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    Chemistry

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    Also known as: 58-56-0, Pyridoxine hcl, Pyridoxol hydrochloride, Vitamin b6, Vitamin b6 hydrochloride, Pyridoxine chloride
    Molecular Formula
    C8H12ClNO3
    Molecular Weight
    205.64  g/mol
    InChI Key
    ZUFQODAHGAHPFQ-UHFFFAOYSA-N
    FDA UNII
    68Y4CF58BV
    Pyridoxine Hydrochloride
    The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
    1 2D Structure

    Pyridoxine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;hydrochloride
    2.1.2 InChI
    InChI=1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H
    2.1.3 InChI Key
    ZUFQODAHGAHPFQ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=NC=C(C(=C1O)CO)CO.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    68Y4CF58BV
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Pyridoxin

    2. Pyridoxine

    3. Pyridoxol

    4. Pyridoxol Hydrochloride

    5. Rodex

    2.3.2 Depositor-Supplied Synonyms

    1. 58-56-0

    2. Pyridoxine Hcl

    3. Pyridoxol Hydrochloride

    4. Vitamin B6

    5. Vitamin B6 Hydrochloride

    6. Pyridoxine Chloride

    7. Hexa-betalin

    8. Alestrol

    9. Becilan

    10. Benadon

    11. Hexavibex

    12. Hexermin

    13. Hexobion

    14. Pyridipca

    15. Beesix

    16. Pydox

    17. Adermine Hydrochloride

    18. Campoviton 6

    19. Aderoxine

    20. Pyridoxinium Chloride

    21. Aderomine Hydrochloride

    22. Hexabione Hydrochloride

    23. Pyridoxin Hydrochloride

    24. Pyridoxinum Hydrochloricum

    25. 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol Hydrochloride

    26. Bendectin

    27. 3,4-pyridinedimethanol, 5-hydroxy-6-methyl-, Hydrochloride

    28. Pyridoxol, Hydrochloride

    29. Pyridoxine (hydrochloride)

    30. 5-hydroxy-6-methyl-3,4-pyridinedimethanol Hydrochloride

    31. Mfcd00012807

    32. 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine Hydrochloride

    33. 3-hydroxy-4,5-dimethylol-alpha-picoline Hydrochloride

    34. 5-hydroxy-6-methyl-3,4-pyridinedicarbinol Hydrochloride

    35. 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;hydrochloride

    36. Bonasanit

    37. (5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol Hydrochloride

    38. Nsc-36225

    39. Adermin Hydrochloride

    40. 5-hydroxy-6-methyl-3,4-pyridinedimethanol, Hydrochloride

    41. 68y4cf58bv

    42. Hexabetalin

    43. Aderoxin

    44. Godabion

    45. Paxadon

    46. Pyridox

    47. Chebi:30961

    48. Pyridoxine Hydrogen Chloride

    49. 8064-77-5

    50. Hexa-betalin (r)

    51. Spondylonal

    52. Rodex (r)

    53. Pn Hcl

    54. Pyridoxin Hydrochloride (vitamin B6 Hydrochloride)

    55. Pyridoxine Monohydrochloride

    56. Pyridoxol (hydrochloride);vitamin B6 (hydrochloride)

    57. 4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol Hydrochloride

    58. Pyridoxine, Hydrochloride

    59. 3,4-pyridinedimethanol, 5-hydroxy-6-methyl-, Hydrochloride (1:1)

