9","unit":"KGS","unitRateFc":"157","totalValueFC":"1192.4","currency":"USD","unitRateINR":10888.878000000001,"date":"22-Jul-2023","totalValueINR":"97999.902","totalValueInUsd":"1192.4","indian_port":"BOMBAY AIR","hs_no":"29334900","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"3RD FLOOR, RUPAM BUILDING, 239,P. D. MELLO ROAD, NEAR G.P.O., MUMBAI,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1702233000,"product":"PRIMAQUINE PHOSPHATE","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"VIATRIS","supplierCountry":"INDIA","foreign_port":"KUALA LUMPUR - INT\\'L","customer":"EPIC INGREDIENTS SDN ","customerCountry":"MALAYSIA","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"10000","totalValueFC":"29732.2","currency":"USD","unitRateINR":825000,"date":"11-Dec-2023","totalValueINR":"2475000","totalValueInUsd":"29732.2","indian_port":"Bombay Air","hs_no":"29334900","bill_no":"5953654","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MALAYSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"564\/A\/22, ROAD NO.92, HYDERABAD,ANDHRA PRADESH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1702492200,"product":"DRUGS: PRIMAQUINE PHOSPHATE\/PRIMAQUINE DIPHOSPHATE USP","address":"48, KANDIVLI INDUSTRIAL ESTATE,","city":"MUMBAI, MAHARASHTRA.","supplier":"IPCA LABORATORIES","supplierCountry":"INDIA","foreign_port":"BANGKOK","customer":"OF","customerCountry":"THAILAND","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"180","totalValueFC":"8661.4","currency":"USD","unitRateINR":14420,"date":"14-Dec-2023","totalValueINR":"721000","totalValueInUsd":"8661.4","indian_port":"Bombay Air","hs_no":"29334900","bill_no":"6032192","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"THAILAND","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"48, KANDIVLI INDUSTRIAL ESTATE,, MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1706466600,"product":"DRUGS - PRIMAQUINE PHOSPHATE \/ PRIMAQUINE DIPHOSPHATE PH.EUR.","address":"48, KANDIVLI INDUSTRIAL ESTATE,","city":"MUMBAI, MAHARASHTRA.","supplier":"IPCA LABORATORIES","supplierCountry":"INDIA","foreign_port":"LIMASSOL","customer":"OF","customerCountry":"CYPRUS","quantity":"475.00","actualQuantity":"475","unit":"KGS","unitRateFc":"220.3","totalValueFC":"101777.4","currency":"USD","unitRateINR":17808.187494736841,"date":"29-Jan-2024","totalValueINR":"8458889.06","totalValueInUsd":"101777.4","indian_port":"JNPT","hs_no":"29334900","bill_no":"7091615","productDescription":"API","marketType":"REGULATED MARKET","country":"CYPRUS","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"48, KANDIVLI INDUSTRIAL ESTATE,, MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1709058600,"product":"DRUGS: PRIMAQUINE PHOSPHATE USP","address":"48, KANDIVLI INDUSTRIAL ESTATE,","city":"MUMBAI, MAHARASHTRA.","supplier":"IPCA LABORATORIES","supplierCountry":"INDIA","foreign_port":"JAKARTA","customer":"OF","customerCountry":"INDONESIA","quantity":"475.00","actualQuantity":"475","unit":"KGS","unitRateFc":"245","totalValueFC":"113972.1","currency":"USD","unitRateINR":19908.84,"date":"28-Feb-2024","totalValueINR":"9456699","totalValueInUsd":"113972.1","indian_port":"Bombay Air","hs_no":"29334900","bill_no":"7912851","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"INDONESIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"48, KANDIVLI INDUSTRIAL ESTATE,, MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1713119400,"product":"DRUGS: PRIMAQUINE PHOSPHATE \/ PRIMAQUINEDIPHOSPHATE","address":"48, KANDIVLI INDUSTRIAL ESTATE,","city":"MUMBAI, MAHARASHTRA.","supplier":"IPCA LABORATORIES","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"GLOBE PHARMACEUTICALS LTD","customerCountry":"BANGLADESH","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"200","totalValueFC":"1966.3","currency":"USD","unitRateINR":16420,"date":"15-Apr-2024","totalValueINR":"164200","totalValueInUsd":"1966.3","indian_port":"Bombay Air","hs_no":"29334900","bill_no":"9141105","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"48, KANDIVLI INDUSTRIAL ESTATE,, MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1713465000,"product":"DRUGS - 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    13-Jan-2021
    27-Nov-2024
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    ABOUT THIS PAGE

