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Chemistry

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Also known as: Mepyramine maleate, 59-33-6, Histatex, Histan, Anisopyradamine, Histosol
Molecular Formula
C21H27N3O5
Molecular Weight
401.5  g/mol
InChI Key
JXYWFNAQESKDNC-BTJKTKAUSA-N
FDA UNII
R35D29L3ZA

Pyrilamine Maleate
A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
1 2D Structure

Pyrilamine Maleate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(Z)-but-2-enedioic acid;N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine
2.1.2 InChI
InChI=1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
2.1.3 InChI Key
JXYWFNAQESKDNC-BTJKTKAUSA-N
2.1.4 Canonical SMILES
CN(C)CCN(CC1=CC=C(C=C1)OC)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
2.1.5 Isomeric SMILES
CN(C)CCN(CC1=CC=C(C=C1)OC)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O
2.2 Other Identifiers
2.2.1 UNII
R35D29L3ZA
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Anthisan

2. Boots Bite And Sting Relief

3. Kriptin

4. Maleate, Mepyramine

5. Maleate, Pyrilamine

6. Mepyramine

7. Mepyramine Maleate

8. Pyranisamine

9. Pyrilamine

2.3.2 Depositor-Supplied Synonyms

1. Mepyramine Maleate

2. 59-33-6

3. Histatex

4. Histan

5. Anisopyradamine

6. Histosol

7. Minihist

8. Pyrilamine Maleate Salt

9. Diaminide Maleate

10. Paraminyl Maleate

11. Antihist

12. Enrumay

13. Histine

14. Paramal

15. Pymafed

16. Pyraninyl

17. Renstamin

18. Pyramal Maleate

19. Stangen Maleate

20. Anthisan Maleate

21. Statomin Maleate

22. Thylogen Maleate

23. Pyra-maleate

24. Neoantergan Maleate

25. Pyranilamine Maleate

26. Pyranisamine Maleate

27. Neo-antergan Maleate

28. 2786 R.p. Maleate

29. Stamine

30. Neo-antergan

31. Nsc-3604

32. 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)pyridine Maleate (1:1)

33. Mls000069668

34. R35d29l3za

35. 1,2-ethanediamine, N-((4-methoxyphenyl)methyl)-n',n'-dimethyl-n-2-pyridinyl-, (z)-2-butenedioate (1:1)

36. Kriptin Maleate

37. Pyra Maleate

38. Prefrin A

39. Dorantamin Maleate

40. (z)-but-2-enedioic Acid;n'-[(4-methoxyphenyl)methyl]-n,n-dimethyl-n'-pyridin-2-ylethane-1,2-diamine

41. 1,2-ethanediamine,n-[(4-methoxyphenyl)methyl]-n',n'-dimethyl-n-2-pyridinyl-,(2z)-2-butenedioate (1:1)

42. Smr000058495

43. Histavet-p (veterinary)

44. (e)-but-2-enedioic Acid;n'-[(4-methoxyphenyl)methyl]-n,n-dimethyl-n'-pyridin-2-ylethane-1,2-diamine

45. N,n-dimethyl-n'-{[4-(methyloxy)phenyl]methyl}-n'-pyridin-2-ylethane-1,2-diamine (2z)-but-2-enedioate

46. Mepyramine Hydrogen Maleinate

47. Pyma

48. Histavet-p

49. Mepiramine Maleate

50. N1-(4-methoxybenzyl)-n2,n2-dimethyl-n1-(pyridin-2-yl)ethane-1,2-diamine Maleate

51. Component Of Pyrdex

52. Pymafed (tn)

53. Ccris 1330

54. Cas-59-33-6

55. Sr-01000000225

56. Nsc 3604

57. Einecs 200-422-7

58. Mfcd00069333

59. Pyrilamine Maleate (usp)

60. Component Of Endotussin-nn

61. Unii-r35d29l3za

62. N-dimethylaminoethyl-n-p-methoxy-alpha-aminopyridine Maleate

63. Pyrilamine Maleate [usan:usp]

64. N,n-dimethyl-n'-(4-methoxybenzyl)-n'-(2-pyridyl)ethylenediamine Maleate

65. N-p-methoxybenzyl-n',n'-dimethyl-n-alpha-pyridylethylenediamine Maleate

66. Prestwick_634

67. Opera_id_1702

68. 2-[[2-(dimethylamino)ethyl](p-methoxybenzyl)amino]pyridine Bimaleate

69. Dsstox_cid_1216

70. P 5514

71. Pyridine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-, Maleate (1:1)

72. Dsstox_rid_76015

73. Dsstox_gsid_21216

74. Schembl27430

75. 1,2-ethanediamine, N-((4-methoxyphenyl)methyl)-n',n'-dimethyl-n-2-pyridinyl-, (2z)-2-butenedioate (1:1)

76. Mls001148634

77. Pyrilamine Maleate; Mepyramine

78. Spectrum1500519

79. Pyrilamine Maleate [mi]

80. Chembl1201006

81. Dtxsid4021216

82. Hms500i17

83. Nsc3604

84. Hms1568j20

85. Hms1920n10

86. Hms2092e11

87. Hms2095j20

88. Hms2234i23

89. Hms2234i24

90. Hms3262b22

91. Hms3411m20

92. Hms3675m20

93. Hms3712j20

94. Pharmakon1600-01500519

95. Pyrilamine Maleate [vandf]

96. Mepyramine Maleate [mart.]

97. Hy-b1281

98. Mepyramine Maleate [who-dd]

99. Pyrilamine Maleate [usp-rs]

100. Tox21_200514

101. Tox21_500890

102. 2-[[2-(dimethylamino)ethyl](p-methoxybenzyl)amino]pyridine Maleate

103. Ccg-39244

104. N-(dimethylamino)ethyl-n-(p-methoxy)-.alpha.-aminopyridine Maleate

105. Nsc757305

106. S4382

107. Akos015950805

108. N-(p-methoxybenzyl)-n',n'-dimethyl-n-.alpha.-pyridylethylenediamine Maleate

109. Lp00890

110. Nsc-757305

111. Pyrilamine Maleate [green Book]

112. Pyrilamine Maleate [orange Book]

113. Mepyramine Maleate [ep Monograph]

114. Ncgc00094209-01

115. Ncgc00094209-02

116. Ncgc00094209-03

117. Ncgc00094209-04

118. Ncgc00094209-05

119. Ncgc00258068-01

120. Ncgc00261575-01

121. 1,2-ethanediamine, N1-((4-methoxyphenyl)methyl)-n2,n2-dimethyl-n1-2-pyridinyl-, (2z)-2-butenedioate (1:1)

122. Pyrilamine Maleate [usp Monograph]

123. Smr000653462

124. B6396

125. Cs-0013057

126. Eu-0100890

127. P2369

128. Prefrin-a Component Pyrilamine Maleate

129. D05660

130. Pyrilamine Maleate Component Of Prefrin-a

131. Wln: T6nj Bn1r Do1&2n1&1 &ov1u1vo

132. Sr-01000000225-2

133. Sr-01000000225-4

134. Sr-01000000225-5

135. Sr-01000000225-8

136. Q27287732

137. N-(p-methoxybenzyl)-n,2-ethanediamine, Maleic Acid Salt

138. 2-[(2-dimethylaminoethyl)(p-methoxybenzyl)amino]pyridine Maleate

139. Mepyramine Maleate, European Pharmacopoeia (ep) Reference Standard

140. 2-[[2-(dimethylamino)ethyl]( P-methoxybenzyl)amino]pyridine Maleate (1:1)

141. Pyrilamine Maleate, United States Pharmacopeia (usp) Reference Standard

142. 1, N-[(4-methoxyphenyl)methyl]-n',n'-dimethyl-n-2-pyridinyl-, (z)-2-butenedioate (1:1)

143. N-(4-methoxyphenyl)methyl-n',n'-dimethyl-n-(2-pyridinyl)-1,2-ethanediamine Maleate

144. N1-(4-methoxybenzyl)-n2,n2-dimethyl-n1-(pyridin-2-yl)ethane-1,2-diaminemaleate

145. Pyrilamine Maleate, Pharmaceutical Secondary Standard; Certified Reference Material

146. N-(4-methoxybenzyl)-n',n'-dimethyl-n-pyridin-2-ylethane-1,2-diamine (2z)-but-2-enedioate

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 401.5 g/mol
Molecular Formula C21H27N3O5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Exact Mass401.19507097 g/mol
Monoisotopic Mass401.19507097 g/mol
Topological Polar Surface Area103 Ų
Heavy Atom Count29
Formal Charge0
Complexity396
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)


Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)


Sleep Aids, Pharmaceutical

Drugs used to induce SLEEP, prevent SLEEPLESSNESS, or treat SLEEP INITIATION AND MAINTENANCE DISORDERS. (See all compounds classified as Sleep Aids, Pharmaceutical.)