    60. Pyridoxinum Hydrochloricum (hungarian)

    61. Smr000674613

    62. Hexa-betalin (tn)

    63. Nsc36225

    64. Ccris 1903

    65. Component Of Alestrol

    66. Hsdb 1212

    67. Tex Six T.r.

    68. Clorhidrato De Piridoxina

    69. Ncgc00164317-01

    70. Vitamin B6-hydrochloride

    71. Einecs 200-386-2

    72. Nsc 36225

    73. Unii-68y4cf58bv

    74. Ai3-19016

    75. Pyridoxine Hydrochloride [jan]

    76. 3-hydroxy-4,5-dihydroxymethyl-2-methylpyridine Hydrochloride

    77. Prestwick_925

    78. Pyridoxine Hydrochloride [usp:jan]

    79. Pyridoxini Hydrochloridum

    80. 4,5-bis(hydroxymethyl)-3-hydroxy-2-methylpyridine Hydrochloride

    81. Pyridoxol (hydrochloride)

    82. Vitamin B6, Hydrochloride

    83. Vitamin B6 (hydrochloride)

    84. Dsstox_cid_10780

    85. Dsstox_rid_79601

    86. Dsstox_gsid_40792

    87. Schembl42293

    88. Mls001074329

    89. Mls002153915

    90. Pyridoxine Hcl [inci]

    91. Pyridoxine Hcl [vandf]

    92. Pyridoxine Hydrochloride, 98%

    93. 3-hydroxy-4,5-dimethylol-.alpha.-picoline Hydrochloride

    94. Chembl1200756

    95. Dtxsid1040792

    96. Hms1569n08

    97. Amy37035

    98. Hy-n0682

    99. Tox21_302476

    100. Pyridoxine Hydrochloride [mi]

    101. S3113

    102. 3-hydroxy-4,5-dimethylol-alpha-pic

    103. Pyridoxine Hydrochloride (jp17/usp)

    104. Pyridoxine Hydrochloride [fcc]

    105. Akos015891679

    106. Pyridoxine Hcl (vitamin B6) Solution

    107. Ccg-220623

    108. Cs-w020418

    109. Pyridoxine Hydrochloride [hsdb]

    110. 3, 5-hydroxy-6-methyl-, Hydrochloride

    111. Pyridoxine Hydrochloride [mart.]

    112. Pyridoxine Hydrochloride [vandf]

    113. Ncgc00180946-01

    114. Ncgc00256911-01

    115. Pyridoxine Hydrochloride [usp-rs]

    116. Pyridoxine Hydrochloride [who-dd]

    117. Pyridoxine Hydrochloride [who-ip]

    118. Pyridoxinum Hydrochloricum [hpus]

    119. Ac-12024

    120. As-11752

    121. Sy061587

    122. Wln: T6nj B1 Cq D1q E1q &gh

    123. Pyridoxine Hydrochloride, >=98% (hplc)

    124. Db-053225

    125. Pyridoxine Hydrochloride, P.a., 98-102%

    126. B2017

    127. Ft-0631260

    128. P0561

    129. Pyridoxine Hydrochloride [green Book]

    130. Sw197042-3

    131. Tpn Component Pyridoxine Hydrochloride

    132. Pyridoxine Hydrochloride [ep Impurity]

    133. Pyridoxine Hydrochloride [orange Book]

    134. D02179

    135. H12039

    136. Pyridoxine Hydrochloride [ep Monograph]

    137. Pyridoxine Hydrochloride [usp Monograph]

    138. Pyridoxine Hydrochloride Component Of Tpn

    139. Pyridoxini Hydrochloridum [who-ip Latin]

    140. Vitamin B6 (as Pyridoxine Hydrochloride)

    141. Bendectin Component Pyridoxine Hydrochloride

    142. Bonjesta Component Pyridoxine Hydrochloride

    143. Diclectin Component Pyridoxine Hydrochloride

    144. Diclegis Component Pyridoxine Hydrochloride

    145. Pyridoxine Hydrochloride (b6), Analytical Standard

    146. Pyridoxine Hydrochloride, Plant Cell Culture Tested

    147. Q-201647

    148. Sr-05000001644-4

    149. Pyridoxine Hydrochloride Component Of Bendectin

    150. Pyridoxine Hydrochloride Component Of Bonjesta

    151. Q26841284

    152. F0001-2400

    153. Pyridoxine Hydrochloride, Saj Special Grade, >=98.0%

    154. Pyridoxine Hydrochloride, Vetec(tm) Reagent Grade, 98%

    155. Pyridoxine Hydrochloride, Meets Usp Testing Specifications

    156. Pyridoxine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    157. 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine Hydrochloride

