Find Remogliflozin Etabonate manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 442201-24-3, Gsk-189075, Gsk-189075a, Gsk189075a, Remogliflozin etabonate [inn], Tr0qt6qsul
Molecular Formula
C26H38N2O9
Molecular Weight
522.6  g/mol
InChI Key
UAOCLDQAQNNEAX-ABMICEGHSA-N
FDA UNII
TR0QT6QSUL

Remogliflozin Etabonate
Remogliflozin Etabonate is an orally available prodrug of remogliflozin, a benzylpyrazole glucoside-based inhibitor of renal sodium-glucose co-transporter subtype 2 (SGLT2) with antihyperglycemic activity. Upon administration and absorption, the inactive prodrug is converted to its active form remogliflozin and acts selectively on the sodium-glucose co-transporter subtype 2 (SGLT2).
1 2D Structure

Remogliflozin Etabonate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
ethyl [(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[5-methyl-1-propan-2-yl-4-[(4-propan-2-yloxyphenyl)methyl]pyrazol-3-yl]oxyoxan-2-yl]methyl carbonate
2.1.2 InChI
InChI=1S/C26H38N2O9/c1-7-33-26(32)34-13-20-21(29)22(30)23(31)25(36-20)37-24-19(16(6)28(27-24)14(2)3)12-17-8-10-18(11-9-17)35-15(4)5/h8-11,14-15,20-23,25,29-31H,7,12-13H2,1-6H3/t20-,21-,22+,23-,25+/m1/s1
2.1.3 InChI Key
UAOCLDQAQNNEAX-ABMICEGHSA-N
2.1.4 Canonical SMILES
CCOC(=O)OCC1C(C(C(C(O1)OC2=NN(C(=C2CC3=CC=C(C=C3)OC(C)C)C)C(C)C)O)O)O
2.1.5 Isomeric SMILES
CCOC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)OC2=NN(C(=C2CC3=CC=C(C=C3)OC(C)C)C)C(C)C)O)O)O
2.2 Other Identifiers
2.2.1 UNII
TR0QT6QSUL
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-(4-isopropoxybenzyl)-1-isopropyl-5-methyl-1h-pyrazol-3-yl 6-o-(ethoxycarbonyl)-beta-d-glucopyranoside

2.3.2 Depositor-Supplied Synonyms

1. 442201-24-3

2. Gsk-189075

3. Gsk-189075a

4. Gsk189075a

5. Remogliflozin Etabonate [inn]

6. Tr0qt6qsul

7. Ethyl (((2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-((4-(4-isopropoxybenzyl)-1-isopropyl-5-methyl-1h-pyrazol-3-yl)oxy)tetrahydro-2h-pyran-2-yl)methyl) Carbonate

8. Ethyl [(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-[5-methyl-1-propan-2-yl-4-[(4-propan-2-yloxyphenyl)methyl]pyrazol-3-yl]oxyoxan-2-yl]methyl Carbonate

9. 5-methyl-4-(4-(1-methylethoxy)benzyl)-1-(1-methylethyl)-1h-pyrazol-3-yl 6-o-(ethoxycarbonyl)-beta-d-glucopyranoside

10. Unii-tr0qt6qsul

11. Kgt-1681

12. Remogliflozin Etabonate [usan]

13. Beta-d-glucopyranoside, 5-methyl-4-((4-(1-methylethoxy)phenyl)methyl)-1-(1-methylethyl)-1h-pyrazol-3-yl, 6-(ethyl Carbonate)

14. Beta-d-glucopyranoside, 5-methyl-4-[[4-(1-methylethoxy)phenyl]methyl]-1-(1-methylethyl)-1h-pyrazol-3-yl, 6-(ethyl Carbonate)

15. S0993

16. Schembl721678

17. Chembl2028665

18. Dtxsid50963191

19. Chebi:177541

20. Gsk 189075a

21. Zinc3979756

22. Remogliflozin Etabonate (usan/inn)

23. Bdbm50559516

24. Gsk189075

25. Bhv-091009

26. Db12935

27. Remogliflozin Etabonate (gsk189075)

28. Remogliflozin Etabonate [who-dd]

29. Br162756

30. Hy-14945

31. Cs-0003650

32. D10055

33. Q7312052

34. 3-(6-o-ethoxycarbonyl-beta-d-glucopyranosyloxy)-4-[(4-isopropoxyphenyl)-methyl]-1-isopropyl-5-methylpyrazole

