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Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Reproxalap, Adx-102, 916056-79-6, Reproxalap [usan], Ns-2, Ald-102
Molecular Formula
C12H13ClN2O
Molecular Weight
236.70  g/mol
InChI Key
GUHFUVLKYSQIOQ-UHFFFAOYSA-N
FDA UNII
F0GIZ22IJH

Reproxalap
Reproxalap (previously ADX 102 or NS-2) is a small molecule inhibitor being developed by Aldeyra Therapeutics investigated against dry eye disease, allergic conjunctivitis, noninfectious anterior uveitis, and Sjgren-Larsson syndrome. NS-2 has orphan drug status due to it being investigated for treatment of Sjogren-Larsson syndrome.
1 2D Structure

Reproxalap

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(3-amino-6-chloroquinolin-2-yl)propan-2-ol
2.1.2 InChI
InChI=1S/C12H13ClN2O/c1-12(2,16)11-9(14)6-7-5-8(13)3-4-10(7)15-11/h3-6,16H,14H2,1-2H3
2.1.3 InChI Key
GUHFUVLKYSQIOQ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)(C1=C(C=C2C=C(C=CC2=N1)Cl)N)O
2.2 Other Identifiers
2.2.1 UNII
F0GIZ22IJH
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Adx-102

2. Ald-102

3. Reproxalap

2.3.2 Depositor-Supplied Synonyms

1. Reproxalap

2. Adx-102

3. 916056-79-6

4. Reproxalap [usan]

5. Ns-2

6. Ald-102

7. F0giz22ijh

8. Reproxalap (usan)

9. Ns2

10. Reproxalap [inn]

11. Unii-f0giz22ijh

12. Adx102

13. Chembl4297210

14. Schembl12228833

15. Gtpl10613

16. Ex-a3715

17. Sb18931

18. Example 5 [wo2018039197a1]

19. Hy-107150

20. Cs-0027443

21. D11309

22. 2-(3-amino-6-chloroquinolin-2-yl)-propan-2-ol

23. 2-quinolinemethanol, 3-amino-6-chloro-alpha,alpha-dimethyl-

24. 2-quinolinemethanol, 3-amino-6-chloro-.alpha.,.alpha.-dimethyl-

2.4 Create Date
2007-06-18
3 Chemical and Physical Properties
Molecular Weight 236.70 g/mol
Molecular Formula C12H13ClN2O
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass236.0716407 g/mol
Monoisotopic Mass236.0716407 g/mol
Topological Polar Surface Area59.1 Ų
Heavy Atom Count16
Formal Charge0
Complexity259
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Mechanism of Action

Reproxalap inhibits Reactive Aldehyde Species (RASP) and is being investigated against dry eye disease, allergic conjunctivitis, noninfectious anterior uveitis, and Sjgren-Larsson syndrome.


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ABOUT THIS PAGE

Reproxalap Manufacturers

A Reproxalap manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Reproxalap, including repackagers and relabelers. The FDA regulates Reproxalap manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Reproxalap API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Reproxalap manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Reproxalap Suppliers

A Reproxalap supplier is an individual or a company that provides Reproxalap active pharmaceutical ingredient (API) or Reproxalap finished formulations upon request. The Reproxalap suppliers may include Reproxalap API manufacturers, exporters, distributors and traders.

click here to find a list of Reproxalap suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Reproxalap GMP

Reproxalap Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Reproxalap GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Reproxalap GMP manufacturer or Reproxalap GMP API supplier for your needs.

Reproxalap CoA

A Reproxalap CoA (Certificate of Analysis) is a formal document that attests to Reproxalap's compliance with Reproxalap specifications and serves as a tool for batch-level quality control.

Reproxalap CoA mostly includes findings from lab analyses of a specific batch. For each Reproxalap CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Reproxalap may be tested according to a variety of international standards, such as European Pharmacopoeia (Reproxalap EP), Reproxalap JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Reproxalap USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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