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Chemistry

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Also known as: Isopropyl phenazone, 479-92-5, Isopropylantipyrine, Isopropylphenazone, 4-isopropylantipyrine, Isopropyrine
Molecular Formula
C14H18N2O
Molecular Weight
230.31  g/mol
InChI Key
PXWLVJLKJGVOKE-UHFFFAOYSA-N
FDA UNII
OED8FV75PY

Propyphenazone
1 2D Structure

Propyphenazone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1,5-dimethyl-2-phenyl-4-propan-2-ylpyrazol-3-one
2.1.2 InChI
InChI=1S/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3
2.1.3 InChI Key
PXWLVJLKJGVOKE-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C(=O)N(N1C)C2=CC=CC=C2)C(C)C
2.2 Other Identifiers
2.2.1 UNII
OED8FV75PY
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazoline-5-one

2. 4-isopropylantipyrine

3. Commotional

4. Demex

5. Hewedolor Propy

6. Isoprochin P

7. Isopropylphenazone

8. Propylphenazone

2.3.2 Depositor-Supplied Synonyms

1. Isopropyl Phenazone

2. 479-92-5

3. Isopropylantipyrine

4. Isopropylphenazone

5. 4-isopropylantipyrine

6. Isopropyrine

7. Isopropylantipyrin

8. Larodon

9. Isopropylantipyrinum

10. Propifenazona

11. Propyphenazonum

12. Propyphenazon

13. Budirol

14. Cibalgina

15. Yoshipyrin

16. 1,5-dimethyl-2-phenyl-4-propan-2-ylpyrazol-3-one

17. 1-phenyl-2,3-dimethyl-4-isopropyl-3-pyrazolin-5-one

18. 1-phenyl-2,3-dimethyl-4-isopropylpyrazol-5-one

19. 4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one

20. Antipyrine, 4-isopropyl-

21. Chebi:135538

22. 3h-pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-

23. Oed8fv75py

24. 4-isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one

25. 2,3-dimethyl-4-isopropyl-1-phenyl-3h-pyrazolin-5-one

26. 3-pyrazolin-5-one, 2,3-dimethyl-4-isopropyl-1-phenyl-

27. 3-pyrazolin-5-one, 4-isopropyl-2,3-dimethyl-1-phenyl-

28. 1,5-dimethyl-2-phenyl-4-(propan-2-yl)-1,2-dihydro-3h-pyrazol-3-one

29. Propyphenazone (4-isopropylantipyrine)

30. 4-isopropylantipyrine;isopropylphenazone

31. Propyphenazone (inn)

32. 4-isopropyl-1,5-dimethyl-2-phenyl-1h-pyrazol-3(2h)-one

33. Ncgc00164612-01

34. Isopropchin

35. Propifenazone

36. 4-isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-one

37. Dsstox_cid_3529

38. Dsstox_rid_77065

39. Propyphenazone [inn]

40. 4-isopropyl-2,3-dimethyl-1-phenyl-5-pyrazolone

41. Dsstox_gsid_23529

42. Propifenazone [dcit]

43. Causyth

44. Propifenazona [inn-spanish]

45. Propyphenazonum [inn-latin]

46. Cas-479-92-5

47. 4-isopropylphenazone

48. Ccris 6716

49. Propyphenazone [inn:ban:dcf]

50. Einecs 207-539-2

51. Unii-oed8fv75py

52. Brn 0204533

53. Yoshipyrin (tn)

54. 5-pyrazolone, 1-phenyl-2,3-dimethyl-4-isopropyl-

55. Propyphenazone,(s)

56. Chemdiv2_002457

57. Epitope Id:124928

58. Propyphenazone [mi]

59. Isopropylantipyrine (jp17)

60. Schembl23393

61. 5-24-01-00408 (beilstein Handbook Reference)

