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Also known as: 496054-87-6, Rgh-896, Radiprodil [inn], 5xgc17zkuf, Chembl182066, 2-(4-(4-fluorobenzyl)piperidin-1-yl)-2-oxo-n-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)acetamide

Molecular Formula

C₂₁H₂₀FN₃O₄

Molecular Weight

397.4 g/mol

InChI Key

GKGRZLGAQZPEHO-UHFFFAOYSA-N

FDA UNII

5XGC17ZKUF

Radiprodil has been used in trials studying the treatment of Infantile Spasms (IS) and Diabetic Peripheral Neuropathic Pain.

1 2D Structure

Radiprodil

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]-2-oxo-N-(2-oxo-3H-1,3-benzoxazol-6-yl)acetamide

2.1.2 InChI

InChI=1S/C21H20FN3O4/c22-15-3-1-13(2-4-15)11-14-7-9-25(10-8-14)20(27)19(26)23-16-5-6-17-18(12-16)29-21(28)24-17/h1-6,12,14H,7-11H2,(H,23,26)(H,24,28)

2.1.3 InChI Key

GKGRZLGAQZPEHO-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CN(CCC1CC2=CC=C(C=C2)F)C(=O)C(=O)NC3=CC4=C(C=C3)NC(=O)O4

2.2 Other Identifiers

2.2.1 UNII

5XGC17ZKUF

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-(4-(4-fluoro-benzyl)-piperidin-1-yl)-2-oxo-n-(2-oxo-2,3-dihydro-benzooxazol-6-yl)-acetamide

2.3.2 Depositor-Supplied Synonyms

1. 496054-87-6

2. Rgh-896

3. Radiprodil [inn]

4. 5xgc17zkuf

5. Chembl182066

6. 2-(4-(4-fluorobenzyl)piperidin-1-yl)-2-oxo-n-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)acetamide

7. 2-(4-((4-fluorophenyl)methyl)piperidin-1-yl)-2-oxo-n-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)acetamide

8. 2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-2-oxo-n-(2-oxo-2,3-dihydro-benzooxazol-6-yl)-acetamide

9. Unii-5xgc17zkuf

10. Radiprodil (rgh-896)

11. Radiprodil [who-dd]

12. Schembl99256

13. Dtxsid80964297

14. Rgh 896

15. Bcp30852

16. Wua05487

17. Bdbm50149684

18. S6644

19. Zinc28363953

20. Db12260

21. 2-[4-(4-fluorobenzyl)piperidin-1-yl]-2-oxo-n-(2-oxo-2,3-dihydrobenzoxazol-6-yl)acetamide

22. Ncgc00386549-01

23. 2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]-2-oxo-n-(2-oxo-3h-1,3-benzoxazol-6-yl)acetamide

24. 2-{4-[(4-fluorophenyl)methyl]piperidin-1-yl}-n-(2-hydroxy-1,3-benzoxazol-6-yl)-2-oxoacetamide

25. Bs-16896

26. Hy-14777

27. Cs-0003554

28. Rgh-896; Rgh896; Rgh 896

29. N16882

30. Q27263011

31. 1-piperidineacetamide, N-(2,3-dihydro-2-oxo-6-benzoxazolyl)-4-[(4-fluorophenyl)methyl]-alpha-oxo-

32. 2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-2-oxo-n-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-acetamide

33. 2-[4-(4-fluorobenzyl)-piperidin-1-yl]-2-oxo-n-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-acetamide

34. N-(2,3-dihydro-2-oxo-6-benzoxazolyl)-4-[(4-fluorophenyl)methyl]-alpha-oxo-1-piperidineacetamide

2.4 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₂₁H₂₀FN₃O₄
Molecular Weight	397.4 g/mol
XLogP3	3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	g/mol
Monoisotopic Mass	g/mol
Topological Polar Surface Area	87.7
Heavy Atom Count	29
Formal Charge	0
Complexity	629
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1