    Primaquine Diphosphate Manufacturers

    A Primaquine Diphosphate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Primaquine Diphosphate, including repackagers and relabelers. The FDA regulates Primaquine Diphosphate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Primaquine Diphosphate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Primaquine Diphosphate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Primaquine Diphosphate Suppliers

    A Primaquine Diphosphate supplier is an individual or a company that provides Primaquine Diphosphate active pharmaceutical ingredient (API) or Primaquine Diphosphate finished formulations upon request. The Primaquine Diphosphate suppliers may include Primaquine Diphosphate API manufacturers, exporters, distributors and traders.

    click here to find a list of Primaquine Diphosphate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Primaquine Diphosphate USDMF

    A Primaquine Diphosphate DMF (Drug Master File) is a document detailing the whole manufacturing process of Primaquine Diphosphate active pharmaceutical ingredient (API) in detail. Different forms of Primaquine Diphosphate DMFs exist exist since differing nations have different regulations, such as Primaquine Diphosphate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Primaquine Diphosphate DMF submitted to regulatory agencies in the US is known as a USDMF. Primaquine Diphosphate USDMF includes data on Primaquine Diphosphate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Primaquine Diphosphate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Primaquine Diphosphate suppliers with USDMF on PharmaCompass.

    Primaquine Diphosphate CEP

    A Primaquine Diphosphate CEP of the European Pharmacopoeia monograph is often referred to as a Primaquine Diphosphate Certificate of Suitability (COS). The purpose of a Primaquine Diphosphate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Primaquine Diphosphate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Primaquine Diphosphate to their clients by showing that a Primaquine Diphosphate CEP has been issued for it. The manufacturer submits a Primaquine Diphosphate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Primaquine Diphosphate CEP holder for the record. Additionally, the data presented in the Primaquine Diphosphate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Primaquine Diphosphate DMF.

    A Primaquine Diphosphate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Primaquine Diphosphate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Primaquine Diphosphate suppliers with CEP (COS) on PharmaCompass.

    Primaquine Diphosphate WC

    A Primaquine Diphosphate written confirmation (Primaquine Diphosphate WC) is an official document issued by a regulatory agency to a Primaquine Diphosphate manufacturer, verifying that the manufacturing facility of a Primaquine Diphosphate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Primaquine Diphosphate APIs or Primaquine Diphosphate finished pharmaceutical products to another nation, regulatory agencies frequently require a Primaquine Diphosphate WC (written confirmation) as part of the regulatory process.

    click here to find a list of Primaquine Diphosphate suppliers with Written Confirmation (WC) on PharmaCompass.

    Primaquine Diphosphate NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Primaquine Diphosphate as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Primaquine Diphosphate API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Primaquine Diphosphate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Primaquine Diphosphate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Primaquine Diphosphate NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Primaquine Diphosphate suppliers with NDC on PharmaCompass.

    Primaquine Diphosphate GMP

    Primaquine Diphosphate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Primaquine Diphosphate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Primaquine Diphosphate GMP manufacturer or Primaquine Diphosphate GMP API supplier for your needs.

    Primaquine Diphosphate CoA

    A Primaquine Diphosphate CoA (Certificate of Analysis) is a formal document that attests to Primaquine Diphosphate's compliance with Primaquine Diphosphate specifications and serves as a tool for batch-level quality control.

    Primaquine Diphosphate CoA mostly includes findings from lab analyses of a specific batch. For each Primaquine Diphosphate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Primaquine Diphosphate may be tested according to a variety of international standards, such as European Pharmacopoeia (Primaquine Diphosphate EP), Primaquine Diphosphate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Primaquine Diphosphate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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