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Also known as: Quinine hcl, 130-89-2, Quinine muriate, Chinimetten, Quinine monohydrochloride, Fema no. 2976
Molecular Formula
C20H25ClN2O2
Molecular Weight
360.9  g/mol
InChI Key
LBSFSRMTJJPTCW-DSXUQNDKSA-N
FDA UNII
7CS0WNO31M

Quinine Hydrochloride
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
1 2D Structure

Quinine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;hydrochloride
2.1.2 InChI
InChI=1S/C20H24N2O2.ClH/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H/t13-,14-,19-,20+;/m0./s1
2.1.3 InChI Key
LBSFSRMTJJPTCW-DSXUQNDKSA-N
2.1.4 Canonical SMILES
COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.Cl
2.1.5 Isomeric SMILES
COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)O.Cl
2.2 Other Identifiers
2.2.1 UNII
7CS0WNO31M
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Biquinate

2. Bisulfate, Quinine

3. Hydrochloride, Quinine

4. Legatrim

5. Myoquin

6. Quinamm

7. Quinbisan

8. Quinbisul

9. Quindan

10. Quinimax

11. Quinine

12. Quinine Bisulfate

13. Quinine Lafran

14. Quinine Sulfate

15. Quinine Sulphate

16. Quinine-odan

17. Quinoctal

18. Quinson

19. Quinsul

20. Strema

21. Sulfate, Quinine

22. Sulphate, Quinine

23. Surquina

2.3.2 Depositor-Supplied Synonyms

1. Quinine Hcl

2. 130-89-2

3. Quinine Muriate

4. Chinimetten

5. Quinine Monohydrochloride

6. Fema No. 2976

7. Ccris 2002

8. Einecs 205-001-1

9. 7549-43-1

10. 7cs0wno31m

11. Anhydrous Quinine Hydrochloride

12. Quinine Hydrochloride Anhydrous

13. Ai3-62121

14. Quinine, Hydrochloride (2:1)

15. Quinine Hydrochloride Dihydrate

16. (r)-[(2s,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;hydrochloride

17. Chininum Muriaticum

18. Quinine Chloride

19. Quinine Hydrochloride Hydrate

20. 6119-47-7

21. Cinchonan-9-ol, 6'-methoxy-, Hydrochloride (1:1), (8alpha,9r)-

22. (r)-(6-methoxyquinolin-4-yl)((1s,2s,4s,5r)-5-vinylquinuclidin-2-yl)methanol Hydrochloride

23. 30860-23-2

24. Chinine Hydrochloride

25. Quinine, Hydrochloride

26. Fema No. 2976, Dihydrate-

27. Einecs 231-437-7

28. Unii-7cs0wno31m

29. Quinine, Monohydrochloride

30. Quininehcl

31. Quinini Hydrochloridum

32. (8alpha,9r)-6'-methoxycinchonan-9-ol Monohydrochloride

33. 6'-methoxycinchonan-9-ol Monohydrochloride, (8alpha,9r)-

34. Cinchonan-9-ol, 6'-methoxy-, Monohydrochloride, (8alpha,9r)-

35. Quinine Hydrochloride (1:1)

36. Schembl184367

37. Chembl588046

38. Dtxsid7044213

39. Tcmdc-123484

40. Tcmdc-125479

41. Cinchonan-9-ol, 6'-methoxy-, Hydrochloride, (8alpha,9r)-

42. Cinchonan-9-ol, 6'-methoxy-, Hydrochloride, (8.alpha.,9r)-

43. Cinchonan-9-ol, 6'-methoxy-, Monohydrochloride, (8-alpha,9r)-

44. Quinine Hydrochloride [fhfi]

45. Mfcd00078498

46. Akos016002029

47. Cinchonan-9-ol, 6'-methoxy-, Monohydrochloride, Dihydrate, (8alpha,9r)-

48. Quinine Hydrochloride [who-dd]

49. 6'-methoxycinchonan-9-ol Hydrochloride

50. As-70722

51. Quinine Monohydrochloride Anhydrous

52. Quinine Hydrochloride Anhydrous [mi]

53. A51181

54. Q27268091

55. (8.alpha.,9r)-6'-methoxycinchonan-9-ol Hydrochloride

56. Cinchonan-9-ol, 6'-methoxy-, Hydrochloride (1:?), (8alpha,9r)-

57. (r)-(6-methoxyquinolin-4-yl)((2s,4s,5r)-5-vinylquinuclidin-2-yl)methanol Hydrochloride