    158. Pyridoxine Hydrochloride, Certified Reference Material, Tracecert(r)

    159. Pyridoxine Hydrochloride, British Pharmacopoeia (bp) Reference Standard

    160. Pyridoxine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    161. Pyridoxin Hydrochloride (vitamin B6 Hydrochloride) 100 Microg/ml In Methanol

    162. Pyridoxine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    163. Pyridoxine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    164. Pyridoxine Hcl (vitamin B6) Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    165. Pyridoxine Hydrochloride, Bioreagent, Suitable For Cell Culture, Suitable For Insect Cell Culture, Suitable For Plant Cell Culture

    166. Pyridoxine Hydrochloride, Pharmagrade, Ep, Manufactured Under Appropriate Gmp Controls For Pharma Or Biopharmaceutical Production

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 205.64 g/mol
    Molecular Formula C8H12ClNO3
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count2
    Exact Mass205.0505709 g/mol
    Monoisotopic Mass205.0505709 g/mol
    Topological Polar Surface Area73.6 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity142
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NamePyridoxine hydrochloride
    Drug LabelPyridoxine Hydrochloride Injection, USP is a sterile solution of pyridoxine hydrochloride in Water for Injection. Each mL contains 100 mg pyridoxine hydrochloride and 0.5% chlorobutanol anhydrous (chloral deriv.). pH adjusted with sodium hydroxid...
    Active IngredientPyridoxine hydrochloride
    Dosage FormInjectable
    RouteInjection
    Strength100mg/ml
    Market StatusPrescription
    CompanyFresenius Kabi Usa

    2 of 2  
    Drug NamePyridoxine hydrochloride
    Drug LabelPyridoxine Hydrochloride Injection, USP is a sterile solution of pyridoxine hydrochloride in Water for Injection. Each mL contains 100 mg pyridoxine hydrochloride and 0.5% chlorobutanol anhydrous (chloral deriv.). pH adjusted with sodium hydroxid...
    Active IngredientPyridoxine hydrochloride
    Dosage FormInjectable
    RouteInjection
    Strength100mg/ml
    Market StatusPrescription
    CompanyFresenius Kabi Usa

    4.2 Therapeutic Uses

    DOSE: USUAL, ORAL OR PARENTERAL, PROPHYLACTIC, 2 MG ONCE A DAY; THERAPEUTIC, 5 TO 150 MG DAILY. DOSE FOR MALNUTRITION IS 5 TO 10 MG DAILY; FOR HYPEREMESIS GRAVIDUM & EMESIS OF RADIATION SICKNESS IS 10 TO 100 MG DAILY.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 960

    ... MAY BE USED PROPHYLACTICALLY TO PREVENT PERIPHERAL NEURITIS IN PATIENTS TREATED WITH ISONIAZID. APPEARS TO AID IN DISSOLUTION OF RENAL STONES OF CALCIUM OXALATE ... INCR EXCRETION OF CALCIUM-CHELATING CITRIC ACID.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 960

    MEDICATION (VET): ... ANTIDOTAL IN MICE & DOGS TO CONVULSIVE EFFECTS OF RODENTICIDE CRIMIDINE.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 647

    ... INFANTS MAY EXHIBIT HYPERIRRITABILITY & EPILEPTIFORM CONVULSIONS DURING FIRST WK OF LIFE THAT PROMPTLY RESPOND TO ADMIN OF PYRIDOXINE. IF UNTREATED, PYRIDOXINE-RESPONSIVE ANEMIA & MENTAL RETARDATION MAY RESULT. /PYRIDOXINE/

    American Medical Association, AMA Department of Drugs. AMA Drug Evaluations. 4th ed. Chicago: American Medical Association, 1980., p. 823

    For more Therapeutic Uses (Complete) data for PYRIDOXINE HYDROCHLORIDE (22 total), please visit the HSDB record page.

