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Rapacuronium

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ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 USDMF

1 API Suppliers
1 USDMF

FINISHED DOSAGE FORMULATIONS

2 FDF Dossiers, 2 FDA Orange Book

2 FDF Dossiers
2 FDA Orange Book

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Raplon, 156137-99-4, Org 9487, Org-9487, 156137-99-4 (bromide), 65q4qdg4kc

Molecular Formula

C₃₇H₆₁BrN₂O₄

Molecular Weight

677.8 g/mol

InChI Key

LVQTUXZKLGXYIU-GWSNJHLMSA-M

FDA UNII

65Q4QDG4KC

1 2D Structure

Rapacuronium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-acetyloxy-10,13-dimethyl-2-piperidin-1-yl-16-(1-prop-2-enylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate;bromide

2.1.2 InChI

InChI=1S/C37H61N2O4.BrH/c1-6-20-39(21-12-9-13-22-39)32-24-30-28-15-14-27-23-33(42-26(3)40)31(38-18-10-8-11-19-38)25-37(27,5)29(28)16-17-36(30,4)35(32)43-34(41)7-2;/h6,27-33,35H,1,7-25H2,2-5H3;1H/q+1;/p-1/t27-,28+,29-,30-,31-,32-,33-,35-,36-,37-;/m0./s1

2.1.3 InChI Key

LVQTUXZKLGXYIU-GWSNJHLMSA-M

2.1.4 Canonical SMILES

CCC(=O)OC1C(CC2C1(CCC3C2CCC4C3(CC(C(C4)OC(=O)C)N5CCCCC5)C)C)[N+]6(CCCCC6)CC=C.[Br-]

2.1.5 Isomeric SMILES

CCC(=O)O[C@H]1[C@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(C[C@@H]([C@H](C4)OC(=O)C)N5CCCCC5)C)C)[N+]6(CCCCC6)CC=C.[Br-]

2.2 Other Identifiers

2.2.1 UNII

65Q4QDG4KC

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Org 9487

2. Org-9487

3. Rapacuronium

4. Raplon

2.3.2 Depositor-Supplied Synonyms

1. Raplon

2. 156137-99-4

3. Org 9487

4. Org-9487

5. 156137-99-4 (bromide)

6. 65q4qdg4kc

7. 1-((2s,3s,5s,8r,9s,10s,13s,14s,16s,17r)-3-acetoxy-10,13-dimethyl-2-(piperidin-1-yl)-17-(propionyloxy)hexadecahydro-1h-cyclopenta[a]phenanthren-16-yl)-1-allylpiperidin-1-ium Bromide

8. Raplon (tn)

9. Ncgc00183839-01

10. Unii-65q4qdg4kc

11. Rapacuronium Bromide [usan:inn:ban]

12. Dsstox_cid_28749

13. Dsstox_rid_83018

14. Dsstox_gsid_48823

15. Schembl41132

16. 1-(3alpha-acetoxy-2beta-(1-piperidinyl)-17beta-(propionyloxy)-5alpha-androsta-16beta-yl)-1-allylpiperidinium Bromide

17. Chembl1200549

18. Dtxsid7048823

19. Rapacuronium Bromide [mi]

20. Rapacuronium Bromide (usan/inn)

21. Rapacuronium Bromide [inn]

22. Rapacuronium Bromide [usan]

23. Rapacuronium Bromide [vandf]

24. Tox21_113304

25. Rapacuronium Bromide [mart.]

26. Rapacuronium Bromide [who-dd]

27. Cs-6564

28. 1-allyl-1-(3alpha,17beta-dihydroxy-2beta-piperidino-5alpha-androstan-16beta-yl)piperidinium Bromide, 3-acetate 17-propionate

29. Hy-16423

30. Piperidinium, 1-((2beta,3alpha,5alpha,16beta,17beta)-3-(acetyloxy)-17-(1-oxopropoxy)-2-(1-piperidinyl)androstan-16-yl)-1-(2-propenyl)-, Bromide

31. Rapacuronium Bromide [orange Book]

32. Cas-156137-99-4

33. D05703

34. Q3419354

35. [(2s,3s,5s,8r,9s,10s,13s,14s,16s,17r)-3-acetyloxy-10,13-dimethyl-2-piperidin-1-yl-16-(1-prop-2-enylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl] Propanoate;bromide

36. 1-allyl-1-(3.alpha.,17.beta.-dihydroxy-2.beta.-piperidino-5.alpha.-androstan-16.beta.-yl)piperidinium Bromide, 3-acetate 17-propionate

2.4 Create Date

2005-12-16

3 Chemical and Physical Properties

Molecular Formula	C₃₇H₆₁BrN₂O₄
Molecular Weight	677.8 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	9
Exact Mass	676.38147 g/mol
Monoisotopic Mass	676.38147 g/mol
Topological Polar Surface Area	55.8 Å²
Heavy Atom Count	44
Formal Charge	0
Complexity	1030
Isotope Atom Count	0
Defined Atom Stereocenter Count	10
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Neuromuscular Nondepolarizing Agents

Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants. (See all compounds classified as Neuromuscular Nondepolarizing Agents.)

API SUPPLIERS

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USDMF

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FDF Dossiers

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FDA Orange Book

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ABOUT THIS PAGE

Rapacuronium Manufacturers

A Rapacuronium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Rapacuronium, including repackagers and relabelers. The FDA regulates Rapacuronium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Rapacuronium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Rapacuronium Suppliers

A Rapacuronium supplier is an individual or a company that provides Rapacuronium active pharmaceutical ingredient (API) or Rapacuronium finished formulations upon request. The Rapacuronium suppliers may include Rapacuronium API manufacturers, exporters, distributors and traders.

click here to find a list of Rapacuronium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Rapacuronium USDMF

A Rapacuronium DMF (Drug Master File) is a document detailing the whole manufacturing process of Rapacuronium active pharmaceutical ingredient (API) in detail. Different forms of Rapacuronium DMFs exist exist since differing nations have different regulations, such as Rapacuronium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Rapacuronium DMF submitted to regulatory agencies in the US is known as a USDMF. Rapacuronium USDMF includes data on Rapacuronium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Rapacuronium USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Rapacuronium suppliers with USDMF on PharmaCompass.

Rapacuronium GMP

Rapacuronium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Rapacuronium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Rapacuronium GMP manufacturer or Rapacuronium GMP API supplier for your needs.

Rapacuronium CoA

A Rapacuronium CoA (Certificate of Analysis) is a formal document that attests to Rapacuronium's compliance with Rapacuronium specifications and serves as a tool for batch-level quality control.

Rapacuronium CoA mostly includes findings from lab analyses of a specific batch. For each Rapacuronium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Rapacuronium may be tested according to a variety of international standards, such as European Pharmacopoeia (Rapacuronium EP), Rapacuronium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Rapacuronium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.