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Chemistry

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Also known as: Melanotan-1, 4-nle-7-phe-alpha-msh, Cuv1647, 75921-69-6, Cuv 1647, Cuv-1647
Molecular Formula
C78H111N21O19
Molecular Weight
1646.8  g/mol
InChI Key
UAHFGYDRQSXQEB-LEBBXHLNSA-N
FDA UNII
QW68W3J66U

Qw68W3J66U
1 2D Structure

Qw68W3J66U

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-5-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
2.1.2 InChI
InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1
2.1.3 InChI Key
UAHFGYDRQSXQEB-LEBBXHLNSA-N
2.1.4 Canonical SMILES
CCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)C)C(=O)N)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CO)NC(=O)C
2.1.5 Isomeric SMILES
CCCC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N5CCC[C@H]5C(=O)N[C@@H](C(C)C)C(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC6=CC=C(C=C6)O)NC(=O)[C@H](CO)NC(=O)C
2.2 Other Identifiers
2.2.1 UNII
QW68W3J66U
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (nle(4),d-phe(7))alpha-msh

2. (nle(4)-dphe(7))alpha-melanocyte-stimulating Hormone

3. 4-nle-7-phe-alpha-msh

4. 4-norleucine-7-d-phenylalanine-alpha-melanocyte-stimulating Hormone

5. 4-norleucyl-7-phenylalanine-alpha-msh

6. Alpha-msh, Nle(4)-phe(7)-

7. Alpha-msh, Norleucyl(4)-d-phenylalanyl(7)-

8. Melanotan-1

9. Msh, 4-nle-7-phe-alpha-

10. Msh, 4-norleucyl-7-phenylalanine-alpha-

11. Mt-1 (nlefmsh)

12. Ndp-alpha-msh

13. Ndp-msh

14. Ndpmsh

2.3.2 Depositor-Supplied Synonyms

1. Melanotan-1

2. 4-nle-7-phe-alpha-msh

3. Cuv1647

4. 75921-69-6

5. Cuv 1647

6. Cuv-1647

7. Qw68w3j66u

8. Scenesse

9. Mt-1 (nlefmsh)

10. Ac-ser-tyr-ser-nle-glu-his-d-phe-arg-trp-gly-lys-pro-val-nh2

11. Msh, 4-nle-7-phe-alpha-

12. Ndp-alpha-msh

13. Mt-i

14. Afamelanotide [inn]

15. Alpha-msh, Nle(4)-phe(7)-

16. 4-norleucyl-7-phenylalanine-alpha-msh

17. Afamelanotida

18. Afamelanotidum

19. Unii-qw68w3j66u

20. Msh, 4-norleucyl-7-phenylalanine-alpha-

21. Mbj 05

22. Alpha-msh, Norleucyl(4)-d-phenylalanyl(7)-

23. Afamelanotidemt-i

24. (nle(4)-dphe(7))alpha-melanocyte-stimulating Hormone

25. 4-norleucine-7-d-phenylalanine-alpha-melanocyte-stimulating Hormone

26. Afamelanotide [mi]

27. Afamelanotide [usan:inn]

28. Afamelanotide [usan]

29. (nle4-d-phe7)-alpha-melanocyte-stimulating Hormone

30. Afamelanotide [who-dd]

31. Alpha-melanotropin, 4-l-norleucine-7-d-phenylalanine-

32. Schembl22463810

33. Chebi:136034

34. Afamelanotide [orange Book]

35. [nle(4),d-phe(7)]-alpha-msh

36. 921a696

37. Nle(4)-d-phe(7)-alpha-melanocyte-stimulating Hormone

38. .alpha.-melanotropin (swine), 4-l-norleucine-7-d-phenylalanine-

39. Acetyl(4-(2s)-2-aminohexanoic Acid,7-d-phenylalanine)human Melanotropin Alpha

40. N-acetyl-l-seryl-l-tyrosyl-l-seryl-l-norleucyl-l-alpha-glutamyl-l-histidyl-d-phenylalanyl-l-arginyl-l-tryptophylglycyl-l-lysyl-l-prolyl-l-valinamide

41. N-acteyl-l-ser-l-tyr-l-ser-l-nle-l-glu-l-his-d-phe-l-arg-l-trp-gly-l-lys-l-pro-l-val-nh2

2.4 Create Date
2007-07-04
3 Chemical and Physical Properties
Molecular Weight 1646.8 g/mol
Molecular Formula C78H111N21O19
XLogP3-3.5
Hydrogen Bond Donor Count23
Hydrogen Bond Acceptor Count22
Rotatable Bond Count51
Exact Mass1645.83651040 g/mol
Monoisotopic Mass1645.83651040 g/mol
Topological Polar Surface Area643 Ų
Heavy Atom Count118
Formal Charge0
Complexity3360
Isotope Atom Count0
Defined Atom Stereocenter Count12
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Affinity Labels

Analogs of those substrates or compounds which bind naturally at the active sites of proteins, enzymes, antibodies, steroids, or physiological receptors. These analogs form a stable covalent bond at the binding site, thereby acting as inhibitors of the proteins or steroids. (See all compounds classified as Affinity Labels.)


Anticarcinogenic Agents

Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved. (See all compounds classified as Anticarcinogenic Agents.)


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Qw68W3J66U manufacturers, exporters & distributors 1

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API | Excipient name

Qw68W3J66U

Synonyms

Melanotan-1, 4-nle-7-phe-alpha-msh, Cuv1647, 75921-69-6, Cuv 1647, Cuv-1647

Cas Number

75921-69-6

Unique Ingredient Identifier (UNII)

QW68W3J66U

Qw68W3J66U Manufacturers

A Qw68W3J66U manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Qw68W3J66U, including repackagers and relabelers. The FDA regulates Qw68W3J66U manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Qw68W3J66U API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Qw68W3J66U Suppliers

A Qw68W3J66U supplier is an individual or a company that provides Qw68W3J66U active pharmaceutical ingredient (API) or Qw68W3J66U finished formulations upon request. The Qw68W3J66U suppliers may include Qw68W3J66U API manufacturers, exporters, distributors and traders.

Qw68W3J66U NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Qw68W3J66U as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Qw68W3J66U API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Qw68W3J66U as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Qw68W3J66U and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Qw68W3J66U NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Qw68W3J66U suppliers with NDC on PharmaCompass.

Qw68W3J66U GMP

Qw68W3J66U Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Qw68W3J66U GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Qw68W3J66U GMP manufacturer or Qw68W3J66U GMP API supplier for your needs.

Qw68W3J66U CoA

A Qw68W3J66U CoA (Certificate of Analysis) is a formal document that attests to Qw68W3J66U's compliance with Qw68W3J66U specifications and serves as a tool for batch-level quality control.

Qw68W3J66U CoA mostly includes findings from lab analyses of a specific batch. For each Qw68W3J66U CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Qw68W3J66U may be tested according to a variety of international standards, such as European Pharmacopoeia (Qw68W3J66U EP), Qw68W3J66U JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Qw68W3J66U USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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