    4.3 Drug Warning

    Pyridoxine is usually nontoxic; however, chronic admin of large dosages has been assoc with adverse neurologic effects. Nausea, headache, paresthesia, somnolence, & incr serum AST (SGOT) & decr serum folic acid concn have been reported. Burning or stinging at the injection site may occur following IM or subcutaneous injection of pyridoxine. Seizures have occurred following IV admin of very large doses. Allergic reactions have been reported occasionally in patients receiving the vitamin.

    McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2000.Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2000 (Plus Supplements)., p. 3319

    Pyridoxine should not be used in patients with a history of sensitivity to the vitamin. According to one manufacturer, pyridoxine should not be administered iv to patients with heart disease.

    McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2000.Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2000 (Plus Supplements)., p. 3319

    Maternal Medication usually Compatible with Breast-Feeding: B6 (pyridoxine): Reported Sign or Symptom in Infant or Effect on Lactation: None. /from Table 6/

    Report of the American Academy of Pediatrics Committee on Drugs in Pediatrics 93 (1): 140 (1994)

    Very large doses of pyridoxine have been reported to have a lactation-inhibiting effect. Using oral doses of 600 mg/day, lactation was successfully inhibited in 95% of patients within 1 week as compared to only 17% of placebo-treated controls. /Pyridoxine/

    Briggs, G.G, R.K. Freeman, S.J. Yaffe. A Reference Guide to Fetal and Neonatal Risk. Drugs in Pregnancy and Lactation. 4th ed. Baltimore, MD: Williams & Wilkins 1994., p. 751

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Vitamin B Complex

    A group of water-soluble vitamins, some of which are COENZYMES. (See all compounds classified as Vitamin B Complex.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Vitamin B 6 [Chemical/Ingredient]; Vitamin B6 Analog [EPC]; Analogs/Derivatives [Chemical/Ingredient]
    5.3 Absorption, Distribution and Excretion

    THE FAT SOLUBLE VITAMINS A, D, & K ARE ABSORBED FROM SKIN, AS ARE LIPID INSOLUBLE VITAMINS, THIAMINE, RIBOFLAVIN, CALCIUM PANTOTHENATE, PYRIDOXINE. /PYRIDOXINE/

    Hayes, W. J., Jr. Toxicology of Pesticides Baltimore: Williams & Wilkins, 1975., p. 149

    ... READILY ABSORBED FROM GI TRACT. ... EXCRETORY PRODUCT ... OF VITAMIN /WHEN IT IS FED TO MAN IS 4-PYRIDOXIC ACID. /PYRIDOXINE/

    Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1563

    Pyridoxine, pyridoxal, and pyridoxamine are readily absorbed from the GI tract following oral administration; however, GI absorption may be diminished in patients with malabsorption syndromes or following gastric resection. Normal serum concentrations of pyridoxine are 30-80 ng/ml.

    McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2000.Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2000 (Plus Supplements)., p. 3318

    Vitamin B6 is stored mainly in the liver with lesser amounts in muscle & brain. The total body store of vitamin B6 is estimated to be about 167 mg. Pyridoxal and pyridoxal phosphate, the principal forms of the vitamin present in blood, are highly protein bound. Pyridoxal crosses the placenta, & plasma concn in the fetus are 5 times > maternal plasma concn. The concn of vitamin B6 in milk is about 150 240 mg/mL following maternal intake of 2.5 5 mg of vitamin B6 daily. Following maternal intake of < 2.5 mg of vitamin B6 daily, vitamin B6 concn in milk averages 130 mg/mL.

    McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2000.Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2000 (Plus Supplements)., p. 3318

    For more Absorption, Distribution and Excretion (Complete) data for PYRIDOXINE HYDROCHLORIDE (6 total), please visit the HSDB record page.

