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Quad Tablet

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FINISHED DOSAGE FORMULATIONS

2 FDF Dossiers, 2 Europe

2 FDF Dossiers
2 Europe

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 2 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
2 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 2 Finished Drug Prices, 2 Annual Reports

globalSalesInformation
1 US Medicaid Prescriptions
2 Finished Drug Prices
2 Annual Reports

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

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API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

667,652,645

Annual Reports (USD Million)

2,036

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Cobicistat & elvitegravir & emtricitabine & tenofovir disoproxil fumarate, Cobicistat + elvitegravir + emtricitabine + tenofovir disoproxil fumarate, Cobicistat and elvitegravir and emtricitabine and tenofovir disoproxil fumarate, Quad, Quad pill, Quad tablet

Molecular Formula

C₉₄H₁₂₀ClF₂N₁₆O₂₇PS₃

Molecular Weight

2106.7 g/mol

InChI Key

FMCLRHTZMTUYMI-JFQFMQNHSA-N

A pharmaceutical preparation of the ANTI-HIV AGENTS elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate that is used in the treatment of HIV INFECTIONS.

1 2D Structure

Quad Tablet

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one;[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate;(E)-but-2-enedioic acid;6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxoquinoline-3-carboxylic acid;1,3-thiazol-5-ylmethyl N-[(2R,5R)-5-[[(2S)-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-4-morpholin-4-ylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate

2.1.2 InChI

InChI=1S/C40H53N7O5S2.C23H23ClFNO5.C19H30N5O10P.C8H10FN3O3S.C4H4O4/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35;1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25;1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5;5-3(6)1-2-4(7)8/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49);4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30);7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1,5-6,13H,2-3H2,(H2,10,11,14);1-2H,(H,5,6)(H,7,8)/b;;;;2-1+/t32-,33-,36+;19-;14-;5-,6+;/m1110./s1

2.1.3 InChI Key

FMCLRHTZMTUYMI-JFQFMQNHSA-N

2.1.4 Canonical SMILES

CC(C)C1=NC(=CS1)CN(C)C(=O)NC(CCN2CCOCC2)C(=O)NC(CCC(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5.CC(C)C(CO)N1C=C(C(=O)C2=C1C=C(C(=C2)CC3=C(C(=CC=C3)Cl)F)OC)C(=O)O.CC(C)OC(=O)OCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OCOC(=O)OC(C)C.C1C(OC(S1)CO)N2C=C(C(=NC2=O)N)F.C(=CC(=O)O)C(=O)O

2.1.5 Isomeric SMILES

C[C@H](CN1C=NC2=C(N=CN=C21)N)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C.CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5.CC(C)[C@@H](CO)N1C=C(C(=O)C2=C1C=C(C(=C2)CC3=C(C(=CC=C3)Cl)F)OC)C(=O)O.C1[C@H](O[C@H](S1)CO)N2C=C(C(=NC2=O)N)F.C(=C/C(=O)O)\C(=O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Elvitegravir Cobicistat Emtricitabine Tenofovir Disoproxil Fumarate Drug Combination

2. Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate

3. Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate Drug Combination

4. Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination

5. Elvitegravir-cobicistat-emtricitabine-tenofovir Disoproxil Fumarate Drug Combination

6. Genvoya

7. Pill, Quad

8. Quad Pill

2.2.2 Depositor-Supplied Synonyms

1. Cobicistat & Elvitegravir & Emtricitabine & Tenofovir Disoproxil Fumarate

2. Cobicistat + Elvitegravir + Emtricitabine + Tenofovir Disoproxil Fumarate

3. Cobicistat And Elvitegravir And Emtricitabine And Tenofovir Disoproxil Fumarate

4. Quad

5. Quad Pill

6. Quad Tablet

7. Evg-cobi-ftc-tdf

8. Cobicistat, Elvitegravir, Emtricitabine, Tenofovir

9. Cobicistat / Elvitegravir / Emtricitabine / Tenofovir Disoproxil

10. Elvitegravir-cobicistat-emtricitabine-tenofovir Disoproxil Fumarate

11. Cobicistat / Elvitegravir / Emtricitabine / Tenofovir Disoproxil Fumarate

12. Cobicistat Mixture With Elvitegravir And Emtricitabine And Tenofovir Disoproxil

13. Cobicistat Mixture With Elvitegravir, Emtricitabine And Tenofovir Disoproxil Fumarate

14. Elvitegravir Mixture With Cobicistat And Emtricitabine And Tenofovir Disoproxil Fumarate

15. Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination

16. 1430117-57-9

2.3 Create Date

2009-10-19

3 Chemical and Physical Properties

Molecular Formula	C₉₄H₁₂₀ClF₂N₁₆O₂₇PS₃
Molecular Weight	2106.7 g/mol
Hydrogen Bond Donor Count	10
Hydrogen Bond Acceptor Count	40
Rotatable Bond Count	48
Exact Mass	2105.7098720 g/mol
Monoisotopic Mass	2104.7065172 g/mol
Topological Polar Surface Area	655 Å²
Heavy Atom Count	144
Formal Charge	0
Complexity	3010
Isotope Atom Count	0
Defined Atom Stereocenter Count	7
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	5

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Stribild
PubMed Health	Elvitegravir/Cobicistat/Emtricitabine/Tenofovir (By mouth)
Drug Classes	Anti-Infective Agent, Antiviral, Reverse Transcriptase Inhibitor Combination
Drug Label	STRIBILD is a fixed-dose combination tablet containing elvitegravir, cobicistat, emtricitabine, and tenofovir DF for oral administration.Elvitegravir is an HIV-1 integrase strand transfer inhibitor.Cobicistat is a mechanism-based inhibitor of cytochr...
Active Ingredient	elvitegravir; Cobicistat; tenofovir disoproxil fumarate; emtricitabine
Dosage Form	Tablet
Route	Oral
Strength	200mg; 150mg; 300mg
Market Status	Prescription
Company	Gilead Sciences

2 of 2
Drug Name	Stribild
PubMed Health	Elvitegravir/Cobicistat/Emtricitabine/Tenofovir (By mouth)
Drug Classes	Anti-Infective Agent, Antiviral, Reverse Transcriptase Inhibitor Combination
Drug Label	STRIBILD is a fixed-dose combination tablet containing elvitegravir, cobicistat, emtricitabine, and tenofovir DF for oral administration.Elvitegravir is an HIV-1 integrase strand transfer inhibitor.Cobicistat is a mechanism-based inhibitor of cytochr...
Active Ingredient	elvitegravir; Cobicistat; tenofovir disoproxil fumarate; emtricitabine
Dosage Form	Tablet
Route	Oral
Strength	200mg; 150mg; 300mg
Market Status	Prescription
Company	Gilead Sciences

4.2 Drug Indication

Treatment of human immunodeficiency virus 1 (HIV 1) infection in adults aged 18 years and over who are antiretroviral treatment-nave or are infected with HIV 1 without known mutations associated with resistance to any of the three antiretroviral agents in Stribild.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-HIV Agents

Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS. (See all compounds classified as Anti-HIV Agents.)

5.2 ATC Code

J05AR09

FDF Dossiers