DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

Virtual Booth

Contact Supplier

Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

$ API Reference Price

$ API Reference Price

DEVELOPMENTS

4 Drugs in Development

4 Drugs in Development

DIGITAL CONTENT

1 STOCK RECAP #PipelineProspector, 1 NEWS #PharmaBuzz

media
1 STOCK RECAP #PipelineProspector
1 NEWS #PharmaBuzz

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 3,782

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

4DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 1787294-07-8, Remibrutinib [inn], Lou064, Remibrutinib [usan], I7mvz8hdnu, Remibrutinib (lou064)

Molecular Formula

C₂₇H₂₇F₂N₅O₃

Molecular Weight

507.5 g/mol

InChI Key

CUABMPOJOBCXJI-UHFFFAOYSA-N

FDA UNII

I7MVZ8HDNU

1 2D Structure

Remibrutinib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[3-[6-amino-5-[2-[methyl(prop-2-enoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide

2.1.2 InChI

InChI=1S/C27H27F2N5O3/c1-4-23(35)34(3)9-10-37-25-24(31-14-32-26(25)30)20-12-18(28)13-22(15(20)2)33-27(36)19-8-7-17(11-21(19)29)16-5-6-16/h4,7-8,11-14,16H,1,5-6,9-10H2,2-3H3,(H,33,36)(H2,30,31,32)

2.1.3 InChI Key

CUABMPOJOBCXJI-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=C(C=C(C=C1NC(=O)C2=C(C=C(C=C2)C3CC3)F)F)C4=C(C(=NC=N4)N)OCCN(C)C(=O)C=C

2.2 Other Identifiers

2.2.1 UNII

I7MVZ8HDNU

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Lou064

2. N-(3-(6-amino-5-(2-(methyl(prop-2-enoyl)amino)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide

2.3.2 Depositor-Supplied Synonyms

1. 1787294-07-8

2. Remibrutinib [inn]

3. Lou064

4. Remibrutinib [usan]

5. I7mvz8hdnu

6. Remibrutinib (lou064)

7. Nvp-lou064-nxa

8. Lou064-nxa

9. N-(3-(6-amino-5-(2-(n-methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide

10. N-[3-[6-amino-5-[2-[methyl(1-oxo-2-propen-1-yl)amino]ethoxy]-4-pyrimidinyl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide

11. N-[3-[6-amino-5-[2-[methyl(prop-2-enoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide

12. Benzamide, N-(3-(6-amino-5-(2-(methyl(1-oxo-2-propen-1-yl)amino)ethoxy)-4-pyrimidinyl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluoro-

13. Unii-i7mvz8hdnu

14. Chembl4483575

15. Schembl16754888

16. Gtpl10457

17. Lou-064

18. Ex-a3421

19. S9660

20. Who 11062

21. Example 6 [wo2015079417a1]

22. Compound 25 [pmid: 32083858]

23. Ac-36985

24. Hy-128757

25. Cs-0103905

26. Us9512084, 6

27. A930622

28. Lou-064;n-(3-(6-amino-5-(2-(n-methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide

2.4 Create Date

2016-02-23

3 Chemical and Physical Properties

Molecular Formula	C₂₇H₂₇F₂N₅O₃
Molecular Weight	507.5 g/mol
XLogP3	3.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	507.20819606 g/mol
Monoisotopic Mass	507.20819606 g/mol
Topological Polar Surface Area	110 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	815
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)

Drugs in Development

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Digital Content

Create Content with PharmaCompass, ask us

STOCK RECAP #PipelineProspector

NEWS #PharmaBuzz

ABOUT THIS PAGE

Find Remibrutinib manufacturers, exporters & distributors on PharmaCompass

Remibrutinib

ACCESS ALL DATA

Browse all information

CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

$ API Reference Price

DEVELOPMENTS

4 Drugs in Development

DIGITAL CONTENT

1 STOCK RECAP #PipelineProspector

1 NEWS #PharmaBuzz

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 3,782

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

4DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

What are you looking for?