    5.4 Metabolism/Metabolites

    ALL THREE FORMS OF VITAMIN B6 /PYRIDOXINE, PYRIDOXAL, & PYRIDOXAMINE/ ARE CONVERTED TO PYRIDOXAL PHOSPHATE IN BODY; PYRIDOXAL IS CONVERTED TO PYRIDOXAL PHOSPHATE BY ENZYME, PYRIDOXAL KINASE ... . /PYRIDOXINE/

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 1570

    /4-PYRIDOXIC ACID/ ... FORMED BY ACTION OF HEPATIC ALDEHYDE OXIDASE ON FREE PYRIDOXAL. ADMIN OF PYRIDOXINE ... RESULTS IN INCR EXCRETION OF PYRIDOXAL ... FIRST TRANSFORMED, DIRECTLY OR INDIRECTLY, TO PYRIDOXAL, WHICH IS THEN OXIDIZED TO 4-PYRIDOXIC ACID ... . /PYRIDOXINE/

    Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 1571

    In erythrocytes, pyridoxine is converted to pyridoxal phosphate and pyridoxamine is converted to pyridoxamine phosphate. In the liver, pyridoxine is phosphorylated to pyridoxine phosphate and transaminated to pyridoxal and pyridoxamine which are rapidly phosphorylated. Riboflavin is required for the conversion of pyridoxine phosphate to pyridoxal phosphate. The principal forms of the vitamin in the blood are pyridoxal and pyridoxal phosphate.

    McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2000.Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2000 (Plus Supplements)., p. 3318

    In humans, an exogenous source of vitamin B6, is required for amino acid metab; the vitamin is also involved in carbohydrate & lipid metab. Pyridoxine, pyridoxal, & pyridoxamine are converted to the active forms of the vitamin, pyridoxal phosphate & pyridoxamine phosphate, which act as coenzymes in a wide variety of reactions in intermed metab. The active forms of the vitamin are involved in transamination of amino acids & in the conversion of tryptophan to niacin. Pyridoxine appears to be essential in the synth of y aminobutyric acid (GABA) within the CNS & in the synth of heme. Pyridoxine deficiency results in the accum & urinary excretion of xanthurenic acid (an intermed metabolite of tryptophan) & in decr glutamic oxaloacetic transaminase activity in erythrocytes; measurement of either of these may be used to diagnose pyridoxine deficiency. For detn of xanthurenic acid excretion, an oral loading dose of 2 10 g of tryptophan is usually given; urine is collected for 8 hours & then analyzed for xanthurenic acid. Urinary excretion of vitamin B6 or 4 pyridoxic acid can also be analyzed to determine pyridoxine deficiency.

    McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2000.Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2000 (Plus Supplements)., p. 3318

    In the liver pyridoxal is oxidized to 4-pyridoxic acid.

    McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2000.Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2000 (Plus Supplements)., p. 3318

    5.5 Biological Half-Life

    TRITIUM-LABELED PYRIDOXINE HYDROCHLORIDE WAS ADMIN TO RATS. ISOTOPE EXCRETION IN URINE OCCURRED WITH HALF-LIFE OF 40-228 DAYS AFTER THE SECOND DAY OF THE EXPT. THE ELIMINATION RATE OF PYRIDOXINE WAS NOT SIGNIFICANTLY AFFECTED BY PYRIDOXINE HYDROCHLORIDE INTAKE.

    PMID:5947254 JOHANSSON S ET AL; AM J PHYSIOL 210 (5): 1086 (1966)

    Biologic half-life of pyridoxine appears to be 15-20 days.

    McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2000.Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2000 (Plus Supplements)., p. 3319

    5.6 Mechanism of Action

    BRAIN GABA PRODN BEGAN TO RISE 7.5 MIN AFTER IP ADMIN OF 10 MG PYRIDOXINE HYDROCHLORIDE & CONTINUED FOR 40 MIN, THEN DECLINED.

