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1. 1-(5'-oxohexyl)-3-methyl-7-propylxanthine
2. Hwa 285
3. Hwa-285
1. 55242-55-2
2. Propentophylline
3. Hextol
4. Hwa 285
5. Karsivan
6. Hwa-285
7. 3-methyl-1-(5-oxohexyl)-7-propylxanthine
8. 3-methyl-1-(5-oxohexyl)-7-propylpurine-2,6-dione
9. 3-methyl-1-(5-oxohexyl)-7-propyl-1h-purine-2,6(3h,7h)-dione
10. 3,7-dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-1h-purine-2,6-dione
11. 1h-purine-2,6-dione, 3,7-dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-
12. Nsc-752424
13. 5rta398u4h
14. 3-methyl-1-(5-oxohexyl)-7-propyl-3,7-dihydro-1h-purine-2,6-dione
15. Ncgc00015861-04
16. Albert-285
17. Dsstox_cid_25189
18. Dsstox_rid_80736
19. Dsstox_gsid_45189
20. Propentofylina
21. Propentofyllinum
22. Hoe-285
23. Propentofylina [inn-spanish]
24. Propentofyllinum [inn-latin]
25. Cas-55242-55-2
26. Sr-01000075642
27. Brn 1156290
28. Unii-5rta398u4h
29. Viviq
30. Propentofylline [inn:ban:jan]
31. 3arx
32. Poy
33. Propentofylline, Solid
34. 3as2
35. Spectrum3_001834
36. Lopac-p-9689
37. Propentofylline (jan/inn)
38. Propentofylline [mi]
39. Lopac0_001015
40. Schembl74602
41. Bspbio_003507
42. Propentofylline [inn]
43. Propentofylline [jan]
44. 5-26-14-00082 (beilstein Handbook Reference)
45. Mls001060796
46. Hwa285
47. Propentofylline [mart.]
48. Chembl1079905
49. Dtxsid4045189
50. Propentofylline [who-dd]
51. Chebi:32061
52. Kbio3_003012
53. Hms2197a12
54. Hms3263k11
55. Hms3355f02
56. Zinc1915505
57. Tox21 110247
58. Tox21_110247
59. Tox21_501015
60. Bdbm50492435
61. Nsc752424
62. Akos016003243
63. Tox21_110247_1
64. Ccg-205095
65. Db06479
66. Lp01015
67. Nsc 752424
68. Sdccgsbi-0050988.p003
69. Ncgc00015861-01
70. Ncgc00015861-02
71. Ncgc00015861-03
72. Ncgc00015861-06
73. Ncgc00015861-07
74. Ncgc00015861-08
75. Ncgc00015861-09
76. Ncgc00094307-01
77. Ncgc00094307-02
78. Ncgc00094307-03
79. Ncgc00178023-01
80. Ncgc00261700-01
81. Smr000486263
82. Sbi-0050988.p002
83. 1-(5-oxohexyl)-3-methyl-7-propylxanthine
84. Db-052700
85. Hy-107203
86. Cs-0027629
87. Eu-0101015
88. Ft-0630675
89. D01630
90. P 9689
91. 242p552
92. Q2888695
93. Sr-01000075642-1
94. Sr-01000075642-5
95. Brd-k59273480-001-01-5
| Molecular Weight | 306.36 g/mol |
|---|---|
| Molecular Formula | C15H22N4O3 |
| XLogP3 | 0.7 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 7 |
| Exact Mass | 306.16919058 g/mol |
| Monoisotopic Mass | 306.16919058 g/mol |
| Topological Polar Surface Area | 75.5 Ų |
| Heavy Atom Count | 22 |
| Formal Charge | 0 |
| Complexity | 454 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Investigated for use/treatment in alzheimer's disease.
Neuroprotective Agents
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)
N - Nervous system
N06 - Psychoanaleptics
N06B - Psychostimulants, agents used for adhd and nootropics
N06BC - Xanthine derivatives
N06BC02 - Propentofylline
Propentofylline is a xanthine derivative and phosphodiesterase inhibitor with purported neuroprotective effects. It inhibits both phosphodiesterase and adenosine uptake. Phosphodiesterase has shown to associated with age-related memory impairment and Alzheimer's disease. -Amyloid protein 142 (42) can induce apoptosis in the cultured hippocampal neurons, suggesting that it plays an important role in causing neurodegeneration in Alzheimer's disease. Propentofylline is also capable of activating a cAMPPKA system, depressing the caspase cascade and modifying Bcl-2 family proteins. Propentofylline blocked both the apoptotic features induced by 42 and further induced an anti-apoptotic protein, Bcl-2. It suggests that the protection of propentofylline on the 42-induced neurotoxicity is caused by enhancing anti-apoptotic action through cAMPPKA system.
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USDMF
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A Propentofylline manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Propentofylline, including repackagers and relabelers. The FDA regulates Propentofylline manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Propentofylline API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Propentofylline manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Propentofylline supplier is an individual or a company that provides Propentofylline active pharmaceutical ingredient (API) or Propentofylline finished formulations upon request. The Propentofylline suppliers may include Propentofylline API manufacturers, exporters, distributors and traders.
click here to find a list of Propentofylline suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Propentofylline DMF (Drug Master File) is a document detailing the whole manufacturing process of Propentofylline active pharmaceutical ingredient (API) in detail. Different forms of Propentofylline DMFs exist exist since differing nations have different regulations, such as Propentofylline USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Propentofylline DMF submitted to regulatory agencies in the US is known as a USDMF. Propentofylline USDMF includes data on Propentofylline's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Propentofylline USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Propentofylline suppliers with USDMF on PharmaCompass.
A Propentofylline written confirmation (Propentofylline WC) is an official document issued by a regulatory agency to a Propentofylline manufacturer, verifying that the manufacturing facility of a Propentofylline active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Propentofylline APIs or Propentofylline finished pharmaceutical products to another nation, regulatory agencies frequently require a Propentofylline WC (written confirmation) as part of the regulatory process.
click here to find a list of Propentofylline suppliers with Written Confirmation (WC) on PharmaCompass.
Propentofylline Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Propentofylline GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Propentofylline GMP manufacturer or Propentofylline GMP API supplier for your needs.
A Propentofylline CoA (Certificate of Analysis) is a formal document that attests to Propentofylline's compliance with Propentofylline specifications and serves as a tool for batch-level quality control.
Propentofylline CoA mostly includes findings from lab analyses of a specific batch. For each Propentofylline CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Propentofylline may be tested according to a variety of international standards, such as European Pharmacopoeia (Propentofylline EP), Propentofylline JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Propentofylline USP).
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