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Profenamine

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ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 USDMF

1 API Suppliers
1 USDMF

FINISHED DOSAGE FORMULATIONS

4 FDF Dossiers, 3 FDA Orange Book, 1 Canada

4 FDF Dossiers
3 FDA Orange Book
1 Canada

DIGITAL CONTENT

1 NEWS #PharmaBuzz

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1 NEWS #PharmaBuzz

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

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API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

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Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Profenamine hydrochloride, 1094-08-2, Ethopropazine hcl, Lysivane, Pardisol, Parfezin

Molecular Formula

C₁₉H₂₅ClN₂S

Molecular Weight

348.9 g/mol

InChI Key

VXPCQISYVPFYRK-UHFFFAOYSA-N

FDA UNII

O00T1I1VRN

1 2D Structure

Profenamine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N,N-diethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride

2.1.2 InChI

InChI=1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H

2.1.3 InChI Key

VXPCQISYVPFYRK-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCN(CC)C(C)CN1C2=CC=CC=C2SC3=CC=CC=C31.Cl

2.2 Other Identifiers

2.2.1 UNII

O00T1I1VRN

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Ethopropazine

2. Lysivane

3. Parsidol

4. Parsitan

5. Profenamine

6. Profenamine Hydrochloride

2.3.2 Depositor-Supplied Synonyms

1. Profenamine Hydrochloride

2. 1094-08-2

3. Ethopropazine Hcl

4. Lysivane

5. Pardisol

6. Parfezin

7. Parphezein

8. Dibutil

9. Profenamine Hcl

10. Profenamine Monohydrochloride

11. Isothazine Hydrochloride

12. 10-(2-(diethylamino)propyl)phenothiazine Monohydrochloride

13. Parsidol Hydrochloride

14. Parsidol Monohydrochloride

15. Nsc-64074

16. Nsc-169467

17. O00t1i1vrn

18. Ethopropazine (hydrochloride)

19. N,n-diethyl-alpha-methyl-10h-phenothiazine-10-ethylamine Monohydrochloride

20. Ethopropazine Monohydrochloride

21. Chembl1200970

22. Chebi:31568

23. N,n-diethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride

24. 42957-54-0

25. Parphezin

26. N,n-diethyl-1-(10h-phenothiazin-10-yl)propan-2-amine Hydrochloride

27. Dsstox_cid_25347

28. Dsstox_rid_80815

29. Dsstox_gsid_45347

30. Parsidol (van)

31. Lysivane Hydrochloride

32. 10-(2-(diethylamino)propyl)-phenothiazin Hydrochloride

33. Profenamine Hydrochloride (jan)

34. N,n-diethyl-alpha-methyl-10h-phenothiazine-10-ethylamine Hydrochloride

35. Profenamine Hydrochloride [jan]

36. Einecs 214-134-4

37. Nsc 64074

38. Unii-o00t1i1vrn

39. Nsc 169467

40. Sr-05000001626

41. Prophenamine Hydrochloride

42. 10h-phenothiazine-10-ethanamine,n-diethyl-.alpha.-methyl-, Monohydrochloride

43. Ethopropazine Hydrochloride [usp]

44. Parsidol (tn)

45. Prestwick_195

46. Einecs 256-019-1

47. L-10-(2-diethylaminopropyl)phenothiazine Hydrochloride

48. Ncgc00016562-01

49. 10-phenothiazineethylamine, N,n-diethyl-alpha-methyl-, Hydrochloride

50. Cas-1094-08-2

51. Schembl123703

52. Spectrum1500293

53. Dtxsid4045347

54. Hms1570h21

55. Hms1920o04

56. Pharmakon1600-01500293

57. Bcp12225

58. Nsc64074

59. Phenothiazine, 10-(2-(diethylamino)propyl)-, Monohydrochloride

60. Tox21_110496

61. Tox21_500873

62. Ccg-40202

63. Nsc169467

64. Nsc757029

65. 10h-phenothiazine-10-ethanamine, N,n-diethyl-alpha-methyl-, Monohydrochloride

66. Akos015901042

67. Tox21_110496_1

68. Lp00873

69. Nsc-757029

70. Ethopropazine Hydrochloride [mi]

71. Ncgc00094678-01

72. Ncgc00094678-02

73. Ncgc00178860-06

74. Ncgc00261558-01

75. Profenamine Hydrochloride [mart.]

76. Profenamine Hydrochloride [who-dd]

77. Ethopropazine Hydrochloride [vandf]

78. Db-040867

79. Hy-107922

80. Cs-0030870

81. Ft-0625740

82. D01118

83. Ethopropazine Hydrochloride [orange Book]

84. Ethopropazine Hydrochloride, >=98% (hplc), Powder

85. Sr-05000001626-2

86. Q27114444

87. 10h-phenothiazine-10-ethanamine,n,n-diethyl-a-methyl-,hydrochloride(1:1)

88. 10h-phenothiazine-10-ethanamine, N,n-diethyl-.alpha.-methyl-, Hydrochloride (1:1)

89. Ethopropazine Hydrochloride;profenamine Hcl; Ethopropazine Hcl; 10-[2-diethylaminopropyl]phenothiazine

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₂₅ClN₂S
Molecular Weight	348.9 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	348.1426977 g/mol
Monoisotopic Mass	348.1426977 g/mol
Topological Polar Surface Area	31.8 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	322
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Muscarinic Antagonists

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

Adrenergic Antagonists

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE. (See all compounds classified as Adrenergic Antagonists.)

Histamine Antagonists

Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only. (See all compounds classified as Histamine Antagonists.)

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