Find Proximetacainum manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

0

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: Proxymetacaine, 499-67-2, 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate, Ophthaine, Proximetacainum, Paracaine
Molecular Formula
C16H26N2O3
Molecular Weight
294.39  g/mol
InChI Key
KCLANYCVBBTKTO-UHFFFAOYSA-N
FDA UNII
B4OB0JHI1X

Proximetacainum
Proparacaine is a benzoic acid derivative anesthetic agent, with local anesthetic activity. Upon administration, proparacaine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels. This inhibits the sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, increases the threshold for electrical stimulation and results in a loss of sensation.
Proparacaine is a Local Anesthetic. The physiologic effect of proparacaine is by means of Local Anesthesia.
1 2D Structure

Proximetacainum

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(diethylamino)ethyl 3-amino-4-propoxybenzoate
2.1.2 InChI
InChI=1S/C16H26N2O3/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3/h7-8,12H,4-6,9-11,17H2,1-3H3
2.1.3 InChI Key
KCLANYCVBBTKTO-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCCOC1=C(C=C(C=C1)C(=O)OCCN(CC)CC)N
2.2 Other Identifiers
2.2.1 UNII
B4OB0JHI1X
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate

2. 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate Monohydrochloride

3. Ak-taine

4. Alcaine

5. Benzoic Acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl Ester

6. Benzoic Acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl Ester, Monohydrochloride*benzoic Acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl Ester, Monohydrochloride

7. Chibro-kerakain

8. Kracaine

9. Kainair

10. Minims Proxymetacaine Hydrochloride

11. Ocu-caine

12. Ophthaine

13. Ophthetic

14. Parcaine

15. Proparacaine Hcl

16. Proparacaine Hydrochloride

17. Proparakain-pos

18. Proxymetacaine

19. Proxymetacaine Hydrochloride

20. Proxymetacaine Monohydrochloride

21. Proxymethacaine

2.3.2 Depositor-Supplied Synonyms

1. Proxymetacaine

2. 499-67-2

3. 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate

4. Ophthaine

5. Proximetacainum

6. Paracaine

7. Alcaine

8. Prossimetacaina [dcit]

9. Ophthetic

10. Kainair

11. Proxymetacainum [inn-latin]

12. Proximetacaina [inn-spanish]

13. 3-amino-4-propoxybenzoic Acid 2-(diethylamino)ethyl Ester

14. Benzoic Acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl Ester

15. Chebi:8485

16. Proxymetacaine (inn)

17. B4ob0jhi1x

18. Prossimetacaina

19. Proximetacaina

20. Proxymetacainum

21. Proxymetacaine [inn]

22. Proxymetacaine [inn:ban]

23. Beta-(diethylamino)ethyl 4-n-propoxybenzoate

24. Ncgc00016991-03

25. Einecs 207-884-9

26. Unii-b4ob0jhi1x

27. Brn 2745891

28. Benzoic Acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl Ester, Hydrochloride

29. Prestwick0_000959

30. Prestwick1_000959

31. Prestwick2_000959

32. Prestwick3_000959

33. Proparacaine [mi]

34. Chembl1196

35. Proparacaine [vandf]

36. Schembl23334

37. Bspbio_000958

38. Mls006011856

39. Spbio_003107

40. Bpbio1_001054

41. Gtpl7283

42. Proxymetacaine [who-dd]

43. Dtxsid30198146

44. Hms3604h05

45. 2,5-dibromopyridine-3-boronicacid

46. Albb-025705

47. Bcp22476

48. Zinc1530762

49. Bbl003355

50. Bdbm50225500

51. Stk520616

52. Akos005457804

53. Db00807

54. Cas-1452000

55. Mrf-0000607

56. Ncgc00016991-01

57. Ncgc00016991-02

58. Ncgc00016991-06

59. Ncgc00016991-13

60. Ac-13440

61. Smr000857219

62. Sbi-0206900.p001

63. Ab00444123

64. Ft-0658833

65. Ft-0674059

66. .beta.-(diethylamino)ethyl 4-n-propoxybenzoate

67. A24938

68. C07383

69. D08448

70. Ab00444123_07

71. Ab00444123_08

72. Q600867

73. J-017667

74. Brd-k79116891-003-03-7

75. 3-amino-4-propoxy-,2-(diethylamino)ethyl Ester Benzoic Acid

76. 3-amino-4-propoxy-benzoic Acid 2-diethylamino-ethyl Ester, Hydrochloride

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 294.39 g/mol
Molecular Formula C16H26N2O3
XLogP32.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Exact Mass294.19434270 g/mol
Monoisotopic Mass294.19434270 g/mol
Topological Polar Surface Area64.8 Ų
Heavy Atom Count21
Formal Charge0
Complexity295
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Used as a local (ophthalmic) anesthetic.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Proparacaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action. More specifically, proparacaine appears to bind or antagonize the function of voltage gated sodium channels.


5.2 MeSH Pharmacological Classification

Anesthetics, Local

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
PROPARACAINE
5.3.2 FDA UNII
B4OB0JHI1X
5.3.3 Pharmacological Classes
Established Pharmacologic Class [EPC] - Local Anesthetic
5.4 ATC Code

S - Sensory organs

S01 - Ophthalmologicals

S01H - Local anesthetics

S01HA - Local anesthetics

S01HA04 - Proxymetacaine


5.5 Metabolism/Metabolites

Plasma


5.6 Mechanism of Action

The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability through the lipid layer of the nerve cell membrane. Proparacaine may alter epithelial sodium channels through interaction with channel protein residues. This limitation prevents the fundamental change necessary for the generation of the action potential.


Listed Dossiers

read-more
read-more

01

Laboratorios Poen

Argentina
BIO Partnering at JPM
Not Confirmed
arrow

Laboratorios Poen

Argentina
arrow
BIO Partnering at JPM
Not Confirmed

Proximetacainum; Fluorescein

Brand Name : Fotoptic

Dosage Form : Ophthalmic Solution

Dosage Strength : 0.5%; 0.25%

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Argentina

blank

01

Laboratorios Poen

Argentina
BIO Partnering at JPM
Not Confirmed
arrow

Laboratorios Poen

Argentina
arrow
BIO Partnering at JPM
Not Confirmed

Proximetacainum; Fluorescein

Dosage : Ophthalmic Solution

Dosage Strength : 0.5%; 0.25%

Brand Name : Fotoptic

Approval Date :

Application Number :

Registration Country : Argentina

blank
Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Market Place

Do you need sourcing support? Ask us

ABOUT THIS PAGE

Proximetacainum Manufacturers

A Proximetacainum manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Proximetacainum, including repackagers and relabelers. The FDA regulates Proximetacainum manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Proximetacainum API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Proximetacainum Suppliers

A Proximetacainum supplier is an individual or a company that provides Proximetacainum active pharmaceutical ingredient (API) or Proximetacainum finished formulations upon request. The Proximetacainum suppliers may include Proximetacainum API manufacturers, exporters, distributors and traders.

Proximetacainum GMP

Proximetacainum Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Proximetacainum GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Proximetacainum GMP manufacturer or Proximetacainum GMP API supplier for your needs.

Proximetacainum CoA

A Proximetacainum CoA (Certificate of Analysis) is a formal document that attests to Proximetacainum's compliance with Proximetacainum specifications and serves as a tool for batch-level quality control.

Proximetacainum CoA mostly includes findings from lab analyses of a specific batch. For each Proximetacainum CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Proximetacainum may be tested according to a variety of international standards, such as European Pharmacopoeia (Proximetacainum EP), Proximetacainum JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Proximetacainum USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty