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    Chemistry

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    Also known as:
    Molecular Formula
    C29H44ClN5O18P4
    Molecular Weight
    910.0  g/mol
    InChI Key
    JDVZOLDKAQEQDD-UHFFFAOYSA-N
    Pyronaridine Tetraphosphate
    1 2D Structure

    Pyronaridine Tetraphosphate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one;phosphoric acid
    2.1.2 InChI
    InChI=1S/C29H32ClN5O2.4H3O4P/c1-37-26-9-8-24-28(33-26)27(23-7-6-21(30)16-25(23)32-24)31-22-14-19(17-34-10-2-3-11-34)29(36)20(15-22)18-35-12-4-5-13-35;4*1-5(2,3)4/h6-9,14-16,32-33H,2-5,10-13,17-18H2,1H3;4*(H3,1,2,3,4)
    2.1.3 InChI Key
    JDVZOLDKAQEQDD-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    COC1=CC=C2C(=C(C3=C(N2)C=C(C=C3)Cl)N=C4C=C(C(=O)C(=C4)CN5CCCC5)CN6CCCC6)N1.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O
    2.1.5 Isomeric SMILES
    COC1=CC=C2C(=C(C3=C(N2)C=C(C=C3)Cl)N=C4C=C(C(=O)C(=C4)CN5CCCC5)CN6CCCC6)N1.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O
    2.2 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 910.0 g/mol
    Molecular Formula C29H44ClN5O18P4
    Hydrogen Bond Donor Count14
    Hydrogen Bond Acceptor Count23
    Rotatable Bond Count6
    Exact Mass909.1320353 g/mol
    Monoisotopic Mass909.1320353 g/mol
    Topological Polar Surface Area380 A^2
    Heavy Atom Count57
    Formal Charge0
    Complexity1130
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count5

    API SUPPLIERS

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    01

    Mangalam Drugs & Organics Ltd

    India

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    Medlab Asia & Asia Health
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    Mangalam Drugs & Organics Ltd

    India

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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    Medlab Asia & Asia Health
    Not Confirmed
    USDMF CEP/COS JDMF EU-WCInactive-api
    ✖

    Date of Issue : 2020-06-11

    Valid Till : 2023-06-10

    Written Confirmation Number : WC-0473

    Address of the Firm :

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    Sibbiotech

    Russia

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    API Reference Price

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    [{"dataSource":"API Export","activeIngredients":"PYRONARIDINE TETRAPHOSPHATE","year":"2021","qtr":"Q1","strtotime":1615401000,"product":"BULK DRUG: PYRONARIDINE TETRAPHOSPHATE","address":"292 PRINCESS STREET2ND FLOOR","city":"MUMBAI ,MAHARASHTRA","supplier":"MANGALAM DRUGS & ORGANICS LTD","supplierCountry":"INDIA","foreign_port":"KARACHI -","customer":"OF","customerCountry":"PAKISTAN","quantity":"1.30","actualQuantity":"1.3","unit":"KGS","unitRateFc":"1357.7","totalValueFC":"1746.8","currency":"USD","unitRateINR":97822.715384615381,"date":"11-Mar-2021","totalValueINR":"127169.53","totalValueInUsd":"1746.8","indian_port":"BOMBAY AIR","hs_no":"29333911","bill_no":"9277414","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"292 PRINCESS STREET2ND FLOOR, MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1677868200,"product":"BULK DRUG : PYRONARIDINE TETRAPHOSPHATE","address":"3RD FLOOR, RUPAM BUILDING, 239,P. D. MELLO ROAD, NEAR G.P.O.","city":"MUMBAI,MAHARASHTRA","supplier":"MANGALAM DRUGS & ORGANICS LTD","supplierCountry":"INDIA","foreign_port":"SHANGHAI","customer":"TO THE ORDER OF","customerCountry":"CHINA","quantity":"7.00","actualQuantity":"7","unit":"KGS","unitRateFc":"1000","totalValueFC":"6759.8","currency":"USD","unitRateINR":79428.571428571435,"date":"04-Mar-2023","totalValueINR":"556000","totalValueInUsd":"6759.8","indian_port":"BOMBAY AIR","hs_no":"29333911","bill_no":"8247925","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"3RD FLOOR, RUPAM BUILDING, 239,P. D. MELLO ROAD, NEAR G.P.O., MUMBAI,MAHARASHTRA","customerAddress":""}]
    11-Mar-2021
    04-Mar-2023
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    Average Price (USD/KGS)

    Number of Transactions

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    Mangalam Drugs & Organics Awarded US$ 274,800 Grant by MMV

    Details:

    The grant will support research and development efforts aimed at improving the technology and efficiency of pyronaridine production for pyronaridine-artesunate combination therapy, Pyramax.


    Lead Product(s): Pyronaridine Tetraphosphate,Artesunate

    Therapeutic Area: Infections and Infectious Diseases Brand Name: Pyramax

    Study Phase: ApprovedProduct Type: Small molecule

    Sponsor: Medicines for Malaria Venture

    Deal Size: $0.2 million Upfront Cash: Undisclosed

    Deal Type: Funding August 27, 2024

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    Lead Product(s) : Pyronaridine Tetraphosphate,Artesunate

    Therapeutic Area : Infections and Infectious Diseases

    Highest Development Status : Approved

    Partner/Sponsor/Collaborator : Medicines for Malaria Venture

    Deal Size : $0.2 million

    Deal Type : Funding

    DEALS_DEV arrow-down

    Mangalam Drugs & Organics Awarded US$ 274,800 Grant by MMV

    Details : The grant will support research and development efforts aimed at improving the technology and efficiency of pyronaridine production for pyronaridine-artesunate combination therapy, Pyramax.

    Brand Name : Pyramax

    Molecule Type : Small molecule

    Upfront Cash : Undisclosed

    August 27, 2024

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