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Chemistry

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Also known as: Cobicistat & elvitegravir & emtricitabine & tenofovir disoproxil fumarate, Cobicistat + elvitegravir + emtricitabine + tenofovir disoproxil fumarate, Cobicistat and elvitegravir and emtricitabine and tenofovir disoproxil fumarate, Quad, Quad pill, Quad tablet
Molecular Formula
C94H120ClF2N16O27PS3
Molecular Weight
2106.7  g/mol
InChI Key
FMCLRHTZMTUYMI-JFQFMQNHSA-N

Quad Tablet
A pharmaceutical preparation of the ANTI-HIV AGENTS elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate that is used in the treatment of HIV INFECTIONS.
1 2D Structure

Quad Tablet

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one;[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate;(E)-but-2-enedioic acid;6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxoquinoline-3-carboxylic acid;1,3-thiazol-5-ylmethyl N-[(2R,5R)-5-[[(2S)-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-4-morpholin-4-ylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
2.1.2 InChI
InChI=1S/C40H53N7O5S2.C23H23ClFNO5.C19H30N5O10P.C8H10FN3O3S.C4H4O4/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35;1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25;1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5;5-3(6)1-2-4(7)8/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49);4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30);7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1,5-6,13H,2-3H2,(H2,10,11,14);1-2H,(H,5,6)(H,7,8)/b;;;;2-1+/t32-,33-,36+;19-;14-;5-,6+;/m1110./s1
2.1.3 InChI Key
FMCLRHTZMTUYMI-JFQFMQNHSA-N
2.1.4 Canonical SMILES
CC(C)C1=NC(=CS1)CN(C)C(=O)NC(CCN2CCOCC2)C(=O)NC(CCC(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5.CC(C)C(CO)N1C=C(C(=O)C2=C1C=C(C(=C2)CC3=C(C(=CC=C3)Cl)F)OC)C(=O)O.CC(C)OC(=O)OCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OCOC(=O)OC(C)C.C1C(OC(S1)CO)N2C=C(C(=NC2=O)N)F.C(=CC(=O)O)C(=O)O
2.1.5 Isomeric SMILES
C[C@H](CN1C=NC2=C(N=CN=C21)N)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C.CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5.CC(C)[C@@H](CO)N1C=C(C(=O)C2=C1C=C(C(=C2)CC3=C(C(=CC=C3)Cl)F)OC)C(=O)O.C1[C@H](O[C@H](S1)CO)N2C=C(C(=NC2=O)N)F.C(=C/C(=O)O)\C(=O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Elvitegravir Cobicistat Emtricitabine Tenofovir Disoproxil Fumarate Drug Combination

2. Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate

3. Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate Drug Combination

4. Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination

5. Elvitegravir-cobicistat-emtricitabine-tenofovir Disoproxil Fumarate Drug Combination

6. Genvoya

7. Pill, Quad

8. Quad Pill

2.2.2 Depositor-Supplied Synonyms

1. Cobicistat & Elvitegravir & Emtricitabine & Tenofovir Disoproxil Fumarate

2. Cobicistat + Elvitegravir + Emtricitabine + Tenofovir Disoproxil Fumarate

3. Cobicistat And Elvitegravir And Emtricitabine And Tenofovir Disoproxil Fumarate

4. Quad

5. Quad Pill

6. Quad Tablet

7. Evg-cobi-ftc-tdf

8. Cobicistat, Elvitegravir, Emtricitabine, Tenofovir

9. Cobicistat / Elvitegravir / Emtricitabine / Tenofovir Disoproxil

10. Elvitegravir-cobicistat-emtricitabine-tenofovir Disoproxil Fumarate

11. Cobicistat / Elvitegravir / Emtricitabine / Tenofovir Disoproxil Fumarate

12. Cobicistat Mixture With Elvitegravir And Emtricitabine And Tenofovir Disoproxil

13. Cobicistat Mixture With Elvitegravir, Emtricitabine And Tenofovir Disoproxil Fumarate

14. Elvitegravir Mixture With Cobicistat And Emtricitabine And Tenofovir Disoproxil Fumarate

15. Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination

16. 1430117-57-9

2.3 Create Date
2009-10-19
3 Chemical and Physical Properties
Molecular Weight 2106.7 g/mol
Molecular Formula C94H120ClF2N16O27PS3
Hydrogen Bond Donor Count10
Hydrogen Bond Acceptor Count40
Rotatable Bond Count48
Exact Mass2105.7098720 g/mol
Monoisotopic Mass2104.7065172 g/mol
Topological Polar Surface Area655 Ų
Heavy Atom Count144
Formal Charge0
Complexity3010
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count5
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameStribild
PubMed HealthElvitegravir/Cobicistat/Emtricitabine/Tenofovir (By mouth)
Drug ClassesAnti-Infective Agent, Antiviral, Reverse Transcriptase Inhibitor Combination
Drug LabelSTRIBILD is a fixed-dose combination tablet containing elvitegravir, cobicistat, emtricitabine, and tenofovir DF for oral administration.Elvitegravir is an HIV-1 integrase strand transfer inhibitor.Cobicistat is a mechanism-based inhibitor of cytochr...
Active Ingredientelvitegravir; Cobicistat; tenofovir disoproxil fumarate; emtricitabine
Dosage FormTablet
RouteOral
Strength200mg; 150mg; 300mg
Market StatusPrescription
CompanyGilead Sciences

2 of 2  
Drug NameStribild
PubMed HealthElvitegravir/Cobicistat/Emtricitabine/Tenofovir (By mouth)
Drug ClassesAnti-Infective Agent, Antiviral, Reverse Transcriptase Inhibitor Combination
Drug LabelSTRIBILD is a fixed-dose combination tablet containing elvitegravir, cobicistat, emtricitabine, and tenofovir DF for oral administration.Elvitegravir is an HIV-1 integrase strand transfer inhibitor.Cobicistat is a mechanism-based inhibitor of cytochr...
Active Ingredientelvitegravir; Cobicistat; tenofovir disoproxil fumarate; emtricitabine
Dosage FormTablet
RouteOral
Strength200mg; 150mg; 300mg
Market StatusPrescription
CompanyGilead Sciences

4.2 Drug Indication

Treatment of human immunodeficiency virus 1 (HIV 1) infection in adults aged 18 years and over who are antiretroviral treatment-nave or are infected with HIV 1 without known mutations associated with resistance to any of the three antiretroviral agents in Stribild.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-HIV Agents

Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS. (See all compounds classified as Anti-HIV Agents.)


5.2 ATC Code

J05AR09


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ABOUT THIS PAGE

Quad Tablet Manufacturers

A Quad Tablet manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Quad Tablet, including repackagers and relabelers. The FDA regulates Quad Tablet manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Quad Tablet API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Quad Tablet Suppliers

A Quad Tablet supplier is an individual or a company that provides Quad Tablet active pharmaceutical ingredient (API) or Quad Tablet finished formulations upon request. The Quad Tablet suppliers may include Quad Tablet API manufacturers, exporters, distributors and traders.

Quad Tablet GMP

Quad Tablet Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Quad Tablet GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Quad Tablet GMP manufacturer or Quad Tablet GMP API supplier for your needs.

Quad Tablet CoA

A Quad Tablet CoA (Certificate of Analysis) is a formal document that attests to Quad Tablet's compliance with Quad Tablet specifications and serves as a tool for batch-level quality control.

Quad Tablet CoA mostly includes findings from lab analyses of a specific batch. For each Quad Tablet CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Quad Tablet may be tested according to a variety of international standards, such as European Pharmacopoeia (Quad Tablet EP), Quad Tablet JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Quad Tablet USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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