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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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NDC API

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0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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Chemistry

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Also known as: 1020172-07-9, Dcc-2036, Dcc-2036 (rebastinib), Dcc 2036, Dcc2036, Rebastinib [usan]
Molecular Formula
C30H28FN7O3
Molecular Weight
553.6  g/mol
InChI Key
WVXNSAVVKYZVOE-UHFFFAOYSA-N
FDA UNII
75017Q6I97

Rebastinib
Rebastinib is an orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity. Upon oral administration, rebastinib binds to and inhibits the Bcr-Abl fusion oncoprotein by changing the conformation of the folded protein to disallow ligand-dependent and ligand-independent activation; in addition, this agent binds to and inhibits Src family kinases LYN, HCK and FGR and the receptor tyrosine kinases TIE-2 and VEGFR-2. Rebastinib may exhibit more potent activity against T315I Bcr-Abl gatekeeper mutant kinases than other Bcr-Abl kinase inhibitors. The TIE-2 and VEGFR-2 receptor tyrosine kinases regulate angiogenesis, respectively, while the Src family kinases Abl, LYN, and HCK Src regulate a variety of cellular responses including differentiation, division, adhesion, and the stress response.
1 2D Structure

Rebastinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
2.1.2 InChI
InChI=1S/C30H28FN7O3/c1-30(2,3)26-17-27(38(37-26)19-7-9-23-18(14-19)6-5-12-33-23)36-29(40)35-24-10-8-20(15-22(24)31)41-21-11-13-34-25(16-21)28(39)32-4/h5-17H,1-4H3,(H,32,39)(H2,35,36,40)
2.1.3 InChI Key
WVXNSAVVKYZVOE-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)(C)C1=NN(C(=C1)NC(=O)NC2=C(C=C(C=C2)OC3=CC(=NC=C3)C(=O)NC)F)C4=CC5=C(C=C4)N=CC=C5
2.2 Other Identifiers
2.2.1 UNII
75017Q6I97
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-(3-fluoro-4-(((3-(2-methyl-2-propanyl)-1-(6-quinolinyl)-1h-pyrazol-5-yl)carbamoyl)amino)phenoxy)-n-methyl-2-pyridinecarboxamide

2.3.2 Depositor-Supplied Synonyms

1. 1020172-07-9

2. Dcc-2036

3. Dcc-2036 (rebastinib)

4. Dcc 2036

5. Dcc2036

6. Rebastinib [usan]

7. 4-(4-(3-(3-(tert-butyl)-1-(quinolin-6-yl)-1h-pyrazol-5-yl)ureido)-3-fluorophenoxy)-n-methylpicolinamide

8. Chebi:62166

9. Dp-1919

10. Dcc-2036 Free Base

11. Rebastinib (usan)

12. 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide

13. 4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide

14. N-[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]-n'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea

15. 75017q6i97

16. 1-[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]-3-{2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yloxy]phenyl}urea

17. 4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide,4-methylbenzenesulfonic Acid;4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]-n-methylpyridine-2-carboxamide,4-methylbenzenesulfonic Acid

18. Rebastinib [usan:inn]

19. 3qri

20. 3qrj

21. Unii-75017q6i97

22. 2-pyridinecarboxamide, 4-(4-((((3-(1,1-dimethylethyl)-1-(6-quinolinyl)-1h-pyrazol-5-yl)amino)carbonyl)amino)-3-fluorophenoxy)-n-methyl-

23. 2-pyridinecarboxamide, 4-[4-[[[[3-(1,1-dimethylethyl)-1-(6-quinolinyl)-1h-pyrazol-5-yl]amino]carbonyl]amino]-3-fluorophenoxy]-n-methyl-

