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1. Ac220 Compound
1. 950769-58-1
2. Ac220
3. Quizartinib (ac220)
4. Ac-220
5. Ac 220
6. Quizartinib Hcl
7. Ac010220
8. Quizartinib Freebase
9. Ac 010220
10. Asp-2689
11. 1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea
12. 7la4o6q0d3
13. Chembl576982
14. N-(5-tert-butylisoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea
15. Chebi:90217
16. 950769-58-1 (free Base)
17. Ac-010220
18. 1132827-21-4 (hcl)
19. 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea
20. 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea
21. N-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride
22. Chembl2386811
23. 1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)-benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea
24. N-(5-(1,1-dimethylethyl)isoxazol-3-yl)-n'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1- B)benzothiazol-2-yl)phenyl)urea
25. N-(5-(1,1-dimethylethyl)isoxazol-3-yl)-n'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)benzothiazol-2-yl)phenyl)urea
26. Urea, N-(5-(1,1-dimethylethyl)-3-isoxazolyl)-n'-(4-(7-(2-(4-morpholinyl)ethoxy) Imidazo(2,1-b)benzothiazol-2-yl)phenyl)-
27. Ac220 Compound
28. Ac220,quizartinib
29. Quizartinib [usan]
30. Quizartinib [usan:inn]
31. Quizartinibum
32. Unii-7la4o6q0d3
33. 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)(1,3)benzothiazol-2-yl)phenyl)urea
34. N-(5-tert-butylisoxazol-3-yl)-n'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)(1,3)benzothiazol-2-yl)phenyl)urea
35. N-(5-tert-butylisoxazol-3-yl)-n'-[4-[7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea
36. Quizartinib, 95%
37. Quizartinib, Ac220
38. Quizartinib, Free Base
39. Ac220 - Quizartinib
40. Quizartinib [mi]
41. Quizartinib; Plx3397
42. Quizartinib [inn]
43. Quizartinib (usan/inn)
44. Quizartinib, Ac010220
45. Schembl72923
46. Quizartinib [who-dd]
47. Mls006011240
48. Gtpl5658
49. Dtxsid70241746
50. Bcpp000443
51. Hms3244k09
52. Hms3244k10
53. Hms3244l09
54. Hms3265g09
55. Hms3265g10
56. Hms3265h09
57. Hms3265h10
58. Hms3654j20
59. Hms3743g21
60. Bcp02224
61. Bdbm50300690
62. Mfcd18074524
63. Nsc756647
64. Nsc799659
65. Nsc800857
66. S1526
67. Zinc43204002
68. Akos015891557
69. Bcp9000223
70. Ccg-264906
71. Cs-0211
72. Db12874
73. Nsc-756647
74. Nsc-799659
75. Nsc-800857
76. Sb16610
77. Ncgc00242493-01
78. Ncgc00242493-02
79. Ncgc00242493-07
80. As-16178
81. Hy-13001
82. Smr004703000
83. Ft-0687630
84. Sw218131-2
85. D09955
86. J-524214
87. Q7272714
88. Brd-k93918653-001-01-4
89. 3-(5-tert-butyl-1,2-oxazol-3-yl)-1-(4-{10-[2-(morpholin-4-yl)ethoxy]-7-thia-2,5-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(12),3,5,8,10-pentaen-4-yl}phenyl)urea
90. N-(5-tert-butyl-isoxazol-3-yl)-n''-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea
91. N-(5-tert-butyl-isoxazol-3-yl)-n'-(4-(7-(2-(morpholin-4-ylethoxy)imidazo(2,1-b) (1,3)benzothiazol-2-yl)phenyl)urea
92. N-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea
93. N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-n'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]urea
| Molecular Weight | 560.7 g/mol |
|---|---|
| Molecular Formula | C29H32N6O4S |
| XLogP3 | 5.6 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 8 |
| Exact Mass | 560.22057470 g/mol |
| Monoisotopic Mass | 560.22057470 g/mol |
| Topological Polar Surface Area | 134 Ų |
| Heavy Atom Count | 40 |
| Formal Charge | 0 |
| Complexity | 849 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Treatment of acute myeloid leukaemia.
Treatment of acute myeloid leukaemia
In preclinical studies, Quizartinib demonstrated dose-dependent activity and favorable drug-like profiles in bioavailability, pharmacokinetics, cytochrome P450 (CYP) liability, and absorption, distribution, metabolism, excretion (ADME).
L01XE
L - Antineoplastic and immunomodulating agents
L01 - Antineoplastic agents
L01E - Protein kinase inhibitors
L01EX - Other protein kinase inhibitors
L01EX11 - Quizartinib
Quizartinib potently inhibits FLT3, a kinase that is mutated in approximately one-third of acute myeloid leukemia cases, and patients with FLT3 mutations are less responsive to traditional therapies.
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A Quizartinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Quizartinib, including repackagers and relabelers. The FDA regulates Quizartinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Quizartinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Quizartinib supplier is an individual or a company that provides Quizartinib active pharmaceutical ingredient (API) or Quizartinib finished formulations upon request. The Quizartinib suppliers may include Quizartinib API manufacturers, exporters, distributors and traders.
Quizartinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Quizartinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Quizartinib GMP manufacturer or Quizartinib GMP API supplier for your needs.
A Quizartinib CoA (Certificate of Analysis) is a formal document that attests to Quizartinib's compliance with Quizartinib specifications and serves as a tool for batch-level quality control.
Quizartinib CoA mostly includes findings from lab analyses of a specific batch. For each Quizartinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Quizartinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Quizartinib EP), Quizartinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Quizartinib USP).
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