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Also known as: 17140-78-2, Propoxyphene napsylate anhydrous, 5o7iw35n3c, Darvon n, [(2s,3r)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate;naphthalene-2-sulfonic acid, Propoxyphene-n

Molecular Formula

C₃₂H₃₇NO₅S

Molecular Weight

547.7 g/mol

InChI Key

VZPXFHVJUUSVLH-MYXGOWFTSA-N

FDA UNII

5O7IW35N3C

Propoxyphene Napsylate is a synthetic diphenyl propionate derivative structurally related to methadone, Propoxyphene Napsylate acts as a central narcotic and analgesic agent by interaction with mu opioid receptors, but with less selectivity then morphine. The dextro-isomer has analgesic effect, while the levo-isomer exerts an antitussive effect. The napsylate salt allows better dosage formulation than the hydrochloride salt. (NCI04)

1 2D Structure

Propoxyphene Napsylate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(2S,3R)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate;naphthalene-2-sulfonic acid

2.1.2 InChI

InChI=1S/C22H29NO2.C10H8O3S/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19;11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h6-15,18H,5,16-17H2,1-4H3;1-7H,(H,11,12,13)/t18-,22+;/m1./s1

2.1.3 InChI Key

VZPXFHVJUUSVLH-MYXGOWFTSA-N

2.1.4 Canonical SMILES

CCC(=O)OC(CC1=CC=CC=C1)(C2=CC=CC=C2)C(C)CN(C)C.C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)O

2.1.5 Isomeric SMILES

CCC(=O)O[C@](CC1=CC=CC=C1)(C2=CC=CC=C2)[C@H](C)CN(C)C.C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)O

2.2 Other Identifiers

2.2.1 UNII

5O7IW35N3C

2.3 Synonyms

2.3.1 MeSH Synonyms

1. D-propoxyphene Napsylate

2. Dextropropoxyphene Napsylate

2.3.2 Depositor-Supplied Synonyms

1. 17140-78-2

2. Propoxyphene Napsylate Anhydrous

3. 5o7iw35n3c

4. Darvon N

5. [(2s,3r)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] Propanoate;naphthalene-2-sulfonic Acid

6. Propoxyphene-n

7. (+)- Propoxyphene Napsylate

8. Propoxyphene 2-naphthalenesulfonate

9. Einecs 241-205-7

10. Unii-5o7iw35n3c

11. 2-butanol, 4-(dimethylamino)-3-methyl-1,2-diphenyl-, Propionate, 2-naphthalenesulfonate

12. Propoxyphene Napsylate ,(s)

13. 2-naphthalenesulfonic Acid, Compd. With (s-(r*,s*))-3-(dimethylamino)-2-methyl-1-phenyl-1-(phenylmethyl)p- Ropyl Propanoate (1:1)

14. Schembl9297768

15. Dtxsid80937986

16. Propoxyphene Napsylate, Anhydrous

17. 2-naphthalenesulfonic Acid, Compd. With (+)-alpha-(2-dimethylamino)-1-methylethyl-alpha-phenylphenethyl Propionate (1:1)

18. Benzeneethanol, Alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, Propanoate (ester), (1s,2r)-, 2-naphthalenesulfonate (salt)

19. Benzeneethanol, Alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, Propanoate (ester), (s-(r*,s*))-, 2-naphthalenesulfonate (salt)

20. Naphthalene-2-sulphonic Acid, Compound With (s-(r*,s*))-1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl Propionate (1:1)

21. Q27262632

22. (2s,3r)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl Propionate Naphthalene-2-sulfonate

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₃₂H₃₇NO₅S
Molecular Weight	547.7 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	10
Exact Mass	547.23924445 g/mol
Monoisotopic Mass	547.23924445 g/mol
Topological Polar Surface Area	92.3 Å²
Heavy Atom Count	39
Formal Charge	0
Complexity	688
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

10 API Suppliers

10 USDMF

FINISHED DOSAGE FORMULATIONS

38 FDF Dossiers

36 FDA Orange Book

2 South Africa

RELATED EXCIPIENT COMPANIES

4 SPI Pharma

2 Seqens

3 DKSH

5 Faran Shimi Pharmaceutical

5 Boai NKY Pharmaceuticals Ltd

12 Gangwal Healthcare

3 Nanjing Well Pharmaceutical

1 ACG Worldwide

5 Actylis

1 Alcedo Pharmachem

7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

31 BASF

10 Corel Pharma Chem

5 DFE Pharma

1 Finar

11 Gangwal Chemicals

5 Ideal Cures Pvt Ltd

3 Ingredion Pharma Solutions

30 Kerry

3 Kima Chemical

6 Lonza Capsugel

14 Microlex e.U

1 Nanjing Bold Chemical

2 Nomisma Healthcare

3 Novo Excipients

4 Pharmatrans-Sanaq

5 Pluviaendo

3 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

1 Qualicaps

19 Roquette

13 Seppic

4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

10 Sigachi Industries

2 The Dow Chemical Company

1 Ulanqab Kema New Material

3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

65 Fillers, Diluents & Binders

48 Coating Systems & Additives

38 Direct Compression

31 Disintegrants & Superdisintegrants

28 Controlled & Modified Release

26 Granulation

24 Thickeners and Stabilizers

23 Solubilizers

17 Lubricants & Glidants

16 Co-Processed Excipients

13 Film Formers & Plasticizers

12 Topical

11 Parenteral

9 Taste Masking

9 Chewable & Orodispersible Aids

7 Emulsifying Agents

5 Empty Capsules

5 API Stability Enhancers

4 Coloring Agents

4 Vegetarian Capsules

3 Rheology Modifiers

3 Surfactant & Foaming Agents

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