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Also known as: 138786-67-1, Pantoloc, Protonix, Pantecta, Zurcal, Pantoprazole sodium salt
Molecular Formula
C16H14F2N3NaO4S
Molecular Weight
405.4  g/mol
InChI Key
YNWDKZIIWCEDEE-UHFFFAOYSA-N

Pantoprazole Sodium
2-pyridinylmethylsulfinylbenzimidazole proton pump inhibitor that is used in the treatment of GASTROESOPHAGEAL REFLUX and PEPTIC ULCER.
1 2D Structure

Pantoprazole Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]benzimidazol-1-ide
2.1.2 InChI
InChI=1S/C16H14F2N3O4S.Na/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;/h3-7,15H,8H2,1-2H3;/q-1;+1
2.1.3 InChI Key
YNWDKZIIWCEDEE-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=C(C(=NC=C1)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F)OC.[Na+]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. By 1023

2. By-1023

3. By1023

4. Pantoprazole

5. Protonix

6. Sk And F 96022

7. Sk And F-96022

8. Sk And F96022

9. Skf 96022

10. Skf-96022

11. Skf96022

2.2.2 Depositor-Supplied Synonyms

1. 138786-67-1

2. Pantoloc

3. Protonix

4. Pantecta

5. Zurcal

6. Pantoprazole Sodium Salt

7. Skf96022 Sodium

8. By-1023 Sodium

9. Chebi:50270

10. Sodium;5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]benzimidazol-1-ide

11. Pantozol Control

12. 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) Sulfinyl)-1h-benzimidazole Sodium

13. Dsstox_cid_24215

14. Dsstox_rid_80123

15. Dsstox_gsid_44215

16. Sodium 5-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

17. Sodium 5-(difluoromethoxy)-2-((3,4-dimethoxypyridin-2-yl)methylsulfinyl)benzo[d]imidazol-1-ide

18. Cas-138786-67-1

19. Anagastra

20. Inipomp

21. Pantorc

22. Peptazol

23. Ulcotenal

24. Citrel

25. Apton

26. Rifun

27. Pantoprazole Sodium;

28. By1023 (sodium)

29. Pantoprazole Sodium,(s)

30. Skf96022 (sodium)

31. Schembl3543

32. Mls001424073

33. Pantoprazole Sodium Monohydrate

34. Chembl1200408

35. Dtxsid7044215

36. Dz-2352a

37. Hms2051l19

38. Hms3393l19

39. Hms3715d12

40. Act02633

41. Tox21_112996

42. Tox21_302362

43. Mfcd01658543

44. S4538

45. Akos015994677

46. Ccg-100980

47. Ks-1093

48. Nc00230

49. S86p671

50. Sb17369

51. By-1023/sk&f-96022

52. Ncgc00255835-01

53. Smr000469592

54. Ft-0602602

55. Ft-0673508

56. A807440

57. B-8610-23/sk&f-96022-z

58. J-516336

59. B-8510-29

60. Q27122012

61. Sodium 5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl] Benzimidazol-1-ide

62. 5-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)sulfinyl)-1h-benzo[d]imidazole, Sodium Salt

63. 5-(difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridyl)methylsulfinyl]benzimidazol-1-ide; Sodium;pantoprazole Sodium

64. Sodium 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-1h-benzimidazole

65. Sodium 5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}benzimidazol-1-ide

2.2.3 Other Synonyms

1. Pantozol

2. S-pantoprazole

3. Pantoprazole

2.3 Create Date
2007-02-09
3 Chemical and Physical Properties
Molecular Weight 405.4 g/mol
Molecular Formula C16H14F2N3NaO4S
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass405.05707772 g/mol
Monoisotopic Mass405.05707772 g/mol
Topological Polar Surface Area90.8 Ų
Heavy Atom Count27
Formal Charge0
Complexity497
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NamePantoprazole sodium
Drug LabelThe active ingredient in pantoprazole sodium delayed-release tablets USP is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl] sulfinyl]-1H-benzimidazole sesquihydrate, a compound that inhibits gastric acid...
Active IngredientPantoprazole sodium
Dosage FormInjectable; Tablet, delayed release
Routeinjection; Iv (infusion); Oral
Strengtheq 20mg base; eq 40mg base/vial; eq 40mg base; 40mg
Market StatusTentative Approval; Prescription
CompanyWockhardt; Mylan Pharms; Hetero Labs Ltd V; Teva Parenteral; Teva; Apotex; Aurobindo Pharma; Torrent Pharms; Sun Pharma Global; Perrigo R And D; Actavis Elizabeth; Macleods Pharms; Jubilant Generics; Kudco Ireland; Ranbaxy Labs; Dr Reddys Labs; Akorn

2 of 4  
Drug NameProtonix iv
Active IngredientPantoprazole sodium
Dosage FormInjectable
RouteIv (infusion)
Strengtheq 40mg base/vial
Market StatusPrescription
CompanyWyeth Pharms

3 of 4  
Drug NamePantoprazole sodium
Drug LabelThe active ingredient in pantoprazole sodium delayed-release tablets USP is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl] sulfinyl]-1H-benzimidazole sesquihydrate, a compound that inhibits gastric acid...
Active IngredientPantoprazole sodium
Dosage FormInjectable; Tablet, delayed release
Routeinjection; Iv (infusion); Oral
Strengtheq 20mg base; eq 40mg base/vial; eq 40mg base; 40mg
Market StatusTentative Approval; Prescription
CompanyWockhardt; Mylan Pharms; Hetero Labs Ltd V; Teva Parenteral; Teva; Apotex; Aurobindo Pharma; Torrent Pharms; Sun Pharma Global; Perrigo R And D; Actavis Elizabeth; Macleods Pharms; Jubilant Generics; Kudco Ireland; Ranbaxy Labs; Dr Reddys Labs; Akorn

4 of 4  
Drug NameProtonix iv
Active IngredientPantoprazole sodium
Dosage FormInjectable
RouteIv (infusion)
Strengtheq 40mg base/vial
Market StatusPrescription
CompanyWyeth Pharms

4.2 Drug Indication

Short-term treatment of reflux symptoms (e. g. heartburn, acid regurgitation) in adults.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Ulcer Agents

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)


Proton Pump Inhibitors

Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX. (See all compounds classified as Proton Pump Inhibitors.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Proton Pump Inhibitors [MoA]; Proton Pump Inhibitor [EPC]
5.3 ATC Code

A02BC02


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02-Jan-2021
29-Oct-2024
KGS
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