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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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ACTIVE PHARMA INGREDIENTS

5 API Suppliers, 3 USDMF, 1 EU WC, 5 NDC API, 1 Listed Suppliers

5 API Suppliers
3 USDMF
1 EU WC
5 NDC API
1 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

8 FDF Dossiers, 1 FDA Orange Book, 2 Europe, 1 Canada, 4 Listed Dossiers

8 FDF Dossiers
1 FDA Orange Book
2 Europe
1 Canada
4 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc, 15 SPI Pharma, 6 DKSH, 2 Faran Shimi Pharmaceutical, 6 Gangwal Healthcare, 1 Pfanstiehl, 4 ACG Worldwide, 1 Aeon Procare, 1 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 1 BASF, 4 Gangwal Chemicals, 3 Ingredion Pharma Solutions, 3 Kerry, 3 Lonza Capsugel, 2 Microlex e.U, 2 Pluviaendo, 1 Qualicaps, 10 Roquette, 1 Seppic, 2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 2 Sigachi Industries

EXCIPIENTS BY APPLICATIONS

35 Fillers, Diluents & Binders, 18 Direct Compression, 13 Chewable & Orodispersible Aids, 13 Taste Masking, 10 Co-Processed Excipients, 8 Empty Capsules, 7 Coating Systems & Additives, 7 Thickeners and Stabilizers, 7 Disintegrants & Superdisintegrants, 4 Granulation, 4 Parenteral, 3 Controlled & Modified Release, 3 Film Formers & Plasticizers, 2 Lubricants & Glidants, 2 Coloring Agents, 1 API Stability Enhancers

excipientsByApplications
35 Fillers, Diluents & Binders
18 Direct Compression
13 Chewable & Orodispersible Aids
13 Taste Masking
10 Co-Processed Excipients
8 Empty Capsules
7 Coating Systems & Additives
7 Thickeners and Stabilizers
7 Disintegrants & Superdisintegrants
4 Granulation
4 Parenteral
3 Controlled & Modified Release
3 Film Formers & Plasticizers
2 Lubricants & Glidants
2 Coloring Agents
1 API Stability Enhancers

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow

media
1 DATA COMPILATION #PharmaFlow

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 2 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
2 Finished Drug Prices

MARKET PLACE

2 APIs, 5 FDF Dossiers

marketPlace
2 APIs
5 FDF Dossiers

REF. STANDARDS & IMPURITIES

1 USP , 1 Others

otherSolutions
1 USP
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

1,661,437

Annual Reports (USD Million)

Finished Drug Prices

72 RELATED EXCIPIENT COMPANIES

137EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 366-70-1, Procarbazine hcl, Matulane, Nathulane, Natunalar, Natulan

Molecular Formula

C₁₂H₂₀ClN₃O

Molecular Weight

257.76 g/mol

InChI Key

DERJYEZSLHIUKF-UHFFFAOYSA-N

FDA UNII

XH0NPH5ZX8

An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.

1 2D Structure

Procarbazine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide;hydrochloride

2.1.2 InChI

InChI=1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H

2.1.3 InChI Key

DERJYEZSLHIUKF-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C)NC(=O)C1=CC=C(C=C1)CNNC.Cl

2.2 Other Identifiers

2.2.1 UNII

XH0NPH5ZX8

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Hydrochloride, Procarbazine

2. Matulane

3. Monohydrobromide, Procarbazine

4. Monohydrochloride, Procarbazine

5. Natulan

6. Procarbazine

7. Procarbazine Monohydrobromide

8. Procarbazine Monohydrochloride

2.3.2 Depositor-Supplied Synonyms

1. 366-70-1

2. Procarbazine Hcl

3. Matulane

4. Nathulane

5. Natunalar

6. Natulan

7. Ibenzmethyzine Hydrochloride

8. Procarbazine.hcl

9. Mih Hydrochloride

10. Pcb Hydrochloride

11. Procarbazine (hydrochloride)

12. Nsc-77213

13. Nci-c01810

14. N-isopropyl-4-((2-methylhydrazinyl)methyl)benzamide Hydrochloride

15. Ro 4-6467/1

16. Chebi:71428

17. Xh0nph5zx8

18. P-(n'-methylhydrazinomethyl)-n-isopropylbenzamide Hydrochloride

19. 366-70-1 (hcl)

