Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood. (See all compounds classified as Histamine H2 Antagonists.)

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

Molecular Formula	C₁₃H₂₃ClN₄O₃S
Molecular Weight	350.87 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	9
Exact Mass	350.1179395 g/mol
Monoisotopic Mass	350.1179395 g/mol
Topological Polar Surface Area	112 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	347
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

1 of 10
Drug Name	Ranitidine hydrochloride
Active Ingredient	Ranitidine hydrochloride
Dosage Form	Tablet; Syrup; Capsule; Injectable
Route	Injection; Oral
Strength	eq 150mg base; eq 15mg base/ml; eq 75mg base; 25mg/ml; eq 300mg base; eq 25mg base/ml
Market Status	Over the Counter; Prescription
Company	Vintage Pharms; Amneal Pharms; Wockhardt; Silarx; Breckenridge Pharm; Teva; Pharm Assoc; Apotex; Torpharm; Shasun Chems; Taro; Sandoz; Par Pharm; Perrigo R And D; Svads Holdings Sa; Glenmark Generics; Amneal Pharms Ny; Ivax Sub Teva Pharms; Hi Tech Pharma

2 of 10
Drug Name	Zantac
PubMed Health	Ranitidine (Injection)
Drug Classes	Antiulcer, Gastric Acid Secretion Inhibitor
Drug Label	The active ingredient in ZANTAC 150 Tablets, ZANTAC 300 Tablets, and ZANTAC Syrup is ranitidine hydrochloride (HCl), USP, a histamine H2-receptor antagonist. Chemically it is N[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N-methyl-2...
Active Ingredient	Ranitidine hydrochloride
Dosage Form	Syrup; Injectable
Route	Injection; Oral
Strength	eq 15mg base/ml; eq 25mg base/ml
Market Status	Prescription
Company	Covis Injectables; Glaxo Grp

3 of 10
Drug Name	Zantac 150
PubMed Health	Ranitidine
Drug Classes	Antiulcer, Gastric Acid Secretion Inhibitor
Drug Label	The active ingredient in ZANTAC 150 Tablets, ZANTAC 300 Tablets, and ZANTAC Syrup is ranitidine hydrochloride (HCl), USP, a histamine H2-receptor antagonist. Chemically it is N[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N-methyl-2...
Active Ingredient	Ranitidine hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	eq 150mg base
Market Status	Over the Counter; Prescription
Company	Boehringer Ingelheim; Glaxo Grp

4 of 10
Drug Name	Zantac 300
Active Ingredient	Ranitidine hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	eq 300mg base
Market Status	Prescription
Company	Glaxo Grp

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

40 API Suppliers

32 USDMF

14 CEP/COS

2 JDMF

5 EU WC

47 KDMF

11 NDC API

7 Listed Suppliers

$ API Reference Price

INTERMEDIATES

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

169 FDF Dossiers

121 FDA Orange Book

21 Europe

8 Canada

19 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - EQ 150MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET;ORAL - EQ 300MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

INJECTABLE;INJECTION - EQ 25MG BASE/ML

TABLET;ORAL - EQ 75MG BASE

TABLET;ORAL - EQ 150MG BASE

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EXCIPIENTS BY APPLICATIONS

72 Fillers, Diluents & Binders

49 Coating Systems & Additives

30 Direct Compression

TABLET;ORAL - EQ 150MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET;ORAL - EQ 300MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons