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Chemistry

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Also known as: Prothionamide, 14222-60-7, 2-propylpyridine-4-carbothioamide, Ektebin, Protionamid, Trevintix
Molecular Formula
C9H12N2S
Molecular Weight
180.27  g/mol
InChI Key
VRDIULHPQTYCLN-UHFFFAOYSA-N
FDA UNII
76YOO33643

Prothionamide
Antitubercular agent similar in action and side effects to ETHIONAMIDE. It is used mostly in combination with other agents.
1 2D Structure

Prothionamide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-propylpyridine-4-carbothioamide
2.1.2 InChI
InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
2.1.3 InChI Key
VRDIULHPQTYCLN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCCC1=NC=CC(=C1)C(=S)N
2.2 Other Identifiers
2.2.1 UNII
76YOO33643
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ektebin

2. Peteha

3. Prothionamide

2.3.2 Depositor-Supplied Synonyms

1. Prothionamide

2. 14222-60-7

3. 2-propylpyridine-4-carbothioamide

4. Ektebin

5. Protionamid

6. Trevintix

7. 2-propylthioisonicotinamide

8. Peteha

9. 2-propyl-thioisonicotinamide

10. Tuberex

11. Protionamidum

12. Protionizina

13. Tebeform

14. 2-propylisonicotinylthioamide

15. 4-pyridinecarbothioamide, 2-propyl-

16. Th-1321

17. 2-propyl-4-pyridinecarbothioamide

18. Rp 9778

19. 2-propyl-4-thiocarbamoylpyridine

20. Isonicotinamide, 2-propylthio-

21. 9778 R.p.

22. 1321 Th

23. Rp-9778

24. Protionamide (inn)

25. Prothionamidum

26. Nsc-758962

27. Protionamide (prothionamide)

28. Mls000042521

29. Protionamida

30. 76yoo33643

31. Ncgc00095164-01

32. Smr000047660

33. Protionamide 100 Microg/ml In Acetonitrile

34. Protionamide [inn]

35. Dsstox_cid_25940

36. Dsstox_rid_81238

37. Dsstox_gsid_45940

38. Protionamidum [inn-latin]

39. Protionamida [inn-spanish]

40. Trevintix (tn)

41. Cas-14222-60-7

42. Th 1321

43. Sr-05000001518

44. Einecs 238-093-7

45. Brn 0118164

46. Protion

47. Protionamide [inn:ban:dcf]

48. Unii-76yoo33643

49. Prothionamide (jp17)

50. Opera_id_999

51. Spectrum2_000019

52. Spectrum3_001964

53. Protionamide [mi]

54. Prothionamide [jan]

55. Schembl74572

56. Bspbio_003564

57. Protionamide [mart.]

58. 5-22-02-00376 (beilstein Handbook Reference)

59. Mls001201789

60. Mls006011877

61. Protionamide [who-dd]

62. Protionamide [who-ip]

63. Spectrum1505316

64. Spbio_000057

65. Chembl1378024

66. Dtxsid7045940

67. Chebi:32066

68. Kbio3_002911

69. Prothionamide, >=99% (hplc)

70. 2-propyl-4-thiocarbamoyl Pyridine

71. Hms1922d06

72. Hms2090j11

73. Hms2235m12

74. Hms3372k04

75. Hms3655o18

76. Hms3715g13

77. Kuc109576n

78. Pharmakon1600-01505316

79. Albb-010476

80. Bcp13522

81. Hy-b0306

82. Ksc-27-052d

83. Zinc3874803

84. Tox21_111463

85. Bbl010291

86. Bdbm50499814

87. Ccg-40049

88. Mfcd00464119

89. Nsc758962

90. Protionamidum [who-ip Latin]

91. S1881

92. Stk366469

93. Stl454225

94. Akos005172678

95. Tox21_111463_1

96. 1321-th

97. Ac-4518

98. Db12667

99. Ks-1282

100. Nsc 758962

101. 2-propylpyridine-4-carbimidothioic Acid

102. Ncgc00095164-02

103. Ncgc00095164-03

104. Ncgc00095164-04

105. Ncgc00095164-05

106. Sbi-0207058.p001

107. Db-042615

108. Ft-0630412

109. P2302

110. Sw199462-2

111. D01195

112. D88012

113. Ab00393463-12

114. Ab01093435-02

115. Ab01093435_03

116. Ab01093435_04

117. A807874

118. Q866657

119. Q-201638

120. Sr-05000001518-1

121. Sr-05000001518-2

122. Sr-05000001518-3

123. Brd-k75360161-001-09-9

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 180.27 g/mol
Molecular Formula C9H12N2S
XLogP31.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass180.07211956 g/mol
Monoisotopic Mass180.07211956 g/mol
Topological Polar Surface Area71 Ų
Heavy Atom Count12
Formal Charge0
Complexity159
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antitubercular Agents

Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy. (See all compounds classified as Antitubercular Agents.)


4.2 ATC Code

J - Antiinfectives for systemic use

J04 - Antimycobacterials

J04A - Drugs for treatment of tuberculosis

J04AD - Thiocarbamide derivatives

J04AD01 - Protionamide


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22-Mar-2021
15-Oct-2022
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ABOUT THIS PAGE

Prothionamide Manufacturers

A Prothionamide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Prothionamide, including repackagers and relabelers. The FDA regulates Prothionamide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Prothionamide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Prothionamide manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Prothionamide Suppliers

A Prothionamide supplier is an individual or a company that provides Prothionamide active pharmaceutical ingredient (API) or Prothionamide finished formulations upon request. The Prothionamide suppliers may include Prothionamide API manufacturers, exporters, distributors and traders.

click here to find a list of Prothionamide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Prothionamide GMP

Prothionamide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Prothionamide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Prothionamide GMP manufacturer or Prothionamide GMP API supplier for your needs.

Prothionamide CoA

A Prothionamide CoA (Certificate of Analysis) is a formal document that attests to Prothionamide's compliance with Prothionamide specifications and serves as a tool for batch-level quality control.

Prothionamide CoA mostly includes findings from lab analyses of a specific batch. For each Prothionamide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Prothionamide may be tested according to a variety of international standards, such as European Pharmacopoeia (Prothionamide EP), Prothionamide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Prothionamide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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