Find Propylhexedrine manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Benzedrex, Hydromethamphetamine, Propylhexedrin, Dristan, Obesin, Hexahydrodesoxyephedrine
Molecular Formula
C10H21N
Molecular Weight
155.28  g/mol
InChI Key
JCRIVQIOJSSCQD-UHFFFAOYSA-N
FDA UNII
LQU92IU8LL

Propylhexedrine
Propylhexedrine is a propylamine derivative with sympathomimetic property. Propylhexedrine binds to and activates alpha-adrenergic receptors in the mucosa of the respiratory tract, thereby mimicking the actions of norepinephrine and epinephrine. This results in vasoconstriction and reduces swelling and inflammation of the mucous membrane lining, therefore relieving nasal and sinus congestion.
1 2D Structure

Propylhexedrine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-cyclohexyl-N-methylpropan-2-amine
2.1.2 InChI
InChI=1S/C10H21N/c1-9(11-2)8-10-6-4-3-5-7-10/h9-11H,3-8H2,1-2H3
2.1.3 InChI Key
JCRIVQIOJSSCQD-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(CC1CCCCC1)NC
2.2 Other Identifiers
2.2.1 UNII
LQU92IU8LL
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Benzedrex

2. Propylhexadrine

3. Propylhexedrine Hydrochloride

4. Propylhexedrine Hydrochloride, (s)-isomer

2.3.2 Depositor-Supplied Synonyms

1. Benzedrex

2. Hydromethamphetamine

3. Propylhexedrin

4. Dristan

5. Obesin

6. Hexahydrodesoxyephedrine

7. Dristan Inhaler

8. Chp-depot

9. 1-cyclohexyl-n-methylpropan-2-amine

10. 101-40-6

11. Propylhexadrine

12. Propylhexedrinum

13. Dl-propylhexedrine

14. Methyl-(1-methyl-2-cyclohexylethyl)amine

15. 1-cyclohexyl-2-(methylamino)propane

16. 1-cyclohexyl-n-methyl-2-propanamine

17. (+/-) Propylhexedrine

18. N,alpha-dimethylcyclohexaneethylamine

19. Nsc 32410

20. 1-cyclohexyl-2-methylaminopropan

21. Cyclohexaneethanamine, N,.alpha.-dimethyl-

22. Nsc-32410

23. Lqu92iu8ll

24. Ncgc00182042-01

25. Cyclohexaneethylamine, N-.alpha.-dimethyl-

26. Propilhexedrina

27. Propilesedrina

28. Propilesedrina [dcit]

29. Einecs 202-939-3

30. Unii-lqu92iu8ll

31. Brn 3194303

32. Propylhexedrinum [inn-latin]

33. 1-cyclohexyl-2-methylaminopropan [german]

34. Propilhexedrina [inn-spanish]

35. (+-)-n,alpha-dimethylcyclohexaneethylamine

36. (cyclohexaneethyl)amine, N-alpha-dimethyl-

37. Beta-cyclohexyl-isopropylmethylamin [german]

38. Propylhexedrine [usp:inn:ban]

39. Beta-cyclohexyl-isopropylmethylamin

40. Cyclohexaneethanamine, N,alpha-dimethyl-, (+-)

41. Einecs 222-741-0

42. Dristan Inhaler (tn)

43. Propylhexedrine Dl-form

44. Dsstox_cid_3526

45. Cyclohexaneethylamine, Alpha,n-dimethyl-

46. Propylhexedrine (usp/inn)

47. Dsstox_rid_77064

48. Cyclohexaneethanamine, N,alpha-dimethyl-, (+-)-

49. Dsstox_gsid_23526

50. Schembl28537

51. Propylhexedrine [inn]

52. 3-12-00-00108 (beilstein Handbook Reference)