API Reference Price

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ROAD,, INDORE, M.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730140200,"product":"ACTIVE PHARMACEUTICAL INGREDIENT -PYRILAMINE MALEATE USP","address":"207\/208,UDYOG BHAVAN,SONAWALA ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"SUPRIYA LIFESCIENCE","supplierCountry":"INDIA","foreign_port":"NEW YORK","customer":"CONSIGNEE","customerCountry":"UNITED STATES","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"80.3","totalValueFC":"73273.5","currency":"USD","unitRateINR":6156.9156299999995,"date":"29-Oct-2024","totalValueINR":"6156915.63","totalValueInUsd":"73273.5","indian_port":"Bombay Air","hs_no":"29333929","bill_no":"5225407","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"207\/208,UDYOG BHAVAN,SONAWALA ROAD,, MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730745000,"product":"ACTIVE PHARMACEUTICAL INGREDIENT -PYRILAMINE MALEATE USP","address":"207\/208,UDYOG BHAVAN,SONAWALA ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"SUPRIYA LIFESCIENCE","supplierCountry":"INDIA","foreign_port":"BARCELONA","customer":"CONSIGNEE","customerCountry":"SPAIN","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"70.3","totalValueFC":"1566.9","currency":"USD","unitRateINR":5289.1700000000001,"date":"05-Nov-2024","totalValueINR":"132229.25","totalValueInUsd":"1566.9","indian_port":"Bombay Air","hs_no":"29333929","bill_no":"5362471","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"207\/208,UDYOG BHAVAN,SONAWALA ROAD,, MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735497000,"product":"ACTIVE PHARMACEUTICAL INGREDIENT -PYRILAMINE MALEATE USP","address":"207\/208,UDYOG BHAVAN,SONAWALA ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"SUPRIYA LIFESCIENCE","supplierCountry":"INDIA","foreign_port":"TORONTO","customer":"CONSIGNEE","customerCountry":"CANADA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"116.3","totalValueFC":"230.6","currency":"USD","unitRateINR":9795.2399999999998,"date":"30-Dec-2024","totalValueINR":"19590.48","totalValueInUsd":"230.6","indian_port":"Bombay Air","hs_no":"29333929","bill_no":"6890480","productDescription":"API","marketType":"REGULATED MARKET","country":"CANADA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"207\/208,UDYOG BHAVAN,SONAWALA ROAD,, MUMBAI ,MAHARASHTRA","customerAddress":""}]
08-Jan-2021
30-Dec-2024
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ABOUT THIS PAGE

Pyrilamine Maleate Manufacturers

A Pyrilamine Maleate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pyrilamine Maleate, including repackagers and relabelers. The FDA regulates Pyrilamine Maleate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pyrilamine Maleate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Pyrilamine Maleate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Pyrilamine Maleate Suppliers

A Pyrilamine Maleate supplier is an individual or a company that provides Pyrilamine Maleate active pharmaceutical ingredient (API) or Pyrilamine Maleate finished formulations upon request. The Pyrilamine Maleate suppliers may include Pyrilamine Maleate API manufacturers, exporters, distributors and traders.

click here to find a list of Pyrilamine Maleate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Pyrilamine Maleate USDMF

A Pyrilamine Maleate DMF (Drug Master File) is a document detailing the whole manufacturing process of Pyrilamine Maleate active pharmaceutical ingredient (API) in detail. Different forms of Pyrilamine Maleate DMFs exist exist since differing nations have different regulations, such as Pyrilamine Maleate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Pyrilamine Maleate DMF submitted to regulatory agencies in the US is known as a USDMF. Pyrilamine Maleate USDMF includes data on Pyrilamine Maleate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Pyrilamine Maleate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Pyrilamine Maleate suppliers with USDMF on PharmaCompass.

Pyrilamine Maleate CEP

A Pyrilamine Maleate CEP of the European Pharmacopoeia monograph is often referred to as a Pyrilamine Maleate Certificate of Suitability (COS). The purpose of a Pyrilamine Maleate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Pyrilamine Maleate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Pyrilamine Maleate to their clients by showing that a Pyrilamine Maleate CEP has been issued for it. The manufacturer submits a Pyrilamine Maleate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Pyrilamine Maleate CEP holder for the record. Additionally, the data presented in the Pyrilamine Maleate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Pyrilamine Maleate DMF.

A Pyrilamine Maleate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Pyrilamine Maleate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Pyrilamine Maleate suppliers with CEP (COS) on PharmaCompass.

Pyrilamine Maleate WC

A Pyrilamine Maleate written confirmation (Pyrilamine Maleate WC) is an official document issued by a regulatory agency to a Pyrilamine Maleate manufacturer, verifying that the manufacturing facility of a Pyrilamine Maleate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Pyrilamine Maleate APIs or Pyrilamine Maleate finished pharmaceutical products to another nation, regulatory agencies frequently require a Pyrilamine Maleate WC (written confirmation) as part of the regulatory process.

click here to find a list of Pyrilamine Maleate suppliers with Written Confirmation (WC) on PharmaCompass.

Pyrilamine Maleate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Pyrilamine Maleate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Pyrilamine Maleate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Pyrilamine Maleate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Pyrilamine Maleate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Pyrilamine Maleate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Pyrilamine Maleate suppliers with NDC on PharmaCompass.

Pyrilamine Maleate GMP

Pyrilamine Maleate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Pyrilamine Maleate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pyrilamine Maleate GMP manufacturer or Pyrilamine Maleate GMP API supplier for your needs.

Pyrilamine Maleate CoA

A Pyrilamine Maleate CoA (Certificate of Analysis) is a formal document that attests to Pyrilamine Maleate's compliance with Pyrilamine Maleate specifications and serves as a tool for batch-level quality control.

Pyrilamine Maleate CoA mostly includes findings from lab analyses of a specific batch. For each Pyrilamine Maleate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Pyrilamine Maleate may be tested according to a variety of international standards, such as European Pharmacopoeia (Pyrilamine Maleate EP), Pyrilamine Maleate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pyrilamine Maleate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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