62. Mls004773970

63. Chembl28318

64. Propyphenazone [mart.]

65. Propyphenazone [who-dd]

66. Dtxsid6023529

67. Isopropylantipyrine [jan]

68. Pxwlvjlkjgvoke-uhfffaoysa-

69. Zinc49151

70. Hms1375p15

71. Hy-a0273

72. Tox21_112233

73. Mfcd00053368

74. Propyphenazone [ep Monograph]

75. S5309

76. Stk766727

77. 1,5-dimethyl-4-(1-methylethyl)-2-phenyl-1,2-dihydro-3h-pyrazol-3-one

78. Akos001725335

79. Tox21_112233_1

80. Ccg-266797

81. Cs-5533

82. Db13524

83. Ncgc00164612-02

84. Ac-12099

85. Bs-16890

86. Propyphenazone 1.0 Mg/ml In Acetonitrile

87. Propyphenazone 100 Microg/ml In Methanol

88. Smr001495368

89. Ft-0654525

90. I0656

91. D01380

92. D91192

93. Q425111

94. Sr-01000536454

95. 4-isopropylantipyrine, Analytical Reference Material

96. Sr-01000536454-1

97. W-106059

98. 4-isopropyl-1,5-dimethyl-2-phenyl-3-pyrazolone

99. Propyphenazone, European Pharmacopoeia (ep) Reference Standard

100. 4-isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-one #

101. Propyphenazone, Pharmaceutical Secondary Standard; Certified Reference Material

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 230.31 g/mol
Molecular Formula C14H18N2O
XLogP31.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass230.141913202 g/mol
Monoisotopic Mass230.141913202 g/mol
Topological Polar Surface Area23.6 Ų
Heavy Atom Count17
Formal Charge0
Complexity340
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)


4.2 ATC Code

N - Nervous system

N02 - Analgesics

N02B - Other analgesics and antipyretics

N02BB - Pyrazolones

N02BB04 - Propyphenazone


API Reference Price

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04-Jan-2021
25-Feb-2025
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ABOUT THIS PAGE

Looking for 479-92-5 / Propyphenazone API manufacturers, exporters & distributors?

Propyphenazone manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Propyphenazone API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Propyphenazone manufacturer or Propyphenazone supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Propyphenazone manufacturer or Propyphenazone supplier.

PharmaCompass also assists you with knowing the Propyphenazone API Price utilized in the formulation of products. Propyphenazone API Price is not always fixed or binding as the Propyphenazone Price is obtained through a variety of data sources. The Propyphenazone Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Propyphenazone

Synonyms

Isopropyl phenazone, 479-92-5, Isopropylantipyrine, Isopropylphenazone, 4-isopropylantipyrine, Isopropyrine

Cas Number

479-92-5

Unique Ingredient Identifier (UNII)

OED8FV75PY

Propifenazona Manufacturers

A Propifenazona manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Propifenazona, including repackagers and relabelers. The FDA regulates Propifenazona manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Propifenazona API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Propifenazona manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Propifenazona Suppliers

A Propifenazona supplier is an individual or a company that provides Propifenazona active pharmaceutical ingredient (API) or Propifenazona finished formulations upon request. The Propifenazona suppliers may include Propifenazona API manufacturers, exporters, distributors and traders.

click here to find a list of Propifenazona suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Propifenazona JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Propifenazona Drug Master File in Japan (Propifenazona JDMF) empowers Propifenazona API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Propifenazona JDMF during the approval evaluation for pharmaceutical products. At the time of Propifenazona JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Propifenazona suppliers with JDMF on PharmaCompass.

Propifenazona CEP

A Propifenazona CEP of the European Pharmacopoeia monograph is often referred to as a Propifenazona Certificate of Suitability (COS). The purpose of a Propifenazona CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Propifenazona EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Propifenazona to their clients by showing that a Propifenazona CEP has been issued for it. The manufacturer submits a Propifenazona CEP (COS) as part of the market authorization procedure, and it takes on the role of a Propifenazona CEP holder for the record. Additionally, the data presented in the Propifenazona CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Propifenazona DMF.

A Propifenazona CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Propifenazona CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Propifenazona suppliers with CEP (COS) on PharmaCompass.

Propifenazona WC

A Propifenazona written confirmation (Propifenazona WC) is an official document issued by a regulatory agency to a Propifenazona manufacturer, verifying that the manufacturing facility of a Propifenazona active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Propifenazona APIs or Propifenazona finished pharmaceutical products to another nation, regulatory agencies frequently require a Propifenazona WC (written confirmation) as part of the regulatory process.

click here to find a list of Propifenazona suppliers with Written Confirmation (WC) on PharmaCompass.

Propifenazona GMP

Propifenazona Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Propifenazona GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Propifenazona GMP manufacturer or Propifenazona GMP API supplier for your needs.

Propifenazona CoA

A Propifenazona CoA (Certificate of Analysis) is a formal document that attests to Propifenazona's compliance with Propifenazona specifications and serves as a tool for batch-level quality control.

Propifenazona CoA mostly includes findings from lab analyses of a specific batch. For each Propifenazona CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Propifenazona may be tested according to a variety of international standards, such as European Pharmacopoeia (Propifenazona EP), Propifenazona JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Propifenazona USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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