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Chemistry

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Also known as: 51-05-8, Procaine hcl, Novocain, Planocaine, Anestil, Naucaine
Molecular Formula
C13H21ClN2O2
Molecular Weight
272.77  g/mol
InChI Key
HCBIBCJNVBAKAB-UHFFFAOYSA-N
FDA UNII
95URV01IDQ

Procaine
A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
1 2D Structure

Procaine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride
2.1.2 InChI
InChI=1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H
2.1.3 InChI Key
HCBIBCJNVBAKAB-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.Cl
2.2 Other Identifiers
2.2.1 UNII
95URV01IDQ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Anuject

2. Geriocaine

3. Gerokit

4. Hewedolor-procain

5. Hydrochloride, Procaine

6. Lophakomp-procain N

7. Novocain

8. Novocaine

9. Prcaine Chlorhydrate Lavoisier

10. Procain Braun

11. Procain Curasan

12. Procain Jenapharm

13. Procain Rdler

14. Procain Steigerwald

15. Procain-loges

16. Procaina Serra

17. Procaine

18. Rwo Procain

2.3.2 Depositor-Supplied Synonyms

1. 51-05-8

2. Procaine Hcl

3. Novocain

4. Planocaine

5. Anestil

6. Naucaine

7. Neocaine

8. Omnicain

9. 2-(diethylamino)ethyl 4-aminobenzoate Hydrochloride

10. Procaine (hydrochloride)

11. Allocaine

12. Scurocaine

13. Jenacaine

14. Medaject

15. Syntocain

16. Rocain

17. Enpro

18. Benzoic Acid, 4-amino-, 2-(diethylamino)ethyl Ester, Monohydrochloride

19. Novocaine Hcl

20. Novocaine Hydrochloride

21. 4-aminobenzoic Acid 2-(diethylamino)ethyl Ester Hydrochloride

22. Procaine (novocaine) Hcl

23. 2-diethylaminoethyl 4-aminobenzoate Hydrochloride

24. Nsc-757280

25. 95urv01idq

26. Sp01a

27. 2-(diethylamino)ethyl P-aminobenzoate Monohydrochloride

28. Chebi:8431

29. Sp-01a

30. Geriocaine

31. Atoxicocaine

32. Chlorocaine

33. Neotonocaine

34. Aminocaine

35. Anadolor

36. Anesthesol

37. Bernocaine

38. Ethocaine

39. Eugerase

40. Herocaine

41. Irocaine

42. Juvocaine

43. Kerocaine

44. Lactocaine

45. Novocainum

46. Paracain

47. Sevicaine

48. Syncaine

49. Topokain

50. Westocaine

51. Cetain

52. Isocaine-heisler

53. Gerovital H3

54. Dsstox_cid_24435

55. Dsstox_rid_80225

56. Dsstox_gsid_44435

57. Rocaine

58. 2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride

59. Mls001304095

60. Benzoic Acid, 4-amino-, 2-(diethylamino)ethyl Ester, Hydrochloride (1:1)

61. Cas-51-05-8

62. Sr-01000076096

63. Ncgc00015864-02

64. Smr000718771

65. Einecs 200-077-2

66. Unii-95urv01idq

67. Procaine Hydrochloride [jan]

68. Gero

69. Ai3-02404

70. Procain Hcl