35. 3-(6-o-ethoxycarbonyl-beta-d-glucopyranosyloxy)-4-[(4-isopropoxyphenyl)methyl]-1-isopropyl-5-methylpyrazole

36. 4-(4-isopropoxybenzyl)-1-isopropyl-5-methyl-1h-pyrazole-3-yl 6-o-(ethoxycarbonyl)-beta-d-glucopyranoside

37. 5-methyl-1-(propan-2-yl)-4-((4-((propan-2-yl)oxy)phenyl)methyl)-1h-pyrazol-3-yl 6-o-(ethoxycarbonyl)-.beta.-d-glucopyranoside

38. 5-methyl-4-(4-(1-methylethoxy)benzyl)-1-(1-methylethyl)-1h-pyrazol-3-yl 6-o- (ethoxycarbonyl)-.beta.-d-glucopyranoside

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 522.6 g/mol
Molecular Formula C26H38N2O9
XLogP33
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count12
Exact Mass522.25773079 g/mol
Monoisotopic Mass522.25773079 g/mol
Topological Polar Surface Area142 Ų
Heavy Atom Count37
Formal Charge0
Complexity704
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Sodium-Glucose Transporter 2 Inhibitors

Compounds that inhibit SODIUM-GLUCOSE TRANSPORTER 2. They lower blood sugar by preventing the reabsorption of glucose by the kidney and are used in the treatment of TYPE 2 DIABETES MELLITUS. (See all compounds classified as Sodium-Glucose Transporter 2 Inhibitors.)


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Looking for 442201-24-3 / Remogliflozin Etabonate API manufacturers, exporters & distributors?

Remogliflozin Etabonate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Remogliflozin Etabonate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Remogliflozin Etabonate manufacturer or Remogliflozin Etabonate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Remogliflozin Etabonate manufacturer or Remogliflozin Etabonate supplier.

PharmaCompass also assists you with knowing the Remogliflozin Etabonate API Price utilized in the formulation of products. Remogliflozin Etabonate API Price is not always fixed or binding as the Remogliflozin Etabonate Price is obtained through a variety of data sources. The Remogliflozin Etabonate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Remogliflozin Etabonate

Synonyms

442201-24-3, Gsk-189075, Gsk-189075a, Gsk189075a, Remogliflozin etabonate [inn], Tr0qt6qsul

Cas Number

442201-24-3

Unique Ingredient Identifier (UNII)

TR0QT6QSUL

About Remogliflozin Etabonate

Remogliflozin Etabonate is an orally available prodrug of remogliflozin, a benzylpyrazole glucoside-based inhibitor of renal sodium-glucose co-transporter subtype 2 (SGLT2) with antihyperglycemic activity. Upon administration and absorption, the inactive prodrug is converted to its active form remogliflozin and acts selectively on the sodium-glucose co-transporter subtype 2 (SGLT2).

Remogliflozin Etabonate Manufacturers

A Remogliflozin Etabonate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Remogliflozin Etabonate, including repackagers and relabelers. The FDA regulates Remogliflozin Etabonate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Remogliflozin Etabonate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Remogliflozin Etabonate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Remogliflozin Etabonate Suppliers

A Remogliflozin Etabonate supplier is an individual or a company that provides Remogliflozin Etabonate active pharmaceutical ingredient (API) or Remogliflozin Etabonate finished formulations upon request. The Remogliflozin Etabonate suppliers may include Remogliflozin Etabonate API manufacturers, exporters, distributors and traders.

click here to find a list of Remogliflozin Etabonate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Remogliflozin Etabonate GMP

Remogliflozin Etabonate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Remogliflozin Etabonate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Remogliflozin Etabonate GMP manufacturer or Remogliflozin Etabonate GMP API supplier for your needs.

Remogliflozin Etabonate CoA

A Remogliflozin Etabonate CoA (Certificate of Analysis) is a formal document that attests to Remogliflozin Etabonate's compliance with Remogliflozin Etabonate specifications and serves as a tool for batch-level quality control.

Remogliflozin Etabonate CoA mostly includes findings from lab analyses of a specific batch. For each Remogliflozin Etabonate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Remogliflozin Etabonate may be tested according to a variety of international standards, such as European Pharmacopoeia (Remogliflozin Etabonate EP), Remogliflozin Etabonate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Remogliflozin Etabonate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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