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Synopsis

Synopsis

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Chemistry

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Also known as: Antibiotic wf-1360, Wf-1360, 90996-54-6, Chebi:72590, C1v1y784e4, Nsc-332598
Molecular Formula
C35H47NO9
Molecular Weight
625.7  g/mol
InChI Key
OWPCHSCAPHNHAV-QIPOKPRISA-N
FDA UNII
C1V1Y784E4

Rhizoxin
Rhizoxin is a macrocyclic lactone. Rhizoxin binds to tubulin and inhibits microtubule assembly, thereby inducing cytotoxicity. This agent also may inhibit endothelial cell-induced angiogenic activity, which may result in decreased tumor cell proliferation. (NCI04)
1 2D Structure

Rhizoxin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1S,3S,5R,8S,10S,11R,13R,14E,16R,17R)-10-hydroxy-8-[(2S,3R,4E,6E,8E)-3-methoxy-4,8-dimethyl-9-(2-methyl-1,3-oxazol-4-yl)nona-4,6,8-trien-2-yl]-11,16-dimethyl-4,7,12,18-tetraoxatetracyclo[15.3.1.03,5.011,13]henicos-14-ene-6,19-dione
2.1.2 InChI
InChI=1S/C35H47NO9/c1-19(13-25-18-41-23(5)36-25)9-8-10-21(3)32(40-7)22(4)27-17-29(37)35(6)30(45-35)12-11-20(2)26-14-24(16-31(38)42-26)15-28-33(43-28)34(39)44-27/h8-13,18,20,22,24,26-30,32-33,37H,14-17H2,1-7H3/b9-8+,12-11+,19-13+,21-10+/t20-,22+,24+,26-,27+,28+,29+,30-,32+,33-,35-/m1/s1
2.1.3 InChI Key
OWPCHSCAPHNHAV-QIPOKPRISA-N
2.1.4 Canonical SMILES
CC1C=CC2C(O2)(C(CC(OC(=O)C3C(O3)CC4CC1OC(=O)C4)C(C)C(C(=CC=CC(=CC5=COC(=N5)C)C)C)OC)O)C
2.1.5 Isomeric SMILES
C[C@@H]1/C=C/[C@@H]2[C@](O2)([C@H](C[C@H](OC(=O)[C@H]3[C@@H](O3)C[C@@H]4C[C@H]1OC(=O)C4)[C@H](C)[C@H](/C(=C/C=C/C(=C/C5=COC(=N5)C)/C)/C)OC)O)C
2.2 Other Identifiers
2.2.1 UNII
C1V1Y784E4
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Wf 1360b

2. Wf 1360c

3. Wf 1360e

4. Wf 1360f

5. Wf-1360

6. Wf1360

2.3.2 Depositor-Supplied Synonyms

1. Antibiotic Wf-1360

2. Wf-1360

3. 90996-54-6

4. Chebi:72590

5. C1v1y784e4

6. Nsc-332598

7. Fr-900216

8. (1s,3s,5r,8s,10s,11r,13r,14e,16r,17r)-10-hydroxy-8-[(2s,3r,4e,6e,8e)-3-methoxy-4,8-dimethyl-9-(2-methyl-1,3-oxazol-4-yl)nona-4,6,8-trien-2-yl]-11,16-dimethyl-4,7,12,18-tetraoxatetracyclo[15.3.1.0(3,5).0(11,13)]henicos-14-ene-6,19-dione

9. (1s,3s,5r,8s,10s,11r,13r,16r,17r,e)-10-hydroxy-8-((2s,3r,4e,6e,8e)-3-methoxy-4,8-dimethyl-9-(2-methyloxazol-4-yl)nona-4,6,8-trien-2-yl)-11,16-dimethyl-4,7,12,18-tetraoxatetracyclo[15.3.1.03,5.011,13]henicos-14-ene-6,19-dione

10. Nsc 332598

11. Brn 5692896

12. Unii-c1v1y784e4

13. Nsc332598

14. Rhizoxin [mi]

15. Schembl15955

16. Chembl379989

17. Dtxsid20897515

18. Crc-87/01

19. E-87/010

20. Q10861060

21. (1s,3s,5r,8s,10s,11r,13r,14e,16r,17r)-10-hydroxy-8-[(2s,3r,4e,6e,8e)-3-methoxy-4,8-dimethyl-9-(2-methyl-1,3-oxazol-4-yl)nona-4,6,8-trien-2-yl]-11,16-dimethyl-4,7,12,18-tetraoxatetracyclo[15.3.1.03,5.011,13]henicos-14-ene-6,19-dione

