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Chemistry

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Also known as: 22204-24-6, Pyrantel embonate, Antiminth, Combantrin, Pyrantel (pamoate), Cp-10,423-16
Molecular Formula
C34H30N2O6S
Molecular Weight
594.7  g/mol
InChI Key
AQXXZDYPVDOQEE-MXDQRGINSA-N
FDA UNII
81BK194Z5M

Pyrantel Pamoate
Broad spectrum antinematodal anthelmintic used also in veterinary medicine.
1 2D Structure

Pyrantel Pamoate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid;1-methyl-2-[(E)-2-thiophen-2-ylethenyl]-5,6-dihydro-4H-pyrimidine
2.1.2 InChI
InChI=1S/C23H16O6.C11H14N2S/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h1-10,24-25H,11H2,(H,26,27)(H,28,29);2,4-6,9H,3,7-8H2,1H3/b;6-5+
2.1.3 InChI Key
AQXXZDYPVDOQEE-MXDQRGINSA-N
2.1.4 Canonical SMILES
CN1CCCN=C1C=CC2=CC=CS2.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
2.1.5 Isomeric SMILES
CN1CCCN=C1/C=C/C2=CC=CS2.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
2.2 Other Identifiers
2.2.1 UNII
81BK194Z5M
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Antiminth

2. Combantrin

3. Embonate, Pyrantel

4. Embovin

5. Pamoate, Pyrantel

6. Pyrantel Embonate

2.3.2 Depositor-Supplied Synonyms

1. 22204-24-6

2. Pyrantel Embonate

3. Antiminth

4. Combantrin

5. Pyrantel (pamoate)

6. Cp-10,423-16

7. Pyrantel (as Pamoate)

8. Embovin

9. (e)-1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidine 4,4'-methylenebis(3-hydroxy-2-naphthoate) (1:1)

10. Nsc-355080

11. Chebi:8655

12. Cp 10423-16

13. 81bk194z5m

14. Nsc355080

15. (e)-1-methyl-2-(2-(thiophen-2-yl)vinyl)-1,4,5,6-tetrahydropyrimidine 4,4'-methylenebis(3-hydroxy-2-naphthoate)

16. Cp-10423-16

17. Cp-10423-18

18. Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)-, (e)-, Compd. With 4,4'-methylenebis(3-hydroxy-2-naphthalenecarboxylic Acid) (1:1)

19. Cobantril

20. Sentry Hc Worm X

21. 2-naphthalenecarboxylic Acid, 4,4'-methylenebis[3-hydroxy-, Compd. With 1,4,5,6-tetrahydro-1-methyl-2-[(1e)-2-(2-thienyl)ethenyl]pyrimidine (1:1)

22. 4-[(3-carboxy-2-hydroxy-1-naphthyl)methyl]-3-hydroxy-naphthalene-2-carboxylic Acid; 1-methyl-2-[(e)-2-(2-thienyl)vinyl]-5,6-dihydro-4h-pyrimidine

23. 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic Acid;1-methyl-2-[(e)-2-thiophen-2-ylethenyl]-5,6-dihydro-4h-pyrimidine

24. Sentry Hc Worm X Ds

25. Einecs 244-837-1

26. Vetscription Sure Shot 2x

27. Nsc 355080

28. Pyirantelpamoate

29. Unii-81bk194z5m

30. Pyrantel Pamoates

31. Pyranteli Embonas

32. Antiminth (tn)

33. Pyrantel Pamoate [usan:usp:jan]

34. 2-naphthalenecarboxylic Acid, 4,4'-methylenebis(3-hydroxy-, Compd. With 1,4,5,6-tetrahydro-1-methyl-2-((1e)-2-(2-thienyl)ethenyl)pyrimidine (1:1)

35. Spectrum5_001373

36. Pyrantel Pamoate, Bioxtra

37. (3-hydroxy-2-naphthoate)

