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Chemistry

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Also known as: 182760-06-1, Er-30346, Bms-207147, Er 30346, Bms 207147, Ravuconazole [inn]
Molecular Formula
C22H17F2N5OS
Molecular Weight
437.5  g/mol
InChI Key
OPAHEYNNJWPQPX-RCDICMHDSA-N
FDA UNII
95YH599JWV

Ravuconazole
Ravuconazole is a triazole with antifungal activity. Ravuconazole inhibits 14a demethylase, an enzyme involved in sterol synthesis, resulting in lysis of the fungal cell wall and fungal cell death. (NCI04)
1 2D Structure

Ravuconazole

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile
2.1.2 InChI
InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-7-6-17(23)8-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1
2.1.3 InChI Key
OPAHEYNNJWPQPX-RCDICMHDSA-N
2.1.4 Canonical SMILES
CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(CN3C=NC=N3)(C4=C(C=C(C=C4)F)F)O
2.1.5 Isomeric SMILES
C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=NC=N3)(C4=C(C=C(C=C4)F)F)O
2.2 Other Identifiers
2.2.1 UNII
95YH599JWV
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1h-1,2,4-triazol-1-yl)-2-butanol

2. Bms-207147

3. Er 30346

4. Er-30346

2.3.2 Depositor-Supplied Synonyms

1. 182760-06-1

2. Er-30346

3. Bms-207147

4. Er 30346

5. Bms 207147

6. Ravuconazole [inn]

7. 95yh599jwv

8. 4-[2-[(2r,3r)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile

9. 194798-96-4

10. P-(2-((alphar,betar)-2,4-difluoro-beta-hydroxy-alpha-methyl-beta-(1h-1,2,4-triazol-1-ylmethyl)phenethyl)-4-thiazolyl)benzonitrile

11. Rcz

12. 4-(2-((2r,3r)-rel-3-(2,4-difluorophenyl)-3-hydroxy-4-(1h-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile

13. 4-[2-[(1r,2r)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1,2,4-triazol-1-yl)propyl]thiazol-4-yl]benzonitrile

14. Benzonitrile, 4-[2-[(1r,2r)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1h-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-

15. Ravuconazol

16. Ravuconazolum

17. Unii-95yh599jwv

18. Benzonitrile, 4-(2-((1r,2r)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1h-1,2,4-triazol-1-yl)propyl)-4-thiazolyl)-

19. Ravuconazole (prop.inn)

20. Ravuconazole [mi]

21. Bms-207147/ravuconazole

22. Ravuconazole [mart.]

23. Ravuconazole [who-dd]

24. Schembl939026

25. Chembl294029

26. Dtxsid40171329

27. Chebi:143825

28. Zinc600547

29. Bcp05803

30. Ex-a3369

31. Bdbm50011476

32. Bms-20714

33. Mfcd00941002

34. Akos015962202

35. Bcp9000424

36. Cs-6927

37. Db06440

38. Bms-207,147

39. 3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1h-1,2,4-triazol-1-yl)-2-butanol

40. 4-[2-[(1r,2r)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1h-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile

41. Hy-14272

42. D02556

43. A855884

44. Q7296826

45. Bms 207147;er 30346;bms207147;er30346;bms-207147;er-30346

46. (1r,2r)-4-[2-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]thiazol-4-yl]benzonitrile

47. (2r,3r)-3-[4-(4-cyanophenyl)thiazol-2-yl]-1-(1h-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-butan-2-ol

48. (2r,3r)-3-[4-(4-cyanophenyl)thiazol-2-yl]-2-(2,4-difluorophenyl)-1-(1h-1,2,4-triazol-1-yl)butan-2-ol

49. 4-(2-((2r,3r)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1h-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile

50. 4-[2-[(2r,3r)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b Utan-2-yl]-1,3-thiazol-4-yl]benzonitrile

51. Benzonitrile, 4-[2-[(1r,2r)-2-(2,4-difluro-phenyl)-2-hydroxy-1-methyl-3-(1h-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-

52. Benzonitrile, 4-[2-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1h-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-, [r-(r*,r*)]-

2.4 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 437.5 g/mol
Molecular Formula C22H17F2N5OS
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass437.11218768 g/mol
Monoisotopic Mass437.11218768 g/mol
Topological Polar Surface Area116 Ų
Heavy Atom Count31
Formal Charge0
Complexity657
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in fungal infections, aspergillosis, candidiasis, and onychomycosis.


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11-Jan-2021
07-Mar-2023
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ABOUT THIS PAGE

Ravuconazole Manufacturers

A Ravuconazole manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ravuconazole, including repackagers and relabelers. The FDA regulates Ravuconazole manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ravuconazole API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Ravuconazole manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Ravuconazole Suppliers

A Ravuconazole supplier is an individual or a company that provides Ravuconazole active pharmaceutical ingredient (API) or Ravuconazole finished formulations upon request. The Ravuconazole suppliers may include Ravuconazole API manufacturers, exporters, distributors and traders.

click here to find a list of Ravuconazole suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Ravuconazole GMP

Ravuconazole Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ravuconazole GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ravuconazole GMP manufacturer or Ravuconazole GMP API supplier for your needs.

Ravuconazole CoA

A Ravuconazole CoA (Certificate of Analysis) is a formal document that attests to Ravuconazole's compliance with Ravuconazole specifications and serves as a tool for batch-level quality control.

Ravuconazole CoA mostly includes findings from lab analyses of a specific batch. For each Ravuconazole CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ravuconazole may be tested according to a variety of international standards, such as European Pharmacopoeia (Ravuconazole EP), Ravuconazole JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ravuconazole USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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