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Also known as: 537-42-8, Trans-pterostilbene, 4-(3,5-dimethoxystyryl)phenol, (e)-4-(3,5-dimethoxystyryl)phenol, 4-[(e)-2-(3,5-dimethoxyphenyl)ethenyl]phenol, 18259-15-9
Molecular Formula
C16H16O3
Molecular Weight
256.30  g/mol
InChI Key
VLEUZFDZJKSGMX-ONEGZZNKSA-N
FDA UNII
26R60S6A5I

Pterostilbene
Pterostilbene is a naturally-derived stilbenoid structurally related to resveratrol, with potential antioxidant, anti-inflammatory, pro-apoptotic, antineoplastic and cytoprotective activities. Upon administration, pterostilbene exerts its anti-oxidant activity by scavenging reactive oxygen species (ROS), thereby preventing oxidative stress and ROS-induced cell damage. It may also activate the nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated pathway and increase the expression of various antioxidant enzymes, such as superoxide dismutase (SOD). In addition, pterostilbene is able to inhibit inflammation by reducing the expression of various inflammatory mediators, such as interleukin (IL) 1beta, tumor necrosis factor alpha (TNF-a), inducible nitric oxide synthase (iNOS), cyclooxygenases (COX), and nuclear factor kappa B (NF-kB). It also inhibits or prevents the activation of many signaling pathways involved in carcinogenesis, and increases expression of various tumor suppressor genes while decreasing expression of certain tumor promoting genes. It also directly induces apoptosis in tumor cells.
1 2D Structure

Pterostilbene

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol
2.1.2 InChI
InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
2.1.3 InChI Key
VLEUZFDZJKSGMX-ONEGZZNKSA-N
2.1.4 Canonical SMILES
COC1=CC(=CC(=C1)C=CC2=CC=C(C=C2)O)OC
2.1.5 Isomeric SMILES
COC1=CC(=CC(=C1)/C=C/C2=CC=C(C=C2)O)OC
2.2 Other Identifiers
2.2.1 UNII
26R60S6A5I
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3',5'-dimethoxy-4e-stilbenol

