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1. Estrovis
2. Ethinyl Estradiol 3 Cyclopentyl Ether
3. Ethinyl Estradiol 3-cyclopentyl Ether
1. 152-43-2
2. Estrovis
3. Estradiol-17-beta 3-cyclopentyl Ether
4. Quinestrolo [dcit]
5. Quinestrolum
6. Quinestrolum [inn-latin]
7. Estrovister
8. Plestrovis
9. Eston
10. 17-alpha-ethinylestradiol 3-cyclopentyl Ether
11. 17alpha-ethynylestradiol 3-cyclopentyl Ether
12. Qui-lea
13. Eecpe
14. Estrovis 4000
15. W 3566
16. W-3566
17. (8r,9s,13s,14s,17r)-3-cyclopentyloxy-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-ol
18. Jr0n7xd5gz
19. Mls000069756
20. Chebi:8716
21. Nsc-759637
22. Ncgc00166146-01
23. Quinestrolo
24. Smr000058815
25. Dsstox_cid_26553
26. Dsstox_rid_81714
27. Dsstox_gsid_46553
28. Quilea
29. 3-o-cyclopentyl-17alpha-ethinyl-estra-1,3,5(10)-triene-3,17beta-diol
30. 17alpha-ethylnyl-1,3,5[10]estratriene-3,17beta-diol 3-cyclopentyl Ether
31. Estrovis (tn)
32. Cas-152-43-2
33. Quinestrol (usan/inn)
34. Einecs 205-803-1
35. Unii-jr0n7xd5gz
36. Quinestriol
37. 3-cyclopentyloxy-17alpha-ethynylestra-1,3,5(10)-trien-17beta-ol
38. Quinestrol [usan:usp:inn:ban]
39. 3-(cyclopentyloxy)-19-nor-17alpha-pregna-1,3,5(10)-trien-20-yn-17-ol
40. Ee2cpe
41. Opera_id_502
42. Quinestrol [mi]
43. Quinestrol [inn]
44. Quinestrol [usan]
45. Quinestrol [vandf]
46. Quinestrol [mart.]
47. Quinestrol [who-dd]
48. Mls001077287
49. Schembl221134
50. Gtpl7097
51. Chembl1201165
52. Dtxsid6046553
53. Quinestrol [orange Book]
54. Hms2235a05
55. 3-(cyclopentyloxy)-17beta-ethynylestra-1,3,5(10)-trien-17-ol
56. Hy-b1012
57. Zinc3875993
58. Ethinylestradiol 3-cyclopentyl Ether
59. Tox21_112340
60. Lmst02010037
61. Mfcd00079189
62. S3671
63. Ethynyl Estradiol-3-cyclopentyl Ether
64. 19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yn-17-ol, 3-(cyclopentyloxy)-
65. Akos025310158
66. Tox21_112340_1
67. Ccg-268221
68. Cs-4525
69. Db04575
70. Nsc 759637
71. 19-norpregna-1,3,5(10)-trien-20-yn-17-ol, 3-(cyclopentyloxy)-, (17alpha)-
72. Ncgc00166146-02
73. 17?-ethynylestradiol 3-cyclopentyl Ether
74. As-13038
75. Q0091
76. C07619
77. C72888
78. D00576
79. 152q432
80. A809306
81. Sr-01000759180
82. Q3927871
83. Sr-01000759180-3
84. W-108053
85. 17a-ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-cyclopentyl Ether
86. 3-(cyclopentyloxy)-19-norpregna-1,3,5(10)-trien-20-yn-17.alpha.-ol
87. Estra-1(10),2,4-trien-17-ol, 3-(cyclopentyloxy)-17-ethynyl-, (17)-
88. 19-norpregna-1,3,5(10)-trien-20-yn-17-ol, 3-(cyclopentyloxy)-, 17.alpha.
89. 3-(cyclopentyloxy)-19-nor-17.alpha.-pregna-1,3,5(10)-trien-20-yn-17-ol
90. (1s,10r,11s,14r,15s)-5-(cyclopentyloxy)-14-ethynyl-15-methyltetracyclo[8.7.0.0?,?.0??,??]heptadeca-2,4,6-trien-14-ol
| Molecular Weight | 364.5 g/mol |
|---|---|
| Molecular Formula | C25H32O2 |
| XLogP3 | 5.3 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 3 |
| Exact Mass | 364.240230259 g/mol |
| Monoisotopic Mass | 364.240230259 g/mol |
| Topological Polar Surface Area | 29.5 Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 613 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 5 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Used in hormone replacement therapy, treating symptoms of menopause such as hot flashes. Also used to treat breast and prostate cancer.
Quinestrol is the 3-cyclopentyl ether of ethinyl estradiol (the active metabolite). After gastrointestinal absorption, it is stored in adipose tissue where it is slowly released and metabolized principally to the parent compound, ethinyl estradiol. Ethinyl estradiol is a synthetic derivative of the natural estrogen estradiol.
Estrogens
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds. (See all compounds classified as Estrogens.)
Absorption
Absorbed following oral administration.
Metabolized principally to the parent compound, ethinyl estradiol. Ethinyl estradiol is metabolized in the liver. Quantitatively, the major metabolic pathway for ethinyl estradiol, both in rats and in humans, is aromatic hydroxylation, as it is for the natural estrogens.
Estrogens diffuse into their target cells and interact with a protein receptor (the estrogen receptor). Estrogen interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).
ABOUT THIS PAGE
A Quinestrol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Quinestrol, including repackagers and relabelers. The FDA regulates Quinestrol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Quinestrol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Quinestrol supplier is an individual or a company that provides Quinestrol active pharmaceutical ingredient (API) or Quinestrol finished formulations upon request. The Quinestrol suppliers may include Quinestrol API manufacturers, exporters, distributors and traders.
click here to find a list of Quinestrol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Quinestrol DMF (Drug Master File) is a document detailing the whole manufacturing process of Quinestrol active pharmaceutical ingredient (API) in detail. Different forms of Quinestrol DMFs exist exist since differing nations have different regulations, such as Quinestrol USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Quinestrol DMF submitted to regulatory agencies in the US is known as a USDMF. Quinestrol USDMF includes data on Quinestrol's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Quinestrol USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Quinestrol suppliers with USDMF on PharmaCompass.
Quinestrol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Quinestrol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Quinestrol GMP manufacturer or Quinestrol GMP API supplier for your needs.
A Quinestrol CoA (Certificate of Analysis) is a formal document that attests to Quinestrol's compliance with Quinestrol specifications and serves as a tool for batch-level quality control.
Quinestrol CoA mostly includes findings from lab analyses of a specific batch. For each Quinestrol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Quinestrol may be tested according to a variety of international standards, such as European Pharmacopoeia (Quinestrol EP), Quinestrol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Quinestrol USP).
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