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ACTIVE PHARMA INGREDIENTS

95 API Suppliers, 31 USDMF, 15 CEP/COS, 19 JDMF, 22 EU WC, 12 KDMF, 12 NDC API, 50 Listed Suppliers, $ API Reference Price

95 API Suppliers
31 USDMF
15 CEP/COS
19 JDMF
22 EU WC
12 KDMF
12 NDC API
50 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

INTERMEDIATES

19 Intermediates Suppliers

19 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

319 FDF Dossiers, 15 FDA Orange Book, 145 Europe, 12 Canada, 36 Australia, 11 South Africa, 100 Listed Dossiers

319 FDF Dossiers
15 FDA Orange Book
145 Europe
12 Canada
36 Australia
11 South Africa
100 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CAPSULE, DELAYED RELEASE;ORAL - 10MG, CAPSULE, DELAYED RELEASE;ORAL - 5MG, TABLET, DELAYED RELEASE;ORAL - 10MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, DELAYED RELEASE;ORAL - 20MG

drugProductComposition
CAPSULE, DELAYED RELEASE;ORAL - 10MG
CAPSULE, DELAYED RELEASE;ORAL - 5MG
TABLET, DELAYED RELEASE;ORAL - 10MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET, DELAYED RELEASE;ORAL - 20MG

RELATED EXCIPIENT COMPANIES

1 Minakem, 1 Evonik, 2 Rochem International Inc, 18 SPI Pharma, 2 Seqens, 7 DKSH, 3 Jai Radhe Sales, 7 Faran Shimi Pharmaceutical, 5 Boai NKY Pharmaceuticals Ltd, 1 Chynops Pharma, 12 Gangwal Healthcare, 7 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 1 ACG Worldwide, 5 Actylis, 1 Aeon Procare, 3 Alcedo Pharmachem, 10 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 1 Avesta Pharma, 37 BASF, 1 Clariant, 14 Corel Pharma Chem, 6 DFE Pharma, 3 Finar, 13 Gangwal Chemicals, 12 Ideal Cures Pvt Ltd, 3 Ingredion Pharma Solutions, 34 Kerry, 4 Kima Chemical, 6 Lonza Capsugel, 18 Microlex e.U, 1 Nanjing Bold Chemical, 1 NEWEDGE Overseas, 2 Nomisma Healthcare, 4 Novo Excipients, 5 Pharmatrans-Sanaq, 7 Pluviaendo, 5 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 18 Roquette, 13 Seppic, 6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 12 Sigachi Industries, 3 The Dow Chemical Company, 1 Ulanqab Kema New Material, 2 Valens Pharmachem, 4 Vasa Pharmachem, 1 Vertellus

relatedExcipients
1 Minakem
1 Evonik
2 Rochem International Inc
18 SPI Pharma
2 Seqens
7 DKSH
3 Jai Radhe Sales
7 Faran Shimi Pharmaceutical
5 Boai NKY Pharmaceuticals Ltd
1 Chynops Pharma
12 Gangwal Healthcare
7 Nanjing Well Pharmaceutical
1 Pfanstiehl
1 ACG Worldwide
5 Actylis
1 Aeon Procare
3 Alcedo Pharmachem
10 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
1 Avesta Pharma
37 BASF
1 Clariant
14 Corel Pharma Chem
6 DFE Pharma
3 Finar
13 Gangwal Chemicals
12 Ideal Cures Pvt Ltd
3 Ingredion Pharma Solutions
34 Kerry
4 Kima Chemical
6 Lonza Capsugel
18 Microlex e.U
1 Nanjing Bold Chemical
1 NEWEDGE Overseas
2 Nomisma Healthcare
4 Novo Excipients
5 Pharmatrans-Sanaq
7 Pluviaendo
5 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
1 Qualicaps
18 Roquette
13 Seppic
6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
12 Sigachi Industries
3 The Dow Chemical Company
1 Ulanqab Kema New Material
2 Valens Pharmachem
4 Vasa Pharmachem
1 Vertellus

EXCIPIENTS BY APPLICATIONS

79 Fillers, Diluents & Binders, 74 Coating Systems & Additives, 45 Controlled & Modified Release, 44 Direct Compression, 41 Disintegrants & Superdisintegrants, 33 Granulation, 33 Solubilizers, 31 Thickeners and Stabilizers, 26 Lubricants & Glidants, 22 Parenteral, 20 Film Formers & Plasticizers, 20 Taste Masking, 20 Topical, 18 Chewable & Orodispersible Aids, 17 Co-Processed Excipients, 12 Emulsifying Agents, 7 API Stability Enhancers, 7 Rheology Modifiers, 5 Empty Capsules, 5 Surfactant & Foaming Agents, 5 Coloring Agents, 4 Vegetarian Capsules, 1 Soft Gelatin

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 13 NEWS #PharmaBuzz

media
2 DATA COMPILATION #PharmaFlow
13 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 139 Finished Drug Prices, 12 Annual Reports

globalSalesInformation
2 US Medicaid Prescriptions
139 Finished Drug Prices
12 Annual Reports

