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Chemistry

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Also known as: 1508-76-5, Kemadrin, Procyclidine hcl, Procyclidine (hydrochloride), Tricyclamol hydrochloride, (r)-tricylamol iodide
Molecular Formula
C19H30ClNO
Molecular Weight
323.9  g/mol
InChI Key
ZFSPFXJSEHCTTR-UHFFFAOYSA-N
FDA UNII
CQC932Z7YW

Procyclidine
A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
1 2D Structure

Procyclidine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol;hydrochloride
2.1.2 InChI
InChI=1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H
2.1.3 InChI Key
ZFSPFXJSEHCTTR-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CCC(CC1)C(CCN2CCCC2)(C3=CC=CC=C3)O.Cl
2.2 Other Identifiers
2.2.1 UNII
CQC932Z7YW
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Arpicolin

2. Hydrochloride, Procyclidine

3. Kemadren

4. Kemadrin

5. Mucinil

6. Osnervan

7. Procyclid

8. Procyclidine

9. Tricyclamol

2.3.2 Depositor-Supplied Synonyms

1. 1508-76-5

2. Kemadrin

3. Procyclidine Hcl

4. Procyclidine (hydrochloride)

5. Tricyclamol Hydrochloride

6. (r)-tricylamol Iodide

7. (+-)-procyclidine Hydrochloride

8. 30953-84-5

9. Nsc-757293

10. 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol;hydrochloride

11. Cqc932z7yw

12. Mls000028556

13. 1-cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol Hydrochloride

14. (+/-)-procyclidine Hydrochlorid

15. Procyclidine Hydrochloride [usp]

16. 1-pyrrolidinepropanol, Alpha-cyclohexyl-alpha-phenyl-, Hydrochloride (1:1)

17. Smr000058821

18. 1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol Hydrochloride

19. Dsstox_cid_25357

20. Dsstox_rid_80823

21. Dsstox_gsid_45357

22. Procyclidine Hydrochloride (usp)

23. Chebi:8449

24. Einecs 216-141-8

25. Alpha-cyclohexyl-alpha-phenyl-1-pyrrolidinepropanol Hydrochloride

26. Unii-cqc932z7yw

27. Sr-01000000095

28. Kemadrin (tn)

29. Prestwick_125

30. Opera_id_270

31. Ncgc00016585-01

32. Cas-1508-76-5

33. Chembl1761

34. Mls001076129

35. Mls002222170

36. Schembl121684

37. Spectrum1500507

38. Dtxsid8045357

39. Regid_for_cid_207841

40. Hms1570j09

41. Hms1920l10

42. Pharmakon1600-01500507

43. Hy-b1487

44. Tox21_110508

45. 1-pyrrolidinepropanol, Alpha-cyclohexyl-alpha-phenyl-, Hydrochloride

46. Ccg-39236

47. Mfcd00079236

48. Nsc757293

49. 1-pyrrolidinepropanol, .alpha.-cyclohexyl-.alpha.-phenyl-, Hydrochloride

50. 1-pyrrolidinepropanol, Alpha-cyclohexyl-alpha-phenyl-, Monohydrochloride

51. Tox21_110508_1

52. Cs-5893

53. Nc00585

54. Nsc 757293

55. Procyclidine Hydrochloride [mi]

56. Ncgc00018186-07

57. Ncgc00094769-01

58. Ncgc00094769-02

59. Ncgc00094769-03

60. Ncgc00094769-04

61. Bs-42188

62. Procyclidine Hydrochloride [mart.]

63. Procyclidine Hydrochloride [vandf]

64. Procyclidine Hydrochloride [usp-rs]

65. Procyclidine Hydrochloride [who-dd]

66. Ft-0674043

67. Sw196436-3

68. D00782

69. Procyclidine Hydrochloride [orange Book]

70. 508p765

71. Procyclidine Hydrochloride [usp Monograph]

72. J-008753

73. Sr-01000000095-4

74. 5-isopropyl-3-methylisoxazole-4-carboxylicacid

75. Q27108083

76. ( Inverted Exclamation Marka)-procyclidine Hydrochlorid

77. ( Inverted Exclamation Marka)-procyclidine Hydrochloride

78. (r)-1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol Hydrochloride

79. .alpha.-cyclohexyl-.alpha.-phenyl-1-pyrrolidinepropanol Hydrochloride

80. Procyclidine Hydrochloride (1-cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol Hydrochloride)

81. Procyclidine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 323.9 g/mol
Molecular Formula C19H30ClNO
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Exact Mass323.2015923 g/mol
Monoisotopic Mass323.2015923 g/mol
Topological Polar Surface Area23.5 Ų
Heavy Atom Count22
Formal Charge0
Complexity301
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antiparkinson Agents

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)


Muscarinic Antagonists

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)


API Reference Price

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02-Jan-2021
22-Nov-2024
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ABOUT THIS PAGE

Procyclidine hydrochloride Manufacturers

A Procyclidine hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Procyclidine hydrochloride, including repackagers and relabelers. The FDA regulates Procyclidine hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Procyclidine hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Procyclidine hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Procyclidine hydrochloride Suppliers

A Procyclidine hydrochloride supplier is an individual or a company that provides Procyclidine hydrochloride active pharmaceutical ingredient (API) or Procyclidine hydrochloride finished formulations upon request. The Procyclidine hydrochloride suppliers may include Procyclidine hydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Procyclidine hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Procyclidine hydrochloride USDMF

A Procyclidine hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Procyclidine hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Procyclidine hydrochloride DMFs exist exist since differing nations have different regulations, such as Procyclidine hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Procyclidine hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Procyclidine hydrochloride USDMF includes data on Procyclidine hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Procyclidine hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Procyclidine hydrochloride suppliers with USDMF on PharmaCompass.

Procyclidine hydrochloride NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Procyclidine hydrochloride as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Procyclidine hydrochloride API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Procyclidine hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Procyclidine hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Procyclidine hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Procyclidine hydrochloride suppliers with NDC on PharmaCompass.

Procyclidine hydrochloride GMP

Procyclidine hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Procyclidine hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Procyclidine hydrochloride GMP manufacturer or Procyclidine hydrochloride GMP API supplier for your needs.

Procyclidine hydrochloride CoA

A Procyclidine hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Procyclidine hydrochloride's compliance with Procyclidine hydrochloride specifications and serves as a tool for batch-level quality control.

Procyclidine hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Procyclidine hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Procyclidine hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Procyclidine hydrochloride EP), Procyclidine hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Procyclidine hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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