    PMID:1193274 ACKROYD B, SMITH WR D; BIOCHEM SOC TRANS 3 (5): 707 (1975)

    NUTRITIONAL NEED FOR VITAMIN B6 IS BASED ON ITS COENZYME FUNCTION IN AN UNUSUALLY LARGE NUMBER OF METABOLIC REACTIONS. ... REQUIRED IN METABOLISM OF AMINO ACIDS, FATS & CARBOHYDRATES & FOR SYNTHESIS OF PHYSIOLOGIC REGULATORS SUCH AS NOREPINEPHRINE, SEROTONIN & HISTAMINE.

    Furia, T.E. (ed.). CRC Handbook of Food Additives. 2nd ed. Cleveland: The Chemical Rubber Co., 1972., p. 90

    PYRIDOXAL PHOSPHATE IS INVOLVED IN SEVERAL METABOLIC TRANSFORMATIONS OF AMINO ACIDS INCLUDING DECARBOXYLATION, TRANSAMINATION, & RACEMIZATION, AS WELL AS ENZYMATIC STEPS IN METABOLISM OF SULFUR-CONTAINING & HYDROXY AMINO ACIDS. /PYRIDOXINE/

    Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 1539

    PYRIDOXINE ... IS AN ESSENTIAL PART OF THE ENZYME GLYCOGEN PHOSPHORYLASE. /PYRIDOXINE/

    Evaluations of Drug Interactions. 2nd ed. and supplements. Washington, DC: American Pharmaceutical Assn., 1976, 1978., p. 452

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    04-Jan-2021
    10-Dec-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - FOR SOLUTION;INTRAVENOUS - 80MG/VIAL...DOSAGE - FOR SOLUTION;INTRAVENOUS - 80MG/VIAL;0.02MG/VIAL;0.001MG/VIAL;5MG/VIAL;0.01MG/VIAL;0.14MG/VIAL;17MG/VIAL;0.2MG/VIAL;1MG/VIAL;1.4MG/VIAL;EQ 1.2MG BASE/VIAL;0.7MG/VIAL;7MG/VIAL

    USFDA APPLICATION NUMBER - 18920

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    DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/...DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;0.03MG/ML

    USFDA APPLICATION NUMBER - 21163

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    DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/...DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML

    USFDA APPLICATION NUMBER - 21163

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    DOSAGE - INJECTABLE;INTRAVENOUS - 200MG/VIAL;...DOSAGE - INJECTABLE;INTRAVENOUS - 200MG/VIAL;0.06MG/VIAL;0.005MG/VIAL;15MG/VIAL;0.005MG/VIAL;0.6MG/VIAL;40MG/VIAL;6MG/VIAL;3.6MG/VIAL;6MG/VIAL;1MG/VIAL;10MG/VIAL;0.15MG/VIAL

    USFDA APPLICATION NUMBER - 21625

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    DOSAGE - INJECTABLE;INJECTION - 20MG/ML;0.006...DOSAGE - INJECTABLE;INJECTION - 20MG/ML;0.006MG/ML;0.05MCG/ML;1.5MG/ML;0.0005MG/ML;0.06MG/ML;4MG/ML;0.6MG/ML;0.36MG/ML;0.6MG/ML;0.1MG/ML;1MG/ML

    USFDA APPLICATION NUMBER - 8809

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    ABOUT THIS PAGE

    Looking for 58-56-0 / Pyridoxine Hydrochloride API manufacturers, exporters & distributors?

    Pyridoxine Hydrochloride manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Pyridoxine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Pyridoxine Hydrochloride manufacturer or Pyridoxine Hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Pyridoxine Hydrochloride manufacturer or Pyridoxine Hydrochloride supplier.

