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ACTIVE PHARMA INGREDIENTS

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JDMF

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Chemistry

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Also known as: 53-60-1, Promazine hcl, Sparine, Starazin, Talofen, Promazine (hydrochloride)
Molecular Formula
C17H21ClN2S
Molecular Weight
320.9  g/mol
InChI Key
JIVSXRLRGOICGA-UHFFFAOYSA-N
FDA UNII
U16EOR79U4

Promazine
A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
1 2D Structure

Promazine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine;hydrochloride
2.1.2 InChI
InChI=1S/C17H20N2S.ClH/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19;/h3-6,8-11H,7,12-13H2,1-2H3;1H
2.1.3 InChI Key
JIVSXRLRGOICGA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31.Cl
2.2 Other Identifiers
2.2.1 UNII
U16EOR79U4
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Hydrochloride, Promazine

2. Promazine

3. Protactyl

4. Sinophenin

5. Sparine

2.3.2 Depositor-Supplied Synonyms

1. 53-60-1

2. Promazine Hcl

3. Sparine

4. Starazin

5. Talofen

6. Promazine (hydrochloride)

7. Promazine Monohydrochloride

8. Rp 4560

9. N,n-dimethyl-3-(10h-phenothiazin-10-yl)propan-1-amine Hydrochloride

10. Nsc-17468

11. Promazinehydrochloride

12. Promazine Hydrochloride [usp]

13. Mls000069671

14. U16eor79u4

15. 10-(3-(dimethylamino)propyl)phenothiazine Monohydrochloride

16. 10h-phenothiazine-10-propanamine, N,n-dimethyl-, Monohydrochloride

17. N-(3-(dimethylamino)propyl)phenothiazine Hydrochloride

18. 10-(3-(dimethylamino)propyl)phenothiazine Hydrochloride

19. Smr000058499

20. Dsstox_cid_26949

21. Dsstox_rid_82026

22. Dsstox_gsid_46949

23. 10-(gamma-dimethylamino-n-propyl)phenothiazine Hydrochloride

24. Promazine Hydrochloride (usp)

25. Chebi:8460

26. N,n-dimethyl-3-phenothiazin-10-ylpropan-1-amine;hydrochloride

27. Chlorowodorek Promazyny

28. Chlorowodorek Promazyny [polish]

29. Cas-53-60-1

30. Sr-01000000228

31. Ncgc00015829-02

32. Einecs 200-179-7

33. Nsc 17468

34. N-[3-(dimethylamino)propyl]phenothiazine Hydrochloride

35. 10-(3-[dimethylamino]propyl)phenothiazine Hydrochloride

36. 10-[3-(dimethylamino)propyl]phenothiazine Hydrochloride

37. Unii-u16eor79u4

38. Esparinal

39. Verofen

40. Ai3-28022

41. Sr-01000000228-4

42. Promazine Chloride

43. Promazine-d6 Hcl

44. Prestwick_974

45. Sparine (tn)

46. Romtiazin Hydrochloride

47. Opera_id_41

48. Sinophenin Hydrochloride

49. Phenothiazine, 10-(3-(dimethylamino)propyl)-, Hydrochloride

50. Propazin (pharmaceutical)

51. Regid_for_cid_5887

52. Mls001148436

53. Mls002222285

54. Schembl123418

55. Spectrum1500509

56. 10-(3-dimethylaminopropyl)phenothiazine Hydrochloride

57. Chembl1200469

58. Dtxsid4046949

59. Hms1570k07

60. Hms1920l14

61. Pharmakon1600-01500509

62. Hy-b1225

63. Nsc17468

64. Phenothiazine, 10-(3-(dimethylamino)propyl)-, Monohydrochloride

65. Promazine Hydrochloride [mi]

66. Tox21_110235

67. Tox21_500961

68. 10-h-phenothiazine-10-propanamine, N,n-dimethyl-, Monohydrochloride

69. Ccg-40284

70. Nsc757300

71. S5428

72. Akos015964305

73. Tox21_110235_1

74. Cs-4873

75. Ks-1384

76. Lp00961

77. Nsc-757300

78. Promazine Hydrochloride [mart.]

79. Promazine Hydrochloride [vandf]

80. Promazine Hydrochloride [usp-rs]

81. Promazine Hydrochloride [who-dd]

82. Ncgc00015829-12

83. Ncgc00094262-01

84. Ncgc00094262-02

85. Ncgc00094262-03

86. Ncgc00094262-04

87. Ncgc00094262-05

88. Ncgc00261646-01

89. Ac-18101

90. Promazine Hydrochloride [green Book]

91. Eu-0100961

92. Ft-0674047

93. Promazine Hydrochloride [orange Book]

94. Promazine Hydrochloride [ep Monograph]

95. Wln: T C666 Bn Isj B3n1&1 &gh

96. D00797

97. D78322

98. P 6656

99. Promazine Hydrochloride [usp Monograph]

100. Sr-01000000228-2

101. Sr-01000000228-8

102. W-105721

103. Q27108085

104. Z2784093694

105. Promazine Hydrochloride, Vetranal(tm), Analytical Standard

106. 10-(.gamma.-dimethylamino-n-propyl)phenothiazine Hydrochloride

107. Dimethyl[3-(10h-phenothiazin-10-yl)propyl]amine Hydrochloride

108. Promazine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

109. 10h-phenothiazine-10-propanamine, N,n-dimethyl-, Hydrochloride (1:1)