MARKET PLACE

47 APIs, 10 FDF Dossiers, 1 EXCIPIENTS

marketPlace
47 APIs
10 FDF Dossiers
1 EXCIPIENTS

PATENTS & EXCLUSIVITIES

6 Health Canada Patents

patents
6 Health Canada Patents

REF. STANDARDS & IMPURITIES

3 USP , 2 JP , 15 Others

otherSolutions
3 USP
2 JP
15 Others

ANALYTICAL

1 BioAnalytical Methods, 2 Analytical Methods

otherMethods
1 BioAnalytical Methods
2 Analytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 278

MARKET PLACE

API

FDF

19INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

319

FDF Dossiers

FDA Orange Book

145

Europe

Canada

Australia

South Africa

100

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

33,838,170

Annual Reports (USD Million)

1,253

Finished Drug Prices

327 RELATED EXCIPIENT COMPANIES

569EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 117976-90-6, Rebeprazole sodium, Pariet, Aciphex, Rabeprazole sodium salt, Dexrabeprazole sodium

Molecular Formula

C₁₈H₂₀N₃NaO₃S

Molecular Weight

381.4 g/mol

InChI Key

KRCQSTCYZUOBHN-UHFFFAOYSA-N

FDA UNII

3L36P16U4R

A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.

1 2D Structure

Rabeprazole

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]benzimidazol-1-ide

2.1.2 InChI

InChI=1S/C18H20N3O3S.Na/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18;/h3-4,6-9H,5,10-12H2,1-2H3;/q-1;+1

2.1.3 InChI Key

KRCQSTCYZUOBHN-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3[N-]2)OCCCOC.[Na+]

2.2 Other Identifiers

2.2.1 UNII

3L36P16U4R

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1h-benzimidazole, 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt

2. 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1h-benzimidazole

3. Aciphex

4. Dexrabeprazole

5. E 3810

6. E3810

7. Ly 307640

8. Ly-307640

9. Ly307640

10. Pariet

11. Rabeprazole

12. Sodium, Rabeprazole

2.3.2 Depositor-Supplied Synonyms

1. 117976-90-6

2. Rebeprazole Sodium

3. Pariet

4. Aciphex

5. Rabeprazole Sodium Salt

6. Dexrabeprazole Sodium

7. Rabeprazole (sodium)

8. (s)-rabeprazole Sodium Salt

9. Aciphex Sprinkle

10. Ly307640 Sodium

11. Sodium Rabeprazole

12. Rabeprazole Sodium [usan]

13. Idiazole

14. Rabeprazole Na

15. Chebi:8769

16. 171440-19-0

17. Ly-307640

18. E3810

19. E-3810 Sodium

20. Sodium;2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]benzimidazol-1-ide

21. Ly-307640 Sodium

22. 3l36p16u4r

23. 1h-benzimidazole, 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt

24. 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridyl)methyl)sulfinyl)benzimidazole Sodium Salt

25. Nsc-759270

26. Dsstox_cid_24205

27. Dsstox_rid_80118

28. Dsstox_gsid_44205

29. 1h-benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-, Sodium Salt (1:1)

30. Rabicip

31. Pepcia

32. Aciphex Sodium

33. Ly 307640 Sodium

34. Habeprazole Sodium

35. Sodium 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)benzo[d]imidazol-1-ide

36. Sodium 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)benzimidazol-1-ide

37. Smr000550493

38. Cas-117976-90-6

39. Ncgc00159518-02

40. E 3810

41. Pariete

42. Unii-3l36p16u4r

43. Pariprazole Sodium

44. Dexrabeprazolesodium

45. Rebeprazole Sodium;

46. Aciphex (tn)

47. Pariet (tn)

48. Rebeprazole Sodium Salt

49. Rabeprazole Sodium- Bio-x

50. Mls001165734

51. Mls006010621

52. Schembl140494

53. Rabeprazole Na [vandf]

54. Chembl1200930

55. Dtxsid3044205

56. Rabeprazole Sodium [jan]

57. Hy-b0656a

58. Rabeprazole Sodium (jp17/usp)

59. Ex-a176

60. Hms2093h10

61. Hms2231e04

62. Hms3373b05

63. Rabeprazole Sodium [mart.]

64. Bcp06639

65. Rabeprazole Sodium [usp-rs]

66. Rabeprazole Sodium [who-dd]

67. Tox21_111736

68. Tox21_302317

69. Ac-715

70. Bdbm50247881

71. Mfcd02092688

72. Rabeprazole Sodium Salt [mi]

73. S4665

74. Rabeprazole Sodium, >=98% (hplc)

75. Akos015895734

76. Akos015962116

77. Akos025310160

78. Tox21_111736_1

79. Am81231

80. Ccg-213574

81. Ccg-268423

82. Nsc 759270

83. Rabeprazole Sodium [orange Book]

84. Ncgc00159518-05

85. Ncgc00255838-01

86. Rabeprazole Sodium [ep Monograph]

87. As-13338

88. Br167318

89. Rabeprazole Sodium [usp Monograph]

90. Ft-0631090

91. Ft-0689461

92. R0115

93. C07865

94. D00724

95. F17418

96. 976r906

97. Sr-01000799133

98. J-010726

99. Q-201655

100. Sr-01000799133-2

101. Q27108142

102. [2-[[4-(3-methoxypropoxy)-3-methyl-2-pyridyl]methylsulfinyl]benzimidazol-1-yl]sodium