53. Propylhexedrine [vandf]

54. Propylhexedrine [mart.]

55. Chembl2105275

56. Dtxsid1023526

57. Propylhexedrine [who-dd]

58. Schembl20780004

59. Wln: L6tj A1y1&m1

60. Chebi:134783

61. N-methyl-1-cyclohexylisopropylamine

62. Nsc32410

63. Tox21_113077

64. Propylhexedrine Dl-form [mi]

65. Stk664138

66. Akos005172629

67. .alpha.,n-dimethylcyclohexaneethylamine

68. Cyclohexaneethanamine,.alpha.-dimethyl-

69. Db06714

70. N,.alpha.-dimethylcyclohexaneethylamine

71. Propylhexedrine [usp Monograph]

72. (1-cyclohexylpropan-2-yl)(methyl)amine

73. Ncgc00182042-03

74. Ncgc00182042-04

75. 3595-11-7

76. Cas-101-40-6

77. N-.alpha.-(dimethylcyclohexane)ethylamine

78. Cyclohexaneethylamine, .alpha.,n-dimethyl-

79. Ft-0674106

80. (cyclohexaneethyl)amine, N-.alpha.-dimethyl-

81. N-(2-cyclohexyl-1-methylethyl)-n-methylamine

82. D05637

83. Ab01331925-02

84. (.+/-.)-n,.alpha.-dimethylcyclohexaneethylamine

85. Q408704

86. (+/-)-n,.alpha.-dimethylcyclohexaneethanamine

87. Cyclohexaneethanamine, N,.alpha.-dimethyl-, (.+/-.)

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 155.28 g/mol
Molecular Formula C10H21N
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count3
Exact Mass155.167399674 g/mol
Monoisotopic Mass155.167399674 g/mol
Topological Polar Surface Area12 Ų
Heavy Atom Count11
Formal Charge0
Complexity95
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

It is used to provide temporary symptomatic relief of nasal congestion due to colds, allergies and allergic rhinitis.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Like other monoamine releasing stimulants propylhexedrine is active as a norepinephrine and dopamine releaser in the central nervous system. The acute effects of the drug closely resemble the physiological and psychological effects of an epinephrine-provoked fight-or-flight response, including increased heart rate and blood pressure, vasoconstriction (constriction of the arterial walls), bronchodilation, and hyperglycemia (increased blood sugar).


5.2 Mechanism of Action

Propylhexidrine causes the norepinephrine, dopamine, and serotonin (5HT) transporters to reverse their direction of flow. This inversion leads to a release of these transmitters from the vesicles to the cytoplasm and from the cytoplasm to the synapse. It also antagonizes the action of VMAT2, causing the release of more neurotransmitters.


API SUPPLIERS

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ABOUT THIS PAGE

Propylhexedrine Manufacturers

A Propylhexedrine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Propylhexedrine, including repackagers and relabelers. The FDA regulates Propylhexedrine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Propylhexedrine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Propylhexedrine Suppliers

A Propylhexedrine supplier is an individual or a company that provides Propylhexedrine active pharmaceutical ingredient (API) or Propylhexedrine finished formulations upon request. The Propylhexedrine suppliers may include Propylhexedrine API manufacturers, exporters, distributors and traders.

click here to find a list of Propylhexedrine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Propylhexedrine USDMF

A Propylhexedrine DMF (Drug Master File) is a document detailing the whole manufacturing process of Propylhexedrine active pharmaceutical ingredient (API) in detail. Different forms of Propylhexedrine DMFs exist exist since differing nations have different regulations, such as Propylhexedrine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Propylhexedrine DMF submitted to regulatory agencies in the US is known as a USDMF. Propylhexedrine USDMF includes data on Propylhexedrine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Propylhexedrine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Propylhexedrine suppliers with USDMF on PharmaCompass.

Propylhexedrine GMP

Propylhexedrine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Propylhexedrine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Propylhexedrine GMP manufacturer or Propylhexedrine GMP API supplier for your needs.

Propylhexedrine CoA

A Propylhexedrine CoA (Certificate of Analysis) is a formal document that attests to Propylhexedrine's compliance with Propylhexedrine specifications and serves as a tool for batch-level quality control.

Propylhexedrine CoA mostly includes findings from lab analyses of a specific batch. For each Propylhexedrine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Propylhexedrine may be tested according to a variety of international standards, such as European Pharmacopoeia (Propylhexedrine EP), Propylhexedrine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Propylhexedrine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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