2. 3',5'-dimethoxy-4trans-stilbenol

3. 3',5'-dimethoxy-resveratrol

4. 3,5-dimethoxy-4'-hydroxy-trans-stilbene

5. 4-((e)-2-(3,5-dimethoxyphenyl)ethenyl)phenol

6. 4trans-(2-(3,5-dimethoxyphenyl)ethenyl)phenol

7. Phenol, 4-((1e)-2-(3,5-dimethoxyphenyl)ethenyl)-

8. Pterostilbene, (e)-

9. Trans-3,5-dimethoxy-4'-hydroxystilbene

10. Trans-pterostilbene

2.3.2 Depositor-Supplied Synonyms

1. 537-42-8

2. Trans-pterostilbene

3. 4-(3,5-dimethoxystyryl)phenol

4. (e)-4-(3,5-dimethoxystyryl)phenol

5. 4-[(e)-2-(3,5-dimethoxyphenyl)ethenyl]phenol

6. 18259-15-9

7. 3',5'-dimethoxy-4-stilbenol

8. 4-[(e)-2-(3,5-dimethoxyphenyl)vinyl]phenol

9. Pterostilbene, (e)-

10. Pterostilben

11. 3,5-dimethoxy-4'-hydroxy-trans-stilbene

12. Trans-3,5-dimethoxy-4'-hydroxystilbene

13. Phenol, 4-[(1e)-2-(3,5-dimethoxyphenyl)ethenyl]-

14. Chembl83527

15. Chebi:8630

16. 4-((e)-2-(3,5-dimethoxyphenyl)ethenyl)phenol

17. 26r60s6a5i

18. 4-[(1e)-2-(3,5-dimethoxyphenyl)ethenyl]phenol

19. 3,5-dimethoxy-4'-hydroxystilbene

20. Phenol, 4-[2-(3,5-dimethoxyphenyl)ethenyl]-

21. Phenol, 4-((1e)-2-(3,5-dimethoxyphenyl)ethenyl)-

22. Mfcd00238710

23. Smr000440694

24. Pterostilbene, Pterocarpus Marsupium

25. 4-((1e)-2-(3,5-dimethoxyphenyl)ethenyl)phenol

26. Pteropure

27. Unii-26r60s6a5i

28. Tero-still-bean

29. 4'-hydroxy-3,5-dimethoxy-trans-stilbene

30. Cpd000440694

31. 4-stilbenol, 3',5'-dimethoxy-, (e)-

32. Phenol, 4-[(1z)-2-(3,5-dimethoxyphenyl)ethenyl]-

33. 3,5-di-o-methylresveratrol

34. Schembl20063

35. Mls000759434

36. Mls000863581

37. Mls001424135

38. Schembl563218

39. Pterostilbene [who-dd]

40. Gtpl2681

41. Megxp0_000345

42. Dtxsid9041106

43. Acon1_000305

44. 4'-hydroxy-3,5-dimethoxystilbene

45. Hms2051b10

46. Hms2270j16

47. Trans-1-(3,5-dimethoxyphenyl)-2-(4-hydroxyphenyl)ethylene

48. Zinc899213

49. Act03896

50. Albb-013778

51. Amy24840

52. Bcp22675

53. Hy-n0828

54. (e)-3',5'-dimethoxy-4-stilbenol

55. Bdbm50131688

56. Lmpk13090015

57. Nsc613735

58. S3937

59. 4''-hydroxy-3,5-dimethoxy Stilbene

60. Akos000277651

61. Akos025310510

62. Ac-5283

63. Ccg-101015

64. Cs-w008773

65. Eh-301 Component Pterostilbene

66. Nc00265

67. Nsc-613735

68. (e)-4'-hydroxy-3,5-dimethoxystilbene

69. Pterostilbene, >=97% (hplc), Solid

70. Ncgc00180691-01

71. As-13710

72. Ls-14484

73. 3,5-dimethoxy-4''-hydroxyl-trans-stilbene

74. Bb 0262300

75. N2126

76. P1924

77. 4-[2-(3,5-dimethoxy-phenyl)-vinyl]-phenol

78. Phenol,4-[2-(3,5-dmethoxyphenyl)ethenyl]-

79. (e)-1-hydroxy-4-(3,5-dimethoxy)styrylbenzene

80. E 4-[2-(3,5-dimethoxy-phenyl)-vinyl]-phenol

81. 259p159

82. 4-[(e)-2-(3,5-dimethoxy-phenyl)-vinyl]-phenol

83. A829757

84. J-523927

85. Phenol, 4-[(e)-2-(3,5-dimethoxyphenyl)ethenyl]-

86. Q2908011

87. W-203025

88. Phenol, 4-(2-(3,5-dimethoxyphenyl)ethenyl)-, (e)-

89. 4-[(e)-2-(3,5-dimethoxyphenyl)vinyl]phenol;pterostilbene

90. Ncgc00180691-03!4-[(e)-2-(3,5-dimethoxyphenyl)ethenyl]phenol

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 256.30 g/mol
Molecular Formula C16H16O3
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass256.109944368 g/mol
Monoisotopic Mass256.109944368 g/mol
Topological Polar Surface Area38.7 Ų
Heavy Atom Count19
Formal Charge0
Complexity270
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Metabolism/Metabolites

Pterostilbene has known human metabolites that include (2S,3S,4S,5R)-6-[4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


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06-Mar-2021
11-Nov-2024
KGS
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Quantity (KGS) & Unit rate (USD/KGS) over time

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ABOUT THIS PAGE

Pterostilbene Manufacturers

A Pterostilbene manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pterostilbene, including repackagers and relabelers. The FDA regulates Pterostilbene manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pterostilbene API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Pterostilbene manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Pterostilbene Suppliers

A Pterostilbene supplier is an individual or a company that provides Pterostilbene active pharmaceutical ingredient (API) or Pterostilbene finished formulations upon request. The Pterostilbene suppliers may include Pterostilbene API manufacturers, exporters, distributors and traders.

click here to find a list of Pterostilbene suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Pterostilbene GMP

Pterostilbene Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Pterostilbene GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pterostilbene GMP manufacturer or Pterostilbene GMP API supplier for your needs.

Pterostilbene CoA

A Pterostilbene CoA (Certificate of Analysis) is a formal document that attests to Pterostilbene's compliance with Pterostilbene specifications and serves as a tool for batch-level quality control.

Pterostilbene CoA mostly includes findings from lab analyses of a specific batch. For each Pterostilbene CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Pterostilbene may be tested according to a variety of international standards, such as European Pharmacopoeia (Pterostilbene EP), Pterostilbene JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pterostilbene USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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