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Chemistry

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Also known as: 57132-53-3, Proglumetacina, Proglumetacine, Proglumetacinum, 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate, Chebi:76263
Molecular Formula
C46H58ClN5O8
Molecular Weight
844.4  g/mol
InChI Key
PTXGHCGBYMQQIG-UHFFFAOYSA-N
FDA UNII
FV919079LU

Proglumetacin
1 2D Structure

Proglumetacin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate
2.1.2 InChI
InChI=1S/C46H58ClN5O8/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9-12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38-33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35/h7-9,11-17,19,31,40H,5-6,10,18,20-30,32H2,1-4H3,(H,48,55)
2.1.3 InChI Key
PTXGHCGBYMQQIG-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCCN(CCC)C(=O)C(CCC(=O)OCCCN1CCN(CC1)CCOC(=O)CC2=C(N(C3=C2C=C(C=C3)OC)C(=O)C4=CC=C(C=C4)Cl)C)NC(=O)C5=CC=CC=C5
2.2 Other Identifiers
2.2.1 UNII
FV919079LU
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3'-(4-(2-(1-p-chlorobenzoyl-5-methoxy-2-methylindol-3-ylacetoxy)ethyl)piperazin-1-yl)propyl-4-benzamido-n,n-dipropylglutaramate (+-) Dimaleate

2. Prodamox

3. Proglumetacin Dimaleate

4. Proglumetacin Maleate

5. Protacine

6. Protaxil

7. Protaxon

2.3.2 Depositor-Supplied Synonyms

1. 57132-53-3

2. Proglumetacina

3. Proglumetacine

4. Proglumetacinum

5. 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate

6. Chebi:76263

7. Fv919079lu

8. Proglumetacin (inn)

9. Ncgc00183024-01

10. Proglumetacin [inn]

11. 3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl Dl-4-benzamido-n,n-dipropylglutaramate 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate (ester)

12. Proglumetacin [inn:ban]

13. Proglumetacine [inn-french]

14. Proglumetacinum [inn-latin]

15. Proglumetacina [inn-spanish]

16. Unii-fv919079lu

17. Bruxel (tn)

18. Proglumetacin [mi]

19. Dsstox_cid_28768

20. Dsstox_rid_83037

21. Dsstox_gsid_48842

22. Schembl27106

23. Proglumetacin [who-dd]

24. Chembl2105825

25. Dtxsid0048842

26. Tox21_113325

27. Db13527

28. Cas-57132-53-3

29. Hy-106560

30. Cs-0026053

31. Ft-0758237

32. D08427

33. A913226

34. Q2208070

35. 5-(dipropylamino)-1,5-dioxopentyl)oxy)propyl)-1-piperazinyl)ethyl Ester, (+/-)-

36. 1h-indole-3-acetic Acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-(4-(3-((4-(benzoylamino)-

37. 1h-indole-3-acetic Acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-(4-(3-((4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl)oxy)propyl)-1-piperazinyl)ethyl Ester

38. 1h-indole-3-acetic Acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl Ester (9ci)

39. 3-(4-(2-(2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indol-3-yl)acetoxy)ethyl)piperazin-1-yl)propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate

40. 3-[4-(2-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indol-3-yl]acetoxy}ethyl)piperazin-1-yl]propyl N(2)-benzoyl-n,n-dipropyl-alpha-glutaminate

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 844.4 g/mol
Molecular Formula C46H58ClN5O8
XLogP37.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count23
Exact Mass843.3973915 g/mol
Monoisotopic Mass843.3973915 g/mol
Topological Polar Surface Area140 Ų
Heavy Atom Count60
Formal Charge0
Complexity1360
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)


4.2 ATC Code

M - Musculo-skeletal system

M01 - Antiinflammatory and antirheumatic products

M01A - Antiinflammatory and antirheumatic products, non-steroids

M01AB - Acetic acid derivatives and related substances

M01AB14 - Proglumetacin


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Looking for 57132-53-3 / Proglumetacin API manufacturers, exporters & distributors?

Proglumetacin manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Proglumetacin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Proglumetacin manufacturer or Proglumetacin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Proglumetacin manufacturer or Proglumetacin supplier.

PharmaCompass also assists you with knowing the Proglumetacin API Price utilized in the formulation of products. Proglumetacin API Price is not always fixed or binding as the Proglumetacin Price is obtained through a variety of data sources. The Proglumetacin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Proglumetacin

Synonyms

57132-53-3, Proglumetacina, Proglumetacine, Proglumetacinum, 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate, Chebi:76263

Cas Number

57132-53-3

Unique Ingredient Identifier (UNII)

FV919079LU

Proglumetacin Manufacturers

A Proglumetacin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Proglumetacin, including repackagers and relabelers. The FDA regulates Proglumetacin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Proglumetacin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Proglumetacin Suppliers

A Proglumetacin supplier is an individual or a company that provides Proglumetacin active pharmaceutical ingredient (API) or Proglumetacin finished formulations upon request. The Proglumetacin suppliers may include Proglumetacin API manufacturers, exporters, distributors and traders.

Proglumetacin GMP

Proglumetacin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Proglumetacin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Proglumetacin GMP manufacturer or Proglumetacin GMP API supplier for your needs.

Proglumetacin CoA

A Proglumetacin CoA (Certificate of Analysis) is a formal document that attests to Proglumetacin's compliance with Proglumetacin specifications and serves as a tool for batch-level quality control.

Proglumetacin CoA mostly includes findings from lab analyses of a specific batch. For each Proglumetacin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Proglumetacin may be tested according to a variety of international standards, such as European Pharmacopoeia (Proglumetacin EP), Proglumetacin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Proglumetacin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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