    PharmaCompass also assists you with knowing the Pyridoxine Hydrochloride API Price utilized in the formulation of products. Pyridoxine Hydrochloride API Price is not always fixed or binding as the Pyridoxine Hydrochloride Price is obtained through a variety of data sources. The Pyridoxine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Pyridoxine Hydrochloride

    Synonyms

    58-56-0, Pyridoxine hcl, Pyridoxol hydrochloride, Vitamin b6, Vitamin b6 hydrochloride, Pyridoxine chloride

    Cas Number

    58-56-0

    Unique Ingredient Identifier (UNII)

    68Y4CF58BV

    About Pyridoxine Hydrochloride

    The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).

    Pyridoxine Hydrochloride Manufacturers

    A Pyridoxine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pyridoxine Hydrochloride, including repackagers and relabelers. The FDA regulates Pyridoxine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pyridoxine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Pyridoxine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Pyridoxine Hydrochloride Suppliers

    A Pyridoxine Hydrochloride supplier is an individual or a company that provides Pyridoxine Hydrochloride active pharmaceutical ingredient (API) or Pyridoxine Hydrochloride finished formulations upon request. The Pyridoxine Hydrochloride suppliers may include Pyridoxine Hydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Pyridoxine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Pyridoxine Hydrochloride USDMF

    A Pyridoxine Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Pyridoxine Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Pyridoxine Hydrochloride DMFs exist exist since differing nations have different regulations, such as Pyridoxine Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Pyridoxine Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Pyridoxine Hydrochloride USDMF includes data on Pyridoxine Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Pyridoxine Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Pyridoxine Hydrochloride suppliers with USDMF on PharmaCompass.

    Pyridoxine Hydrochloride JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Pyridoxine Hydrochloride Drug Master File in Japan (Pyridoxine Hydrochloride JDMF) empowers Pyridoxine Hydrochloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Pyridoxine Hydrochloride JDMF during the approval evaluation for pharmaceutical products. At the time of Pyridoxine Hydrochloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Pyridoxine Hydrochloride suppliers with JDMF on PharmaCompass.

    Pyridoxine Hydrochloride KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Pyridoxine Hydrochloride Drug Master File in Korea (Pyridoxine Hydrochloride KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Pyridoxine Hydrochloride. The MFDS reviews the Pyridoxine Hydrochloride KDMF as part of the drug registration process and uses the information provided in the Pyridoxine Hydrochloride KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Pyridoxine Hydrochloride KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Pyridoxine Hydrochloride API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Pyridoxine Hydrochloride suppliers with KDMF on PharmaCompass.

    Pyridoxine Hydrochloride CEP

    A Pyridoxine Hydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Pyridoxine Hydrochloride Certificate of Suitability (COS). The purpose of a Pyridoxine Hydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Pyridoxine Hydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Pyridoxine Hydrochloride to their clients by showing that a Pyridoxine Hydrochloride CEP has been issued for it. The manufacturer submits a Pyridoxine Hydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Pyridoxine Hydrochloride CEP holder for the record. Additionally, the data presented in the Pyridoxine Hydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Pyridoxine Hydrochloride DMF.

    A Pyridoxine Hydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Pyridoxine Hydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Pyridoxine Hydrochloride suppliers with CEP (COS) on PharmaCompass.

    Pyridoxine Hydrochloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Pyridoxine Hydrochloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Pyridoxine Hydrochloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Pyridoxine Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Pyridoxine Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Pyridoxine Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Pyridoxine Hydrochloride suppliers with NDC on PharmaCompass.

    Pyridoxine Hydrochloride GMP

    Pyridoxine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Pyridoxine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pyridoxine Hydrochloride GMP manufacturer or Pyridoxine Hydrochloride GMP API supplier for your needs.

    Pyridoxine Hydrochloride CoA

    A Pyridoxine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Pyridoxine Hydrochloride's compliance with Pyridoxine Hydrochloride specifications and serves as a tool for batch-level quality control.

    Pyridoxine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Pyridoxine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Pyridoxine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Pyridoxine Hydrochloride EP), Pyridoxine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pyridoxine Hydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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