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RGI-2001

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 USDMF

1 API Suppliers
1 USDMF

DEVELOPMENTS

3 Drugs in Development

3 Drugs in Development

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

3DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Krn7000, 158021-47-7, Krn 7000, Krn-7000, Alpha-galactosylceramide, .alpha.-galcer

Molecular Formula

C₅₀H₉₉NO₉

Molecular Weight

858.3 g/mol

InChI Key

VQFKFAKEUMHBLV-BYSUZVQFSA-N

FDA UNII

WX671898JF

Alpha Galactosylceramide is a potent alpha galactosylceramide modified from marine-sponge that stimulates the immune system to exhibit antitumor activity.

1 2D Structure

RGI-2001

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[(2S,3S,4R)-3,4-dihydroxy-1-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadecan-2-yl]hexacosanamide

2.1.2 InChI

InChI=1S/C50H99NO9/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-27-29-31-33-35-37-39-45(54)51-42(41-59-50-49(58)48(57)47(56)44(40-52)60-50)46(55)43(53)38-36-34-32-30-28-16-14-12-10-8-6-4-2/h42-44,46-50,52-53,55-58H,3-41H2,1-2H3,(H,51,54)/t42-,43+,44+,46-,47-,48-,49+,50-/m0/s1

2.1.3 InChI Key

VQFKFAKEUMHBLV-BYSUZVQFSA-N

2.1.4 Canonical SMILES

CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO)O)O)O)C(C(CCCCCCCCCCCCCC)O)O

2.1.5 Isomeric SMILES

CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@@H]1[C@@H]([C@H]([C@H]([C@H](O1)CO)O)O)O)[C@@H]([C@@H](CCCCCCCCCCCCCC)O)O

2.2 Other Identifiers

2.2.1 UNII

WX671898JF

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Krn 7000

2. Krn 7000, 1s-(1r*,2r*,3s*)-beta-d-galacto Isomer

3. Krn-7000

4. Krn7000

2.3.2 Depositor-Supplied Synonyms

1. Krn7000

2. 158021-47-7

3. Krn 7000

4. Krn-7000

5. Alpha-galactosylceramide

6. .alpha.-galcer

7. Ccris 8968

8. Agl-582

9. Galalpha-cer(t18:0/26:0)

10. Chebi:466659

11. 1-o-(alpha-d-galactopyranosyl)-n-hexacosanoylphytosphingosine

12. Alpha-galcer(t18:0/26:0)

13. Wx671898jf

14. Rgi-7000

15. (2s,3s,4r)-1-o-(alpha-d-galactosyl)-n-hexacosanoyl-2-amino-1,3,4-octadecanetriol

16. N-{(1s,2r,3s)-1-[(alpha-d-galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl}hexacosanamide

17. N-[(2s,3s,4r)-1-(alpha-d-galactopyranosyloxy)-3,4-dihydroxyoctadecan-2-yl]hexacosanamide

18. N-((2s,3s,4r)-3,4-dihydroxy-1-(((2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)octadecan-2-yl)hexacosanamide

19. Unii-wx671898jf

20. Rgi-2001

21. Alpha-gc(c26)

22. Alpha-gc (c26)

23. Alpha-galactosyl Ceramide

24. Epitope Id:130694

25. Schembl512949

26. Chembl384200

27. Dtxsid40935847

28. Chemid158021477

29. Glxc-26234

30. Ex-a5755

31. Mfcd00939559

32. Zinc87496076

33. Db12232

34. Ac-31508

35. N-[(2s,3s,4r)-3,4-dihydroxy-1-[(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadecan-2-yl]hexacosanamide

36. C16892

37. Alpha-galactosylceramide(a-gal-cer) (synthetic)

38. Q27105159

39. 1-o-(alpha-d-galactosyl)-n-hexacosanoylphytosphingosine

40. (2s,3s,4r)-1-o-(alpha-d-galactosyl)-n-hexacosanoyl-2-amino-1,3,4-octadecanetriol, >=95% (tlc)

41. Hexacosanamide, N-((1s,2s,3r)-1-((.alpha.-d-galactopyranosyloxy)methyl)-2,3-dihydroxyheptadecyl)-

42. Hexacosanamide, N-(1-((alpha-d-galactopyranosyloxy)methyl)-2,3-dihdyroxyheptadecyl)-, (1s-(1r*,2r*,3s*))-

43. Hexacosanamide, N-[(1s,2s,3r)-1-[(alpha-d-galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl]-

44. Hexacosanamide, N-[(1s,2s,3r)-1-[(alpha-d-galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl]- (9ci)

45. Hexacosanamide, N-[1-[(alpha-d-galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl]-, [1s-(1r*,2r*,3s*)]-

46. N-((2s,3s,4r)-3,4-dihydroxy-1-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yloxy)octadecan-2-yl)hexaicosanamide

47. N-{(1s,2s,3r)-1-[(alpha-d-galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl}hexacosanamide

48. Wurcs=2.0/1,1,0/[a2112h-1a_1-5_1*occ^sc^sc^rcccccccccccccc/6o/5o/4ncccccccccccccccccccccccccc/24=o]/1/

2.4 Create Date

2005-07-20

3 Chemical and Physical Properties

Molecular Formula	C₅₀H₉₉NO₉
Molecular Weight	858.3 g/mol
XLogP3	16
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	44
Exact Mass	857.73198374 g/mol
Monoisotopic Mass	857.73198374 g/mol
Topological Polar Surface Area	169 Å²
Heavy Atom Count	60
Formal Charge	0
Complexity	928
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adjuvants, Immunologic

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

API SUPPLIERS

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USDMF

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Drugs in Development

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ABOUT THIS PAGE

RGI-2001 Manufacturers

A RGI-2001 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of RGI-2001, including repackagers and relabelers. The FDA regulates RGI-2001 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. RGI-2001 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

RGI-2001 Suppliers

A RGI-2001 supplier is an individual or a company that provides RGI-2001 active pharmaceutical ingredient (API) or RGI-2001 finished formulations upon request. The RGI-2001 suppliers may include RGI-2001 API manufacturers, exporters, distributors and traders.

click here to find a list of RGI-2001 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

RGI-2001 USDMF

A RGI-2001 DMF (Drug Master File) is a document detailing the whole manufacturing process of RGI-2001 active pharmaceutical ingredient (API) in detail. Different forms of RGI-2001 DMFs exist exist since differing nations have different regulations, such as RGI-2001 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A RGI-2001 DMF submitted to regulatory agencies in the US is known as a USDMF. RGI-2001 USDMF includes data on RGI-2001's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The RGI-2001 USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of RGI-2001 suppliers with USDMF on PharmaCompass.

RGI-2001 GMP

RGI-2001 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of RGI-2001 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right RGI-2001 GMP manufacturer or RGI-2001 GMP API supplier for your needs.

RGI-2001 CoA

A RGI-2001 CoA (Certificate of Analysis) is a formal document that attests to RGI-2001's compliance with RGI-2001 specifications and serves as a tool for batch-level quality control.

RGI-2001 CoA mostly includes findings from lab analyses of a specific batch. For each RGI-2001 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

RGI-2001 may be tested according to a variety of international standards, such as European Pharmacopoeia (RGI-2001 EP), RGI-2001 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (RGI-2001 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.