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Pritelivir

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Synopsis

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Chemistry

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Also known as: 348086-71-5, Bay 57-1293, Bay-57-1293, Aic316, Pritelivir [inn], N-methyl-n-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide

Molecular Formula

C₁₈H₁₈N₄O₃S₂

Molecular Weight

402.5 g/mol

InChI Key

IVZKZONQVYTCKC-UHFFFAOYSA-N

FDA UNII

07HQ1TJ4JE

Pritelivir is a thiazolylamide and helicase-primase enzyme inhibitor that is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Pritelivir inhibits the helicase-primase complex and prevents helicase or primase catalytic cycling of viral DNA, which interferes with DNA replication and growth. This agent does not require activation by HSV thymidine kinase and has a longer plasma half-life than nucleoside analogues.

1 2D Structure

Pritelivir

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-methyl-N-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-(4-pyridin-2-ylphenyl)acetamide

2.1.2 InChI

InChI=1S/C18H18N4O3S2/c1-12-17(27(19,24)25)26-18(21-12)22(2)16(23)11-13-6-8-14(9-7-13)15-5-3-4-10-20-15/h3-10H,11H2,1-2H3,(H2,19,24,25)

2.1.3 InChI Key

IVZKZONQVYTCKC-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=C(SC(=N1)N(C)C(=O)CC2=CC=C(C=C2)C3=CC=CC=N3)S(=O)(=O)N

2.2 Other Identifiers

2.2.1 UNII

07HQ1TJ4JE

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Aic316

2. Bay 57-1293

3. N-(5-(aminiosulfonyl)-4-methyl-1,3-thiazol-2-yl)-n-methyl-2-(4-(2-pyridinyl)phenyl)acetamide

2.3.2 Depositor-Supplied Synonyms

1. 348086-71-5

2. Bay 57-1293

3. Bay-57-1293

4. Aic316

5. Pritelivir [inn]

6. N-methyl-n-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide

7. Bay57-1293

8. Aic-316

9. N-methyl-n-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-(4-pyridin-2-ylphenyl)acetamide

10. 07hq1tj4je

11. Pritelivir (bay 57-1293)

12. 348086-71-5 (free Base)

13. Bay 57-1293;aic316

14. Unii-07hq1tj4je

15. Benzeneacetamide, N-(5-(aminosulfonyl)-4-methyl-2-thiazolyl)-n-methyl-4-(2-pyridinyl)-

16. N-(5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl)-n-methyl-2-(4-(2-pyridinyl)phenyl)acetamide

17. N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide

18. N-methyl-n-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide

19. N-methyl-n-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-[4-(pyridin-2-yl)phenyl]acetamide

20. Pritelivir;aic316

21. Pritelivir [who-dd]

22. Pritelivirbay-57-1293

23. Schembl1074614

24. Pritelivir(bay 57-1293)

25. Chembl4069597

26. Aic 316

27. Dtxsid70188344

28. Ex-a247

29. Hms3653b15

30. Hms3744e03

31. Bcp08742

32. Yna08671

33. Zinc3955689

34. Mfcd18633192

35. S7546

36. Akos026750515

37. Ccg-268675

38. Cs-1693

39. Db11844

40. Ks-5353

41. Sb19731

42. Ncgc00378984-02

43. Ac-33065

44. Da-42669

45. Hy-15303

46. Ls-14637

47. N-(5-(aminiosulfonyl)-4-methyl-1,3-thiazol-2-yl)-n-methyl-2-(4-(2-pyridinyl)phenyl)acetamide

48. Ft-0732285

49. Sw219861-1

50. A13324

51. A857450

52. Q15410303

53. N-methyl-n-(4-methyl-5-sulfamoyl-thiazol-2-yl)-2-[4-(2-pyridyl)phenyl]acetamide

54. Bay-571293; Aic-316; Aic 316;n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide;n-methyl-n-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide

55. N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl] Acetamide

56. N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridyl)phenyl]acetamide

57. N-[5-(aminosulphonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide

2.4 Create Date

2005-08-01

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₁₈N₄O₃S₂
Molecular Weight	402.5 g/mol
XLogP3	2.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	402.08203280 g/mol
Monoisotopic Mass	402.08203280 g/mol
Topological Polar Surface Area	143 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	617
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

Antiviral Agents

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

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ABOUT THIS PAGE

Pritelivir Manufacturers

A Pritelivir manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pritelivir, including repackagers and relabelers. The FDA regulates Pritelivir manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pritelivir API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Pritelivir Suppliers

A Pritelivir supplier is an individual or a company that provides Pritelivir active pharmaceutical ingredient (API) or Pritelivir finished formulations upon request. The Pritelivir suppliers may include Pritelivir API manufacturers, exporters, distributors and traders.

Pritelivir GMP

Pritelivir Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Pritelivir GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pritelivir GMP manufacturer or Pritelivir GMP API supplier for your needs.

Pritelivir CoA

A Pritelivir CoA (Certificate of Analysis) is a formal document that attests to Pritelivir's compliance with Pritelivir specifications and serves as a tool for batch-level quality control.

Pritelivir CoA mostly includes findings from lab analyses of a specific batch. For each Pritelivir CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Pritelivir may be tested according to a variety of international standards, such as European Pharmacopoeia (Pritelivir EP), Pritelivir JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pritelivir USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.