22. (1s-(1r*,3r*,5s*,8r*(1r*,2s*,3e,5e,7e),10r*,11s*,13s*,14e,16s*,17s*))-10-hydroxy-8-(2-methoxy-1,3,7-trimethyl-8-(2-methyl-4-oxazolyl)-3,5,7-octatrienyl)-11,16-dimethyl-4,7,12,18-tetraoxatetracyclo(15.3.1.03,5.011,13)heneicos-14-ene-6,19-dione

23. 4,7,12,18-tetraoxatetracyclo(15.3.1.03,5.011,13)heneicos-14-ene-6,19-dione, 10-hydroxy-8-(2-methoxy-1,3,7-trimethyl-8-(2-methyl-4-oxazolyl)-3,5,7-octatrienyl)-11,16-dimethyl-, (1s-(1r*,3r*,5s*,8r*(1r*,2s*,3e,5e,7e),10r*,11s*,13s*,14e,16s*,17s*))-

24. 4,7,12,18-tetraoxatetracyclo[15.3.1.03,5.011,13]heneicos-14-ene-6,19-dione, 10-hydroxy-8-[(1s,2r,3e,5e,7e)-2-methoxy-1,3,7-trimethyl-8-(2-methyl-4-oxazolyl)-3,5,7-octatrienyl]-11,16-dimethyl-, (1s,3s,5r,8s,10s,11r,13r,16s,17r)-

25. Hydroxy-[(1s,2r,3e,5e,7e)-2-methoxy-1,3,7-trimethyl-8-(2-methyloxazol-4-yl)octa-3,5,7-trienyl]-dimethyl-[?]dione

2.4 Create Date
2006-04-28
3 Chemical and Physical Properties
Molecular Weight 625.7 g/mol
Molecular Formula C35H47NO9
XLogP35.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass625.32508208 g/mol
Monoisotopic Mass625.32508208 g/mol
Topological Polar Surface Area133 Ų
Heavy Atom Count45
Formal Charge0
Complexity1210
Isotope Atom Count0
Defined Atom Stereocenter Count11
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count4
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antibiotics, Antineoplastic

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)


Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


Tubulin Modulators

Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES. (See all compounds classified as Tubulin Modulators.)


ABOUT THIS PAGE

Rhizoxin Manufacturers

A Rhizoxin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Rhizoxin, including repackagers and relabelers. The FDA regulates Rhizoxin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Rhizoxin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Rhizoxin Suppliers

A Rhizoxin supplier is an individual or a company that provides Rhizoxin active pharmaceutical ingredient (API) or Rhizoxin finished formulations upon request. The Rhizoxin suppliers may include Rhizoxin API manufacturers, exporters, distributors and traders.

click here to find a list of Rhizoxin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Rhizoxin USDMF

A Rhizoxin DMF (Drug Master File) is a document detailing the whole manufacturing process of Rhizoxin active pharmaceutical ingredient (API) in detail. Different forms of Rhizoxin DMFs exist exist since differing nations have different regulations, such as Rhizoxin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Rhizoxin DMF submitted to regulatory agencies in the US is known as a USDMF. Rhizoxin USDMF includes data on Rhizoxin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Rhizoxin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Rhizoxin suppliers with USDMF on PharmaCompass.

Rhizoxin GMP

Rhizoxin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Rhizoxin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Rhizoxin GMP manufacturer or Rhizoxin GMP API supplier for your needs.

Rhizoxin CoA

A Rhizoxin CoA (Certificate of Analysis) is a formal document that attests to Rhizoxin's compliance with Rhizoxin specifications and serves as a tool for batch-level quality control.

Rhizoxin CoA mostly includes findings from lab analyses of a specific batch. For each Rhizoxin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Rhizoxin may be tested according to a variety of international standards, such as European Pharmacopoeia (Rhizoxin EP), Rhizoxin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Rhizoxin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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