24. Dp 1919

25. Rebastinib [inn]

26. Dcc-2036; Rebastinib

27. Rebastinib(dcc-2036)

28. Rebastinib [who-dd]

29. Mls006011270

30. Gtpl9173

31. Schembl2034290

32. Chembl1738757

33. Dtxsid40144533

34. Bdbm185674

35. Hms3656h07

36. Hms3672i07

37. Amy39865

38. Bcp02345

39. Ex-a2046

40. Mfcd19443646

41. Nsc774831

42. Nsc800863

43. S2634

44. Zinc63933734

45. Akos025404839

46. Bcp9000591

47. Ccg-264972

48. Cs-1038

49. Db13005

50. Nsc-774831

51. Nsc-800863

52. Sb16618

53. Ncgc00263172-01

54. Ncgc00263172-09

55. 4-(4-(3-(3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl)ureido)-3-fluorophenoxy)-n-methylpicolinamide

56. Ac-30301

57. As-17048

58. Da-34916

59. Hy-13024

60. Smr004703020

61. Ft-0760974

62. Sw219251-1

63. J3.653.310b

64. D10334

65. Q27088522

66. 4-(3-fluoro-4-(((3-(2-methyl-2-propanyl)-1-(6-quinolinyl)-1h-pyrazol-5-yl)carbamoyl)amino)phenoxy)-n-methyl-2-pyridinecarboxamide

67. 4-(4-(((3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl)carbamoyl(amino)-3-fluorophenoxy)-n-methylpyridin-2-carboxamide

68. N-(3-(1,1-dimethylethyl)-1-(quinolin-6-yl)-1h-pyrazol-5-yl)-n'-(2-fluoro-4-((2- (methylcarbamoyl)pyridin-4-yl)oxy)phenyl)urea

2.4 Create Date
2008-12-01
3 Chemical and Physical Properties
Molecular Weight 553.6 g/mol
Molecular Formula C30H28FN7O3
XLogP34.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass553.22376594 g/mol
Monoisotopic Mass553.22376594 g/mol
Topological Polar Surface Area123 Ų
Heavy Atom Count41
Formal Charge0
Complexity904
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)


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ABOUT THIS PAGE

Looking for 1020172-07-9 / Rebastinib API manufacturers, exporters & distributors?

Rebastinib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Rebastinib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Rebastinib manufacturer or Rebastinib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Rebastinib manufacturer or Rebastinib supplier.

PharmaCompass also assists you with knowing the Rebastinib API Price utilized in the formulation of products. Rebastinib API Price is not always fixed or binding as the Rebastinib Price is obtained through a variety of data sources. The Rebastinib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Rebastinib

Synonyms

1020172-07-9, Dcc-2036, Dcc-2036 (rebastinib), Dcc 2036, Dcc2036, Rebastinib [usan]

Cas Number

1020172-07-9

Unique Ingredient Identifier (UNII)

75017Q6I97

About Rebastinib

Rebastinib is an orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity. Upon oral administration, rebastinib binds to and inhibits the Bcr-Abl fusion oncoprotein by changing the conformation of the folded protein to disallow ligand-dependent and ligand-independent activation; in addition, this agent binds to and inhibits Src family kinases LYN, HCK and FGR and the receptor tyrosine kinases TIE-2 and VEGFR-2. Rebastinib may exhibit more potent activity against T315I Bcr-Abl gatekeeper mutant kinases than other Bcr-Abl kinase inhibitors. The TIE-2 and VEGFR-2 receptor tyrosine kinases regulate angiogenesis, respectively, while the Src family kinases Abl, LYN, and HCK Src regulate a variety of cellular responses including differentiation, division, adhesion, and the stress response.

Rebastinib Manufacturers

A Rebastinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Rebastinib, including repackagers and relabelers. The FDA regulates Rebastinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Rebastinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Rebastinib Suppliers

A Rebastinib supplier is an individual or a company that provides Rebastinib active pharmaceutical ingredient (API) or Rebastinib finished formulations upon request. The Rebastinib suppliers may include Rebastinib API manufacturers, exporters, distributors and traders.

Rebastinib GMP

Rebastinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Rebastinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Rebastinib GMP manufacturer or Rebastinib GMP API supplier for your needs.

Rebastinib CoA

A Rebastinib CoA (Certificate of Analysis) is a formal document that attests to Rebastinib's compliance with Rebastinib specifications and serves as a tool for batch-level quality control.

Rebastinib CoA mostly includes findings from lab analyses of a specific batch. For each Rebastinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Rebastinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Rebastinib EP), Rebastinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Rebastinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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