71. P-aminobenzoyldiethylaminoethanol Hydrochloride

72. Diethylaminoethanol 4-aminobenzoate Hydrochloride

73. Procaine Hydrochloride [usp:jan]

74. 2-diethylaminoethyl P-aminobenzoate Hydrochloride

75. Novocain (tn)

76. Prestwick_530

77. Mfcd00013000

78. P-aminobenzoic Acid 2-diethylaminoethyl Ester Hydrochloride

79. Procaine, Hydrochloride

80. Ec 200-077-2

81. Schembl27720

82. Mls001336055

83. Mls001336056

84. Spectrum1500504

85. Chembl1200841

86. Dtxsid1044435

87. Procaine Hydrochloride, >=97%

88. Hy-b0546a

89. Hms1568i03

90. Hms1920l06

91. Pharmakon1600-01500504

92. Procaine Hydrochloride [mi]

93. Procaine Hydrochloride (jp17/usp)

94. Tox21_110248

95. Tox21_302114

96. Tox21_500966

97. Benzoic Acid, P-amino-, 2-(diethylamino)ethyl Ester, Monohydrochloride

98. Ccg-39234

99. Nsc757280

100. S4023

101. Procaine Hydrochloride [vandf]

102. Akos006029122

103. Procaine Hydrochloride [mart.]

104. Tox21_110248_1

105. Bs-4445

106. Ks-5259

107. Lp00966

108. Nc00527

109. Nsc 757280

110. Procaine Hydrochloride [usp-rs]

111. Procaine Hydrochloride [who-dd]

112. Ncgc00015864-07

113. Ncgc00094267-01

114. Ncgc00094267-02

115. Ncgc00094267-03

116. Ncgc00094267-04

117. Ncgc00094267-05

118. Ncgc00255993-01

119. Ncgc00261651-01

120. Ac-14461

121. Bp166251

122. Procaine Hydrochloride [green Book]

123. Procaine Hydrochloride [ep Impurity]

124. Procaine Hydrochloride [orange Book]

125. A1163

126. Eu-0100966

127. Procaine Hydrochloride [ep Monograph]

128. Sw196719-3

129. Procaine Hydrochloride [usp Monograph]

130. Procaini Hydrochloridum [who-ip Latin]

131. Bim-0050939.0001

132. C07894

133. D00740

134. D78370

135. P 9879

136. Cardioplegin Component Procaine Hydrochloride

137. Q3680934

138. Sr-01000076096-1

139. Sr-01000076096-6

140. W-105920

141. Procaine Hydrochloride 100 Microg/ml In Acetonitrile

142. Z256708908

143. Procaine Hydrochloride, Vetranal(tm), Analytical Standard

144. Procaine Hydrochloride 1.0 Mg/ml In Acetonitrile (as Free Base)

145. Procaine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

146. Procaine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

147. Procaine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

2.4 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 272.77 g/mol
Molecular Formula C13H21ClN2O2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Exact Mass272.1291556 g/mol
Monoisotopic Mass272.1291556 g/mol
Topological Polar Surface Area55.6 Ų
Heavy Atom Count18
Formal Charge0
Complexity222
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anesthetics, Local

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)


