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Chemistry

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Also known as: Palison, 136-69-6, Protokylol hcl, Caytine hydrochloride, Nsc-113490, 7u7o8q48io
Molecular Formula
C18H22ClNO5
Molecular Weight
367.8  g/mol
InChI Key
LOVXREQUMZKFCM-UHFFFAOYSA-N
FDA UNII
7U7O8Q48IO

Protokylol
Protokylol Hydrochloride is the hydrochloride salt form of protokylol, a derivative of the beta-adrenergic receptor agonist isoproterenol with bronchodilator activity. Protokylol binds to beta-2 adrenergic receptors in bronchial smooth muscle, thereby activating intracellular adenyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP levels cause relaxation of bronchial smooth muscle, relieve bronchospasms, improve mucociliary clearance and inhibit the release of mediators of immediate hypersensitivity from cells, especially from mast cells.
1 2D Structure

Protokylol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[2-[1-(1,3-benzodioxol-5-yl)propan-2-ylamino]-1-hydroxyethyl]benzene-1,2-diol;hydrochloride
2.1.2 InChI
InChI=1S/C18H21NO5.ClH/c1-11(6-12-2-5-17-18(7-12)24-10-23-17)19-9-16(22)13-3-4-14(20)15(21)8-13;/h2-5,7-8,11,16,19-22H,6,9-10H2,1H3;1H
2.1.3 InChI Key
LOVXREQUMZKFCM-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(CC1=CC2=C(C=C1)OCO2)NCC(C3=CC(=C(C=C3)O)O)O.Cl
2.2 Other Identifiers
2.2.1 UNII
7U7O8Q48IO
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Alpha-(alpha-methyl-3,4-methylenedioxyphenethylamino)methyl Protocatechuyl Alcohol

2. Caytine

3. Protokylol

2.3.2 Depositor-Supplied Synonyms

1. Palison

2. 136-69-6

3. Protokylol Hcl

4. Caytine Hydrochloride

5. Nsc-113490

6. 7u7o8q48io

7. Caytine Hydrochloride; Nsc 113490

8. Asmetil

9. Biturix

10. Beres

11. Atma-sanol

12. 4-[2-[1-(1,3-benzodioxol-5-yl)propan-2-ylamino]-1-hydroxyethyl]benzene-1,2-diol;hydrochloride

13. Einecs 205-254-8

14. Nsc 113490

15. Unii-7u7o8q48io

16. Protokylolhydrochlorid

17. Protoklol Hydrochloride

18. 4-(2-{[2-(1,3-benzodioxol-5-yl)-1-methylethyl]amino}-1-hydroxyethyl)-1,2-benzenediol Hydrochloride

19. 1,2-benzenediol, 4-(2-((2-(1,3-benzodioxol-5-yl)-1-methylethyl)amino)-1-hydroxyethyl)-, Hcl

20. 4-(2-((2-(1,3-benzodioxol-5-yl)-1-methylethyl)amino)-1-hydroxyethyl)-1,2-benzenediol Hcl

21. 1,2-benzenediol, 4-(2-((2-(1,3-benzodioxol-5-yl)-1-methylethyl)amino)-1-hydroxyethyl)-, Hydrochloride

22. Schembl210099

23. Chembl1200893

24. Dtxsid30929210

25. Nsc113490

26. Protokylol Hydrochloride [mi]

27. Protokylol Hydrochloride [mart.]

28. Protokylol Hydrochloride [who-dd]

29. Alpha-(((alpha-methyl-3,4-methylenedioxyphenethyl)amino)methyl)protocatechuyl Alcohol, Hydrochloride

30. Benzyl Alcohol, 3,4-dihydroxy-alpha-(((alpha-methyl-3,4-(methylenedioxy)phenethyl)amino)methyl)-, Hydrochloride

31. Ft-0674124

32. Protokylol Hydrochloride [green Book]

33. Protokylol Hydrochloride [orange Book]

34. Q27268861

35. Wln: T56 Bo Do Chj G1y1 & M1yqr Cq Dq & Gh

36. 1, 4-[2-[[2-(1,3-benzodioxol-5-yl)-1-methylethyl]amino]-1-hydroxyethyl]-, Hydrochloride

37. .alpha.-(((.alpha.-methyl-3,4-methylenedioxyphenethyl)amino)methyl)protocatechuyl Alcohol, Hydrochloride

38. 4-(2-{[1-(2h-1,3-benzodioxol-5-yl)propan-2-yl]amino}-1-hydroxyethyl)benzene-1,2-diol--hydrogen Chloride (1/1)

39. Benzyl Alcohol,4-dihydroxy-.alpha.-[[[.alpha.-methyl-3,4-(methylenedioxy)phenethyl]amino]methyl]-, Hydrochloride

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 367.8 g/mol
Molecular Formula C18H22ClNO5
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass367.1186505 g/mol
Monoisotopic Mass367.1186505 g/mol
Topological Polar Surface Area91.2 Ų
Heavy Atom Count25
Formal Charge0
Complexity396
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2

ABOUT THIS PAGE

Protokylol Manufacturers

A Protokylol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Protokylol, including repackagers and relabelers. The FDA regulates Protokylol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Protokylol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Protokylol Suppliers

A Protokylol supplier is an individual or a company that provides Protokylol active pharmaceutical ingredient (API) or Protokylol finished formulations upon request. The Protokylol suppliers may include Protokylol API manufacturers, exporters, distributors and traders.

Protokylol GMP

Protokylol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Protokylol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Protokylol GMP manufacturer or Protokylol GMP API supplier for your needs.

Protokylol CoA

A Protokylol CoA (Certificate of Analysis) is a formal document that attests to Protokylol's compliance with Protokylol specifications and serves as a tool for batch-level quality control.

Protokylol CoA mostly includes findings from lab analyses of a specific batch. For each Protokylol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Protokylol may be tested according to a variety of international standards, such as European Pharmacopoeia (Protokylol EP), Protokylol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Protokylol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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