38. Schembl41025

39. 2-naphthalenecarboxylic Acid, 4,4'-methylenebis(3-hydroxy-, Compd. With (e)-1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)pyrimidine (1:1)

40. Pyrantel Pamoate [mi]

41. Spectrum1500517

42. Pyrantel Pamoate [jan]

43. Pyrantel Pamoate (jp17/usp)

44. Schembl7793068

45. Pyrantel Pamoate [usan]

46. Chembl1599768

47. Pyrantel Pamoate [vandf]

48. Hms500m16

49. Pyrantel Pamoate Sigmaultra,(s)

50. Amy3564

51. Dtxsid40897057

52. Pyrantel Embonate [mart.]

53. Pyrantel Pamoate [usp-rs]

54. Hms1920n06

55. Hms2090j21

56. Hms2092e07

57. Pharmakon1600-01500517

58. Pyrantel Embonate [who-dd]

59. Pyrantel Embonate [who-ip]

60. Ccg-39242

61. Mfcd00072037

62. Nsc757303

63. S2501

64. Stl481883

65. Pyrantel Pamoate [green Book]

66. Akos015908224

67. Cs-3869

68. Nsc-757303

69. Idi1_000254

70. Pyrantel Embonate [ep Monograph]

71. Pyrantel Pamoate [usp Monograph]

72. Ncgc00094552-01

73. Ncgc00094552-02

74. Ncgc00094552-03

75. Pyranteli Embonas [who-ip Latin]

76. 2-naphthoic Acid, 4,4'-methylenebis(3-hydroxy-, Compd. With (e)-1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidine (1:1)

77. 4,4'-methylenebis(3-hydroxy-2-naphthoic) Acid, Compound With (e)-1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidine (1:1)

78. Ac-24204

79. As-12185

80. Bp166202

81. Hy-12640

82. Sbi-0051499.p003

83. C07389

84. D00486

85. F21340

86. 204p246

87. A816013

88. Sr-05000001708

89. Q3489331

90. Sr-05000001708-1

91. Pyrantel Pamoate, Vetranal(tm), Analytical Standard

92. (e)-1-methyl-2-(2-(thiophen-2-yl)vinyl)-1,4,5,6

93. Pyrantel Embonate, European Pharmacopoeia (ep) Reference Standard

94. Pyrantel Pamoate, United States Pharmacopeia (usp) Reference Standard

95. Pyrimidine,1,4,5,6-tetrahydro-1-methyl-2-[(1e)-2-(2-thienyl)ethenyl]-

96. (e)-1,5,6-tetrahydro-1-methyl-2-[2-(2-thienyl)vinyl]pyrimidine 4,4'-methylenebis[3-hydroxy-2-naphthoate] (1:1)

97. 2-naphthalenecarboxylic Acid,4'-methylenebis[3-hydroxy-, Compd. With (e)-1,4,5,6-tetrahydro-1-methyl-2-[2-(2-thienyl)ethenyl]pyrimidine (1:1)

98. 2-naphthoic Acid,4'-methylenebis[3-hydroxy-, Compd. With (e)-1,4,5,6-tetrahydro-1-methyl-2-[2-(2-thienyl)vinyl]pyrimidine (1:1)

99. 4,4'-methanediylbis(3-hydroxynaphthalene-2-carboxylic Acid) - 1-methyl-2-[(e)-2-(thiophen-2-yl)ethenyl]-1,4,5,6-tetrahydropyrimidine (1:1)

100. 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic Acid,1-methyl-2-[(e)-2-thiophen-2-ylethenyl]-5,6-dihydro-4h-pyrimidine

101. Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-[2-(-2-thienyl)ethenyl-, (e)-, With 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylic Acid (1:1)

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 594.7 g/mol
Molecular Formula C34H30N2O6S
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass594.18245785 g/mol
Monoisotopic Mass594.18245785 g/mol
Topological Polar Surface Area159 Ų
Heavy Atom Count43
Formal Charge0
Complexity816
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antinematodal Agents

Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice. (See all compounds classified as Antinematodal Agents.)


