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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Profenamine hydrochloride, 1094-08-2, Ethopropazine hcl, Lysivane, Pardisol, Parfezin
Molecular Formula
C19H25ClN2S
Molecular Weight
348.9  g/mol
InChI Key
VXPCQISYVPFYRK-UHFFFAOYSA-N
FDA UNII
O00T1I1VRN

Profenamine
1 2D Structure

Profenamine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N,N-diethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride
2.1.2 InChI
InChI=1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H
2.1.3 InChI Key
VXPCQISYVPFYRK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN(CC)C(C)CN1C2=CC=CC=C2SC3=CC=CC=C31.Cl
2.2 Other Identifiers
2.2.1 UNII
O00T1I1VRN
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ethopropazine

2. Lysivane

3. Parsidol

4. Parsitan

5. Profenamine

6. Profenamine Hydrochloride

2.3.2 Depositor-Supplied Synonyms

1. Profenamine Hydrochloride

2. 1094-08-2

3. Ethopropazine Hcl

4. Lysivane

5. Pardisol

6. Parfezin

7. Parphezein

8. Dibutil

9. Profenamine Hcl

10. Profenamine Monohydrochloride

11. Isothazine Hydrochloride

12. 10-(2-(diethylamino)propyl)phenothiazine Monohydrochloride

13. Parsidol Hydrochloride

14. Parsidol Monohydrochloride

15. Nsc-64074

16. Nsc-169467

17. O00t1i1vrn

18. Ethopropazine (hydrochloride)

19. N,n-diethyl-alpha-methyl-10h-phenothiazine-10-ethylamine Monohydrochloride

20. Ethopropazine Monohydrochloride

21. Chembl1200970

22. Chebi:31568

23. N,n-diethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride

24. 42957-54-0

25. Parphezin

26. N,n-diethyl-1-(10h-phenothiazin-10-yl)propan-2-amine Hydrochloride

27. Dsstox_cid_25347

28. Dsstox_rid_80815

29. Dsstox_gsid_45347

30. Parsidol (van)

31. Lysivane Hydrochloride

32. 10-(2-(diethylamino)propyl)-phenothiazin Hydrochloride

33. Profenamine Hydrochloride (jan)

34. N,n-diethyl-alpha-methyl-10h-phenothiazine-10-ethylamine Hydrochloride

35. Profenamine Hydrochloride [jan]

36. Einecs 214-134-4

37. Nsc 64074

38. Unii-o00t1i1vrn

39. Nsc 169467

40. Sr-05000001626

41. Prophenamine Hydrochloride

42. 10h-phenothiazine-10-ethanamine,n-diethyl-.alpha.-methyl-, Monohydrochloride

43. Ethopropazine Hydrochloride [usp]

44. Parsidol (tn)

45. Prestwick_195

46. Einecs 256-019-1

47. L-10-(2-diethylaminopropyl)phenothiazine Hydrochloride

48. Ncgc00016562-01

49. 10-phenothiazineethylamine, N,n-diethyl-alpha-methyl-, Hydrochloride

50. Cas-1094-08-2

51. Schembl123703

52. Spectrum1500293

53. Dtxsid4045347

54. Hms1570h21

55. Hms1920o04

56. Pharmakon1600-01500293

57. Bcp12225

58. Nsc64074

59. Phenothiazine, 10-(2-(diethylamino)propyl)-, Monohydrochloride

60. Tox21_110496

61. Tox21_500873

62. Ccg-40202

63. Nsc169467

64. Nsc757029

65. 10h-phenothiazine-10-ethanamine, N,n-diethyl-alpha-methyl-, Monohydrochloride

66. Akos015901042

67. Tox21_110496_1

68. Lp00873

69. Nsc-757029

70. Ethopropazine Hydrochloride [mi]

71. Ncgc00094678-01

72. Ncgc00094678-02

73. Ncgc00178860-06

74. Ncgc00261558-01

75. Profenamine Hydrochloride [mart.]

76. Profenamine Hydrochloride [who-dd]

77. Ethopropazine Hydrochloride [vandf]

78. Db-040867

79. Hy-107922

80. Cs-0030870

81. Ft-0625740

82. D01118

83. Ethopropazine Hydrochloride [orange Book]

84. Ethopropazine Hydrochloride, >=98% (hplc), Powder

85. Sr-05000001626-2

86. Q27114444

87. 10h-phenothiazine-10-ethanamine,n,n-diethyl-a-methyl-,hydrochloride(1:1)

88. 10h-phenothiazine-10-ethanamine, N,n-diethyl-.alpha.-methyl-, Hydrochloride (1:1)

89. Ethopropazine Hydrochloride;profenamine Hcl; Ethopropazine Hcl; 10-[2-diethylaminopropyl]phenothiazine

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 348.9 g/mol
Molecular Formula C19H25ClN2S
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass348.1426977 g/mol
Monoisotopic Mass348.1426977 g/mol
Topological Polar Surface Area31.8 Ų
Heavy Atom Count23
Formal Charge0
Complexity322
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Muscarinic Antagonists

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)


Adrenergic Antagonists

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE. (See all compounds classified as Adrenergic Antagonists.)


Histamine Antagonists

Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only. (See all compounds classified as Histamine Antagonists.)


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ABOUT THIS PAGE

Profenamine Manufacturers

A Profenamine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Profenamine, including repackagers and relabelers. The FDA regulates Profenamine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Profenamine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Profenamine Suppliers

A Profenamine supplier is an individual or a company that provides Profenamine active pharmaceutical ingredient (API) or Profenamine finished formulations upon request. The Profenamine suppliers may include Profenamine API manufacturers, exporters, distributors and traders.

click here to find a list of Profenamine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Profenamine USDMF

A Profenamine DMF (Drug Master File) is a document detailing the whole manufacturing process of Profenamine active pharmaceutical ingredient (API) in detail. Different forms of Profenamine DMFs exist exist since differing nations have different regulations, such as Profenamine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Profenamine DMF submitted to regulatory agencies in the US is known as a USDMF. Profenamine USDMF includes data on Profenamine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Profenamine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Profenamine suppliers with USDMF on PharmaCompass.

Profenamine GMP

Profenamine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Profenamine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Profenamine GMP manufacturer or Profenamine GMP API supplier for your needs.

Profenamine CoA

A Profenamine CoA (Certificate of Analysis) is a formal document that attests to Profenamine's compliance with Profenamine specifications and serves as a tool for batch-level quality control.

Profenamine CoA mostly includes findings from lab analyses of a specific batch. For each Profenamine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Profenamine may be tested according to a variety of international standards, such as European Pharmacopoeia (Profenamine EP), Profenamine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Profenamine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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