58. (r)-[(2s,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol Hydrochloride

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 360.9 g/mol
Molecular Formula C20H25ClN2O2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass360.1604557 g/mol
Monoisotopic Mass360.1604557 g/mol
Topological Polar Surface Area45.6 Ų
Heavy Atom Count25
Formal Charge0
Complexity457
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Analgesics, Non-Narcotic

A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)


Muscle Relaxants, Central

A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)


Antimalarials

Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)


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THOMAS MOUNT"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1639161000,"product":"QUININE HYDROCHLORIDE 2AQ NATURAL","address":"PLOT NO. 25, 26 AND 46, IIND CROSS ANEKAL TALUK","city":"Bengaluru","supplier":"GIVAUDAN","supplierCountry":"MADAGASCAR","foreign_port":"N\/A","customer":"GIVAUDAN INDIA PRIVATE ","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"136.6","totalValueFC":"137.5","currency":"USD","unitRateINR":"10368.4","date":"11-Dec-2021","totalValueINR":"10368.35","totalValueInUsd":"137.5","indian_port":"BOMBAY AIR","hs_no":"29392090","bill_no":"6642829","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MADAGASCAR","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"","customerAddress":"PLOT NO. 25, 26 AND 46, IIND CROSS ANEKAL TALUK"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1674757800,"product":"QUININE HYDROCHLORIDE (GOODS ARE FOR TESTING, ANALYSIS AND DEVELOPMENT PURPOSE ONLY AND NOT FOR COMMERCIAL USE)","address":"OFFICENO 5-6COMMERCE AVENUE PAUD R D,S NO 127 MAHAGANESH COL KOTHRUD","city":"PUNE,MAHARASHTRA","supplier":"INTERNATIONAL BUSINESS NETWORKS ","supplierCountry":"INDONESIA","foreign_port":"NA","customer":"BATAVIA PHARMA PRIVATE ","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"115","totalValueFC":"2894","currency":"USD","unitRateINR":"9464.5","date":"27-Jan-2023","totalValueINR":"236612.5","totalValueInUsd":"2894","indian_port":"BOMBAY AIR","hs_no":"29392020","bill_no":"4362447","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"INDONESIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"OFFICENO 5-6COMMERCE AVENUE PAUD R D,S NO 127 MAHAGANESH COL KOTHRUD"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1676399400,"product":"QUININE HYDROCHLORIDE DIHYDRATE (SAMPLE FOR FSSAI)","address":"PLOT NO 1109 1110 VILLAGE,PIRANGU T MULSHI PUNE","city":"PUNE,MAHARASHTRA","supplier":"PT. SINKONA INDONESIA LESTARI","supplierCountry":"INDONESIA","foreign_port":"NA","customer":"COCA COLA INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"114","totalValueFC":"135.8","currency":"USD","unitRateINR":"11212.8","date":"15-Feb-2023","totalValueINR":"11212.83","totalValueInUsd":"135.8","indian_port":"BOMBAY AIR","hs_no":"29392020","bill_no":"4657648","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"INDONESIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT NO 1109 1110 VILLAGE,PIRANGU T MULSHI PUNE"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1683484200,"product":"QUININE HYDROCHLORIDE 2AQ NATURAL","address":"D PLOT NO 262ND CROSSJIGANI INDUSTRIAL AREAJIGANIANEKAL TALUKBANGALORE","city":"BENGALURU","supplier":"GIVAUDAN AUSTRALIA PTY ","supplierCountry":"MADAGASCAR","foreign_port":"SYDNEY","customer":"GIVAUDAN INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"128.4","totalValueFC":"386.7","currency":"USD","unitRateINR":"10606.1","date":"08-May-2023","totalValueINR":"31818.36","totalValueInUsd":"386.7","indian_port":"BOMBAY AIR","hs_no":"29392020","bill_no":"0","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"Madagascar","selfForZScoreResived":"Pharma Grade","supplierPort":"SYDNEY","supplierAddress":"","customerAddress":"D PLOT NO 262ND CROSSJIGANI INDUSTRIAL AREAJIGANIANEKAL TALUKBANGALORE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725388200,"product":"QUININE HYDROCHLORIDE DIHYDRATE NAT","address":"140, OLD MAHABALIPURAM ROAD,","city":"CHENNAI, TAMIL NADU.","supplier":"SYMRISE","supplierCountry":"MADAGASCAR","foreign_port":"MUNICH","customer":"SYMRISE","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"144.3","totalValueFC":"175.9","currency":"USD","unitRateINR":"14739.5","date":"04-Sep-2024","totalValueINR":"14739.46","totalValueInUsd":"175.9","indian_port":"Madras Air","hs_no":"29392090","bill_no":"5421358","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MADAGASCAR","selfForZScoreResived":"Pharma Grade","supplierPort":"MUNICH","supplierAddress":"A-JAUMANN-INDUSTRIEPARK 9 86720 NOERDLINGEN GERMANY GERMANY GERMANY","customerAddress":"140, OLD MAHABALIPURAM ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730658600,"product":"QUININE HYDROCHLORIDE (AROMATIC CHEMICAL)","address":"1-5 SEVEN WELLS STREET","city":"CHENNAI ,TAMILNADU","supplier":"QIMPEXX NETHERLANDS B.V","supplierCountry":"MADAGASCAR","foreign_port":"AMSTERDAM, SCHIPHOL","customer":"INTERNATIONAL FLAVORS AND FRAGRANCES","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"110","totalValueFC":"2930.7","currency":"USD","unitRateINR":"9892.7","date":"04-Nov-2024","totalValueINR":"247316.83","totalValueInUsd":"2930.7","indian_port":"Madras Air","hs_no":"29392090","bill_no":"6491866","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MADAGASCAR","selfForZScoreResived":"Pharma Grade","supplierPort":"AMSTERDAM, SCHIPHOL","supplierAddress":"STEIJNLAAN 26 1217 JS HILVERSUMP.O BOX 2225 1200 CE HILVERSUM SDNF NL","customerAddress":"1-5 SEVEN WELLS STREET"}]
13-Jan-2021
04-Nov-2024
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ABOUT THIS PAGE