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LTD.NO.88 YANGZI ROAD, SHIJIAZHUANG,HEBEI, SDNF CHINA","customerAddress":"SURVEY NO.144 146, VILLAGE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734892200,"product":"PROCAINE BENZYLPENICILLIN(BULK STERILE) IP(5000BOU) BENZYLPENICILLIN SODIUM (BULK STERILE) I.P.","address":"9th Floor, N. G. Tower","city":"Ahmedabad","supplier":"CSPC PHARMACEUTICAL GROUP","supplierCountry":"CHINA","foreign_port":"XINGANG (CHINA)","customer":"ZENEX ANIMAL HEALTH INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"5000.00","actualQuantity":"5000","unit":"KGS","unitRateFc":"28","totalValueFC":"141616.4","currency":"USD","unitRateINR":"2406.6","date":"23-Dec-2024","totalValueINR":"12033000","totalValueInUsd":"141616.4","indian_port":"JNPT","hs_no":"29411010","bill_no":"7399393","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Sterile","supplierPort":"XINGANG (CHINA)","supplierAddress":"TD. NO.88 YANGZI ROAD, ECONOMIC & T ECHNOLOGICAL DEVELOPMENT ZONE, SHIJ IAZHUANG CITY, HEBEI PROVINCE, CHIN China","customerAddress":"9th Floor, N. G. Tower"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735497000,"product":"PROCAINE BENZYLPENICILLIN STERILE (BENZYLPENICILLIN PROCAINE) MONOHYDRATE STERILE) (2100 BOU)PROCAINE BENZYLPENICILLIN STERILE (BENZYLPENICILLIN PROCAINE","address":"DEV ASHISH, 1ST FLOOR, NR. KLASSIC","city":"AHMEDABAD\/GUJARAT","supplier":"CSPC PHARMACEUTICAL GROUP","supplierCountry":"CHINA","foreign_port":"XINGANG (CHINA)","customer":"INJECT CARE PARENTERALS ","customerCountry":"INDIA","quantity":"2100.00","actualQuantity":"2100","unit":"KGS","unitRateFc":"33","totalValueFC":"70100.1","currency":"USD","unitRateINR":"2836.4","date":"30-Dec-2024","totalValueINR":"5956335","totalValueInUsd":"70100.1","indian_port":"JNPT","hs_no":"29411010","bill_no":"7521988","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Sterile","supplierPort":"XINGANG (CHINA)","supplierAddress":"NO. 88 YANGZI ROAD,ECONOMIC AND TEC HNOLOGICAL DEVELOPMENT ZONE, SHIJIA ZHUANG CITY, HEBEI PROVINCE CHINA CHINA","customerAddress":"DEV ASHISH, 1ST FLOOR, NR. KLASSIC"}]
05-Jan-2021
30-Dec-2024
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Average Price (USD/KGS)

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Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

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ABOUT THIS PAGE

Procaine Manufacturers

A Procaine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Procaine, including repackagers and relabelers. The FDA regulates Procaine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Procaine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Procaine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Procaine Suppliers

A Procaine supplier is an individual or a company that provides Procaine active pharmaceutical ingredient (API) or Procaine finished formulations upon request. The Procaine suppliers may include Procaine API manufacturers, exporters, distributors and traders.

click here to find a list of Procaine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Procaine USDMF

A Procaine DMF (Drug Master File) is a document detailing the whole manufacturing process of Procaine active pharmaceutical ingredient (API) in detail. Different forms of Procaine DMFs exist exist since differing nations have different regulations, such as Procaine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Procaine DMF submitted to regulatory agencies in the US is known as a USDMF. Procaine USDMF includes data on Procaine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Procaine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Procaine suppliers with USDMF on PharmaCompass.

Procaine JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Procaine Drug Master File in Japan (Procaine JDMF) empowers Procaine API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Procaine JDMF during the approval evaluation for pharmaceutical products. At the time of Procaine JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Procaine suppliers with JDMF on PharmaCompass.

Procaine CEP

A Procaine CEP of the European Pharmacopoeia monograph is often referred to as a Procaine Certificate of Suitability (COS). The purpose of a Procaine CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Procaine EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Procaine to their clients by showing that a Procaine CEP has been issued for it. The manufacturer submits a Procaine CEP (COS) as part of the market authorization procedure, and it takes on the role of a Procaine CEP holder for the record. Additionally, the data presented in the Procaine CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Procaine DMF.

A Procaine CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Procaine CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Procaine suppliers with CEP (COS) on PharmaCompass.

Procaine NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Procaine as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Procaine API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Procaine as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Procaine and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Procaine NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Procaine suppliers with NDC on PharmaCompass.

Procaine GMP

Procaine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Procaine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Procaine GMP manufacturer or Procaine GMP API supplier for your needs.

Procaine CoA

A Procaine CoA (Certificate of Analysis) is a formal document that attests to Procaine's compliance with Procaine specifications and serves as a tool for batch-level quality control.

Procaine CoA mostly includes findings from lab analyses of a specific batch. For each Procaine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Procaine may be tested according to a variety of international standards, such as European Pharmacopoeia (Procaine EP), Procaine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Procaine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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