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Pyrantel pamoate (for manufacturing purposes only)

Registration Number : 221MF10046

Registrant's Address : Sethna 4th floor 55 Maharshi karve road Marine Lines,Mumbai-400002,INDIA

Initial Date of Registration : 2009-02-25

Latest Date of Registration : 2018-10-12

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Pyrantel Pamoate/ Pyrantel Embonate IP/USP/EP

Date of Issue : 2022-07-27

Valid Till : 2025-07-21

Written Confirmation Number : WC-0087-(Annexure-1)

Address of the Firm : Plot No.1 to 5, 31 to 35 & 48 to 51, 26 & K/201, Village Lakhmapur, Taluka Dindo...

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Submission : 1996-05-23

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API Reference Price

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SG HIGHWAY, ISCON CROSS ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1701109800,"product":"PYRANTEL PAMOATE. 76770. B\/N: 36-MC. MFG. DT. 21\/03\/2023 EXP. DT. 03\/2028","address":"SUR. NO. 377\/1B, BS. UDHYAN BUNGLO","city":"AHMEDABAD,GUJARAT","supplier":"COPRIMA S.L.","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"XYLOPIA LABS PRIVATE ","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"400","totalValueFC":"2019.9","currency":"USD","unitRateINR":"33640","date":"28-Nov-2023","totalValueINR":"168200","totalValueInUsd":"2019.9","indian_port":"Ahmedabad Air","hs_no":"29349990","bill_no":"8972405","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"C\/PABLO PICASSO 15, 08213 POLINYA ,BARCELONASDNF SPAIN","customerAddress":"SUR. NO. 377\/1B, BS. UDHYAN BUNGLO"}]
09-Jan-2021
30-Oct-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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Europe

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01

Antibody Engineering
Not Confirmed
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Antibody Engineering
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Pyrantel

Brand Name : Combantrin

Dosage Form : Pirantel 250Mg 8 Joined' Oral Use

Dosage Strength : 8 cpr mast 250 mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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02

Antibody Engineering
Not Confirmed
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Antibody Engineering
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Pyrantel

Brand Name : Combantrin

Dosage Form : Pirantel 5% 30Ml Oral Use

Dosage Strength : os suspe 30 ml 250 mg/5 ml

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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EDQM

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01

EDQM, Council of Europe

Pyrantel impurity A

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CPHI Middle east
Not Confirmed
CPHI Middle east
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Pyrantel impurity A

CAS Number : n/a

Quantity Per Vial : 20 mg

Sale Unit : 1

Order Code : Y0000403

Batch No : 2

Price (€) : 79

Storage : +5°C ± 3°C

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02

EDQM, Council of Europe

Pyrantel embonate

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CPHI Middle east
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CPHI Middle east
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Pyrantel embonate

CAS Number : 22204-24-6

Quantity Per Vial : 10 mg

Sale Unit : 1

Order Code : Y0000402

Batch No : 1

Price (€) : 79

Storage : +5°C ± 3°C

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USP

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USP

U.S.A
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USP

U.S.A
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Not Confirmed

Pyrantel Related Compound A (25 mg) ((Z)-1-Me...

CAS Number :

Quantity Per Vial : 25

Sale Unit : mg

Price : $835.00

Details : Material Origin- Chemical Synthesis; USMCA- N...

Monograph :

Storage :

Code/Batch No : Catalog #1584014 / R044X0

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02

USP

U.S.A
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CPHI Middle east
Not Confirmed

USP

U.S.A
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Pyrantel Pamoate (500 mg)

CAS Number : 22204-24-6

Quantity Per Vial : 500

Sale Unit : mg

Price : $245.00

Details : Material Origin- Chemical Synthesis; USMCA- N...

Monograph :

Storage :

Code/Batch No : Catalog #1584003 / R06040

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