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Razuprotafib

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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Synopsis

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Chemistry

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Also known as: 1008510-37-9, Akb-9778, Razuprotafib [inn], Razuprotafib [usan], 0wax4ut396, Razuprotafib (usan)

Molecular Formula

C₂₆H₂₆N₄O₆S₃

Molecular Weight

586.7 g/mol

InChI Key

KWJDHELCGJFUHW-SFTDATJTSA-N

FDA UNII

0WAX4UT396

Razuprotafib is a small molecule inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP), with potential vasculature stabilizing activity. Upon administration, razuprotafib targets, binds to and inhibits VE-PTP, which is a negative regulator of the endothelial cell (EC)-specific receptor tyrosine kinase (RTK) Tie2. This restores Tie2 activation, which may improve endothelial function and stabilize blood vessels. VE-PTP is upregulated in stressed endothelium associated with a variety of diseases. Tie2 plays an important role in endothelial function and vascular stability. A decrease in Tie2 activation leads to vascular leakage and inflammation.

1 2D Structure

Razuprotafib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[4-[(2S)-2-[[(2S)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-(2-thiophen-2-yl-1,3-thiazol-4-yl)ethyl]phenyl]sulfamic acid

2.1.2 InChI

InChI=1S/C26H26N4O6S3/c1-36-26(32)29-21(15-17-6-3-2-4-7-17)24(31)27-20(22-16-38-25(28-22)23-8-5-13-37-23)14-18-9-11-19(12-10-18)30-39(33,34)35/h2-13,16,20-21,30H,14-15H2,1H3,(H,27,31)(H,29,32)(H,33,34,35)/t20-,21-/m0/s1

2.1.3 InChI Key

KWJDHELCGJFUHW-SFTDATJTSA-N

2.1.4 Canonical SMILES

COC(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CC=C(C=C2)NS(=O)(=O)O)C3=CSC(=N3)C4=CC=CS4

2.1.5 Isomeric SMILES

COC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)NS(=O)(=O)O)C3=CSC(=N3)C4=CC=CS4

2.2 Other Identifiers

2.2.1 UNII

0WAX4UT396

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Akb-9778

2.3.2 Depositor-Supplied Synonyms

1. 1008510-37-9

2. Akb-9778

3. Razuprotafib [inn]

4. Razuprotafib [usan]

5. 0wax4ut396

6. Razuprotafib (usan)

7. [4-[(2s)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-(2-thiophen-2-yl-1,3-thiazol-4-yl)ethyl]phenyl]sulfamic Acid

8. Carbamic Acid, N-((1s)-2-oxo-1-(phenylmethyl)-2-(((1s)-2-(4-(sulfoamino)phenyl)-1-(2-(2-thienyl)-4-thiazolyl)ethyl)amino)ethyl)-, C-methyl Ester

9. N-(4-{(2s)-2-{(2s)-2-[(methoxycarbonyl)amino]-3-phenylpropanamido}-2-[2-(thiophen-2-yl)-1,3-thiazol-4-yl]ethyl}phenyl)sulfamic Acid

10. Razuprotafib [usan:inn]

11. Unii-0wax4ut396

12. Razuprotafib [who-dd]

13. Schembl679459

14. Chembl3931971

15. Gtpl11336

16. Akb9778

17. Bdbm359124

18. Us10220048, Compound Aa34

19. Who 10271

20. Compound Aa34 [us10220048]

21. At18581

22. Hy-109041

23. Cs-0031483

24. D11540

25. N-(4-((2s)-2-((2s)-2-((methoxycarbonyl)amino)- 3-phenylpropanamido)-2-(2-(thiophen-2-yl)-1,3-thiazol4-yl)ethyl)phenyl)sulfamic Acid

2.4 Create Date

2010-07-26

3 Chemical and Physical Properties

Molecular Formula	C₂₆H₂₆N₄O₆S₃
Molecular Weight	586.7 g/mol
XLogP3	3.7
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	12
Exact Mass	586.10144808 g/mol
Monoisotopic Mass	586.10144808 g/mol
Topological Polar Surface Area	212 Å²
Heavy Atom Count	39
Formal Charge	0
Complexity	906
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 Mechanism of Action

Razuprotafib inhibits [VE-PTP](https://go.drugbank.com/bio_entities/BE0003769) (a negative regulator of Tie2 in diseased blood vessels) by binding and inhibiting the intracellular catalytic domain of VE-PTP that inactivates Tie2. This in turn allows razuprotafib to restore Tie2 activation to allow for enhancement of endothelial function and stabilization of blood vessels. Razuprotafib is being investigated against diabetic vascular complications and acute respiratory distress syndrome (ARDS) in COVID-19.

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ABOUT THIS PAGE

Razuprotafib Manufacturers

A Razuprotafib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Razuprotafib, including repackagers and relabelers. The FDA regulates Razuprotafib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Razuprotafib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Razuprotafib Suppliers

A Razuprotafib supplier is an individual or a company that provides Razuprotafib active pharmaceutical ingredient (API) or Razuprotafib finished formulations upon request. The Razuprotafib suppliers may include Razuprotafib API manufacturers, exporters, distributors and traders.

Razuprotafib GMP

Razuprotafib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Razuprotafib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Razuprotafib GMP manufacturer or Razuprotafib GMP API supplier for your needs.

Razuprotafib CoA

A Razuprotafib CoA (Certificate of Analysis) is a formal document that attests to Razuprotafib's compliance with Razuprotafib specifications and serves as a tool for batch-level quality control.

Razuprotafib CoA mostly includes findings from lab analyses of a specific batch. For each Razuprotafib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Razuprotafib may be tested according to a variety of international standards, such as European Pharmacopoeia (Razuprotafib EP), Razuprotafib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Razuprotafib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.