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Chemistry

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Also known as: 9004-70-0, Piroxilina, Pyroxyline, Pyroxylinum, Pyroxylin, Gun cotton
Molecular Formula
C18H21N11O38
Molecular Weight
999.4  g/mol
InChI Key
FJWGYAHXMCUOOM-QHOUIDNNSA-N

Pyroxylin
A nitrocellulose solution in ether and alcohol. Collodion has a wide range of uses in industry including applications in the manufacture of photographic film, in fibers, in lacquers, and in engraving and lithography. In medicine it is used as a drug solvent and a wound sealant.
1 2D Structure

Pyroxylin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(2S,3R,4S,5R,6R)-2-[(2R,3R,4S,5R,6S)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2R,3R,4S,5R,6S)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate
2.1.2 InChI
InChI=1S/C18H21N11O38/c30-19(31)52-1-4-7(58-17-14(65-27(46)47)12(63-25(42)43)9(60-22(36)37)6(56-17)3-54-21(34)35)10(61-23(38)39)13(64-26(44)45)16(55-4)59-8-5(2-53-20(32)33)57-18(67-29(50)51)15(66-28(48)49)11(8)62-24(40)41/h4-18H,1-3H2/t4-,5-,6-,7-,8-,9-,10+,11+,12+,13-,14-,15-,16+,17+,18+/m1/s1
2.1.3 InChI Key
FJWGYAHXMCUOOM-QHOUIDNNSA-N
2.1.4 Canonical SMILES
C(C1C(C(C(C(O1)OC2C(OC(C(C2O[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-])CO[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-])OC3C(C(C(C(O3)CO[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-]
2.1.5 Isomeric SMILES
C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-])CO[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-])O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Celloidin

2. Cellulose Nitrate

3. Collodion

4. Collodion Cotton

5. Cotton, Collodion

6. Nitrate, Cellulose

7. Pyroxylin

2.2.2 Depositor-Supplied Synonyms

1. 9004-70-0

2. Piroxilina

3. Pyroxyline

4. Pyroxylinum

5. Pyroxylin

6. Gun Cotton

7. Cellulose Nitrate

8. Cellulose Tetranitrate

9. Chebi:53325

10. [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] Nitrate

2.3 Create Date
2009-11-19
3 Chemical and Physical Properties
Molecular Weight 999.4 g/mol
Molecular Formula C18H21N11O38
XLogP33.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count38
Rotatable Bond Count18
Exact Mass999.0048952 g/mol
Monoisotopic Mass999.0048952 g/mol
Topological Polar Surface Area652 Ų
Heavy Atom Count67
Formal Charge0
Complexity1820
Isotope Atom Count0
Defined Atom Stereocenter Count15
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

In medicine it is used as a drug solvent and a wound sealant.

National Library of Medicine's Medical Subject Headings online file (MeSH, 2010)


CHIEFLY TO SEAL SMALL WOUNDS OR FOR PREPN OF MEDICATED COLLODIONS. ... /FLEXIBLE COLLODION/ APPLIED EXTERNALLY TO CUTS & SMALL BURNS AS PROTECTIVE. ITS APPLICATION IS ACCOMPANIED BY CONSIDERABLE PAIN, BUT IT IS EFFECTIVE AS ANTISEPTIC & FOR EXCLUDING AIR FROM OPEN WOUNDS.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 717


MEDICATION (VET): SKIN PROTECTANT

O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 417


VEHICLE FOR PROLONGED-CONTACT APPLICATION OF MEDICINALS

American Hospital Formulary Service. Volumes I and II. Washington, DC: American Society of Hospital Pharmacists, to 1984., p. 84:24


Corn removers.

Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New York, NY 2007., p. 321


4.2 Drug Warning

A case of an unusual caustic ingestion involving Compound W, an over the counter wart remover is presented. Chemical burns of the tongue, pharynx and larynx developed. The active ingredient in this preparation: salicylic acid in a flexible collodion vehicle produces caustic injury through a keratolytic action, which may be enhanced by the presence of collodion.

PMID:3778605 Sacchetti A, Ramoska E; Am J Emerg Med 4 (6): 554-5 (1986)


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Explosive Agents

Substances that are energetically unstable and can produce a sudden expansion of the material, called an explosion, which is accompanied by heat, pressure and noise. Other things which have been described as explosive that are not included here are explosive action of laser heating, human performance, sudden epidemiological outbreaks, or fast cell growth. (See all compounds classified as Explosive Agents.)


Tissue Adhesives

Substances used to cause adherence of tissue to tissue or tissue to non-tissue surfaces, as for prostheses. (See all compounds classified as Tissue Adhesives.)


Market Place

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ABOUT THIS PAGE

Pyroxylin Manufacturers

A Pyroxylin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Pyroxylin, including repackagers and relabelers. The FDA regulates Pyroxylin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Pyroxylin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Pyroxylin Suppliers

A Pyroxylin supplier is an individual or a company that provides Pyroxylin active pharmaceutical ingredient (API) or Pyroxylin finished formulations upon request. The Pyroxylin suppliers may include Pyroxylin API manufacturers, exporters, distributors and traders.

Pyroxylin GMP

Pyroxylin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Pyroxylin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Pyroxylin GMP manufacturer or Pyroxylin GMP API supplier for your needs.

Pyroxylin CoA

A Pyroxylin CoA (Certificate of Analysis) is a formal document that attests to Pyroxylin's compliance with Pyroxylin specifications and serves as a tool for batch-level quality control.

Pyroxylin CoA mostly includes findings from lab analyses of a specific batch. For each Pyroxylin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Pyroxylin may be tested according to a variety of international standards, such as European Pharmacopoeia (Pyroxylin EP), Pyroxylin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Pyroxylin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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