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Chemistry

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Also known as: Ranitidine bismutrex, Tritec, Gr 122311x, Gr-122311x, 7aj51i17kg, 128345-62-0
Molecular Formula
C19H27BiN4O10S
Molecular Weight
712.5  g/mol
InChI Key
XAUTYMZTJWXZHZ-UHFFFAOYSA-K
FDA UNII
7AJ51I17KG

Ranitidine Bismuth Citrate
Ranitidine Bismuth Citrate is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the action of histamine, released by enterochromaffin-like (ECL) cells, at the histamine H2-receptors on parietal cells in the stomach, thereby inhibiting the normal and meal-stimulated secretion of stomach acid. In addition, other substances that promote acid secretion have a reduced effect on parietal cells when the H2 receptors are blocked.
1 2D Structure

Ranitidine Bismuth Citrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
bismuth;1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;2-hydroxypropane-1,2,3-tricarboxylate
2.1.2 InChI
InChI=1S/C13H22N4O3S.C6H8O7.Bi/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10;/h4-5,9,14-15H,6-8,10H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;;+3/p-3
2.1.3 InChI Key
XAUTYMZTJWXZHZ-UHFFFAOYSA-K
2.1.4 Canonical SMILES
CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Bi+3]
2.2 Other Identifiers
2.2.1 UNII
7AJ51I17KG
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Azanplus

2. Gr 122311x

3. Gr-122311x

4. Gr122311x

5. Pylorid

6. Raniberl

7. Tritec

2.3.2 Depositor-Supplied Synonyms

1. Ranitidine Bismutrex

2. Tritec

3. Gr 122311x

4. Gr-122311x

5. 7aj51i17kg

6. 128345-62-0

7. Ranitidine (bismuth Citrate)

8. Azamplus

9. Elicodil

10. Helirad

11. Pylorisan

12. Unii-7aj51i17kg

13. Ranitidine Bismuth Citrate [usan]

14. Ranitidine Bismuth Citrate [usan:ban]

15. Schembl415304

16. Chembl2111286

17. Dtxsid801027716

18. Ranitidine Bismuth Citrate [mi]

19. N-(2-((5-((dimethylamino)methyl)furfuryl)thio)ethyl)-n'-methyl-2-nitro-1,1-ethenediamine, Compound With Bismuth(3(+)) Citrate (1:1)

20. Ranitidine Bismuth Citrate [vandf]

21. Ranitidine Bismuth Citrate [mart.]

22. Ranitidine Bismuth Citrate [who-dd]

23. Ranitidine Bismuth Citrate [orange Book]

24. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Bismuth(3(+)) Salt (1:1), Compd. With N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-n'-methyl-2-nitro-1,1-ethenediamine (1:1)

25. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Bismuth(3+) Salt (1:1), Compd. With N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-n'-methyl-2-nitro-1,1-ethenediamine (1:1)

26. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Bismuth(3+) Salt, Compd. With N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-n'-methyl-2-nitro-1,1-ethenediamine (1:1:1)

27. N-(2-((5-((dimethylamino)methyl)furfuryl)thio)ethyl)-n'-methyl-2-nitro-1,1-ethenediamine, Compound With Bismuth(3+) Citrate (1:1)

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 712.5 g/mol
Molecular Formula C19H27BiN4O10S
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count14
Rotatable Bond Count11
Exact Mass712.12519 g/mol
Monoisotopic Mass712.12519 g/mol
Topological Polar Surface Area252 Ų
Heavy Atom Count35
Formal Charge0
Complexity558
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count1
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Histamine H2 Antagonists

Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood. (See all compounds classified as Histamine H2 Antagonists.)


Anti-Ulcer Agents

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)


4.2 ATC Code

A - Alimentary tract and metabolism

A02 - Drugs for acid related disorders

A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)

A02BA - H2-receptor antagonists

A02BA07 - Ranitidine bismuth citrate


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ABOUT THIS PAGE

Ranitidine Bismuth Citrate Manufacturers

A Ranitidine Bismuth Citrate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ranitidine Bismuth Citrate, including repackagers and relabelers. The FDA regulates Ranitidine Bismuth Citrate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ranitidine Bismuth Citrate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Ranitidine Bismuth Citrate Suppliers

A Ranitidine Bismuth Citrate supplier is an individual or a company that provides Ranitidine Bismuth Citrate active pharmaceutical ingredient (API) or Ranitidine Bismuth Citrate finished formulations upon request. The Ranitidine Bismuth Citrate suppliers may include Ranitidine Bismuth Citrate API manufacturers, exporters, distributors and traders.

Ranitidine Bismuth Citrate GMP

Ranitidine Bismuth Citrate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ranitidine Bismuth Citrate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ranitidine Bismuth Citrate GMP manufacturer or Ranitidine Bismuth Citrate GMP API supplier for your needs.

Ranitidine Bismuth Citrate CoA

A Ranitidine Bismuth Citrate CoA (Certificate of Analysis) is a formal document that attests to Ranitidine Bismuth Citrate's compliance with Ranitidine Bismuth Citrate specifications and serves as a tool for batch-level quality control.

Ranitidine Bismuth Citrate CoA mostly includes findings from lab analyses of a specific batch. For each Ranitidine Bismuth Citrate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ranitidine Bismuth Citrate may be tested according to a variety of international standards, such as European Pharmacopoeia (Ranitidine Bismuth Citrate EP), Ranitidine Bismuth Citrate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ranitidine Bismuth Citrate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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