110. N,n-dimethyl-3-(10h-phenothiazin-10-yl)-1-propanamine Hydrochloride

111. Promazine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

112. Promazine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 320.9 g/mol
Molecular Formula C17H21ClN2S
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass320.1113975 g/mol
Monoisotopic Mass320.1113975 g/mol
Topological Polar Surface Area31.8 Ų
Heavy Atom Count21
Formal Charge0
Complexity285
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)


Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)


Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


API SUPPLIERS

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Sanofi

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API Reference Price

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VAISHNODE"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1690569000,"product":"LEVOMEPROMAZINE MALEATE","address":"SIDCO GARMENT COMPLEX, III FLOOR, GUINDY, Contact No: 04442225000\/044","city":"CHENNAI\/TAMIL NADU-","supplier":"EGIS PHARMACEUTICALS PLC","supplierCountry":"HUNGARY","foreign_port":"NA","customer":"APEX LABORATORIES","customerCountry":"INDIA","quantity":"20.44","actualQuantity":"20.44","unit":"KGS","unitRateFc":"389","totalValueFC":"9069.5","currency":"EUR","unitRateINR":"36468.7","date":"29-Jul-2023","totalValueINR":"745420.879","totalValueInUsd":"9069.5","indian_port":"MADRAS AIR","hs_no":"29420090","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"SIDCO GARMENT COMPLEX, III FLOOR, GUINDY, Contact No: 04442225000\/044"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1700245800,"product":"CHLORPROMAZINE HYDROCHLORIDE USP","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"EUROAPI","supplierCountry":"FRANCE","foreign_port":"MARSEILLE","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"509.56","actualQuantity":"509.558","unit":"KGS","unitRateFc":"325","totalValueFC":"167255.3","currency":"USD","unitRateINR":"27332.5","date":"18-Nov-2023","totalValueINR":"13927494.04","totalValueInUsd":"167255.3","indian_port":"Bombay Air","hs_no":"29349990","bill_no":"8823263","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"MARSEILLE","supplierAddress":"15 RUE TRAVERSIERE 75012 PARIS SASUSOCIETE PAR ACTIONS SIMPLIFLEE A ASSOCIE UNIQUE France","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1702665000,"product":"(RE-IMPORT ) PHARMACEUTICAL RAW MATERIAL CHLORPROMAZINE HCLUSP 43 VIDE SB NO. 3564027 DT. 18.08.2022 BATCH NO-CPZ110622","address":"4, PODAR CHAMBERS, 4TH FLOOR,","city":"MUMBAI, MAHARASHTRA","supplier":"GOODMEN CHEMICALS CO.,LTD.","supplierCountry":"INDIA","foreign_port":"LAEM CHABANG","customer":"INDOSOL EXPORTS","customerCountry":"INDIA","quantity":"75.00","actualQuantity":"75","unit":"KGS","unitRateFc":"75.5","totalValueFC":"5734.4","currency":"USD","unitRateINR":"6364.7","date":"16-Dec-2023","totalValueINR":"477348.75","totalValueInUsd":"5734.4","indian_port":"JNPT","hs_no":"29343000","bill_no":"9268487","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"LAEM CHABANG","supplierAddress":"3 SOI TIWANON 3 YAEK 9,TAMBON TALADKHWAN,AMPHUR MUANG NONTHABURI,11000SDNF Thailand","customerAddress":"4, PODAR CHAMBERS, 4TH FLOOR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1708885800,"product":"CHLOROPROMAZINE BP\/USP (CHLOROPROMAZINE HYDROCHLORIDE BP)","address":"25, 2ND PULIYUR MAIN ROAD,","city":"CHENNAI, TAMILNADU","supplier":"HANGZHOU DAWN RAY ","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"MEDOPHARM PRIVATE LIMITED","customerCountry":"INDIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"98.5","totalValueFC":"99599.5","currency":"USD","unitRateINR":"8264.2","date":"26-Feb-2024","totalValueINR":"8264150","totalValueInUsd":"99599.5","indian_port":"Madras Sea","hs_no":"29419090","bill_no":"2301094","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"1613 GUANGYIN BUILDING, NO.42E.FENGQI ROAD, HANGZHOUSDNF CHINA","customerAddress":"25, 2ND PULIYUR MAIN ROAD,"}]
03-Apr-2021
28-Oct-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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