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1. 54-35-3
2. Duphapen
3. Hostacillin
4. Hydracillin
5. Procaine Benzylpenicillin
6. 1lw5k9cir1
7. Retardillin
8. Depocillin
9. Nopcaine
10. Vetspen
11. Vitablend
12. Jenacillin O
13. Micro-pen
14. Penicillin Procaine
15. 2-(diethylamino)ethyl 4-aminobenzoate;(2s,5r,6r)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
16. 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid,3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2s,5r,6r)-, Compd. With2-(diethylamino)ethyl 4-aminobenzoate (1:1)other Ca Index Names:benzoic Acid, 4-amino-, 2-(diethylamino)ethyl Ester,mono[(2s,5r,6r)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2
17. Penzal N 300
18. Procain-penicillin
19. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3,3-dimethyl-7-oxo-6-((2-phenylacetyl)amino)- (2s,5r,6r)-, Compd. With 2-(diethylamino)ethyl 4-aminobenzoate (1:1)
20. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)- (2s,5r,6r)-, Compd. With 2-(diethylamino)ethyl 4-aminobenzoate (1:1)
21. 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2s,5r,6r)-, Compd. With 2-(diethylamino)ethyl 4-aminobenzoate (1:1)
22. Benzylpenicillin Novocaine Salt
23. Benzilpenillina Procainica [dcit]
24. Benzilpenillina Procainica
25. Einecs 200-205-7
26. Unii-1lw5k9cir1
27. Procainebenzylpenicillin
28. Penicillin G. Procaine
29. Chembl1628385
30. Dtxsid30883227
31. Anhydrous Procaine Penicillin
32. Mfcd00079285
33. S4979
34. Akos015896161
35. Penicillin G Procaine Anhydrous
36. Penicillin G Procaine Salt Monohydrate
37. Db09320
38. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-, Compd. With 2-(diethylamino)ethyl P-aminobenzoate (1:1)
39. As-15252
40. E707
41. 130p649
42. A830119
43. Q3435660
44. 2-(diethylamino)ethyl 4-azanylbenzoate; (2s,5r,6r)-3,3-dimethyl-7-oxidanylidene-6-(2-phenylethanoylamino)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
45. 4-aminobenzoic Acid 2-(diethylamino)ethyl Ester; (2s,5r,6r)-3,3-dimethyl-7-oxo-6-[(1-oxo-2-phenylethyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
| Molecular Weight | 570.7 g/mol |
|---|---|
| Molecular Formula | C29H38N4O6S |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 11 |
| Exact Mass | 570.25120612 g/mol |
| Monoisotopic Mass | 570.25120612 g/mol |
| Topological Polar Surface Area | 168 Ų |
| Heavy Atom Count | 40 |
| Formal Charge | 0 |
| Complexity | 752 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 3 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 2 |
For the treatment of a number of bacterial infections such as syphilis, anthrax, mouth infections, pneumonia and diphtheria.
FDA Label
It is an antibiotic against penicillin-susceptible microorganisms with bactericidal effect. Like all penicillins, procaine benzylpenicillin interferes with the synthesis of the bacterial cell wall peptidoglycan. It acts through the inhibition of biosynthesis of cell-wall peptidoglycan, rendering the cell wall osmotically unstable. It is part of the penicillin and beta lactam family of antibacterial drugs.
J - Antiinfectives for systemic use
J01 - Antibacterials for systemic use
J01C - Beta-lactam antibacterials, penicillins
J01CE - Beta-lactamase sensitive penicillins
J01CE09 - Procaine benzylpenicillin
Absorption
After intramuscular injection, it dissolves slowly at the site of injection, giving a plateau type of blood level at about 4 hours which falls slowly over a period of the next 15 to 20 hours.
Route of Elimination
The drug is rapidly and predominantly cleared via renal elimination, with 90% being through tubular secretion. Approximately 60 -90 % of a dose of parenteral penicillin G is excreted in the urine within 24 to 36 hours.
Volume of Distribution
The drug is distributed throughout the body tissues in widely varying amounts and spinal fluid to a lesser degree. Highest levels are found in the kidneys with lesser amounts in the liver, skin, and intestines. It displays low solubility thus results in blood serum levels much lower but more prolonged than other parenteral penicillins.
Procaine is rapidly hydrolyzed by plasma esterases to nontoxic metabolites.
Intramuscular injection of benzylpenicillin has a plasma half-life of 30 minutes.
Procaine benzylpenicillin is hydrolyzed into penicillin G once it is released from the injection site. Penicillin G attaches to the penicillin-binding proteins on bacterial cell wall and inhibit the transpeptidation enzyme that crosslinks the peptide chains attached to the backbone of the peptidoglycan. The final bactericidal event involves the inactivation of an inhibitor of autolytic enzymes in the cell wall, leading to lysis of the bacterium.
Market Place
ABOUT THIS PAGE
A Procaine Penicillin G manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Procaine Penicillin G, including repackagers and relabelers. The FDA regulates Procaine Penicillin G manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Procaine Penicillin G API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Procaine Penicillin G manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Procaine Penicillin G supplier is an individual or a company that provides Procaine Penicillin G active pharmaceutical ingredient (API) or Procaine Penicillin G finished formulations upon request. The Procaine Penicillin G suppliers may include Procaine Penicillin G API manufacturers, exporters, distributors and traders.
click here to find a list of Procaine Penicillin G suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
Procaine Penicillin G Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Procaine Penicillin G GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Procaine Penicillin G GMP manufacturer or Procaine Penicillin G GMP API supplier for your needs.
A Procaine Penicillin G CoA (Certificate of Analysis) is a formal document that attests to Procaine Penicillin G's compliance with Procaine Penicillin G specifications and serves as a tool for batch-level quality control.
Procaine Penicillin G CoA mostly includes findings from lab analyses of a specific batch. For each Procaine Penicillin G CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Procaine Penicillin G may be tested according to a variety of international standards, such as European Pharmacopoeia (Procaine Penicillin G EP), Procaine Penicillin G JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Procaine Penicillin G USP).
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