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Chemistry

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Also known as: 946150-57-8, Remetinostat [usan], Shp-141, Methylparaben suberohydroxamic acid phenyl ester, Methyl 4-((8-(hydroxyamino)-8-oxooctanoyl)oxy)benzoate, Nsc-748492
Molecular Formula
C16H21NO6
Molecular Weight
323.34  g/mol
InChI Key
XDZAHHULFQIBFE-UHFFFAOYSA-N
FDA UNII
37NT056AT4

Remetinostat
Remetinostat is a topical formulation containing the histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Upon cutaneous administration, SHP-141 selectively binds to and inhibits HDAC, resulting in an accumulation of highly acetylated histones in the skin (dermis and epidermis), the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes. These events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins. Topical administration of SHP-141 allows for high concentrations of this agent locally while minimizing systemic toxicity.
1 2D Structure

Remetinostat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
methyl 4-[8-(hydroxyamino)-8-oxooctanoyl]oxybenzoate
2.1.2 InChI
InChI=1S/C16H21NO6/c1-22-16(20)12-8-10-13(11-9-12)23-15(19)7-5-3-2-4-6-14(18)17-21/h8-11,21H,2-7H2,1H3,(H,17,18)
2.1.3 InChI Key
XDZAHHULFQIBFE-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC(=O)C1=CC=C(C=C1)OC(=O)CCCCCCC(=O)NO
2.2 Other Identifiers
2.2.1 UNII
37NT056AT4
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Methyl 4-(8-(hydroxyamino)-8-oxooctanoyl)oxybenzoate

2.3.2 Depositor-Supplied Synonyms

1. 946150-57-8

2. Remetinostat [usan]

3. Shp-141

4. Methylparaben Suberohydroxamic Acid Phenyl Ester

5. Methyl 4-((8-(hydroxyamino)-8-oxooctanoyl)oxy)benzoate

6. Nsc-748492

7. 37nt056at4

8. Benzoic Acid, 4-((8-(hydroxyamino)-1,8-dioxooctyl)oxy)-, Methyl Ester

9. Methyl 4-{[8-(hydroxyamino)-8-oxooctanoyl]oxy}benzoate

10. Unii-37nt056at4

11. Remetinostat (usan/inn)

12. Remetinostat [inn]

13. Remetinostat [who-dd]

14. Methyl 4-[8-(hydroxyamino)-8-oxooctanoyl]oxybenzoate

15. Chembl3707219

16. Schembl12682510

17. Dtxsid20647779

18. Shp-141shp-141

19. Bcp30561

20. Ex-a3219

21. Wmb15057

22. Nsc748492

23. Akos037649302

24. Db14869

25. Nsc 748492

26. Bs-17956

27. Db-088836

28. Hy-100365

29. Cs-0018698

30. D10977

31. Shp-141; Shp 141; Shp141; Shape

32. Q27256692

33. Benzoic Acid,8-dioxooctyl]oxy]-, Methyl Ester (mp-shape)

2.4 Create Date
2008-08-25
3 Chemical and Physical Properties
Molecular Weight 323.34 g/mol
Molecular Formula C16H21NO6
XLogP32
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count11
Exact Mass323.13688739 g/mol
Monoisotopic Mass323.13688739 g/mol
Topological Polar Surface Area102 Ų
Heavy Atom Count23
Formal Charge0
Complexity390
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Remetinostat Manufacturers

A Remetinostat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Remetinostat, including repackagers and relabelers. The FDA regulates Remetinostat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Remetinostat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Remetinostat Suppliers

A Remetinostat supplier is an individual or a company that provides Remetinostat active pharmaceutical ingredient (API) or Remetinostat finished formulations upon request. The Remetinostat suppliers may include Remetinostat API manufacturers, exporters, distributors and traders.

Remetinostat GMP

Remetinostat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Remetinostat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Remetinostat GMP manufacturer or Remetinostat GMP API supplier for your needs.

Remetinostat CoA

A Remetinostat CoA (Certificate of Analysis) is a formal document that attests to Remetinostat's compliance with Remetinostat specifications and serves as a tool for batch-level quality control.

Remetinostat CoA mostly includes findings from lab analyses of a specific batch. For each Remetinostat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Remetinostat may be tested according to a variety of international standards, such as European Pharmacopoeia (Remetinostat EP), Remetinostat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Remetinostat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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