20. Nsc-77213 Hcl

21. Mbh

22. 1-(p-isopropylcarbamoylbenzyl)-2-methylhydrazine Hydrochloride

23. 1-methyl-2-(p-isopropylcarbamoylbenzyl)hydrazine Hydrochloride

24. 1-methyl-2-p-(isopropylcarbamoyl)benzohydrazine Hydrochloride

25. N-isopropyl-p-(2-methylhydrazinomethyl)benzamide Hydrochloride

26. Nsc 77213

27. 2-(p-(isopropylcarbamoyl)benzyl)-1-methylhydrazine Hydrochloride

28. N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide Hydrochloride

29. Ro-4-6467 Hydrochloride

30. Nsc77213

31. Nci-c 01810

32. Nci-c-01810

33. Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-, Monohydrochloride

34. Procarbazine Hydrochloride (matulane)

35. Ro-46467/1

36. Ro 4 6467/1

37. 4-[(2-methylhydrazinyl)methyl]-n-propan-2-ylbenzamide;hydrochloride

38. Dsstox_cid_1190

39. N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide Hydrochloride

40. Dsstox_rid_76000

41. Dsstox_gsid_21190

42. Natulan Hydrochloride

43. Procarbazine Chloridrate

44. Ibenzmethyzin Hydrochloride

45. 4-[(2-methylhydrazin-1-yl)methyl]-n-(propan-2-yl)benzamide Hydrochloride

46. Ccris 531

47. Ncgc00016438-01

48. Ro-4646711

49. Cas-366-70-1

50. Ibz

51. Ro-4-6467/1

52. Einecs 206-678-6

53. Unii-xh0nph5zx8

54. Ai3-50844

55. Sr-01000763375

56. Matulane (tn)

57. Mfcd00072082

58. N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide Hydrochloride

59. Procarbazine Hydrochloride [usan:usp:jan]

60. N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide Monohydrochloride

61. P-toluamide, N-isopropyl-alpha-(2-methylhydrazino)-, Hydrochloride

62. Procarbazini Hydrochloridum

63. Chlorhydrate De 1-methyl 2 P (isopropylcarbamoyl)benzyl-hydrazine [french]

64. Schembl4012

65. Methyl)benzamide Hydrochloride

66. Procarbazine Monohydrochloride

67. Mls001401414

68. P-toluamide, Monohydrochloride

69. Chembl1200410

70. Dtxsid3021190

71. Amy8865

72. Hms1571o06

73. Bcp02880

74. Chlorhydrate De 1-methyl 2 P (isopropylcarbamoyl)benzyl-hydrazine

75. Procarbazine Hydrochloride (natulan)

76. Tox21_110439

77. Tox21_302318

78. Bdbm50247906

79. P-toluamide, N-isopropyl-alpha-(2-methylhydrazino)-, Monohydrochloride

80. S1995

81. Wln: 1y1&mvr D1mm1 &gh

82. N-isopropyl-4-((2-methylhydrazinyl)

83. Akos015895395

84. Tox21_110439_1

85. Ccg-100985

86. Nc00235

87. Procarbazine Hydrochloride (jp17/usp)

88. Procarbazine Hydrochloride [mi]

89. Procarbazine Hydrochloride [jan]

90. Ncgc00016438-04

91. Ncgc00255389-01

92. Procarbazine Hydrochloride [iarc]

93. Procarbazine Hydrochloride [usan]

94. Ac-12163

95. As-13285

96. Bp164298

97. Hy-13733

98. Procarbazine Hydrochloride [mart.]

99. Procarbazine Hydrochloride [vandf]

100. Ro 4-646711

101. Smr000469151

102. Bcp0726000264

103. Procarbazine Hydrochloride [usp-rs]

104. Procarbazine Hydrochloride [who-dd]

105. Procarbazine Hydrochloride [who-ip]

106. Db-048987

107. Procarbazine Hydrochloride, >=98% (hplc)

108. Ft-0603386

109. P2550

110. C07376

111. D00478

112. Procarbazine Hydrochloride [orange Book]

113. 366p701

114. A823326

115. Procarbazine Hydrochloride [usp Monograph]

116. Procarbazini Hydrochloridum [who-ip Latin]

117. Sr-01000763375-4

118. Q26840941

119. Z1550675463

120. 4-[(methylhydrazo)methyl]-n-propan-2-ylbenzamide Hydrochloride

121. Methyl-[[4-(propan-2-ylcarbamoyl)phenyl]methylamino]azanium;chloride

122. N-isopropyl-4-((2-methylhydrazinyl)methyl)benzamidehydrochloride

123. 4-[(2-methyl-hydrazino)-methyl]-benzoic Acid Isopropylamide Hydrochloride

124. 4-[(2-methylhydrazinyl)methyl]-n-propan-2-yl-benzamide Hydrochloride

125. N-isopropyl-.alpha.-(2-methylhydrazino)-p-toluamide Monohydrochloride

126. Procarbazine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date

2005-08-01

3 Chemical and Physical Properties

Molecular Formula	C₁₂H₂₀ClN₃O
Molecular Weight	257.76 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	257.1294900 g/mol
Monoisotopic Mass	257.1294900 g/mol
Topological Polar Surface Area	53.2 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	210
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Matulane
PubMed Health	Procarbazine (By mouth)
Drug Classes	Antineoplastic Agent
Drug Label	Matulane (procarbazine hydrochloride), a hydrazine derivative antineoplastic agent, is available as capsules containing the equivalent of 50 mg procarbazine as the hydrochloride. Each capsule also contains cornstarch, mannitol and talc. Gelatin capsu...
Active Ingredient	Procarbazine hydrochloride
Dosage Form	Capsule
Route	Oral
Strength	eq 50mg base
Market Status	Prescription
Company	Sigma Tau

2 of 2
Drug Name	Matulane
PubMed Health	Procarbazine (By mouth)
Drug Classes	Antineoplastic Agent
Drug Label	Matulane (procarbazine hydrochloride), a hydrazine derivative antineoplastic agent, is available as capsules containing the equivalent of 50 mg procarbazine as the hydrochloride. Each capsule also contains cornstarch, mannitol and talc. Gelatin capsu...
Active Ingredient	Procarbazine hydrochloride
Dosage Form	Capsule
Route	Oral
Strength	eq 50mg base
Market Status	Prescription
Company	Sigma Tau