Quinine Hydrochloride Manufacturers

A Quinine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Quinine Hydrochloride, including repackagers and relabelers. The FDA regulates Quinine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Quinine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Quinine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Quinine Hydrochloride Suppliers

A Quinine Hydrochloride supplier is an individual or a company that provides Quinine Hydrochloride active pharmaceutical ingredient (API) or Quinine Hydrochloride finished formulations upon request. The Quinine Hydrochloride suppliers may include Quinine Hydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Quinine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Quinine Hydrochloride USDMF

A Quinine Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Quinine Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Quinine Hydrochloride DMFs exist exist since differing nations have different regulations, such as Quinine Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Quinine Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Quinine Hydrochloride USDMF includes data on Quinine Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Quinine Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Quinine Hydrochloride suppliers with USDMF on PharmaCompass.

Quinine Hydrochloride JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Quinine Hydrochloride Drug Master File in Japan (Quinine Hydrochloride JDMF) empowers Quinine Hydrochloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Quinine Hydrochloride JDMF during the approval evaluation for pharmaceutical products. At the time of Quinine Hydrochloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Quinine Hydrochloride suppliers with JDMF on PharmaCompass.

Quinine Hydrochloride CEP

A Quinine Hydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Quinine Hydrochloride Certificate of Suitability (COS). The purpose of a Quinine Hydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Quinine Hydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Quinine Hydrochloride to their clients by showing that a Quinine Hydrochloride CEP has been issued for it. The manufacturer submits a Quinine Hydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Quinine Hydrochloride CEP holder for the record. Additionally, the data presented in the Quinine Hydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Quinine Hydrochloride DMF.

A Quinine Hydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Quinine Hydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Quinine Hydrochloride suppliers with CEP (COS) on PharmaCompass.

Quinine Hydrochloride WC

A Quinine Hydrochloride written confirmation (Quinine Hydrochloride WC) is an official document issued by a regulatory agency to a Quinine Hydrochloride manufacturer, verifying that the manufacturing facility of a Quinine Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Quinine Hydrochloride APIs or Quinine Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Quinine Hydrochloride WC (written confirmation) as part of the regulatory process.

click here to find a list of Quinine Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

Quinine Hydrochloride NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Quinine Hydrochloride as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Quinine Hydrochloride API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Quinine Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Quinine Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Quinine Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Quinine Hydrochloride suppliers with NDC on PharmaCompass.

Quinine Hydrochloride GMP

Quinine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Quinine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Quinine Hydrochloride GMP manufacturer or Quinine Hydrochloride GMP API supplier for your needs.

Quinine Hydrochloride CoA

A Quinine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Quinine Hydrochloride's compliance with Quinine Hydrochloride specifications and serves as a tool for batch-level quality control.

Quinine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Quinine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Quinine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Quinine Hydrochloride EP), Quinine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Quinine Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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