103. Sodium;2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]-1h-benzimidazole

104. 1h-benzimidazole,2-[[[4-(3-methoxypropoxy)- 3-methyl-2-pyridinyl]methyl]sulfinyl]-,sodium Salt

105. 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1h-benzimidazole, Sodium Salt

106. Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

2.4 Create Date

2007-02-09

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₂₀N₃NaO₃S
Molecular Weight	381.4 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	8
Exact Mass	381.11230696 g/mol
Monoisotopic Mass	381.11230696 g/mol
Topological Polar Surface Area	81.5 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	446
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Aciphex
PubMed Health	Rabeprazole (By mouth)
Drug Classes	Antiulcer, Gastric Acid Secretion Inhibitor
Drug Label	The active ingredient in ACIPHEX Delayed-Release Tablets is rabeprazole sodium, a substituted benzimidazole that inhibits gastric acid secretion. Rabeprazole sodium is known chemically as 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]-methyl]sulfiny...
Active Ingredient	Rabeprazole sodium
Dosage Form	Tablet, delayed release
Route	oral; Oral
Strength	20mg
Market Status	Prescription
Company	Eisai; Eisai Medcl Res

2 of 4
Drug Name	Rabeprazole sodium
Drug Label	The active ingredient in ACIPHEX Delayed-Release Tablets is rabeprazole sodium, a substituted benzimidazole that inhibits gastric acid secretion. Rabeprazole sodium is known chemically as 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]-methyl]sulfiny...
Active Ingredient	Rabeprazole sodium
Dosage Form	Tablet, delayed release
Route	Oral
Strength	20mg
Market Status	Prescription
Company	Mylan Pharms; Kremers Urban Dev; Teva Pharms Usa; Torrent Pharms; Lupin; Dr Reddys Labs

3 of 4
Drug Name	Aciphex
PubMed Health	Rabeprazole (By mouth)
Drug Classes	Antiulcer, Gastric Acid Secretion Inhibitor
Drug Label	The active ingredient in ACIPHEX Delayed-Release Tablets is rabeprazole sodium, a substituted benzimidazole that inhibits gastric acid secretion. Rabeprazole sodium is known chemically as 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]-methyl]sulfiny...
Active Ingredient	Rabeprazole sodium
Dosage Form	Tablet, delayed release
Route	oral; Oral
Strength	20mg
Market Status	Prescription
Company	Eisai; Eisai Medcl Res

4 of 4
Drug Name	Rabeprazole sodium
Drug Label	The active ingredient in ACIPHEX Delayed-Release Tablets is rabeprazole sodium, a substituted benzimidazole that inhibits gastric acid secretion. Rabeprazole sodium is known chemically as 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]-methyl]sulfiny...
Active Ingredient	Rabeprazole sodium
Dosage Form	Tablet, delayed release
Route	Oral
Strength	20mg
Market Status	Prescription
Company	Mylan Pharms; Kremers Urban Dev; Teva Pharms Usa; Torrent Pharms; Lupin; Dr Reddys Labs

4.2 Drug Indication

Treatment of duodenal ulcer, Treatment of gastric ulcer, Treatment of gastro-oesophageal reflux disease, Treatment of Helicobacter pylori in patients with peptic ulcer disease, Treatment of Zollinger-Ellison syndrome

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Ulcer Agents

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

Proton Pump Inhibitors

Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX. (See all compounds classified as Proton Pump Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Proton Pump Inhibitors [MoA]; Proton Pump Inhibitor [EPC]

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - CAPSULE, DELAYED RELEASE;ORAL - 10MG

USFDA APPLICATION NUMBER - 204736

DOSAGE - CAPSULE, DELAYED RELEASE;ORAL - 5MG

USFDA APPLICATION NUMBER - 204736

DOSAGE - TABLET, DELAYED RELEASE;ORAL - 10MG ...DOSAGE - TABLET, DELAYED RELEASE;ORAL - 10MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20973

DOSAGE - TABLET, DELAYED RELEASE;ORAL - 20MG

USFDA APPLICATION NUMBER - 20973

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Rabeprazole Sodium

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

95 API Suppliers

31 USDMF

15 CEP/COS

19 JDMF

22 EU WC

12 KDMF

12 NDC API

50 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

INTERMEDIATES

19 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

319 FDF Dossiers

15 FDA Orange Book

145 Europe

12 Canada

36 Australia

11 South Africa

100 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CAPSULE, DELAYED RELEASE;ORAL - 10MG

CAPSULE, DELAYED RELEASE;ORAL - 5MG

TABLET, DELAYED RELEASE;ORAL - 10MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET, DELAYED RELEASE;ORAL - 20MG

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TABLET, DELAYED RELEASE;ORAL - 10MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons