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Chemistry

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Also known as: 1269662-73-8, Shr-1258, Cjn36eqm0h, Shr1258, 1269662-73-8 (free base), (r,e)-n-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide
Molecular Formula
C32H31ClN6O3
Molecular Weight
583.1  g/mol
InChI Key
SADXACCFNXBCFY-IYNHSRRRSA-N
FDA UNII
CJN36EQM0H

Pyrotinib
Pyrotinib is an orally bioavailable, dual kinase inhibitor of the epidermal growth factor receptor (EGFR or HER-1) and the human epidermal growth factor receptor 2 (ErbB2 or HER-2), with potential antineoplastic activity. Upon oral administration, pyrotinib binds to and inhibits both EGFR and HER2, which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumor cells. EGFR and HER2 are receptor tyrosine kinases that are upregulated in various tumor cell types and play major roles in tumor cell proliferation and tumor vascularization.
1 2D Structure

Pyrotinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide
2.1.2 InChI
InChI=1S/C32H31ClN6O3/c1-3-41-30-17-27-25(16-28(30)38-31(40)12-10-24-8-6-14-39(24)2)32(21(18-34)19-36-27)37-22-9-11-29(26(33)15-22)42-20-23-7-4-5-13-35-23/h4-5,7,9-13,15-17,19,24H,3,6,8,14,20H2,1-2H3,(H,36,37)(H,38,40)/b12-10+/t24-/m1/s1
2.1.3 InChI Key
SADXACCFNXBCFY-IYNHSRRRSA-N
2.1.4 Canonical SMILES
CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CC5CCCN5C
2.1.5 Isomeric SMILES
CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)/C=C/[C@H]5CCCN5C
2.2 Other Identifiers
2.2.1 UNII
CJN36EQM0H
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 1269662-73-8

2. Shr-1258

3. Cjn36eqm0h

4. Shr1258

5. 1269662-73-8 (free Base)

6. (r,e)-n-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide

7. 2-propenamide, N-(4-((3-chloro-4-(2-pyridinylmethoxy)phenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-3-((2r)-1-methyl-2-pyrrolidinyl)-, (2e)-

8. Pyrotinib Racemate

9. (e)-n-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-3-[(2r)-1-methylpyrrolidin-2-yl]prop-2-enamide

10. Unii-cjn36eqm0h

11. Airuini

12. 1246089-97-3

13. Pyrotinib(shr-1258)

14. Pyrotinib [who-dd]

15. Gtpl9662

16. Schembl9948753

17. Chembl3647420

18. Bdbm139991

19. Bcp29458

20. Wzb08997

21. S8852

22. Cs-7940

23. Db14993

24. Compound 12 [pmid: 28115222]

25. Hy-104065

26. 4679b

27. A17068

28. Us8901140, 5

29. Shr-1258; Shr1258; Shr 1258

30. Q27275495

31. (e)-n-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]-3-[(2r)-1-methylpyrrolidin-2-yl]prop-2-enamide

2.4 Create Date
2011-04-25
3 Chemical and Physical Properties
Molecular Weight 583.1 g/mol
Molecular Formula C32H31ClN6O3
XLogP35.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count10
Exact Mass582.2146166 g/mol
Monoisotopic Mass582.2146166 g/mol
Topological Polar Surface Area112 Ų
Heavy Atom Count42
Formal Charge0
Complexity960
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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